Biological role of micrornas micro rna that regulates. Medical search. Frequent questions

For detecting and quantifying the expression of specific miRNAs, RNA was reverse transcribed using a Bulge-Loop™ miRNA qRT-PCR Primer Set and quantified by SYBR Green-based real-time PCR analysis in the FTC-3000P PCR instrument. (biomedcentral.com)
miRNA inhibitors (anti-miRs) and artificial miRNAs (miRNA mimics) are two general approaches to balance the dysregulated miRNA levels that make it possible to treat various biological disorders. (cmbr-journal.com)
In this study, in general, the biogenesis and the role of miRNAs, the origin of miRNAs, viral miRNAs, miRNA detection procedures, in silico miRNA analysis tools, miRNA-based therapies and their obstacles, and miRNAs as potential non-invasive biomarkers are discussed. (cmbr-journal.com)
Unlike previous studies, which focused solely on miRNA feature signatures for the final multiclass data set, this study tracks changes in clinical and biological relevance after each addition of cancer tissue type. (daitime.com)
MicroRNA (miRNA) are a class of functional small RNA that target mRNA to affect their abundance and translational efficiency. (biomedcentral.com)
Of particular importance is miRNA-21 (MIR21) due to its role in regulating programmed cell death 4 (PDCD4). (biomedcentral.com)
The single-stranded mature miRNA can then associate with an Argonaute protein, which mediates its function of mRNA regulation through direct mRNA target cleavage or interactions with associated RNA-induced silencing complex (RISC) proteins [ 24 ]. (biomedcentral.com)
Another type of molecule, called micro RNA (miRNA) can bind to mRNA and stop the translation of mRNA into protein. (ukri.org)
previous investigations, we developed a miRNA domain-specific application ontology, Ontology for MIcroRNA Target (OMIT), to provide the community with common data elements and data exchange standards in the miRNA research. (philarchive.org)
MicroRNAs (miRNA), short (17?24 nucleotides), non-coding RNAs that have been identified in various organisms including mammalian cells, are thought to play a key role in several biological processes [38-41]. (buyresearchchemicalss.net)
Based on our identified miRNA-regulated network, we discovered three drugsBX-912, daunorubicin, and midostaurinthat can be repositioned to treat lung cancer, which was not known before. (cdc.gov)
Based on our identified miRNA-regulated molecular machinery, an inhibitor of PDK1/Akt BX-912, an anthracycline antibiotic daunorubicin, and a multi-targeted protein kinase inhibitor midostaurin were discovered as potential repositioning drugs for treating lung cancer. (cdc.gov)

MicroRNAs (miRNAs) are a category of small nonencoding RNAs of 22 nucleotides in length. (hindawi.com)
MicroRNAs are small noncoding RNAs, 18 to 25 nucleotides in length, that negatively regulate gene expression," she said. (uga.edu)
microRNAs are small RNA molecules, typically 20 to 25 nucleotides in length, that do not encode proteins but instead regulate gene expression. (regulusrx.com)

microRNAs are ~22nt-long non-coding RNAs that post-transcriptionally regulate the expression of genes, often by binding to the 3' untranslated region of mRNA, targeting the transcript for degradation. (wikipedia.org)
For the mRNA analysis, RNA (1 mg) was reverse-transcribed by using the PrimeScript RT reagent Kit with gDNA Eraser (Tiangen), the mRNA level of the AK4 gene was quantified using duplex-qRT-PCR analysis where the Taqman probes with different fluorescence for β-actin were used in the FTC-3000P. (biomedcentral.com)
These vesicles are carriers of active or non-autonomous function biomolecules, such as proteins, lipids, DNA, mRNA and non-coding regulatory RNA. (spandidos-publications.com)
Thus, the maturing oocyte is reliant on processes such as post-transcriptional gene regulation (PTGR) to regulate the mRNA and protein repertoire. (biomedcentral.com)
The inability to transcribe mRNA during this stage of development and the probable necessity for post-transcriptional gene regulation (PTGR) suggests an important role for non-coding RNA in the maturing oocyte. (biomedcentral.com)
CircRNAs play a critical role in biological processes including transcription, mRNA splicing, RNA decay and translation [ 15 ]. (ijbs.com)
An intermediate between DNA and protein is called messenger RNA (mRNA), and neurons can transport mRNA to the parts of the neuron close to synapses and locally control the synthesis of a particular protein that is important for those synapses at a particular time. (ukri.org)
MicroRNAs (miRNAs) are a class of small noncoding RNA molecules that negatively regulate the expression of target genes by either mRNA degradation or translational inhibition. (biomedcentral.com)

The varied roles of mir-279, both in the developing and adult fly, highlight the utility of microRNAs in regulating unique biological processes. (wikipedia.org)
The results of these analyses revealed that the differentially expressed exosomal miRNAs participate in multiple biological processes, such as gene expression, synthesis of biomolecules, cell development, differentiation, and signal transduction, among others. (hindawi.com)
Most of these paracrine secretions include soluble factors and exosomes, which regulate the repair and regeneration processes at sites of damage by affecting cell proliferation, migration, and differentiation [ 22 , 23 ]. (hindawi.com)
They regulate gene expression through different mechanisms [ 10 ] and play a diverse role in many cellular processes [ 11 - 14 ]. (hindawi.com)
MiRNAs are key regulators of all biological processes and their abnormal function contributes to many diseases, including fibrotic (scarring) skin disorders. (debra.org.uk)
MicroRNAs (miRNAs) play vital roles in regulating various biological processes. (biomedcentral.com)
Damage-regulated autophagy modulator 2(DRAM2) is associated with autophagy processes. (cancerindex.org)
and they are involved in many biological processes in plants, such as root growth and development. (chinaagrisci.com)
They are involved in any biological processes such as the regulation of cell proliferation and differentiation, apoptosis, signaling, and defense responses through their spatio-temporal expression manner. (cmbr-journal.com)
Thus, they regulate various biological and pathological processes, including cancer formation and development. (daitime.com)
However, understanding how these data science techniques correlate with established biological processes to advance integration into the clinical environment is key. (daitime.com)
Circular RNAs (circRNAs) are a large group of endogenous non-coding RNAs which are key members of gene regulatory processes. (ijbs.com)
Research has indicated that microRNAs (miRNAs), a special class of non-coding RNAs (ncRNAs), can perform important roles in different biological and pathological processes. (philarchive.org)
MicroRNAs (miRNAs) have been identified as important posttranscriptional regulators involved in various biological and pathological processes of cells, but their association with tumor chemoresistance has not been fully understood. (biomedcentral.com)

This observation highlights how microRNAs regulate pleiotropic neural genes, determining the divergence of sensory systems. (wikipedia.org)
Given this phenotype, one might expect miR-279 to directly regulate clock genes within the core-clock neurons. (wikipedia.org)
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. (nature.com)
microRNA (miR) is a highly conserved non-coding small RNA widely distributed in eukaryotic cells, 18-25 nucleotides long, being capable of affecting the biological functions of other genes by binding to the 3'UTR end of its target gene ( 4 , 5 ) . (researchsquare.com)
The genes of two octopus species show an increase in microRNAs-which are linked to the development of advanced cells with specific functions-over evolutionary time that has so far only been found in humans, mammals, and other vertebrates. (sflorg.com)
This is the only instance in all of the invertebrates of dramatic microRNA increase and those genes are all expressed in the brain," he says. (sflorg.com)
For nearly 15 years, Peterson and his research group have sequenced the genes of various animal species in order to link microRNAs to complex tissue development and brain evolution. (sflorg.com)
Peterson's research has shown that creatures such as placental mammals whose genes have increased in number and complexity over evolutionary time also exhibit increasing concentrations of microRNAs. (sflorg.com)
On the other hand, organisms such as parasites have lost ancestral genes-and microRNAs-as they have become less complex. (sflorg.com)
The two places you get this-in placental mammals and cephalopods-is also where we see these microRNA-expressed genes. (sflorg.com)
microRNA-33a and b (miR-33a/b), which differ by only two nucleotides, are intronic microRNAs located within the sterol response element binding protein genes SREBF2 and SREBF1 , respectively, which code for transcription factors that regulate cholesterol and fatty acid metabolism. (regulusrx.com)
Analysis of gene expression profiles identified groups of genes involved in metabolic pathways that were up-regulated in the absence of miR-21, in particular genes involved in lipid metabolism and enhanced oxygen radical production. (mirnablog.com)
More than 700 microRNAs have been identified in the human genome, and over one-third of all human genes are believed to be regulated by microRNAs. (mirnablog.com)
A single microRNA can regulate entire networks of genes. (mirnablog.com)
miRNAs' functions are realized by regulating their respective target genes (targets). (philarchive.org)
It has been suggested that over 30% of protein coding genes in humans are regulated by microRNA [42]. (buyresearchchemicalss.net)
Experimentally confirmed target genes were identified for the 73 diagnostic miRNAs, from which proliferation genes were selected from CRISPR-Cas9/RNA interference (RNAi) screening assays. (cdc.gov)

mir-279 is a short RNA molecule found in Drosophila melanogaster that belongs to a class of molecules known as microRNAs. (wikipedia.org)
An international team led by researchers at Dartmouth and the Max Delbrück Center in Germany report in the journal Science Advances that octopuses are the first known invertebrates-creatures that lack a backbone and constitute roughly 95% of animal species-to contain a high number of gene-regulating molecules known as microRNAs. (sflorg.com)

MicroRNAs (miRNAs) are non-coding RNAs that block protein production by interacting with specific mRNAs. (debra.org.uk)
MicroRNAs are known as the 'dark matter' of the animal genome-they don't make protein, but they regulate the expression of proteins. (sflorg.com)
MicroRNAs are known as the 'dark matter' of the animal genome-they don't make protein, but they regulate the expression of proteins," Peterson says, referring to the hypothetical form of matter thought to constitute most of the universe. (sflorg.com)
Exosomes are one of the most researched classes of extracellular vesicles because they are carriers of targeted protein and DNA/RNA loads. (spandidos-publications.com)
Our main hypothesis is that PICK1 plays an important role in regulating protein synthesis close to active synapses via its interaction with Argonaute2. (ukri.org)
Using these cells we will be able to understand more about the mechanisms that regulate the local control of protein synthesis in neurons in response to synaptic activity, and hence further our knowledge of the mechanisms that underlie long-term memory. (ukri.org)
Next we explored the roles of miR-27a and its target Raf Kinase Inhibitory Protein (RKIP) in regulating cisplatin resistance and metastasis in lung adenocarcinoma. (biomedcentral.com)
Although more and animals and plants and regulate gene/protein expression more progressions have been made about the through direct complementarity between their 5' region pathogenesis of asthma in recent years, the increasing and the 3' untranslated region of target mRNAs. (cdc.gov)

By transporting "cargos" such as proteins, RNAs, DNAs, and lipids [ 26 ], exosomes regulate the eventual fate of recipient cells. (hindawi.com)
The DNA instructions are transcribed into RNA molecules called messenger RNAs (mRNAs), which serve to produce these proteins (translation). (debra.org.uk)
However, some RNAs, called non-coding RNAs, are not translated into proteins but regulate the amount of proteins produced. (debra.org.uk)
Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. (cancerindex.org)
Exosomal markers include microRNAs like miR-21 and miR-141, plus various proteins that belong in functional groups such as tetraspanins (CD9, CD63 and CD81), heat shock proteins (Hsp70, Hsp73 and Hsp90) and membrane transporters (GTPases) ( 4 ). (spandidos-publications.com)
Many have been assigned roles in modulating the local translation of proteins that are essential to dendritic spine morphogenesis, synaptic function and memory formation. (ukri.org)
MiRNAs silence target mRNAs via the RNA-induced silencing complex (RISC), of which Argonaute proteins (Ago) are the major subunit. (ukri.org)

Altogether, our findings elucidate conserved cellular and molecular mechanisms through which miR-34/449 regulate motile ciliogenesis. (nature.com)
However, recent studies have confirmed that epigenetic mechanisms play an important role in the pathophysiological process of T2D ( 3 ) . (researchsquare.com)
However, it is unclear how cerebral ischemic stroke regulates cardiac function, what are the direct effects of stroke on cardiac function, and what are the underlying molecular mechanisms. (justia.com)
To better understand the biological mechanisms of chemoresistance in lung adenocarcinoma cells and search for the reversion opportunities, we made use of a cisplatin-sensitive and derived resistant lung cancer cell line pair (A549 and A549/ CDDP). (biomedcentral.com)

Conclusion Our results demonstrate that a subset of microRNAs regulated during osteogenic differentiation of MSCs is responsive to perturbation of the PDGF pathway. (buyresearchchemicalss.net)

MicroRNAs (miRNAs) serve a role in gene expression, primarily by interacting with messenger RNAs, and may be potential biomarkers for detecting cancer. (spandidos-publications.com)
The profound roles of exosomes in homeostasis, stress and several pathological conditions, in conjunction with their selective and cell‑specific composition/function, allude to their use as promising circulating clinical biomarkers of systemic stress and specific pathologic states, and as biocompatible vehicles of therapeutic cargo. (spandidos-publications.com)

MicroRNAs (miRNAs) are highly conserved, single-stranded, small non-coding RNAs that have been shown to act as essential regulators of gene expression at the posttranscriptional level. (frontiersin.org)

He, L. & Hannon, G. J. MicroRNAs: small RNAs with a big role in gene regulation. (nature.com)
Lee, R. C., Feinbaum, R. L. & Ambros, V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 . (nature.com)
MiRNAs (miRNAs) are small non-coding RNAs which are recognized as vital and evolutionarily ancient components of gene regulation [ 1 ]. (biomedcentral.com)
miRNAs are a family of small non-coding RNAs that emerged as significant and versatile regulators involved in regulation of immune responses. (frontiersin.org)
Exosomes are small lipid bilayer-surrounded extracellular vesicles released from cells into the extracellular space or biological fluids ( 1 , 2 ). (spandidos-publications.com)
MicroRNAs, or miRNAs, are a class of small non-coding ribonucleic acids (RNA), which are essential for all biological functions. (daitime.com)
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate several gene expressions, pathways, and complex biological networks at the cellular level acting either exclusively or together with other miRNAs. (justia.com)
MicroRNAs (miRNAs) are small noncoding endogenous RNA molecules that repress target mRNAs through complementary binding in the message 3'-UTR. (ukri.org)
Small interfering RNA-mediated RKIP knockdown revealed similar effects as that of ectopic miR-27a expression, while overexpression of RKIP attenuated the function of miR-27a in lung adenocarcinoma cells. (biomedcentral.com)

MiRNAs are approximately 19- to 25-nucleotide estimated about 250,000 and mortality does not appear single-stranded, noncoding RNAs that exist in both to correlate well with prevalence. (cdc.gov)

MiRNAs regulate both transcriptional and post-transcriptional gene expression as well as regulate several circuits involved in tissue repair, inflammation, hypoxia-response, and angiogenesis. (justia.com)
In addition, circRNAs can regulate gene expression at transcriptional or post-transcriptional levels by titrating microRNAs (miRNAs), regulating transcription and interfering with splicing [ 13 , 14 ]. (ijbs.com)
CCCTC-binding factor (CTCF) is a conserved transcription factor that performs diverse roles in transcriptional regulation and chromatin architecture. (preprints.org)
MicroRNAs (miRNAs) are an integral part of the post-transcriptional machinery of gene expression and have been implicated in the carcinogenic cascade. (cdc.gov)

LA JOLLA, Calif. , Sept. 8, 2011 / PRNewswire / -- Regulus Therapeutics Inc ., a biopharmaceutical company leading the discovery and development of innovative medicines targeting microRNAs, today announced the presentation of recent advances in its microRNA therapeutic preclinical programs for the treatment of metabolic diseases and cancer. (regulusrx.com)
In a talk titled 'Therapeutic Targeting of microRNAs,' Dr. Gibson will present new data demonstrating that the inhibition of microRNA-33 with proprietary oligonucleotide anti-miRs in animal models increased levels of HDL-cholesterol (the 'good' cholesterol) and reduced levels of triglycerides. (regulusrx.com)
In addition, Regulus collaborators Markus Stoffel , Ph.D., M.D. of ETH Zurich will be chairing a session titled 'Targeting microRNA,' and Thomas Thum , M.D., Ph.D. of Medical School Hannover, Germany will be presenting a talk on 'Therapeutic targeting of individual cardiac cell types by microRNA antagonists. (regulusrx.com)
Regulus is advancing multiple microRNA therapeutic programs to the clinic in the areas of fibrosis, immuno-inflammatory disease, metabolic disease, and oncology. (regulusrx.com)
Understanding the roles of Asthma is a worldwide problem, the prevalence of miRNAs in asthma pathogenesis may also aid to asthma ranged from 1% to 18% of the population in explore new therapeutic targets. (cdc.gov)

Additional preclinical data presented by Regulus confirmed that microRNA-21 is upregulated in human cancers and that microRNA-21 inhibition impacts tumor burden and significantly increases survival in preclinical models of hepatocellular carcinoma. (regulusrx.com)
Modulating miR-320d function by transfection of miR-320 mimics or inhibitor led to inhibition or promotion of GCA cell proliferation and invasion, thus regulating tumor progression in GCA-tumor bearing mice. (biomedcentral.com)

Up- or down-regulation of miR-199a-3p and/or the AK4 gene was done to detect their roles in OS multi-drug resistance using drug resistance profiling assays. (biomedcentral.com)
In her research, Murph is specifically looking at fragments of microRNA material in the obese mice involved in the regulation of cancer gene expression. (uga.edu)
The mere existence of microRNA in biological systems reveals complex layers of epigenetic regulation that govern the outcome of cellular signaling. (uga.edu)
Growing evidence show that miRNAs play an important role in the regulation of immunity and inflammation. (frontiersin.org)
Because of their expanding roles in the endocrine regulation of homeostasis and stress, and their involvement in human pathophysiology, exosomes are now the epicenter of a new field, termed 'exosomics' ( 3 ). (spandidos-publications.com)
The main role of miRNAs in the human body is gene regulation. (daitime.com)
The mechanism analysis of miR-320d/FoxM1 showed that FoxM1 has two miR-320d binding sites in its 3′-untranslated region (3′-UTR), that contributes to regulation of the cell biological behaviors. (biomedcentral.com)
Recently, the importance of epigenetic regulation via microRNA in controlling stem cell activities has been recognized [31-37]. (buyresearchchemicalss.net)
MicroRNAs participate in the regulation of asthma, the goal of this study is to summarize recent researches on the roles of microRNAs in the pathogenesis of asthma. (cdc.gov)
MicroRNAs not only participate in determining DCs phenotype and then naive T lymphocyte differentiation, but also participate in the regulation of airway inflammation and airway remodeling in asthma. (cdc.gov)
Zhang et al cytokines, mediators and signals and closely related to demonstrated that microRNA let-7i was upregulated immune regulation. (cdc.gov)

Furthermore, we demonstrated that miR-21 regulates inflammatory responses through NF-κB signaling pathways. (frontiersin.org)
Their multi‑functional cargo have been indicated to regulate a vast number of biological pathways in target cells. (spandidos-publications.com)
Recent studies have shown that miR-33a/b regulates the cholesterol and fatty acid pathways in a negative feedback loop. (regulusrx.com)
The journal article titled, "MicroRNA 21 Promotes Fibrosis of the Kidney by Silencing Metabolic Pathways," is now available in Science Translational Medicine and on the publications page of the Regulus website at www.regulusrx.com . (mirnablog.com)
This approach not only identifies characteristic classes of differentiation-specific mRNAs and microRNAs, but begins to link E-4031 dihydrochloride regulated molecules with specific cellular pathways. (buyresearchchemicalss.net)
In addition, Ingenuity Pathway Analysis (IPA) integrated with PCR array data showed that the JAK1/STAT3 pathway was significantly altered in cells overexpressing DEFB1, suggesting this to be one of the pathways by which defensin regulates IAV replication in HBEpCs. (cdc.gov)

Du, T. & Zamore, P. D. microPrimer: the biogenesis and function of microRNA. (nature.com)

An improvement in our understanding of the role that miRNAs play in AP may represent an attractive way to develop new diagnostic and prognostic tools for use in future clinical applications. (hindawi.com)
miRNAs play an inevitable role in the life cycle of eukaryotic cells. (cmbr-journal.com)
Overall, this thesis reports multiple findings and tools that can help us better understand the process of prostate cancer bone metastasis and the role that miRNAs play in this process. (lu.se)

The discovery of microRNA in humans during the last decade is one of the most exciting scientific breakthroughs in recent history. (regulusrx.com)
Regulus' lead program for fibrosis targets miR-21, which is up-regulated in fibrotic tissues of humans. (mirnablog.com)

Circular RNAs (circRNAs) are a class of endogenous non-coding RNAs with a covalently closed continuous loop that lacks 5'-3' polarity structure. (ijbs.com)

More recently, a unique set of microRNA have been shown to be associated with embryonic stem cells [43-48]. (buyresearchchemicalss.net)

Exosomes are found in abundance in endosome-derived components, which are considered to play important roles in intercellular communication due to their ability to transfer "cargos" [ 24 , 25 ]. (hindawi.com)
The results of the present study indicate that microRNAs play important roles in regulating asthma immune responses. (cdc.gov)

I specifically remember finding a new microRNA and realizing how incredible it was to be the first person to see this biological molecule in writing," Chabot says. (sflorg.com)

The role of these molecules in controlling scarring (fibrosis) may make them targets for EB therapies. (debra.org.uk)
This study aimed to investigate whether miR-720 targets Rab35 to regulate insulin secretion in MIN6 cells and its molecular mechanism, and the clinical value of miR-720 as a specific biomarker of T2D. (researchsquare.com)
Therefore, the aim of the current study was to investigate whether miR-720 targets Rab35 to regulate insulin secretion in MIN6 cells and its molecular mechanism, and the clinical value of miR-720 as a specific biomarker of T2D. (researchsquare.com)
Furthermore, microRNAs are also shown to be targets for asthma therapy in the future. (cdc.gov)

Regulus is developing microRNA therapeutics targeting miR-33 using proprietary chemically modified anti-miR oligonucleotides delivered systemically. (regulusrx.com)
LA JOLLA, Calif., Feb. 16, 2012 /PRNewswire/ - Regulus Therapeutics Inc., a biopharmaceutical company leading the discovery and development of innovative medicines targeting microRNAs, today announced that new preclinical data investigating the role of microRNA-21 (miR-21) in the treatment of kidney fibrosis has been published in the journal Science Translational Medicine . (mirnablog.com)

These microRNAs are expressed at high levels in several human embryonic stem cell (ESC) and human embryonal carcinoma cell (EC) lines [49, 50] and decrease upon differentiation into embryoid body (EB) for two weeks in culture [50] supporting their association with the stem cell state. (buyresearchchemicalss.net)

Is MicroRNA-127 a Novel Biomarker for Acute Pancreatitis with Lung Injury? (hindawi.com)
circPVT1 is significantly up-regulated in the osteosarcoma tissues, and circPVT1 may be a biomarker for the diagnosis of osteosarcoma [ 17 ]. (ijbs.com)

Without limitation, some embodiments comprise methods, systems, and/or compositions relating to microRNAs and/or cell based therapies and the use of the same in the research, diagnosis, or treatment of injury or disease. (justia.com)

Using cell culture, animal and patient studies, we investigated the biological role of microRNA-96 (miR-96) and microRNA-379 (miR-379) in prostate cancer bone metastasis. (lu.se)

The collective findings indicate that miR-21 plays a regulatory role in host-pathogen interactions through IRAK4-mediated NF-κB signaling pathway. (frontiersin.org)

The Ct values of the target miRs were normalized to the Ct values of U6 RNA before quantification using the 2 −ΔΔ Ct method. (biomedcentral.com)

A set of microRNAs bioinformatically predicted to respond to PDGF signalling was experimentally confirmed by direct PDGF inhibition. (buyresearchchemicalss.net)

For the first time, our analyses will investigate the expression levels of a large number of miRNAs and their functional role in RDEB fibrosis. (debra.org.uk)
In the published study, Regulus and its collaborators from the University of Washington investigated the role of miR-21 in kidney fibrosis. (mirnablog.com)
Regulus has identified several microRNAs that are dysregulated in fibrosis. (mirnablog.com)

We conducted RNA sequencing (RNA-Seq) of 103 tissues from rapeseed cultivar ZhongShuang11 (ZS11) at seven developmental stages (seed germination, seedling, bolting, initial flowering, full-bloom, podding, and maturation). (preprints.org)
Simple Summary: This study identified a set of 73 microRNAs (miRNAs) that can accurately detect lung cancer tumors from normal lung tissues. (cdc.gov)
This study identified a set of 73 microRNAs (miRNAs) that classified lung cancer tumors from normal lung tissues with an overall accuracy of 96.3% in the training patient cohort (n = 109) and 91.7% in unsupervised classification and 92.3% in supervised classification in the validation set (n = 375). (cdc.gov)

Their study, "Identification of circulating microRNA patterns in patients in psoriasis and psoriatic arthritis," was published online in Rheumatology (Oxford) in February 2023. (medpagetoday.com)

Then we used miR-720 mimic, miR-720 inhibitor and dual luciferase reporter gene assays to prove miR-720 regulate insulin secretion by targeting Rab35 in MIN6 cells. (researchsquare.com)
miR-720 regulated insulin secretion by targeting Rab35 in MIN6 cells. (researchsquare.com)

Considering the potential role of miR-127 in the vital biological process of inflammation, we hypothesized that miR-127 may serve as a marker of AP with LI. (hindawi.com)
Thus, to maintain a balance between host preservation and inflammatory pathology, the immune response and inflammation need to be tightly regulated. (frontiersin.org)

Rab functions are accompanied by cyclical activation and inactivation of GTP-bound and GDP-bound forms between the cytosol and plasma membrane that are regulated by upstream regulators ( 15 ) . (researchsquare.com)

The results of the research were published in the journal of the Institute of Electrical and Electronics Engineers IEEE Xplore ( "Exploration of the Relevance of MicroRNA Signatures for Cancer Detection and Classification of Multiclass Cancers" ), indicating that models with a greater number of cancer classes shift towards focusing on cancer-diverse miRNAs with greater relevance to the functionality being characterized. (daitime.com)

Yet, the prevalence of microRNAs in both octopuses and vertebrates suggest a common role for the molecules in advanced cognition. (sflorg.com)

Conservation and divergence of microRNAs in Populus. (chinaagrisci.com)

Identification of non-coding RNAs (ncRNAs) has been significantly improved over the past decade. (philarchive.org)
Identification of non-coding RNAs (ncRNAs) has been significantly enhanced due to the rapid advancement in sequencing technologies. (philarchive.org)
miR-27a was significantly up-regulated in cisplatin-resistant lung adenocarcinoma A549/CDDP cells compared with parental A549 cells. (biomedcentral.com)

MicroRNA signatures were shown to differ between patients with psoriasis and psoriatic arthritis and may be able to aid in early detection in patients with psoriasis who might progress to psoriatic arthritis. (medpagetoday.com)

Accumulating evidence has demonstrated that miRNAs have a key role in drug resistance and EMT. (biomedcentral.com)

MicroRNAs were first reported in 1993 by Victor Ambros, a professor at Dartmouth from 1992 to 2007 who is now a professor at the University of Massachusetts Medical School. (sflorg.com)

A microRNA component of the p53 tumour suppressor network. (nature.com)
This thesis focuses on microRNAs (miRNAs), which modulate gene expression in healthy and tumour cells. (lu.se)

Most Caenorhabditis elegans microRNAs are individually not essential for development or viability. (nature.com)
miR-127 is originally found to be highly expressed in human and murine embryos and has a critical role in lung development and placental formation [ 34 , 35 ]. (hindawi.com)
Athens, Ga. - Mandi Murph in the University of Georgia College of Pharmacy is focusing her research efforts on the role of obesity in the promotion and development of women's cancer, both breast cancer and ovarian cancer. (uga.edu)
Lifestyle preferences play a leading role in the development of obesity in that consumed but unexpended calories are stored as fat, yet diet and exercise have become low priority solutions to weight gain, especially in the older population. (uga.edu)
The miRNAs regulate root elongation, lateral root (LR) formation and adventitious root (AR) development in response to hormone signaling, nutrient uptake and biotic/abiotic stress. (chinaagrisci.com)
This review provides multiple perspectives on the involvement of miRNAs in regulating root growth and development in plants. (chinaagrisci.com)
Our exciting data show that inhibiting dysregulated microRNAs with our proprietary anti-miR oligonucleotides are effective at altering disease pathogenesis in animal models and provide us confidence to move these programs forward into clinical development,' said Dr. Gibson. (regulusrx.com)
The development of non-coding RNA ontology. (philarchive.org)
Recent evidences demonstrate that dysregulated expression of microRNA-320d (miR-320d) has been associated with several cancer development and progression. (biomedcentral.com)
However, studies focusing on the role and mechanism of miR-320d in the progression and development of GCA are still lacking. (biomedcentral.com)
In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that beta-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development. (cdc.gov)

Th)1 cells.5 Meanwhile, the function and immunity of with genetic predisposition, involving multiple cells, DCs are closely regulated by miRNAs. (cdc.gov)

In Drosophila melanogaster the loss of microRNA-279 results in the ectopic formation of CP2 neurons (a type of CO2-sensing neuron) within the maxillary palp, a distal segment in the antenna. (wikipedia.org)
Rather, miR-279 affects the output from core-clock neurons by post-transcriptionally regulating upd, a ligand for JAK/STAT signaling. (wikipedia.org)
miR-279 fine-tunes JAK/STAT signaling in the ovary by negatively regulating stat (unlike the neurons, where it is reported to regulate upd). (wikipedia.org)
Our preliminary data show that PICK1, which regulates AMPAR trafficking and dendritic spine morphology during synaptic plasticity, interacts with Ago2 in neurons. (ukri.org)

Anatomy3

Organisms1

Chemicals and Drugs23

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes20

Disciplines and Occupations1

Information Science3

MiRNA12

Nucleotides in length3

MRNA8

Processes14

Genes17

Molecules known as microRNAs2

Protein8

Proteins7

Mechanisms4

Osteogenic differentiation1

Biomarkers2

Highly conserved1

Small9

Single-stranded1

Transcriptional4

Therapeutic5

Tumor2

Regulation11

Pathways6

Biogenesis1

MiRNAs play3

Humans2

Endogenous1

Embryonic stem1

Important roles2

Molecule1

Targets4

Therapeutics2

Differentiation1

Biomarker2

Therapies1

Metastasis1

Regulatory1

Quantification1

Inhibition1

Fibrosis3

Tissues3

20231

Targeting2

Inflammation2

Regulators1

Cancers1

Prevalence1

Divergence1

Significantly3

Signatures1

Demonstrated that miRNAs1

19931

Tumour2

Development11

Genetic1

Neurons4