Biological molecular sequence data. Medical search. Frequent questions

Humans have been mapping the world for several millennia, but genomes have been mapped and explored for just a single century with the greatest advancements in making a sequence reference map of the human genome possible in the past 30 years. (scienceblogs.com)
A reference genome sequence is a map that provides the essential coordinate system for annotating the functional regions of the genome and comparing differences between individuals' genomes. (scienceblogs.com)
Examination of the DNA sequences of the corresponding genes showed that these regions of low identity were typically caused by a frameshift in one of the two genomes relative to the other. (cdc.gov)
2012 . Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes. (sc.edu)
Stowers genomics scientist Marco Blanchette, PhD, who interviewed the interns in Eugene, says the demand for biologists proficient in data analysis has skyrocketed due to next-generation sequencing technology, which allows analyses of entire genomes. (stowers.org)
To investigate the Korean wolf's genetic affiliations and taxonomic status, we sequenced and analysed the genomes of a Korean wolf dated to the beginning of the 20th century, and a captive wolf originally from the Pyongyang Central Zoo. (bvsalud.org)
Read about how NEB scientists use Golden Gate Assembly, data-optimized assembly design (DAD) and online tools to design one-pot assemblies of medium to high complexity genomes. (neb.com)
Here we investigate three sets of whole HCV genomes in order to directly compare the evolution of whole HCV genomes at different biological levels: within- and among-hosts. (ox.ac.uk)
Here, many private ( Click here for one example ) and public cohorts are developing, each differing in priorities, pace, and approaches, which could lead to millions of genomes sequenced in the next few years ( see table ). (cdc.gov)

Genetic analysis is error prone and the data require validation because the methods for collecting DNA sequences create artifacts and the reference sequence used for comparative analyses is incomplete. (scienceblogs.com)
The primary goal of this course is to introduce the field of bioinformatics and to familiarize your self with working in the UNIX/LINUX environment, standard DNA sequence analyses, and online database resources. (nova.edu)
Apply the appropriate bioinformatics analyses to address real biological questions. (nova.edu)
The main purpose of the CKQ questionnaire was to collect data on factors which may cause transient elevations in CPK (a history of recent injury or heavy physical exertion) so that data analysts can account for such cases in their analyses of the relationship of CPK to health conditions. (cdc.gov)
has experience in omics data analyses and is proficient in R. (nature.com)
High-throughput sequencing (HTS), particularly DNA metabarcoding, enables community-wide analyses of diversity and interactions at unprecedented scales and at a fraction of the cost that was previously possible. (springer.com)
In the last two decades, DNA barcoding, the sequencing of short species-specific amplicons, has considerably simplified community analyses (Hebert et al. (springer.com)
This provides the opportunity for ecologists, evolutionary biologists and molecular biologists to incorporate bioinformatic analyses into their existing research program to approach their research questions from an interdisciplinary angle. (lu.se)
Several downstream analyses are performed and their utility in applied ecology, evolutionary biology and molecular biology research will be discussed with guest speakers. (lu.se)
More comprehensive molecular analyses may hold more promise in developing models to predict treatment of a disease as heterogeneous as RA, write the authors, led by chief investigator Costantino Pitzalis, MD , head of the Centre for Experimental Medicine and Rheumatology at Queen Mary University of London. (medscape.com)

The course will cover basic molecular biology topics such as information storage and readout by DNA, RNA, and proteins. (princeton.edu)
Previous work in this area has been on modeling the assembly structure of the type III secretion system and prediction of the high-resolution structures of homo-oligomeric proteins using limited experimental data from Nuclear Magnetic Resonance (NMR) in order to speed up the process of structure determination. (lu.se)

DNA sequences evolve through duplication and mutation and, as a result, contain many repeated sequences of different sizes, which complicates data analysis. (scienceblogs.com)
Other sources of experimental information include X-ray diffraction, biotinylation, sequence mutation and deletion, solution binding and chemical cross-linking data. (lu.se)

The amino acid sequence (31-32 residues) of the central filament region of β-keratins is highly conserved throughout all reptiles and birds suggesting that this domain has changed little in ~285 Ma of evolution (Fraser and Parry, 2010). (sc.edu)
Presently we are using molecular dating approaches, such as BEAST, to gain a better understanding of the how the molecular evolution of the avian β-keratins relates to the evolutionary origin of feathers. (sc.edu)
Our approach is to combine molecular dating techniques with knowledge of the sauropsid fossil record, feather development, molecular evolution of the avian β-keratins, and the biophysical properties of feathers to gain a better understanding of feather evolution. (sc.edu)
Thus the evolutionary origin of feathers does not coincide with the molecular evolution of feather β-keratins found in modern birds. (sc.edu)
2013 . Molecular evolution and expression of archosaurian b ‐ keratins: Diversification and expansion of archosaurian β ‐ keratins and the origin of feather β ‐ keratins. (sc.edu)
2011 . Linking the molecular evolution of avian beta keratins to the evolution of feathers. (sc.edu)
Genome sequencing has documented the importance of mobile DNA activities and major genome restructuring events at key junctures in evolution: exon shuffling, changes in cis-regulatory sites, horizontal transfer, cell fusions and whole genome doublings. (naturalgenesis.net)
Despite the virus' public health importance and a wealth of sequence data, basic aspects of HCV molecular evolution remain poorly understood. (ox.ac.uk)
This confirms that differences in molecular evolution between biological scales are not restricted to HIV and may represent a common feature of chronic RNA viral infection. (ox.ac.uk)

This year three University of Oregon (UO) graduate students headed to Stowers to learn how to apply computer analysis to molecular genetics, a booming discipline known as bioinformatics. (stowers.org)
The primary goal of this course is to introduce the student to the field of bioinformatics and the skills needed to manipulate datasets from biological studies. (nova.edu)
This text helps readers to overcome the most frustrating aspects of data processing to focus on the pleasures of scientific inquiry.Although many of the techniques are relevant to molecular bioinformatics, the motivation for the text is much broader, focusing on topics and techniques that are applicable to a range of scientific endeavors. (nova.edu)
Dotmatics recently announced the new release of their data visualization and analysis solution, Vortex, with new bioinformatics features that are tailored to support biologics discovery. (technologynetworks.com)
Bioinformatics analysis of the complete sequence of a typical H. influenzae conjugative resistance element, ICEHin1056, revealed the shared evolutionary origin of this element. (ox.ac.uk)
Speak to a representative from QIAGEN Bioinformatics to take a closer look at a few representative data sets of variants that have been through the QCI™ Interpret workflow. (qiagen.com)
The purpose of the course is for students to acquire a general understanding of bioinformatics concepts and tools commonly used in biology and molecular biology. (lu.se)
You will be trained to conduct bioinformatics research with purpose of answering scientific questions in various biological subject areas. (lu.se)
The aim of the course is to provide the students with a general understanding of several major bioinformatics concepts and tools commonly used in biology and molecular biology. (lu.se)
More specifically, the course gives an overview of the most commonly used methods within applied bioinformatics within the fields of biology and molecular biology. (lu.se)
For admission to the course, English 6/English B and entry requirements for the Master's programme in Bioinformatics, or knowledge corresponding to 120 credits in biomedicine or molecular biology, is required. (lu.se)

We addressed the question of polymorphism in M. tuberculosis by comparing protein-coding genes in two completely sequenced genotypes, H37Rv and CDC1551 ( 4 ). (cdc.gov)
We applied the BLASTP program ( 5 ) to identify, for each predicted protein sequence in the H37Rv genome (GenBank accession no. (cdc.gov)
Quantitative assays for HCV antigen-specific CD4+ and CD8+ T-cell responses, and flow cytometric assays for analysis of the phenotype of T cells, in addition to viral sequencing of core protein, were performed throughout the treatment and follow-up period over 18 months. (ox.ac.uk)
A key focus for the UCLA center will be creating and testing cloud-based tools for integrating and analyzing data about protein markers linked to cardiovascular disease. (feedburner.com)
DNA and protein molecular sequence data from environmental microbial samples encode key pieces of information on which species inhabit these environments and how they function. (newswise.com)
Our latest issue of NEB Expressions covers lyophilized assays for regulated markets, our new phi29-XT RCA Kit, web tool updates, and solutions for automating DNA assembly, sequencing, mutagenesis, cell-free protein expression and more! (neb.com)
Data were acquired using unbiased data-independent mass spectrometry (MS). Statistically significant and measures were processed in ProteinLynx Global Server and sequenced using in-house software EndogeSeq against selective subsets of a mouse UniProt protein database. (cdc.gov)
Many biological processes are controlled by large multi-component protein assemblies, the size and complexity of which typically precludes the determination of their high-resolution structures. (lu.se)
Our goal is to use high-resolution structural modeling techniques guided by constraints taken from lower resolution experimental data to generate structural models of important biological protein assemblies for which high resolution structural determination is unfeasible. (lu.se)
We are also interested in understanding how oligomerization specificity is encoded in protein sequence and structure, in particular in coiled-coils. (lu.se)
Areas that will be covered include: sequence databases, pairwise and multiple sequence alignment, searches in sequence databases, amino acid substitution matrices, secondary structure, prediction of RNA and polypeptides, and models for protein classification. (lu.se)

But I hadn't met many PhD students who knew how to analyze their own data," she says. (stowers.org)
If I were to pursue a PhD or a career in biology, I would want to know how to analyze my own data. (stowers.org)
We are interested in working with partners to generate data, to analyze data, and to share (and re-use) data for the broader benefit of the scientific community. (sfu.ca)
Provides students with the knowledge required to collect, analyze and interpret molecular sequence data using phylogenetic methodologies. (csueastbay.edu)
The development of CCI databases is beneficial for researchers who want to analyze single-cell sequencing data or study CCI through molecular experiments. (bvsalud.org)
Andrew discusses the challenges associated with harnessing large data sets and the implications that could arise from the inability to sufficiently access, share and analyze scientific data in terms of biopharmaceutical and small molecule discovery. (technologynetworks.com)
Learn how to use Expression to investigate molecular responses to perturbations in biological systems and normalize and analyze array data and summaries from NGS studies that use intensity, aligned read and count data formats. (jmp.com)
You will also use new computational strategies to analyze your data and integrate them with readily available multi-omics adult datasets. (nature.com)

With the discovery of the structure of DNA by Francis Crick and James Watson in 1953, the realm of molecular biology opened up, leading to advances in cell biology, developmental biology and molecular genetics. (wikipedia.org)
Important concepts and elements of molecular biology, biochemistry, genetics, and cell biology, are examined in an experimental context. (princeton.edu)
Further, she has been listed amongst Thomson Reuters 100 "most highly cited researchers" in Molecular Biology and Genetics consecutively since 2014. (genetics.org.uk)

Molecular structures and models helped scientists realize that this approach might work. (scienceblogs.com)
Enormous volumes of biological, chemical, and clinical data are generated every day, from genomic sequences to molecular structures and patient health records. (promozik.org)
The laboratory will offer hands-on experience in recording signals from single neurons, examining neural structures, and analysis of whole-brain functional brain imaging data. (princeton.edu)
In the past few years, several structures of algal and invertebrate fucans have been solved, and many aspects of their biological activity have been elucidated. (unboundmedicine.com)
The availability of purified fucans and fucan fractions with simple, but varied structures, in conjunction with the development of new enzymatic tools, demonstrate that the biological properties of sulfated fucans are not only a simple function of their charge density but also are determined by detailed structural features. (unboundmedicine.com)
The methods developed in this project will allow scientists to discover community structures hidden within very large graphs built out of high‐throughput biological data. (newswise.com)
By measuring the self-diffusion of molecules in biological tissues, we obtain information about microscopic structures that are too small to resolve in conventional images. (lu.se)

Her work dissects the genetic landscape of common complex diseases through the integration of large-scale data sets on genomic sequence variation, clinical information and molecular read outs, with a particular focus on endocrine and metabolic traits. (genetics.org.uk)
In recent years, the United Kingdom (UK) has made a major commitment to developing a large scale population cohort study (100,000 genome project), linking high quality genomic sequence data to electronic health record information for the purposes of scientific discovery and clinical care improvement. (cdc.gov)

These molecular genetic discoveries, plus a consideration of how mobile DNA rearrangements increase the efficiency of generating functional genomic novelties, make it possible to formulate a 21st century view of interactive evolutionary processes. (naturalgenesis.net)
To these data we applied the evolutionary theory of task specialisation (ParetoTI) to identify and characterise distinct archetypes, i.e. molecular subtypes, of LNETs. (who.int)

Whole-genome sequencing of non-model organisms is now widely accessible and has allowed a range of questions in the field of molecular ecology to be investigated with greater power. (lu.se)
Molecular Ecology published by John Wiley & Sons Ltd. (lu.se)
Specified Elective Courses" must exclusively be selected from amongst a list of courses within the categories of either "Pollution Control and Modeling", or "Molecular Ecology and Microbial Biotechnology", or "Socio-Ecological Sustainability" concentration areas. (boun.edu.tr)

We aligned ( 6 ) the putative orthologous pairs of amino acid sequences (N = 3,428), then imposed this alignment on the DNA sequences. (cdc.gov)
Visual inspection of amino acid alignments showed that certain alignments, usually near the N-terminus or C-terminus, had regions of very low sequence identity. (cdc.gov)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)

The current methods for determining a DNA sequence rely on mimicking the processes used in nature to replicate DNA and copy chromosomes before cells divide. (scienceblogs.com)
By analyzing patient data, AI models can identify suitable candidates for clinical trials, optimizing patient recruitment processes. (promozik.org)
You will be expected to review data for the validation of new alleles, analyse production data to improve lab processes, and present your findings in publications. (jobs.ac.uk)
The biological processes in which it is involved are not known. (yeastrc.org)
Variants must be examined within the context of complex biological processes, and rapidly increasing throughput makes analysis labor intensive. (qiagen.com)

After the deoxyribonucleic acid (DNA) sequence of the human genome was completed in 2003, the reference sequence underwent several improvements and today provides the underlying comparative resource for a multitude genetic assays and biochemical measurements. (scienceblogs.com)
Classical genetic techniques as well as molecular and genomic approaches will be discussed. (princeton.edu)
She is co-founder and co-chair of the International Common Disease Alliance, aimed at accelerating discovery from genetic maps to biological mechanisms to physiology and medicine. (genetics.org.uk)

Studies are needed to understand the breadth of ENM's toxic potential and biological effects on humans. (cdc.gov)

Critical Reviews in Biochemistry and Molecular Biology. (cdc.gov)

Advances in DNA sequencing technology have made it increasingly affordable to sequence a person's entire genome, but managing genomic and related data from millions of individuals is a daunting challenge. (feedburner.com)
See how to use Next Generation Sequencing to help find molecular candidates for new therapies, medical advances and diagnostic tools and molecular technologies. (jmp.com)
keeps up with the current literature on advances in single-cell and spatial sequencing. (nature.com)
Major technological advances in affordable nucleic acid sequencing have allowed for an explosion of sequencing data and molecular tools available for researchers in biological sciences. (lu.se)

Such a direct method for reading a sequence could be faster and more accurate than current approaches. (scienceblogs.com)
Investigators also will train the next generation of experts and develop data science approaches for use by scientists. (feedburner.com)
Finally, we assessed further technical improvements, such as nanopore adaptive sequencing and bioinformatic tools using pangenomes, which have the potential to further expand our knowledge of a number of genomic regions that remain challenging to study with classical resequencing approaches. (lu.se)
2006 ). The recent advent of molecular metabarcoding approaches is just starting to revolutionize our ability to characterize biological communities (Cristescu 2014 ). (springer.com)

We constructed a cell-cell interaction database (CCIDB) containing the biological and clinical contexts involved in each interaction. (bvsalud.org)
By publicly releasing clinical and genomic data from more than 25,000 patients," he added, "we hope that this will become a valuable resource for the community that will empower researchers and facilitate the study of metastatic disease. (genomeweb.com)
Together with molecular data across 341 to 468 cancer genes profiled with the MSK-IMPACT clinical sequencing assay , these insights made it possible to compare molecular features found in tumors from primary or metastatic sites in individuals with or without metastases. (genomeweb.com)
Clinical and genomic data generated for participants from the MSK-MET cohort so far is available online via the cBioPortal for Cancer Genomics database. (genomeweb.com)
QIAGEN Clinical Insight (QCI™) for Somatic Cancer is an integrated clinical decision support solution designed specifically for routine somatic cancer testing laboratories assessing next-generation sequencing (NGS) data. (qiagen.com)
Getting from raw sequencing data to clinical insight continues to be one of the most significant challenges in modern molecular testing. (qiagen.com)
Using QIAGEN Clinical Insight, we have been able to consolidate all portions of the variant interpretation and reporting process, while decreasing total analysis time and increasing the amount of clinically relevant data that we can report to our clinicians. (qiagen.com)
Additionally, we identified six tumours, termed supra-carcinoids, that displayed genuine carcinoid-like morphology, but had clinical and molecular characteristics of LNECs. (who.int)
The focus of our work is to better understand the biological and clinical characteristics of these molecular groups of carcinoids. (who.int)
To address this aim we have designed the lungNENomics study, an international cohort of over 250 cases of pulmonary carcinoids, with clinical data and central pathology review, as well as whole-genome sequencing, RNA sequencing, DNA methylation array, and digital spatial profiling data. (who.int)
In this newest study, researchers combined data from two clinical studies with identical design: the Stratification of Biological Therapies by Pathobiology in Biologic-Naive Patients With Rheumatoid Arthritis (STRAP) trial, taking place in the United Kingdom, and STRAP-EU, which recruited patients from the European Union. (medscape.com)

This grant from the National Human Genome Research Institute (NHGRI) funds the Center for Big Data in Translational Genomics, a multi-institutional partnership based at UC Santa Cruz and led by David Haussler, professor of biomolecular engineering and director of the UC Santa Cruz Genomics Institute. (feedburner.com)
The Center for Big Data in Translational Genomics will develop new protocols and tools for genomic data and test them in four pilot projects. (feedburner.com)
Cecilia Lindgren is Director of the Oxford Big Data Institute, University of Oxford, UK, where she is also a Professor of Genomics of Endocrinology and Metabolism, a Wellcome Trust Investigator, and a Senior Research Fellow at St. Anne's College. (genetics.org.uk)
The Centre for Infectious Disease Genomics and One Health at SFU is an interdisciplinary group of researchers with backgrounds in microbiology, molecular biology, computer science, cognitive science, statistics, public health, and genomics. (sfu.ca)

In fact, these models and the research they inspired led to the first commercial systems for nanopore sequencing. (scienceblogs.com)
Nanopore sequencing methods were not easy to develop. (scienceblogs.com)
The first commercial system for nanopore sequencing ( Oxford Nanopore Technologies Ltd ) required 20 years of scientific trial and error. (scienceblogs.com)
The first problem that needed to be solved in getting nanopore sequencing to work was to figure out how to make smaller holes. (scienceblogs.com)

Although the concept of zoology as a single coherent field arose much later, the zoological sciences emerged from natural history reaching back to the biological works of Aristotle and Galen in the ancient Greco-Roman world. (wikipedia.org)
This course fulfills the requirement for students majoring in the biological sciences and satisfies the biology requirement for entrance into medical school. (princeton.edu)
At WSU, he holds affiliate faculty positions at the Molecular Plant Sciences Graduate Program and the Paul G. Allen School for Global Animal Health. (newswise.com)

Our facility includes a state-of-the-art molecular laboratory for microbial sample processing and omics data generation and access to high-performance computing clusters and cloud computing (courtesy of Compute Ca nada) to provide a "one-stop-shop" for research and collaboration. (sfu.ca)

1994. Recurrent origin of a sexually selected trait in Xiphophorus fishes inferred from a molecular phylogeny. (ccri.edu)

Machine learning models can predict the interactions between drug compounds and biological targets, enabling researchers to pinpoint compounds with the highest likelihood of success. (promozik.org)
Researchers can now share data, insights, and findings seamlessly, facilitating a collective effort to tackle complex diseases. (promozik.org)
As one of 11 centers nationwide, UCLA will create analytic tools to address the daunting challenges facing researchers in accessing, standardizing and sharing scientific data to foster new discoveries in medicine. (feedburner.com)
Given the diversity of microorganisms (bacteria, viruses, parasites) and the complex of biological phenomena that we seek to understand, data-driven research in microbiology requires researchers to collaborate and to share data. (sfu.ca)
Developing technologies to foster data harmonization and sharing, and building trusted networks of health care practitioners, researchers, and policy makers are therefore key focuses of the Centre. (sfu.ca)
As they reported in Cell on Thursday, the researchers analyzed targeted panel sequence data for 15,632 primary and 10,143 metastatic tumors from a total of 25,755 metastatic cancer patients in the MSK-MET cohort, including patients who had matched primary and metastatic tumor samples sequenced. (genomeweb.com)
Using electronic health record data, the researchers searched for patients with metastatic disease and information about the timing of metastasis. (genomeweb.com)

Topics include bio-sequence comparison and analysis, functional site prediction, structure prediction and analysis, and biological data analysis. (uga.edu)
PIQMEE: Bayesian phylodynamic method for analysis of large datasets with duplicate sequences. (cdc.gov)
Enter DataONE: the Data Observation Network for Earth, a collaboration of distributed organizations with data centers and science networks, including the Knowledge Network for Biocomplexity (KNB) administered by UC Santa Barbara's National Center for Ecological Analysis and Synthesis (NCEAS). (feedburner.com)
The center's findings will help shape guidelines for future data integration and analysis, and the management of data from electronic health records. (feedburner.com)
The goal of this research is to develop novel parallel algorithms for graph‐theoretic analysis of biological data on next‐generation supercomputing platforms. (newswise.com)
From this initial success, Dotmatics has built a complete suite of integrated informatics products , including an electronic laboratory notebook (Studies Notebook), assay data management system (Studies), registration for small molecules (Register) and biopharmaceuticals (Bioregister), analysis and visualization (Vortex) and workflow management (Cascade). (technologynetworks.com)
We discuss amplicon-based DNA barcoding and metabarcoding for the analysis of community diversity and molecular gut content analysis for assessing predator-prey relationships. (springer.com)
The primary aim of the course is that the students shall acquire deeper understanding of, and skills in, basic concepts and tools for comparative sequence analysis, including various types of primary and secondary sequence databases. (lu.se)
These data have been combined with previously published LNET data to perform integrative analysis using multi-omics factor analysis (MOFA), resulting in a molecular map of lung neuroendocrine neoplasms for exploration. (who.int)
Multi-omics integration analysis of 319 carcinoids resulted in a molecular map forming a distinctive tetrahedron. (who.int)

While completing original research, you will employ techniques used by cell and molecular biologists and developmental geneticists. (princeton.edu)

The current reference genome sequence is a collection of sequences, an assembly, that include sequences assembled into chromosomes, sequences that are part of structurally complex regions that cannot be assembled, patches (fixes) that cannot be included in the primary sequence, and high variability sequences that are organised into alternate loci. (scienceblogs.com)
A new article demonstrates that it's possible to assign the sex of individuals by considering the ratio of sequences aligning to chromosomes X and Y. This seems quite useful, since often ancient DNA is extracted from isolated finds where there isn't enough of the skeleton to make a sex determination morphologically. (blogspot.com)

The cellular and molecular basis of innate and acquired immunity will be discussed in detail. (princeton.edu)
For this, you will use a combination of advanced cellular and molecular techniques in developing mice, from viral axon tracing, to single-cell and spatial RNA sequencing. (nature.com)
has some laboratory experience and is ready to learn new cellular and molecular biology techniques. (nature.com)
This limits the surveillance of the sequence space for esterases potentially leading to new versatile biocatalysts and new insights into their role in cellular function. (inrae.fr)
There are new opportunities to using data from molecular and cellular studies in order to bring together a fuller biological understanding of how chemicals induce neoplasia. (cdc.gov)

We hypothesized that molecular profiling of tumors can provide useful information to investigate these questions. (genomeweb.com)

Promoting best practice in nucleotide sequence data sharing. (cdc.gov)

The prediction of esterases substrate promiscuity level from sequence data and the molecular reasons why certain such enzymes are more promiscuous than others, remain to be elucidated. (inra.fr)
We found a structural parameter that helps ranking (classifying) promiscuity level of esterases from sequence data at 94% accuracy. (inrae.fr)

ICEHin1056 has homology to 20 contiguous sequences in the National Center for Biotechnology Information database. (ox.ac.uk)
A 1700 base pair cDNA for a putative Magadi tilapia urea transporter (mtUT) was cloned, sequenced and found to display high homology with urea transporters from mammals, amphibians and other fishes. (mcmaster.ca)
Areas that will be covered include: sequence databases, pairwise and multiple sequence alignment, homology searches in sequence databases and subcellular localization prediction. (lu.se)

Discovery of this second putative receptor site provides a dual-receptor paradigm that could explain much of the molecular mechanisms of pyrethroid action and resistance as well as the high selectivity of pyrethroids on insect vs. mammalian sodium channels. (duke.edu)

We designed custom adapters (Table S5) so that the standard Illumina sequencing primers would not interfere with our library. (nih.gov)

A major advance in the study of the molecular basis of these changes was the cloning of cDNA encoding the enzyme. (nih.gov)
Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: molecular cloning, expression and biological properties. (ox.ac.uk)

In this project, we use principles from multidimensional solid-state NMR spectroscopy to design new MRI pulse sequences and data processing methods for investigating cell density, shape, alignment, heterogeneity, and membrane permeability. (lu.se)

Topics include aligning molecular sequence data, analyzing data with parsimony, likelihood and Bayesian methods, and utilizing phylogenetic information for hypothesis testing. (csueastbay.edu)
However, morphological methods are imprecise for juvenile individuals and fragmentary remains, and molecular methods that rely on particular sex-specific marker loci such as the amelogenin gene suffer from allelic dropout and sensitivity to modern contamination. (blogspot.com)

DNA sequence data are interpreted through biochemical experiments or comparisons to other DNA sequences. (scienceblogs.com)
Your role will involve designing and conducting experiments, analysing data, and presenting findings to internal and external stakeholders. (jobs.ac.uk)

The reference genome sequence is always product of understanding at a set point in time and continues to evolve. (scienceblogs.com)

questions CKQ010 CKD070) collects survey participant interview data to help interpret NHANES laboratory data for serum Creatine Phosphokinase (CPK). (cdc.gov)
QCI Interpret is an evidence-based decision support software intended as an aid in the interpretation of variants observed in genomic sequencing data. (qiagen.com)

Systematic comparison of these homologous sequences resulted in identification of a conserved syntenic genomic island consisting of up to 33 core genes in 16 beta- and gamma-Proteobacteria. (ox.ac.uk)

Esterases receive special attention because their wide distribution in biological systems and environments and their importance for physiology and chemical synthesis. (inra.fr)

While progress has been made in recent years in the characterisation of pulmonary carcinoids, little is known about the underlying biology or developmental origins of these molecular groups, hampering efforts to identify predictive markers and suitable therapeutic options. (who.int)

Instead it is an assembly of consensus sequences that are designed to deal with variation in the human population and uncertainty in the data. (scienceblogs.com)
DNA sequence variation happens on large and small scales with respect to the lengths of the DNA differences to include single base changes, insertions, deletions, duplications and rearrangements. (scienceblogs.com)
Wu AH, Smith A, Wians F. Interpretation of creatine kinase and aldolase for statin-induced myopathy: Reliance on serial testing based on biological variation. (cdc.gov)

At the beginning of the 21st century, molecular cell biology has revealed a dense structure of information-processing networks that use the genome as an interactive read-write memory system rather than an organism blueprint. (naturalgenesis.net)
Molecular cell biology has uncovered sophisticated networks in all organisms. (naturalgenesis.net)

Mapping short-read sequences against multiple alternative references improves genotyping comprehensiveness at the S-locus thereby contributing to more accurate assessments of allelic frequencies. (lu.se)

Glioma grading, molecular feature classification, and microstructural characterization using MR diffusional variance decomposition (DIVIDE) imaging. (lu.se)

However, some remarkable differences among species in the molecular mechanisms involved in regulating the enzyme have been discovered. (nih.gov)

Next, in 2012 she was appointed a Scholar in Residence at the Broad Institute of Harvard and MIT, USA before returning to Oxford to join the Big Data Institute with Gil McVean in 2015, where she was appointed Director in 2021. (genetics.org.uk)

Lectures will give an overview at levels ranging from molecular signaling to cognitive science with a focus on the neuroscience of everyday life, from the general (love, memory, and personality) to the particular (jet lag, autism, and weight loss). (princeton.edu)

This lecture and laboratory course will acquaint non-biology majors with the theory and practice of modern molecular biology, focusing on topics of current interest to society. (princeton.edu)
Individuals who are interested in an early research experience that substitutes for MOL350-Laboratory in Molecular Biology can enroll in this course. (princeton.edu)
laboratory animal data. (cdc.gov)

The project is expected to yield valuable scientific insights on the molecular underpinnings of health and disease states. (cdc.gov)

However, traditional Sanger sequencing-based DNA barcoding protocols can be prohibitively expensive and laborious when large community samples have to be processed. (springer.com)

As a Senior Molecular Biologist, you will be responsible for developing and implementing molecular biology techniques to support our research programs. (jobs.ac.uk)

Despite these challenges, we have learned to make reactions smaller and run them in massively parallel formats to make sequencing very fast and cheap. (scienceblogs.com)
In its second phase, DataONE will target goals that enable scientific innovation and discovery while massively increasing the scope, interoperability and accessibility of data. (feedburner.com)

If you are a highly motivated Senior Molecular Biologist with a passion for scientific discovery and innovation, we encourage you to apply for this exciting opportunity. (jobs.ac.uk)
From these presentations it appears that scientific and health services leadership in the UK are well on their way to developing a robust national program that addresses long term needs regarding data collection and interpretation as well as delivery of care. (cdc.gov)

We can find no data for thiol radical cations, which suggests that these are high I-CBP112 web energy species with E? (ezh2inhibitor.com)
Using those comparisons, we built a network (or graph) and used that network to mine for clusters or groups that represent the key biological building blocks (species groups or functional modules). (newswise.com)
Here, using both physiological and molecular studies, we describe the mechanism of branchial urea excretion in this species. (mcmaster.ca)
These low and high-resolution data sets originates from T3SSes from different species and can also be collected from other structurally homologous systems, such as the flagella. (lu.se)

SAGO statement on newly released SARS-CoV-2 metagenomics data from China CDC on GISAID. (who.int)

The structure of biological tissues can be mimicked by carefully designed colloidal model systems such as emulsions, gels, and liquid crystals. (lu.se)

development and solution of statistical and mathematical biological models. (uga.edu)

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Analyze8

Genetics3

Structures7

Genomic sequence2

Evolutionary2

Ecology3

Amino acid3

Processes5

Genetic3

Humans1

Biochemistry1

Advances4

Approaches4

Clinical11

Genomics4

Nanopore4

Sciences3

Omics data1

Phylogeny1

Researchers7

Analysis10

Biologists1

Chromosomes2

Cellular5

Investigate1

Nucleotide1

Promiscuity level2

Homology3

Putative1

Primers1

Cloning2

Alignment1

Methods2

Experiments2

Continues to evolve1

Interpret2

Genes1

Physiology1

Developmental1

Variation3

Cell biology2

Allelic1

Characterization1

Mechanisms1

20211

Cognitive science1

Laboratory3

Insights1

Samples1

Biology techniques1

Massively2

Scientific2

Species4

Metagenomics1

Structure of biological1

Models1