Biological trait markers of depression. Medical search. Frequent questions

The time has come to ask if we have invented a science (psychiatry) that has little to do with reality, and to answer that, the creation of multicentric data bases is proposed, in which biological (not just brain based), social, personal, clinical, etc. variables are integrated, to finally obtain correlations that allow us a reclassification of brain pathology that would be useful to offer integral and personalized treatments. (bvsalud.org)
Three months after quitting smoking, levels of dopamine in the brain return to normal, according to a new study published in the journal Biological Psychiatry . (psychcentral.com)
This observation raises the possibility that one might target these deficits with new treatments," said Dr. John Krystal, editor of Biological Psychiatry . (psychcentral.com)
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging , 2 (7), 619-625. (northwestern.edu)
Together, this work has resulted in multiple peer-reviewed publications in leading national and international journals including Molecular Psychiatry and Biological Psychiatry . (edu.au)

Specifically, borderline personality disorder traits were significantly more strongly associated with composite explicit self-concept measures than any of depression, anxiety, or autism traits scores were. (biomedcentral.com)
Therefore, "females are 'protected' from the combined effects of autism-linked genes, such that it takes a larger number of random genetic events for them to manifest autism traits" (Wigdor et al. (autism.org)

However, stigma, discrimination, and negative experiences can contribute to stress that puts transgender at risk for problems like depression and anxiety. (lifespan.org)
Our final dataset includes within-subject (n = 288, general population) measures of explicit self-concept (using both the Self Concept Clarity Scale and Self Concept and Identity Measure), implicit self-prioritisation in a shape-label matching task (for both reaction time and sensitivity) and measurement of traits for five psychiatric conditions (autism, borderline personality disorder, schizophrenia, depression and anxiety). (biomedcentral.com)
An aggressive behavior assessment, the Self-Rating Depression Scale (SDS), and the State-Trait Anxiety Inventory (STAI) were used to characterize the participants' mental health status. (hindawi.com)
Many ADHD adults therefore struggle with anxiety, depression, and imposter syndrome. (feverpr.com)
Associations of depression-anxiety and dyslipidaemia with subclinical carotid arterial disease: Findings from the Whitehall II Study. (ucl.ac.uk)
Many of these veterans have met screening or diagnostic criteria for PTSD (20%-39%), often co-occurring with depression, anxiety, substance use disorders, and chronic pain (7,8). (cdc.gov)

Depression is the most common psychiatric disorder worldwide. (biomedcentral.com)
Each testing visit involved the patients being given a psychiatric score using the "Hamilton Rating Scale for Depression-17. (medicalnewstoday.com)
This study explores the relations between different constructs of self-cognition and how variability within them relates to psychiatric traits. (biomedcentral.com)
We then test whether these dimensions of self-cognition support a binary distinction between psychiatric conditions that either are or are not characterised in terms of self, or whether they support self-cognition as transdiagnostically predictive of the traits associated with psychiatric conditions. (biomedcentral.com)
Results show that implicit self-prioritisation measures were not correlated with the explicit self-concept measures nor the psychiatric trait measures. (biomedcentral.com)
In contrast, all the psychiatric traits scores were predicted, to varying degrees, by poorer explicit self-concept quality. (biomedcentral.com)
Independently, each of these traits is a symptom of a myriad of different psychiatric disorders. (bipolarchild.com)

Developing models to understand complex trait genetics. (colorado.edu)
GCTA: a tool for genome-wide complex trait analysis. (research.com)

Researchers believe that some individuals possess certain traits making them more vulnerable to addiction. (psychcentral.com)

Studies in human monozygotic twins have provided evidence that genetic factors affect "normal" sleep patterns as well, meaning ones where no individual has been diagnosed with an altered phenotypic sleep trait. (wikipedia.org)

In this 1999 publication, researchers were also able to conclude that this trait has an autosomal dominant mode of inheritance with high penetrance. (wikipedia.org)
This category is inherited as an autosomal recessive trait and is characterized by altered peroxisome assembly, resulting in multiple peroxisome enzyme deficiencies, complex developmental sequelae, and progressive disabilities. (medscape.com)

Major depression accounts for 60% of suicides, followed by schizophrenia , alcoholism, substance abuse, borderline personality disorder , Huntington's disease, and epilepsy. (minddisorders.com)
Hyper-connection of critical brain structures for emotion, specifically the limbic system comprising the amygdala, hippocampus and other critical structures, was therefore thought to be the biological underpinning that determined hyper-religiosity and other personality features in TLE. (buddhiclinic.com)
Relationship of monoamine oxidase A binding to adaptive and maladaptive personality traits. (mpg.de)
Second, it attributes her experiences to socially unacceptable characteristics or personality traits. (healthyplace.com)
Indeed, scientists have found genetic linkages to a number of behavioral characteristics, ranging from basic personality traits to sexual orientation to spirituality (for examples, see Mustanski et al. (coursehero.com)

Familial sleep traits are more specific than CRSD because they are heritable and involve a wide range of Mendelian genes. (wikipedia.org)
In humans, there are multiple genes involved in this molecular biological clock, which when mutated may result in sleep disorders such as Familial Advanced Sleep Phase (FASP), Familial Delayed Sleep Phase (FDSP), and Familial Natural Short Sleep (FNSS). (wikipedia.org)
Some mutations in Mendelian genes that are involved in the TTFL have been identified as the causes of these sleep traits, including PER2, PER3, CRY2, CRY1. (wikipedia.org)
We applied novel statistical tools for polygenic architectures to investigate if there are common genes for depression, coronary artery disease and cardiovascular risk factors (body mass index, blood pressure, lipids, type 2 diabetes and c-reactive protein). (plos.org)
in particular, genetic markers of risk, and integrating these genes with core brain and body measures including magnetic resonance imaging (MRI), electroencephalography (EEG), and electrocardiography (ECG). (edu.au)
In recent decades, developments for molecular genetics have assisted in the discovery of genes or markers associated with traits that affect the quality of meat. (innspub.net)
Although we are all biological organisms, we also exist in an environment that is incredibly important in determining not only when and how our genes express themselves, but also in what combination. (coursehero.com)
Genes are also associated with temperament and a number of psychological disorders, such as depression and schizophrenia. (coursehero.com)
So while it is true that genes provide the biological blueprints for our cells, tissues, organs, and body, they also have significant impact on our experiences and our behaviors. (coursehero.com)

We here investigated overlap at the genome-wide level and in individual loci between depression, coronary artery disease and cardiovascular risk factors. (plos.org)
We used the bivariate causal mixture model (MiXeR) to quantify genome-wide polygenic overlap and the conditional/conjunctional false discovery rate (pleioFDR) method to identify shared loci, based on genome-wide association study summary statistics on depression (n = 450,619), coronary artery disease (n = 502,713) and nine cardiovascular risk factors (n = 204,402-776,078). (plos.org)
Peter M. Visscher mainly focuses on Genetics, Genome-wide association study, Genetic association, Single-nucleotide polymorphism and Quantitative trait locus. (research.com)

The high heritability of the FOH trait, refinement of the dimensionally derived symptoms that associate with it, and the fact that the CBQ can identify with 96% accuracy children whose profiles fit the phenotype make us optimistic that we are on the right path for a meaningful genetic analysis. (bipolarchild.com)
His is doing research in Gene, Heritability, Quantitative trait locus, Genetic variation and Genome, both of which are found in Genetics. (research.com)

Precision medicine (PM) is personalized medicine that can develop targeted medical therapies for the individual patient, in which "omics" sciences lead to an integration of data that leads to highly predictive models of the functioning of the individual biological system. (cdc.gov)

His Genetics and Genetic variation, Quantitative trait locus, Linkage disequilibrium, Human height and Gene investigations all form part of his Genetics research activities. (research.com)
1997. DNA marker technology: a revolution in animal genetics. (innspub.net)

Familial sleep traits are heritable variations in sleep patterns, resulting in abnormal sleep-wake times and/or abnormal sleep length. (wikipedia.org)
Disruptions to these rhythms in humans may affect the duration, onset, and/or quality of sleep during this cycle, resulting in familial sleep traits. (wikipedia.org)
Instead of being disorders, familial sleep traits are variations in an individual's biological tendencies of sleep-wake times, and are only considered syndromes if affected individuals complain about life interference, in which case they may fall under the category of Circadian Rhythm Sleep Disorders (CRSD) that affect sleep timing and circadian rhythms. (wikipedia.org)
With some familial sleep traits, there may be a shift in an individual's chronotype, which describes the time of sleep-wake behaviors that result from circadian rhythms. (wikipedia.org)
Familial sleep traits have been difficult to study due to the various environmental influences (such as entraining daily alarms, artificial light at night, and caffeine or stimulant intake) that can contribute to different behavioral phenotypes in humans. (wikipedia.org)
We previously reported that cortical thinning may serve as a potential biomarker for risk for familial depression. (northwestern.edu)
We now test stability of cortical thinning across 8 years, and whether thinning mediates associations between familial risk and depressive traits. (northwestern.edu)
Thinning at the first time point predicted anger and hostility at the second time point and mediated the relationship between familial risk and these traits. (northwestern.edu)

These meta-analyses consistently show that depression increases the risk of overall mortality (RR = 1.81) and the development of cardiovascular-related outcomes, such as heart disease (RR = 1.81), diabetes (RR = 1.60), hypertension (RR = 1.42), stroke (RR = 1.34) and obesity (RR = 1.58). (biomedcentral.com)
Meta-analyses also indicate that depression increases the risk of developing Alzheimer's disease (RR = 1.66) and to a lesser extent even cancer (RR = 1.29). (biomedcentral.com)
Most meta-analyses have been based on longitudinal studies using depressive symptom checklists which pick up many subthreshold depression cases. (biomedcentral.com)

Circadian rhythms are coordinated physiological and biological changes that oscillate on an approximately 24-hour cycle. (wikipedia.org)
Aside from inborn physiological reflexes, no behavior or psychological trait is truly hard-wired. (mypsychology.my)

These seem to be good markers for suicidal behavior in males who have bipolar mood disorders or males in the general population who commit impulsive violent suicide," adds Dr. Niculescu. (medicalnewstoday.com)

The heterogeneity of the depression concept seems to play a differentiating role: metabolic syndrome and inflammation up-regulations appear more specific to the atypical depression subtype, whereas hypercortisolemia appears more specific for melancholic depression. (biomedcentral.com)

The Marine Resiliency Study (MRS) is singular among these investigations in its combined study of operational units and its biological, psychological, and social scope. (cdc.gov)

This review finishes with potential treatment implications for the downward spiral in which different depressive symptom profiles and biological dysregulations may impact on each other and interact with somatic health decline. (biomedcentral.com)
When depressive feelings turn into a chronic, disabling disorder interfering with daily life, a clinical diagnosis of major depressive disorder (MDD or shortly termed depression) ensues. (biomedcentral.com)
Methods Participants were from a three-generation family study of depression, where second- and third-generation offspring were characterized as being at high or low risk for depression based on the presence/absence of major depressive disorder in the first generation. (northwestern.edu)

Depression refers to a range of mental problems characterized by loss of interest and enjoyment in ordinary experiences, low mood and associated emotional, cognitive, physical and behavioral symptoms. (biomedcentral.com)
They are being prohibited from playing sports, changing their names or gender markers on legal documents, accessing support at school, and obtaining essential, even lifesaving, medical and behavioral health care. (lifespan.org)
In the multivariate adjusted models, after controlling for age, education, marital status, and BMI, we found a positive association between NH 3 and prisoners, but not blood H 2 S. While the functions of the two toxicants were quite different, blood NH 3 may be a potential biological risk factor for behavioral disorders and blood H 2 S showed neuroprotection. (hindawi.com)
Raised for dozens of generations in the lab of senior author Huda Akil, Ph.D., at the U-M Molecular and Behavioral Neuroscience Institute under carefully controlled conditions, the two breeds act as a way to study the effects of genetic and inherited traits on addiction-related behaviors. (technologynetworks.com)
While traits like mania and depression remain important, this analysis finds that they are not the central behavioral dimensions of PBD. (bipolarchild.com)

The list of symptoms above is in no way all-encompassing and does not include many ADHD traits that lead to employees with ADHD being more motivated and productive than their peers. (feverpr.com)
Most measures of depression severity are based on the number of reported symptoms, and threshold scores are often used to classify individuals as healthy or depressed. (biomedcentral.com)
This method - and research results based on it - are valid if depression is a single condition, and all symptoms are equally good severity indicators. (biomedcentral.com)
Furthermore, specific life events predict increases in particular depression symptoms, and there is evidence for direct causal links among symptoms. (biomedcentral.com)
This practice of constructing sum-scores and collapsing individuals with different symptoms into one undifferentiated category is based on the assumption that depression is a single condition, and that all symptoms are interchangeable and equally good indicators. (biomedcentral.com)
Patients may first experience other symptoms, including reduced sense of smell, sleep disturbances, depression , and constipation , alongside very few motor symptoms or even none at all. (medscape.com)

Due to the exposure of African Americans to a unique trajectory of stressors throughout life, it may be critical to understand the relationship between psychosocial stress and underlying biological mechanisms that influence disease activity and pathology in this high risk group. (scirp.org)
Measures of psychosocial and biological indicators of stress were collected in all of the patients in each of the study conditions before and after intervention activities, as well as four months' post-intervention, to assess the effectiveness of the program in reducing perceived and biological indicators of stress. (scirp.org)

Our results showed polygenic overlap between depression, coronary artery disease and several cardiovascular risk factors and suggest molecular mechanisms underlying the association between depression and increased cardiovascular disease risk. (plos.org)

NIMH R25 MH019918 2/2024-1/2029 Workshop on statistical genetic methods for human complex traits. (colorado.edu)

We suggest that the pervasive use of sum-scores to estimate depression severity has obfuscated crucial insights and contributed to the lack of progress in key research areas such as identifying biomarkers and more efficacious antidepressants. (biomedcentral.com)

Epidemiological and clinical studies have found associations between depression and cardiovascular disease risk factors, and coronary artery disease patients with depression have worse prognosis. (plos.org)
One study found that the plasma level of H 2 S was markedly lower in patients with depression [ 14 ]. (hindawi.com)

The active compound curcumin is believed to have a wide range of biological effects including anti-inflammatory, antioxidant, antitumor, antibacterial, and antiviral activities, which have shown a lot of potential for use in clinical medicine. (blogspot.com)
Peroxisome biogenesis disorders: Biological, clinical and pathophysiological perspectives. (medscape.com)
The biological properties and clinical potential of stem cells elicit that are generated must not be unduly sensitive to small fluctu- continued scientific, commercial, and public interest. (lu.se)

This study highlights the importance of investigating evolutionary changes in reproductive strategy and associated traits during biological invasions. (plos.org)
Overweight and obesity are associated with neuronal injury in the human cerebellum and hippocampus in young adults: A combined MRI, serum marker and gene expression study. (mpg.de)
The various areas that Peter M. Visscher examines in his Quantitative trait locus study include Genetic marker, Expression quantitative trait loci, Genetic linkage, Linkage and Family-based QTL mapping. (research.com)

According to Seligman, pessimistic people are two to eight times more at risk of depression, a significant statistic in a country that seems a half step away from putting Prozac in its drinking water. (lisefunderburg.com)
Depression has been shown to subsequently increase the risk of, for example, cardiovascular, stroke, diabetes and obesity morbidity. (biomedcentral.com)
ConjFDR identified 79 unique loci associated with depression and coronary artery disease or cardiovascular risk factors. (plos.org)
Loci associated with increased risk for depression were also associated with increased risk of coronary artery disease and higher total cholesterol, low-density lipoprotein and c-reactive protein levels, while there was a mixed pattern of effect direction for the other risk factors. (plos.org)
Studies have found associations between depression and both cardiovascular disease risk factors and worse cardiovascular disease prognosis. (plos.org)
We also identified 79 unique genomic variants associated with depression and coronary artery disease or the risk factors. (plos.org)
She took up a postdoctoral research position at the Brain Dynamics Centre based within the Westmead Millennium Institute, with a focus on the genetic and brain markers of risk for mental health. (edu.au)

Isn't bipolar disorder all about mania and depression? (bipolarchild.com)
This novel understanding of the dimensions of bipolar disorder in childhood puts us on much firmer footing as we move towards the identification of biological markers. (bipolarchild.com)

We recorded the identity of the first male to copulate and after the 48 h-period, we examined female fecundity and share of paternity, using molecular markers. (plos.org)

Cutoff values based on sum-scores from rating scales such as the Beck Depression Inventory (BDI) [ 8 ] or the Hamilton Rating Scale for Depression (HRSD) [ 9 ] are routinely used as the main criterion to enroll participants in research studies. (biomedcentral.com)

Background A biological marker of vulnerability should precede onset of illness and be independent of disease course. (northwestern.edu)

In patients who are untreated or diagnosed late, severe neurological impairment, wasting, and depression develop, subsequently leading to a high mortality rate. (medscape.com)
Non-invasive fatty liver markers predict liver disease mortality in the United States population. (cdc.gov)

The researchers say they found that the marker SAT1, alongside a series of others, was a strong "biological signal" associated with suicidal thoughts. (medicalnewstoday.com)
The researchers expected this deficit to remain even after quitting, which would suggest it could be a marker of vulnerability for nicotine addiction. (psychcentral.com)

Proceedings of the Royal Society B:Biological Sciences 290(2006): 20231668. (sb-roscoff.fr)

While it is good to be reminded that we are ultimately biological beings who developed strategies to survive our evolutionary past, 'hard-wired' is a very misleading and inaccurate word. (mypsychology.my)
Reproductive strategy affects population dynamics and genetic parameters that can, in turn, affect evolutionary processes during the course of biological invasion. (plos.org)
Life-history traits associated with reproductive strategy are therefore potentially good candidates for rapid evolutionary shifts during invasions. (plos.org)

They published a paper in 2001 that presented data showing a phenotypically characterized case of Advanced Sleep Phase Syndrome to provide further evidence that this trait can be hereditary. (wikipedia.org)
Evidence linking depression to metabolic syndrome abnormalities indicates that depression is especially associated with its obesity-related components (for example, abdominal obesity and dyslipidemia). (biomedcentral.com)

Results: Participation in the workshops had large effects upon depression (d = 1.63 and d = 1.68), social/role activities limitations (d =1.15), health distress (d = 1.13 and d = 0.78), fatigue (d = 1.03), pain (d = 0.96), and lupus self-efficacy (d = 0.85). (scirp.org)
Opposing effects of plant traits on diversification. (sb-roscoff.fr)
Serotonin transporter occupancy and the functional neuroanatomic effects of citalopram in geriatric depression. (mpg.de)

Now suffering from a host of medical complications as a result of years of hormone treatment, including phantom pain in his groin and bouts of severe depression, he is five years into his detransition journey and is reintegrating with his anatomically male body. (christianpost.com)

The observed increased somatic risks associated with depression are substantial. (biomedcentral.com)

But the findings reveal new information about the roles played by both inherited traits and addiction-related changes in the brain. (technologynetworks.com)

It is a big problem in the civilian realm, it is a big problem in the military realm and there are no objective markers. (medicalnewstoday.com)

These results suggest that Red Sindhi cattle breed can be implied for breed admixture and marker assisted selection in cattle breeding. (innspub.net)

Sex" (female or male) is based on chromosomes, gonads, hormones, and genitals and is a biological descriptive which does not consider lived experiences or the influence of social and cultural structures (Mulak et al. (autism.org)

Bear and Fedio (1977) provided a biological explanation for this syndrome (the sensory-limbic hyperconnection" hypothesis). (buddhiclinic.com)

It's also the first demonstration that a DNA tag called an epigenetic marker can predispose an individual to addiction and relapse. (technologynetworks.com)
The more that addiction is seen as having biological roots and origins in genetic traits that are inherited through families or amplified by drug taking, the better treatment options and public policy around drugs and drug users can be, she hopes. (technologynetworks.com)

Biological embedding of chronic stress across two generations within marginalized communities. (utah.edu)

Depression is one of the most prevalent diseases globally: 6% of the population meets the MDD criteria at a specific time point. (biomedcentral.com)

Of 13.9K variants influencing depression, 9.5K (SD 1.0K) were shared with body-mass index. (plos.org)
Of 4.4K variants influencing systolic blood pressure, 2K were shared with depression. (plos.org)
Depression shared 68% of genetic variants with body mass index and 14% and with systolic blood pressure. (plos.org)

This is largely due to the facts that depression is common, has a major impact on functioning and quality of life, and affects persons often in early life and for sustained periods, thereby causing many disease years. (biomedcentral.com)

periods of hyperfocus, 'masking' (hiding neurodivergent traits), and lengthy to-do lists can take their toll. (feverpr.com)

Anatomy8

Organisms2

Diseases7

Chemicals and Drugs15

Analytical, Diagnostic and Therapeutic Techniques and Equipment45

Psychiatry and Psychology35

Phenomena and Processes54

Disciplines and Occupations5

Anthropology, Education, Sociology and Social Phenomena8

Technology, Industry, Agriculture1

Humanities1

Information Science10

Named Groups1

Health Care33

Geographicals1

Psychiatry5

Autism traits2

Anxiety6

Psychiatric7

Complex trait2

Certain traits1

Phenotypic1

Autosomal2

Personality5

Genes9

Genome-wide3

Heritability2

Predictive1

Genetics2

Familial8

Meta-analyses3

Physiological2

Behavior1

Heterogeneity1

Psychological1

Depressive3

Behavioral5

Symptoms6

Psychosocial2

Mechanisms1

Methods1

Insights1

Patients with depression2

Clinical3

Study3

Risk7

Bipolar2

Molecular1

Participants1

Illness1

Mortality2

Researchers2

Sciences1

Evolutionary3

Evidence2

Effects3

Severe1

Risks1

Findings1

Objective1

Results1

Social1

Syndrome1

Addiction2

Chronic1

Diseases1

Variants3

Major1

Periods1