Biological receptor epidermal growth factor. Medical search. Frequent questions

The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). (wikipedia.org)
Deficient signaling of the EGFR and other receptor tyrosine kinases in humans is associated with diseases such as Alzheimer's, while over-expression is associated with the development of a wide variety of tumors. (wikipedia.org)
Interruption of EGFR signalling, either by blocking EGFR binding sites on the extracellular domain of the receptor or by inhibiting intracellular tyrosine kinase activity, can prevent the growth of EGFR-expressing tumours and improve the patient's condition[citation needed]. (wikipedia.org)
Epidermal growth factor receptor (EGFR) is a transmembrane protein that is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor alpha (TGF-α). (wikipedia.org)
Upon activation by its growth factor ligands, EGFR undergoes a transition from an inactive monomeric form to an active homodimer. (wikipedia.org)
In addition to forming homodimers after ligand binding, EGFR may pair with another member of the ErbB receptor family, such as ErbB2/Her2/neu, to create an activated heterodimer. (wikipedia.org)
Additionally, the kinase domain of the EGFR can cross-phosphorylate the tyrosine residues of other receptors with which it is aggregated and thereby activate itself. (wikipedia.org)
Although a number of studies have shown that patients with activating mutations in exons 18-21 of the epidermal growth factor receptor (EGFR) gene respond particularly well to gefitinib and erlotinib, a prospective, randomised study was needed to differentiate between the prognostic and predictive value of EGFR mutations. (ersjournals.com)
This review considers the current evidence linking biomarker profile to efficacy of epidermal growth factor receptor (EGFR)-targeted therapy in advanced nonsmall cell lung cancer (NSCLC) and the clinical implications of recent findings. (ersjournals.com)
In NSCLC, activation of the EGFR/HER1 pathway results in a signalling cascade that promotes tumour growth and progression 6 . (ersjournals.com)
Tyrosine kinase inhibitors (TKIs) against the human epidermal growth factor receptor (EGFR) are now standard treatment in the clinic for patients with advanced EGFR mutant non-small-cell lung cancer (NSCLC). (researchgate.net)
Ligands that activate the epidermal growth factor receptor (EGFR) are synthesized as membrane-anchored precursors that appear to be proteolytically released by members of the ADAM family of metalloproteases. (nih.gov)
These cells express both transforming growth factor alpha and amphiregulin and require autocrine signaling through the EGFR for proliferation and migration. (nih.gov)
Metalloprotease inhibitors also reduced growth of EGF-responsive tumorigenic cell lines and were synergistic with the inhibitory effects of antagonistic EGFR antibodies. (nih.gov)
Our results indicate that soluble rather than membrane-anchored forms of the ligands mediate most of the biological effects of EGFR ligands. (nih.gov)
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) commonly targeted for inhibition by anti-cancer therapeutics. (biorxiv.org)
The epidermal growth factor receptor (EGFR) is a HER-family receptor tyrosine kinase (RTK) that is involved in cell signaling in healthy tissue. (biorxiv.org)
To mediate these processes, the extracellular ligand binding region of EGFR senses environmental cues via interactions with one of its 7 known ligands, of which epidermal growth factor (EGF) is the most well characterized ( 2 , 3 ). (biorxiv.org)
The discovery of epidermal growth factor receptor (EGFR) mutations in never-smokers has been the most relevant finding ever in non-small cell lung cancer. (aacrjournals.org)
The ErbB/HER family of receptor tyrosine kinases (RTKs) consists of four family members: the epidermal growth factor receptor (EGFR/ErbB1), HER2 (ErbB2/Neu), HER3 (ErbB3), and HER4 (ErbB4). (plos.org)
Assessment of the epidermal growth factor receptor (EGFR) mutational status has become crucial in recent years in the molecular classification of patients with lung cancer. (spandidos-publications.com)
The epidermal growth factor receptor (EGFR) tyrosine kinase (TK) plays an important role in the pathogenesis of NSCLC. (bmj.com)
Alterations in receptor tyrosine kinases (TKs), such as the epidermal growth factor receptor (EGFR) and insulin-like growth factor receptor 1, include overexpression, amplification or mutations. (bmj.com)
Thus, GAGs/PGs may modulate downstream signaling of key cellular mediators including insulin growth factor receptor (IGFR), epidermal growth factor receptor (EGFR), estrogen receptors (ERs), or Wnt members. (hindawi.com)
Epidermal growth factor receptor (EGFR) mutants play an important role in NSCLC progression. (jcancer.org)
The small molecule compound, Erlotinib is a receptor tyrosine kinase inhibitor (EGFR antagonist) and belongs to molecular targeted therapy Drugs. (lookchem.com)
It can inhibit the phosphorylation reaction through competing with adenosine triphosphate to bind to the catalytic region of the receptor tyrosine kinase, thereby blocking the down-proliferation signaling and inhibiting the activity of the tumor cell ligand-dependent HER-1/EGFR, thus achieving the inhibition of the proliferation of tumor cells. (lookchem.com)
Epidermal growth factor receptor (EGFR) mutation positive (M+) non-small cell lung cancer (NSCLC) is emerging as an important subtype of lung cancer comprising 10% to 15% of non-squamous tumours. (altmetric.com)
Epidermal growth factor receptor (EGFR) and its ligands have been implicated in liver fibrosis. (bvsalud.org)
We previously reported that the epidermal growth factor receptor (EGFR) is required for stimulation of IL-6 and IL-8 secretion by cultured airway epithelial cells in response to an aqueous extract of settled dust from these facilities (HDE, hogbarn dust extract) [AmJRespCritCareMed,177,A158,2008]. (cdc.gov)

HER2 is a member of the cErbB family of receptor tyrosine kinases, and is responsible for HER2-mediated signal transduction in the cytoplasm. (carcinogenesis.com)
Phosphorylated tyrosine residues recruit various intracellular adaptor and effector molecules that result in the propagation of growth promoting signal transduction cascades [1] , [2] . (plos.org)
These studies suggest that the reovirus infection process is closely coupled to the EGF receptor-mediated cell signal transduction pathway. (mcmaster.ca)

Amplification of the human epidermal growth factor receptor 2 ( HER2 ) gene and overexpression of the HER2 protein is found in 15%-20% of patients with gastric and gastroesophageal junction cancer. (wjgnet.com)
The prognostic properties of HER2 overexpression and amplification are still under debate, but a large number of studies seem to indicate that HER2 is a negative prognostic factor. (wjgnet.com)
With the addition of trastuzumab, a monoclonal antibody targeting the human epidermal growth factor receptor-2 (HER2), improvements in overall survival have been observed among patients with advanced HER2-positive disease. (carcinogenesis.com)
One type of breast cancer is identified by the human epidermal growth factor receptor 2 (HER2) gene amplification. (carcinogenesis.com)
The HER2 receptor does not bind to any known ligands, however, its dimerization arm is innately positioned in an open conformation. (plos.org)
Multi-omic analysis of 579 patients with hormone receptor-positive (HR + )/human epidermal growth factor receptor 2-negative (HER2 − ) breast cancer identifies subgroups of the disease with distinct biological and clinical features. (nature.com)
There are various kinds of invasive cancers with cells lacking progesterone and estrogen receptors and no increase in the protein named HER2 on the surface. (healthresource4u.com)
Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, is a type I membrane glycoprotein and belongs to the epidermal growth factor receptor family. (whdsbio.cn)
HER2 itself has no ligand binding domain and therefore cannot bind growth factors, but it binds tightly with other ligand binding epidermal growth factor receptor family members to form a heterodimer, which stabilizes ligand binding and enhances kinase-mediated downstream signals Pathways, such as mitogen-activated protein kinase and phosphatidylinositol-3 kinase. (whdsbio.cn)
HER2 plays an important role in the regulation of development, cancer, neuromuscular signaling and cell growth and differentiation. (whdsbio.cn)
The HER2 produced by our company is a recombinant protein derived from mammalian cells, with high purity, good immunogenicity and high biological activity. (whdsbio.cn)

This process leads to the activation of each receptors' tyrosine kinase and the subsequent phosphorylation of tyrosine residues located on their C-terminal tails. (plos.org)
Neuregulin is a signaling protein for ErbB2/ErbB4 receptor heterodimers on the cardiac muscle cells, playing an important role in heart structure and function through inducing ErbB2/ErbB4 receptor phosphorylation and cardiomyocyte differentiation. (prospecbio.com)
Epidermal growth factor receptor phosphorylation and downstream signaling by an aqueous extract of hog barn dust in airway epithelial cells. (cdc.gov)

HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands. (wikipedia.org)
Classically, HER family members function from the cell surface, where binding to cognate ligands can induce receptor homo- or hetero-dimerization with other HER family receptors [3] . (plos.org)
GAGs and PGs perform multiple functions in specific stages of the metastatic cascade due to their defined structure and ability to interact with both ligands and receptors regulating cancer pathogenesis. (hindawi.com)
Free glycosaminoglycans (GAGs) and proteoglycan- (PG-) containing GAGs, key effectors of cell surface, pericellular and extracellular microenvironments, perform multiple functions in cancer by virtue of their coded structure and their ability to interact with both ligands and receptors that regulate cancer growth [ 1 - 4 ]. (hindawi.com)

and transmembrane receptor protein tyrosine kinase signaling pathway. (nih.gov)

Unlike other breast cancer types, it is characterized by absence of hormonal receptors of estrogen, progesterone as well as human epidermal growth factor receptor 2, rendering it unsuitable for hormonal therapy and a perfect candidate for chemotherapy. (thescipub.com)
Most patients had positive estrogen and progesterone receptors. (who.int)
We performed a cost-minimization analysis to compare the cost of biomarker analysis for estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 status with immunohistochemistry versus STRAT4. (bvsalud.org)

If there is cell mutation, the growth of the cells can rise without any limit. (healthresource4u.com)
Guarnaccia C, Dhir S, Pintar A, Pongor S. The tetralogy of Fallot-associated G274D mutation impairs folding of the second epidermal growth factor repeat in Jagged-1. (medlineplus.gov)

Journal of Biological Chemistry , 282 (42) , 30929 -30937. (swansea.ac.uk)

In the first case study, we observed that the real biological networks were most sensitive to overexpression/state-flip and edge-addition/-reverse mutations among node-based and edgetic mutations, respectively. (researchgate.net)
Overexpression of receptors in breast cancer is closely related to disease recurrence and poor prognosis. (whdsbio.cn)

Loss of growth homeostasis by genetic decoupling of cell division from biomass growth: implication for size control mechanisms. (wiko-berlin.de)
Experimentally characterized genetic interaction networks in model organisms provide important insights into relationships between different biological functions. (researchgate.net)
We describe a computational methodology allowing to systematically and quantitatively characterize a Boolean mathematical model of a biological network in terms of genetic interactions between all loss of function and gain of function mutations with respect to all model phenotypes or outputs. (researchgate.net)
However, it has not been directly shown that hepatocellular genetic ablation of either this receptor tyrosine kinase or ERBB3, its interactive signaling partner, affects hepatic fibrosis. (bvsalud.org)

Pathogen-associated molecular patterns released by infecting organisms not only bind immune receptors on inflammatory cells but also bind receptors on cells in the heart ( 8 ). (frontiersin.org)

The consecutive stages of cancer growth and dissemination are obligatorily perpetrated through specific interactions of the tumor cells with their microenvironment. (hindawi.com)
The consecutive steps of tumor growth, local invasion, intravasation, extravasation, and invasion of anatomically distant sites are obligatorily perpetrated through specific interactions of the tumor cells with their microenvironment. (hindawi.com)
Breast cancer is characterized by the growth of a malignant tumor arising from breast cells. (healthresource4u.com)
Serine Protease Inhibitor Kazal Type 1 Promotes Proliferation of Pancreatic Cancer Cells through the Epidermal Growth Factor Receptor. (prospecbio.com)
Violin plots show distribution of expression levels for epidermal growth factor receptor 2 (SMED30029442) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
Expression of epidermal growth factor receptor 2 (SMED30029442) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells. (stowers.org)
Violin plots show distribution of expression levels for epidermal growth factor receptor 2 (SMED30029442) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells. (stowers.org)
This enhancement of infection efficiency requires a functional EGF receptor since it was not observed in cells expressing a mutated (kinase-inactive) EGF receptor. (mcmaster.ca)
Starting with basics: "All cancers arise as a result of the acquisition of a series of fixed DNA sequence abnormalities, mutations, many of which ultimately confer a growth advantage upon the cells in which they have occurred. (anti-agingfirewalls.com)
It connects with other proteins called Notch receptors, which are bound to the membranes of adjacent cells. (medlineplus.gov)
At these sites, which are a compound of stromal cells, extracellular matrix and soluble factors, complex molecular interactions that maintain the essential properties of stem cells occur, such as self-renewal and differentiation into multiple lineages, according to the organism's needs. (bvsalud.org)

We found that metalloprotease inhibitors reduced cell proliferation in direct proportion to their effect on transforming growth factor alpha release. (nih.gov)

Receptor binding by cannabinoids leads to stimulation of the endogenous cannabinoid system, thereby causing endogenous cannabinoids (eCBs) to change in level, with a concomitant reduction in the release of gamma-aminobutyric acid (GABA) and glutamate. (news-medical.net)

Activation of the receptor is important for the innate immune response in human skin. (wikipedia.org)

Orthologous to human ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). (nih.gov)
Clinically relevant improvements in survival have been attained by administering targeted therapy to the appropriate patient population: for example, the addition of trastuzumab to standard first-line chemotherapy in patients with human epidermal growth factor receptor-positive (HER2+) metastatic breast cancer 3 . (ersjournals.com)
Novel therapeutic agents, in particular those that specifically target members of the human epidermal growth factor receptor (HER (ErbB1)) pathway, have shown encouraging therapeutic efficacy. (bmj.com)
however, such operational efficiencies are unlikely, and more laboratories are pursuing human epidermal growth factor receptor-2 analysis as targeted therapies become increasingly available. (bvsalud.org)

High-mobility group protein box 1 (HMGB1) is overexpressed and reported to be a prognostic factor in patients with non-small-cell lung cancer (NSCLC). (jcancer.org)
Nerve injury can occur even in diabetic patients, whose blood glucose is well controlled and have no other risk factors. (magiran.com)
The growth phase of melanoma was vertical in 13 (92.9%) patients and radial phase in one (7.1%) patient. (magiran.com)
Identifying Clinicopathological Factors Associated with Oncotype DX 21-Gene Recurrence Score: A Real-World Retrospective Cohort Study of Breast Cancer Patients in Quebec City, Canada. (cdc.gov)

Both of these active ingredients act on the cannabinoid receptor 1 (CB1), with THC a partial agonist and CBD a negative allosteric modulator. (news-medical.net)

His clinical features included a papulopustular rash, dry skin, chronic diarrhoea, abnormalities of hair growth, breathing difficulties and electrolyte imbalances. (wikipedia.org)
Clinical outcomes and Oncotype DX Breast Recurrence Score® in early-stage BRCA-associated hormone receptor-positive breast cancer. (cdc.gov)
Other factors have been suggested to correlate with response to immunotherapy based on clinical and preclinical studies, including elevated type 1 helper T cell (Th1) tumoral gene signature, [ 11 ] and IFN-γ expression, possibly attributable to its ties to other proteins and cytokines within the tumor microenvironment. (medscape.com)

Toll-like receptors are transmembrane glycoproteins, which recognize many PAMPs with extracellular domains and aggravate the exaggerated inflammatory response to bacterial infection through activating nuclear factor (NF)-κB ( 12 ). (frontiersin.org)

Notch receptors are cell surface glycoproteins that play key roles in a number of developmental cascades in metazoa. (rcsb.org)

Nuclear localized HER family receptor tyrosine kinases (RTKs) have been observed in primary tumor specimens and cancer cell lines for nearly two decades. (plos.org)
Proto-oncogenic factors help in cell growth. (healthresource4u.com)
BackgroundIL-6 receptor (IL-6R) signaling drives development of T cell populations important to type 1 diabetes pathogenesis. (bvsalud.org)

Paula studied protein delivery to lysosomes at the Cambridge Institute of Medical Research for her first postdoc, and for her second she investigated the role of ubiquitin in the signalling and down-regulation of growth factor receptors at the Physiological Laboratory, University of Liverpool. (swansea.ac.uk)
The Ubiquitin Isopeptidase UBPY Regulates Endosomal Ubiquitin Dynamics and Is Essential for Receptor Down-regulation. (swansea.ac.uk)

Our results are the first to tubes (SWCNT) suggest the potential to interact report disruption of the mitotic spindle by with critical biological structures. (cdc.gov)

Here we describe the efficient synthesis, folding, and structural characterization of EGF repeat 12 (EGF 12) of a mouse Notch-1 receptor bearing different O-fucose glycan chains. (rcsb.org)
Boyer-Di Ponio J, Wright-Crosnier C, Groyer-Picard MT, Driancourt C, Beau I, Hadchouel M, Meunier-Rotival M. Biological function of mutant forms of JAGGED1 proteins in Alagille syndrome: inhibitory effect on Notch signaling. (medlineplus.gov)

Across all dose levels, average steady-state plasma PF-04691502 concentrations approximated or exceeded the target concentration of 16.2 ng/mL required for ≥75 % tumor growth inhibition in preclinical models. (researchgate.net)

Control of growth factor receptor dynamics by reversible ubiquitination. (swansea.ac.uk)

Incidence rates in the general population are closely associated with the incidence of tobacco smoking, as the majority of lung cancer cases are linked to this single risk factor ( 2 ). (spandidos-publications.com)

Cohen shared the 1986 Nobel Prize in Medicine with Rita Levi-Montalcini for their discovery of growth factors. (wikipedia.org)

To accomplish this goal, various intracellular regions of HER3 were fused to the DNA binding domain of the yeast transcription factor Gal4 (Gal4DBD) and tested for their ability to transactivate Gal4 UAS-luciferase. (plos.org)

There are many different risk factors that lead to breast cancer. (healthresource4u.com)
Despite methodological differences, findings evidence that although IBC presents particular features (lower survival rate and worse prognostics than most types of breast cancer), very few studies examine its epidemiology and specific risk factors in depth and use any other therapeutic approaches than those commonly used for other breast cancer subtypes. (bvsalud.org)
Breast cancer is the most frequent cancer among wom- but not in limited-resource settings with weak health en worldwide, affecting 2.1 million women annually and systems (4) . (who.int)

However, the regions of each receptor that confer transcriptional potential remain poorly defined. (plos.org)

Membrane-bound HER receptors activate numerous tumor promoting signaling cascades via this mechanism, including the PI3K/AKT, Ras/Raf/Mek/Erk, PLCγ/PKC, and signal transducer and activator of transcription (STAT) pathways [1] , [2] . (plos.org)

Anatomy23

Organisms8

Diseases17

Chemicals and Drugs123

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes52

Disciplines and Occupations1

Information Science3

Health Care1

EGFR30

Signal transduction3

HER211

Phosphorylation3

Ligands4

Transmembrane receptor protei1

Progesterone3

Mutation2

Journal of Biolog1

Overexpression2

Genetic4

Immune receptors1

Cells11

Proliferation1

Endogenous1

Innate immune r1

Human4

Patients4

Allosteric1

Clinical3

Extracellular domains1

Glycoproteins1

Cell3

Ubiquitin2

Disruption1

Notch2

Tumor growth1

Dynamics1

Closely1

Discovery1

Intracellular1

Breast cancer3

Confer1

Transcription1