Biological target proteins inhibitor protein. Medical search. Frequent questions

Pexmetinib is a potent inhibitor of cytokine synthesis, via the dual inhibition of p38 mitogen-activated protein kinase (MAPK), and Tie2/Tek receptor tyrosine kinase. (adooq.com)
Potent inhibitor of protein phosphatase 1 (PP1) and 2A (PP2A). (enzolifesciences.com)
Palcitoclax [APG-1252] is a novel and potent inhibitor of the Bcl-2 family of proteins and induces apoptosis in tumor cells. (pharmiweb.com)
1 Moreover, taurine is a potent inhibitor of protein glycation and formation of AGEs (advanced glycation endproducts) that are responsible for many of the complications of diabetes as well as contributing importantly to other age-associated diseases. (life-enhancement.com)

It is a small molecule inhibitor that targets various biological pathways and has shown promising results in preclinical studies. (thebiotek.com)
It is a small molecule inhibitor that targets various biological pathways, including protein kinases, phosphodiesterases, and histone deacetylases. (thebiotek.com)
Targetmol can provide a variety of small molecule inhibitors of hot signaling pathways for research and development. (targetmol.com)
Molecular features of these tumors have expanded our vision of tumorigenesis and progression and provided abundant specifically targeted pathways [ 5 ]. (hindawi.com)
In this review, we summarize the basic principles manipulating the abovementioned epigenetic pathways and highlight the evidence of the promising clinical and preclinical results using small-molecule inhibitors against chromatin regulators for cancer treatment. (frontiersin.org)
Mechanistically, we found that lycopene and sorafenib could additively inhibit the mitogen-activated protein kinase (MAPK) pathways, as shown by the protein phosphorylation of ERK1/2, JNK1/2 and p38 were reduced additively. (frontiersin.org)
Integrating this baseline information with genetics and biological knowledge will allow focus on the immune pathways for target prioritization and the development of the next generation of hypotheses. (genengnews.com)
Phosphorylation of residue Y515 promotes association of TrkB with the adaptor protein Shc and activation of PI3-kinase (PI3K)/Akt, MAPK signaling pathways whereas phosphorylation of residue Y816 promotes association of phospholipase Cγ1 (PLCγ1) and signaling mediated by IP3 and DAG ( Reichardt, 2006 ). (jneurosci.org)
Chemical biologist Daniel Bachovchin designs selective inhibitors to study enzymes and pathways in cancer and immune system signaling. (mskcc.org)
p97) is an essential regulator of protein degradation in multiple pathways and has emerged as a target for cancer therapy. (ox.ac.uk)

RWJ-67657 is a potent p38 MAPK inhibitor. (adooq.com)
PD 169316 (PD169316) is a selective inhibitor of p38 MAPK.1 that inhibits p38 MAPK with an IC50 of 89 nM. (adooq.com)

The mechanism of action of HLCL-61 hydrochloride involves the inhibition of specific enzymes and proteins that play a crucial role in cell function and signal transduction. (thebiotek.com)
Mathematical modeling of signal transduction networks has previously been used to map out thermodynamical using rate equations is increasingly attracting attention as a properties of protein-folding models (6,7). (lu.se)

China-based HUTCHMED received approval for its multi-receptor tyrosine kinase inhibitor Sulanda in China for the treatment of pancreatic and extra-pancreatic NETs in June last year and December 2020, respectively. (ronnyallan.net)

SB202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase. (adooq.com)

Beshanzuenones C ( 2 ) and D ( 3 ) are isolated from the critically endangered Chinese fir tree species Abies beshanzuensis and demonstrated weak inhibiting activity against protein tyrosine phosphatase 1B (PTP1B). (acs.org)
Our chemical total syntheses of these Abies sesquiterpenoids have enabled (i) the validation of beshanzuenone C's weak PTP1B inhibiting potency, (ii) identification of new synthetic analogs with promising and selective protein tyrosine phosphatase SHP2 inhibiting potency, and (iii) preparation of azide-tagged probe molecules for target identification via a chemoproteomic approach. (acs.org)
SEVI is a breakdown product of prostatic acid phosphatase, a common protein in semen. (medicalxpress.com)
Some of the proteotoxic effects of VCP depletion depended on the eIF2α phosphatase, protein phosphatase 1 regulatory subunit 15A (PPP1R15A)/PP1c, but not on mTORC1, although there appeared to be cross-talk between them. (ox.ac.uk)

2 - Ribosome biogenesis, a promising target in cancer therapies. (cnrs.fr)
Because SEVI can markedly influence HIV infectivity, it forms a rather attractive target for future therapies" said Greene. (medicalxpress.com)
The initial data with our drug candidates, including MDM2-p53 inhibitor APG-115, novel Bcl-2/Bcl-xL dual inhibitor palcitoclax or APG-1252, and IAP inhibitor APG-1387, support further study with great potential in combination therapies," said Dr. Dajun Yang, Chairman & CEO of Ascentage Pharma. (pharmiweb.com)
Understanding the molecular signaling mechanisms by which SE transforms a brain from normal to epileptic may reveal novel targets for preventive and disease-modifying therapies. (jneurosci.org)
Chemical Biologist Minkui Luo develops cutting-edge tools, technologies and concepts to annotate functions of protein-posttranslational modifications and designs inhibitors for cancer therapies. (mskcc.org)
Interestingly, in the last decade, three orally administered protein / peptide-based therapies have been approved, namely Mycapssa® (2020), Trulance® (2017) and Linzess® (2012) across different geographies. (rootsanalysis.com)
Given the ongoing research and development initiatives and an encouraging response to the already marketed drugs, the oral protein / peptide therapies market is poised to witness significant growth over the coming decade. (rootsanalysis.com)

The scientists looked for antagonists of HSPG that might interfere with the binding of SEVI to the virus and target cells. (medicalxpress.com)

Involved or implicated in a wide spectrum of diseases, trypsin-like serine proteases comprise well studied drug targets and anti-targets that can be subdivided into two major classes. (rcsb.org)
The reversible phosphorylation of proteins on serine, threonine, and tyrosine residues represents a fundamental strategy used by eukaryotic organisms to regulate a host of biological functions, including DNA replication, cell cycle progression, energy metabolism, and cell growth and differentiation. (rupress.org)

After decades of effort, epigenetic modification has represented the hallmarks of different cancer types, and the enzymes involved in this process have provided novel targets for antitumor therapy development . (frontiersin.org)
Here, we summarize the different types of epigenetic enzymes which target corresponding protein domains, emphasize DNA methylation , histone modifications, and microRNA-mediated cooperation with epigenetic modification, and highlight recent achievements in developing targets for epigenetic inhibitor therapy. (frontiersin.org)
This article reviews current anticancer small-molecule inhibitors targeting epigenetic modified enzymes and displays their performances in different stages of clinical trials. (frontiersin.org)

Levels of cellular protein phosphorylation are modulated both by protein kinases and phosphatases. (rupress.org)
Protein phosphorylation can regulate enzyme function, mediate protein-protein interactions, alter subcellular localization, and control protein stability. (rupress.org)

SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27. (adooq.com)
Novel targeted inhibitors, like heat shock protein 90 inhibitors and deacetylase inhibitors, raise patient's life quality [ 6 ]. (hindawi.com)

APG-115 is a highly potent MDM2-p53 inhibitor, and our data on liposarcoma presented in last year's ASCO report were promising," said Prof. Xing Zhang, Chief Physician of Melanoma and Sarcoma Medical Oncology Unit of Sun Yat-sen University Cancer Center. (pharmiweb.com)

DUSP8 may be a T-cell biomarker and therapeutic target for asthma and atopic dermatitis. (bvsalud.org)
Studies have shown that recombinant TGF-ß1 protein has beneficial effects in mouse depression models, indicating TGF-ß1 might be a potential therapeutic target for depression and nasal sprays having the advantage of being fast acting delivery method. (bvsalud.org)
As a result, exploring potential therapeutic target and diagnostic marker is of immense significance to the improvement of glioma sufferer's survival. (hindawi.com)
The cellular mechanisms that control protein degradation may constitute a non-oncogenic cancer cell vulnerability and, therefore, a therapeutic target. (ox.ac.uk)

Dr. Liu's research group primarily employs X-ray crystallography in combination with mechanistic, biological and computational methods to study proteins involved in bacterial infections and other human diseases. (luc.edu)
VCP inhibition had an impact on two key regulators of protein synthesis, eukaryotic initiation factor 2α (eIF2α) and mechanistic target of rapamycin complex 1 (mTORC1), and attenuated global protein synthesis. (ox.ac.uk)

Through collaborative efforts, we are also interested in elucidating the mechanism of allosteric regulators and rational drug design against protein targets in humans. (luc.edu)

Oral Proteins and Peptides Market (4th E. (rootsanalysis.com)
The field of oral proteins / peptides has enormous opportunities. (rootsanalysis.com)
I believe the field will continue to grow at a rapid pace considering the healthy clinical pipeline of oral proteins / peptides. (rootsanalysis.com)
The oral proteins and peptides market is estimated to be worth $1.4 billion in 2022 and and likely to grow to $8.3 billion by 2035. (rootsanalysis.com)
However, with the technological advancements in delivery formulations, oral delivery of therapeutic interventions has gained significant traction, prompting stakeholders to leverage their expertise in the development of orally administrable proteins / peptides. (rootsanalysis.com)
Several recent developments have taken place in the field of oral peptides and proteins. (rootsanalysis.com)
We use structure based modeling and computational protein design methods to optimize the protein sequence of proteins and peptides in order to control their assembly. (lu.se)

SX 011 is a selective p38α, p38β and JNK-2 inhibitor. (adooq.com)

The following protocol describes combined surface and intracellular protein staining with TotalSeq™-B antibodies, with or without TotalSeq™-B hashtag antibodies using the Single Cell 3' v3.1 Feature Barcoding technology from 10x Genomics. (biolegend.com)
This protocol has been validated solely for the detection of surface or intracellular protein expression with the corresponding TotalSeq™-B antibodies. (biolegend.com)
This includes TotalSeq™ antibodies targeting intracellular proteins of interest. (biolegend.com)
Enzymatic digestion may result in alterations of surface protein epitopes and impact staining with TotalSeq™ antibodies. (biolegend.com)
Abcam: antibodies, proteins, kits. (abcam.com)
Due to the wide range of binding targets, their large interaction surfaces and biophysical properties, LRR proteins have been suggested as alternatives to antibodies as scaffolds for protein binding. (lu.se)

We also look forward to more clinical studies and molecular biological evidence of APG-115. (pharmiweb.com)
Epigenetic drugs show significant effects on both preclinical and clinical studies in which the target development and research offer a promising direction for cancer therapy. (frontiersin.org)
Future studies are further needed to address their off-target effects and cytotoxicity to improve their clinical translation. (frontiersin.org)
Although this proposition is supported by the clinical success of proteasome inhibitors in some malignancies, most cancers are resistant to proteasome inhibition. (ox.ac.uk)

Using this YaxAB nanopore, we demonstrate label-free, single-molecule detection of interactions between the anticancer Bcl-xL protein and small-molecule drugs as well as the Bak-BH3 peptide. (nature.com)

Recently, we isolated a novel negative regulator of epidermal growth factor receptor (EGFR), termed EGFR-related protein (ERRP), whose expression attenuates EGFR activation. (aacrjournals.org)
target of receptor NFB, and multiple components of the complement cascade ( 10 - 15 ). (cdc.gov)
Image analysis of the matched maps identified 7 proteins that were either over- or down-expressed: activated protein kinase c receptor (LACK), alpha tubulin (×2), prostaglandin f2-alpha synthase, protein disulfide isomerase, vesicular transport protein and a hypothetical protein. (who.int)

Thus, users are advised to fully validate their application if they desire to obtain high quality data that includes surface proteins, intracellular proteins, and RNA expression data. (biolegend.com)
Depending on your experimental set up, you may find abundant intracellular targets such as cytokines. (biolegend.com)
VCP inhibitors also perturbed intracellular amino acid levels, activated eukaryotic translation initiation factor 2α kinase 4 (EIF2AK4), and enhanced cellular dependence on amino acid supplies, consistent with a failure of amino acid homeostasis. (ox.ac.uk)

These RNPs are involved in a wide range of cellular and biochemical functions, from maturation of different classes of RNAs to protein synthesis, and represent some of the most complicated molecular machines. (cnrs.fr)
Inadequate fine-tuning of protein synthesis and failure of amino acid homeostasis following inhibition of the ATPase VCP/p97. (ox.ac.uk)
Thus, cancer cell death following VCP inhibition was linked to inadequate fine-tuning of protein synthesis and activity of PPP1R15A/PP1c. (ox.ac.uk)
Thus, depletion of VCP enzymatic activity triggers cancer cell death in part through inadequate regulation of protein synthesis and amino acid metabolism. (ox.ac.uk)

We found that pharmacological depletion of VCP enzymatic activity with mechanistically different inhibitors robustly induced proteotoxic stress in solid cancer and multiple myeloma cells, including cells that were insensitive, adapted, or clinically resistant to proteasome inhibition. (ox.ac.uk)
However, a block on protein translation that was itself cytotoxic alleviated stress signaling and reduced cell death triggered by VCP inhibition. (ox.ac.uk)
Many of the observed effects of VCP inhibition differed from the effects triggered by proteasome inhibition or by protein misfolding. (ox.ac.uk)

Pharmaceutical research has successfully incorporated a wealth of molecular modeling methods, within a variety of drug discovery programs, to study complex biological and chemical systems. (mdpi.com)
The targeted pathogens include Pseudomonas aeruginosa , Burkholderia cepacia complex , Klebsiella pneumonia et al, all of which are known for their ability to resist widely used antibiotics such as penicillin. (luc.edu)
It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. (thermofisher.com)
ACC and FASN also interact with each other, indicating that all three proteins may be components of a large multi-enzyme complex. (elifesciences.org)
We are open to collaborations where we are implicated at various levels: protein cloning, production and purification, binding studies and/or structure solution of the protein of interest in complex with small molecular compounds. (cnrs.fr)
Scientists in SKI's Chemical Biology Program are developing chemical technologies to discover new molecular probes, using those probes to dissect the complex functions and mechanisms of proteins and other biological targets, and leveraging that understanding to investigate novel therapeutics to treat human diseases. (mskcc.org)
Sometimes it seems that the more you know, the more complex biological systems seem to become! (life-enhancement.com)
In order to improve and expand applications of Cas9, we recently undertook crystallographic studies to elucidate the atomic structure of the Cas9-sgRNA-target DNA tertiary complex 14 , thus enabling rational engineering of Cas9 and sgRNA. (cdc.gov)

A hydrogen bond unique to Ser190 protease-arylamidine complexes between O gamma(Ser190) and the inhibitor amidine confers an intrinsic preference for such inhibitors toward Ser190 proteases over Ala190 counterparts. (rcsb.org)

Small molecule inhibitors can bind to target proteins and reduce their biological activity and are often used as tools in biological and pharmacological research. (targetmol.com)

Following the doctrine of "Structure Determines Function", our research evolves around determining key protein structures that are mechanistically informative on biochemical processes. (luc.edu)

It has been widely established that cancer is associated with epigenetic modification, which is reversible and becomes an attractive target for drug development. (frontiersin.org)
Achieving systematic, genome-scale perturbations within intact biological systems is important for elucidating gene function and epigenetic regulation. (cdc.gov)

Heeseon An's lab studies protein degradation in health and disease using chemical, biological, and proteomics tools. (mskcc.org)
ABSTRACT In order to define the protein expressional changes related to the process of meglumine antimoniate resistance in anthroponotic cutaneous leishmaniasis (CL), we performed a comparative proteomics analysis on sensitive and resistant strains of Leishmania tropica isolated from Iranian CL patients. (who.int)
The study shows the usefulness of proteomics in identifying proteins that may express differences between sensitive and resistant L. tropica isolates. (who.int)

Broadly used in modern drug design, molecular docking methods explore the ligand conformations adopted within the binding sites of macromolecular targets. (mdpi.com)
The team "RNA Molecular Machines and human pathlogies " specialises in structural biology of proteins and RNA, and of their complexes with small molecules. (cnrs.fr)
How hDM2 activity by association with ribosomal proteins is regulated at molecular level remains elusive. (cnrs.fr)
will use all the techniques of integrative structural biology toolbox to study the human RB/p53 regulon to complete the molecular details of the interaction between hDM2, p53, ribosomal proteins and other ongenic factors. (cnrs.fr)
miR-381-3p/ANTXR1 axis is expected to be a molecular target for glioma. (hindawi.com)
We observed functions of overexpressing miR-381-3p on glioma progression and explored corresponding functional mechanism which will provide a theoretical basis for miR-381-3p serving as a molecular target. (hindawi.com)
Understanding the molecular signaling mechanisms underlying the development of TLE may identify novel therapeutic targets. (jneurosci.org)
Revealing how molecular interactions are optimized to control both oligomerization state and assembly pathway in protein assemblies is of vital importance for our understanding of biomedically important biological assemblies, as well as for efforts to manipulate them. (lu.se)
Our goal is to achieve molecular level control of protein self-assembly. (lu.se)

A variety of approaches, including biochemical purification, gene isolation by homology, and genetic screens, have been successfully used for the identification of putative protein kinases and phosphatases. (rupress.org)

Discovering a specific agent, which targets multiple members of the erbB family, would be important in pancreatic cancer therapy. (aacrjournals.org)
Meanwhile, targeted therapy has entered the field of view of scientists. (hindawi.com)
Manufactured by Novartis, this is a targeted biological therapy or more accurately, a mammalian Target of Rapamycin (mTOR) inhibitor. (ronnyallan.net)
Since the approval of the first protein / peptide-based therapy ( recombinant human insulin ) in 1982, there has been a substantial increase in the R&D initiatives focused on such products. (rootsanalysis.com)

however, these targets are generally not specific for tumor cells. (ronnyallan.net)

We aim to contribute to the understanding of the regulation of p53 by ribosomal proteins and ribosome assembly factors and build on our previous results to propose molecules which impact the RB/p53 pathway. (cnrs.fr)
The Fap7 ribosome assembly factor is involved in regulates ribosomal RNA processing and is essential for embryogenesis and tumour growth, most probably through the ribosomal protein-hDM2-p53 pathway. (cnrs.fr)

Surfen interferes with the binding of SEVI to both target cells and HIV-1 virions but does not cause the SEVI fibrils to break up. (medicalxpress.com)
This led them to hypothesize that the SEVI fibrils bind target cells by interacting with cell-surface HSPG, naturally occurring anionic carbohydrate polymers with a structure that is closely related to heparin sulfate. (medicalxpress.com)
The ability to custom-make novel protein containers, fibrils, and channels will have major impact on nanobiotechnology. (lu.se)

Ribonucleoproteins (RNPs) are complexes composed of proteins and RNA molecules that play crucial roles in the cell. (cnrs.fr)
We have targeted several different aspects of RNP maturation with a focus on small protein complexes which are autonomous building blocks of the RNP. (cnrs.fr)
Where possible, we have also tackled protein/RNA complexes, when the RNA binding site is known. (cnrs.fr)

In drug discovery, efficient screening of protein-drug interactions (PDIs) is hampered by the limitations of current biophysical approaches. (nature.com)
The biophysical properties of the designed proteins are then experimentally tested in the lab. (lu.se)

The therapeutic efficacy of drugs is mediated by physical interaction with their cognate targets (mainly proteins). (nature.com)
Among them, ABT-737 is well-known as a potent small-molecule inhibitor of the Bak-BH3/Bcl-xL interaction 24 . (nature.com)
Remarkably, DUSP8 protein levels and the DUSP8-Pur-α interaction were indeed increased in the cytoplasm of T cells from people with asthma and patients with atopic dermatitis. (bvsalud.org)
Our activity in structural biology frequently brings to us collaborations from biologists and chemist who want to obtain structural information on their biological target or its interaction with novel therapeutic compounds. (cnrs.fr)

Although protein-protein interactions (PPIs) are promising targets, drugging them is one of the key challenges in drug discovery 19 . (nature.com)
The atomic interactions between subunits in protein assemblies are finely tuned to control affinity as well as quaternary structure. (lu.se)
Large protein assemblies are typically held together by weak interactions between individual components but the multiplicity of interactions among the large number of subunits can lead to exquisite specificity. (lu.se)
Repeat proteins feature prominently in biology and serves as a diverse scaffold for protein-protein interactions. (lu.se)

We are interested in how LRR proteins evolved, the self-assembly properties of individual repeats and the rational design of protein binders using this versatile scaffold. (lu.se)

The rising popularity of this upcoming class of therapeutics has led to the reformulation / development of oral protein / peptide-based product candidates for the treatment of a myriad of disease indications across multiple therapeutic areas ( including but not limited to metabolic disorders, gastrointestinal disorders, autoimmune disorders ). (rootsanalysis.com)
Protein / peptide-based therapeutics have revolutionized the pharmaceutical landscape, this can be attributed to the wide applications and target specific nature of such interventions. (rootsanalysis.com)

We use computational protein design methods to change protein sequence in order to modify the oligomerization properties of coiled coils. (lu.se)
Rämisch S, Weiniger U, Martinsson J, Akke M and Andre I "Computational design of Leucine-Rich Repeat proteins with a defined geometry" Proc Natl Acad Sci, 2014, pii: 201413638. (lu.se)

Taken together, our results present the YaxAB nanopore as a robust platform for label-free, ultrasensitive, single-molecule detection of PDIs, opening up a possibility for low-cost, highly efficient drug discovery against diverse drug targets. (nature.com)
Mammalian GABA Aminotransferase and human Ornithine Aminotransferase are studied as drug targets in neurological disorder and hepatic cancer respectively. (luc.edu)

Because SEVI can so greatly enhance HIV infectivity, supplementing current HIV microbicide candidates with SEVI inhibitors, such as surfen, might increase their potency and overall effectiveness," Greene explained. (medicalxpress.com)

Besides biological insight, this could provide a structural canvas for the design of novel molecules targeting this pathway. (cnrs.fr)
We also synthesize a library consisting of 70,290 guides targeting all human RefSeq coding isoforms to screen for genes which, upon activation, confer resistance to a BRAF inhibitor. (cdc.gov)

The discovery was published in the current issue of the Journal of Biological Chemistry . (medicalxpress.com)

These targets are critical for different biological functions but converge on virulence expression in persistent infections such as the lung infection in patients with cystic fibrosis. (luc.edu)
responsible for many different biological functions, in- 1. (lu.se)

The syntheses feature a palladium-catalyzed hydrocarbonylative lactonization to install the 6,6-fused bicyclic ring system and a Dreiding-Schmidt reaction to build the oxaspirolactone moiety of these target molecules. (acs.org)

The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). (thermofisher.com)
It is important to recognize that because of the biological activity of these contaminants, dose-response relationships obtained using technical grade methoxychlor may not be directly applicable to pure methoxychlor. (cdc.gov)

On Target 3 , on-going studies aim to modulate GabR-dependent transcription regulation to weaken bacterial stress response. (luc.edu)

During the last we have contributed to the understanding of RNP biogenesis using structural biology to determine the structure of proteins involved in these processes. (cnrs.fr)
Arvin Dar's lab develops chemical tools and probes to explore disease mechanisms and the structural biology of cancer targets. (mskcc.org)

Additionally, she has held positions as Director of the Medicinal Chemistry Moderatorship, member of the Fellowship Central committee, Head of Organic, Medicinal and Biological Chemistry at the School of Chemistry, Director of Postgraduate Teaching and Learning, Director of Research and Director of Global Relationships at the School of Chemistry, Director of Dublin Chemistry postgraduate program, Tutor and served in numerous College committees and selection panels. (tcd.ie)
besides, she has driven the foundation of the Division of Medicinal and Biological Chemistry within the Institute of Chemistry of Ireland (ICI) and its adherence to the European Federation of Medicinal Chemistry and Chemical Biology (EFMC) in 2022. (tcd.ie)

For example, the innate immune system relies mainly on LRRs for target recognition. (lu.se)

Anatomy14

Organisms12

Diseases1

Chemicals and Drugs134

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Phenomena and Processes53

Disciplines and Occupations5

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture2

Information Science7

Health Care1

Potent inhibitor4

Pathways10

MAPK2

Signal Transduction2

Kinase inhibitor1

Cell-permeable1

Phosphatase4

Therapies7

Antagonists1

Serine2

Enzymes3

Phosphorylation2

Heat shock p2

Highly potent1

Therapeutic target4

Mechanistic2

Humans1

Peptides7

Selective1

Antibodies6

Clinical4

Anticancer1

Receptor3

Intracellular3

Synthesis4

Inhibition3

Complex8

Proteases1

Pharmacological1

Mechanistically1

Epigenetic2

Proteomics3

Molecular9

Kinases1

Therapy4

Tumor cells1

Ribosome2

Fibrils3

Complexes3

Biophysical2

Interaction4

Interactions4

Rational1

Therapeutics2

Computational2

Drug targets2

Candidates1

Targeting2

Journal of Biolog1

Different biological functions2

Molecules1

Activity2

Regulation1

Structural biology2

Chemistry2

Innate immune1