Biological functions biological function of genes. Medical search. Frequent questions

The differentially expressed genes (DEGs) in AD were screened in GSE48350 dataset. (nature.com)
The differentially expressed oxidative stress genes (DEOSGs) were analyzed by intersection of DEGs and oxidative stress-related genes. (nature.com)
In this study, we performed a new bioinformatics analysis on microarray-based gene expression data obtained from the public domain to explore genes that were differentially induced by drugs between the group of capreomycin and PA-824 and the group of mainly the first-line TB drugs. (hindawi.com)
By integrating two datasets (GSE77459 and GSE92681) in the GEO database using the sva and limma packages of R, differentially expressed genes (DEGs) of pulpitis were identified. (researchsquare.com)
Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed on differentially expressed genes (DEGs). (spandidos-publications.com)
The results showed that USF1 significantly regulates 350 differentially expressed genes (DEGs). (spandidos-publications.com)

This protein encoded by this gene belongs to the WD repeat-containing family of proteins, which function in the formation of protein-protein complexes in a variety of biological pathways. (nih.gov)
WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases. (nih.gov)
Protein-protein interaction (PPI) networks and modules were constructed to identify hub genes with the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and Cytoscape. (researchsquare.com)
This gene encodes one of three calmodulin proteins which are members of the EF-hand calcium-binding protein family. (nih.gov)
Gene ontology functional enrichment analysis was performed using search tool for the retrieval of interacting genes/proteins. (ijpsonline.com)
To tackle this issue, the development of network-based methods has become an effective tool in analyzing complex relationships among great number of entities such as genes and proteins. (biomedcentral.com)
Genome annotation disclosed 29 SARS-CoV-2 gene products - including 16 non-structural proteins, 4 structural proteins and 9 accessory factors. (news-medical.net)
In short, from a total of 437 high-confidence interacting proteins that bind to one or more SARS-CoV-2 genes, the researchers have identified several gene products, M protein, NSP6, ORF3a, ORF6 and ORF7b that interacted with host cell membrane proteins and complexes. (news-medical.net)

Loss-of-function mutations in CFAP57 cause multiple morphological abnormalities of the flagella in humans and mice. (nih.gov)
Mutations in the myocilin gene have been found in up to four percent of people with adult-onset glaucoma and 10 percent with juvenile-onset glaucoma. (nih.gov)
Until now, there was little reason to suspect this new role for myocilin, since mutations in the myocilin gene do not appear to cause peripheral nerve disorders. (nih.gov)
Those gene variants, or mutations, also interfered with larger-scale functioning of the brain, interfering with communication among layers and hemispheres, a phenomenon confirmed by previous study of the autistic brain, according to Geschwind. (medicaldaily.com)
Denys-Drash syndrome (DDS) is a rare disorder consisting of the triad of congenital nephropathy, Wilms tumor , and intersex disorders resulting from mutations in the Wilms tumor suppressor ( WT1 ) gene. (medscape.com)
Denys-Drash syndrome is the result of mutations in the WT1 gene on chromosome band 11p13. (medscape.com)
Point mutations in the WT1 gene result in loss of its regulatory function, with the consequent abnormalities in glomerular formation and gonadal differentiation seen in Denys-Drash syndrome. (medscape.com)
Mutations that disrupt the second alternative splicing site of the WT1 gene alter the normal ratio of KTS-positive/negative isoforms from 2:1 to 1:2 and result in abnormalities in glomerular formation and gonadal differentiation seen in Frasier syndrome. (medscape.com)
Germline mutations in other genes such as TNFRSF11A, ZNF687 and PFN1, have also been associated with the development of the disease. (bvsalud.org)

MicroRNAs (miRNAs or miRs) are involved in the post-transcriptional regulation of gene expression via complete or partial base pairing with the 3′untranslated region of target genes ( 3 ). (spandidos-publications.com)
As a TF, USF1 has a bidirectional regulatory function, being able to regulate gene expression by activating or suppressing the promoter region of target genes ( 5 , 6 ). (spandidos-publications.com)
Exons 1-6 of the WT1 gene encode the regulatory domain, which regulates expression of target genes, and exons 7-10 encode the 4 zinc fingers of the DNA-binding region of the WT1 protein. (medscape.com)

By manipulating the neuronal activity of pacemaker neurons, the researchers showed that changes in the electrical activity of clock neurons produce major changes in the expression of circadian genes. (nyu.edu)
A new study published in Science indicates that cocaine sensitization -- which is linked to addiction -- might be associated with circadian genes, the genes that set the biological clock. (sciencedaily.com)
The flies used by Hirsh's team were mutated to lack certain circadian genes. (sciencedaily.com)
Flies containing functional circadian genes did become sensitized to cocaine. (sciencedaily.com)
This indicates that certain circadian genes not only play a critical role in regulating the biological clock, but they may also function in ways that allow susceptibility to drug addiction. (sciencedaily.com)

Enrichment analysis was performed by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes. (nature.com)
Then, the DEGs were analysed to identify biological pathways of dental pulp inflammation with Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and Gene Set Enrichment Analysis (GSEA). (researchsquare.com)
Gene ontology functional enrichment analysis revealed twenty eight biological processes and 10 molecular functions associated with cognitive impairment. (ijpsonline.com)
A putative function has been assigned, using the gene ontology approach, to the set of genes harboring at least one SSR. (researchgate.net)

A total of 470 DEGs comprising 394 upregulated and 76 downregulated genes were found in pulpitis tissue. (researchsquare.com)
GO analysis revealed that the DEGs were enriched in biological processes related to inflammation, and the enriched pathways in the KEGG pathway analysis were cytokine-cytokine receptor interaction, chemokine signalling pathway and NF-κB signalling pathway. (researchsquare.com)
The upregulated DEGs were primarily protein‑coding genes enriched in immune and inflammation response pathways, while the downregulated DEGs were mainly coding long non‑coding (lnc)RNAs, indicating the regulatory function of USF1. (spandidos-publications.com)
Promoter region motif analysis indicated that ETV5 has more binding motifs and genes than USF1 itself for USF1‑regulated DEGs, indicating that USF1 may indirectly modulate gene expression by regulating ETV5 expression in Huh7 cells. (spandidos-publications.com)
In summary, the results demonstrated that USF1 binds to the promoter region of thousands of genes and affects a large part of DEGs indirectly. (spandidos-publications.com)

We performed a multi-omics interrogation to define gene expression and chromatin remodeling associated with ASXL1 MT in chronic myelomonocytic leukemia (CMML). (nature.com)
Chromatin remodeling of promoters and enhancers is strongly associated with gene expression and heterogenous among overexpressed genes. (nature.com)
The microenvironments of the low- and high-risk groups were assessed using xCell, the expression of immune checkpoints was determined, and gene set variation analysis (GSVA) was performed. (hindawi.com)
The immune-related DEOSGs and hub genes were identified by weighted gene co-expression network analysis (WGCNA) and protein-protein interaction (PPI) analysis, respectively. (nature.com)
The mRNA expression of diagnostic genes was determined by qRT-PCR analysis. (nature.com)
Oxidative stress is involved in the modulation of gene expression patterns and metabolic activities, characterized by the disruption of redox homeostasis 7 . (nature.com)
Splicing of introns is required for the expression of most eukaryotic genes. (biomedcentral.com)
Genes whose expression levels rise and fall similarly in a large set of samples, may be considered coexpressed. (mdpi.com)
By integrating different datasets from the Gene Expression Omnibus (GEO) database, we analysed a merged expression matrix of pulpitis, aiming to identify biological pathways and diagnostic biomarkers of pulpitis. (researchsquare.com)
We, therefore, tested the hypothesis that hypoxia would enhance or "prime" microglial pro-inflammatory gene expression in response to a later inflammatory challenge without programmatically increasing basal levels of pro-inflammatory cytokine expression. (frontiersin.org)
We used RNA sequencing coupled with chromatin immunoprecipitation sequencing to analyze primed microglial inflammatory gene expression and modifications to histone H3 lysine 4 trimethylation (H3K4me3) at the promoters of primed genes. (frontiersin.org)
This gene has no protein-coding homolog in any other genome but its presence is supported by evidence from expression and hybridization data. (ubc.ca)
FUT6 and CGNL1 were downregulated in HNSCC compared with adjacent healthy tissue and the expression levels of these genes were associated with tumor stage. (spandidos-publications.com)
Gene co-expression networks are widely studied in the biomedical field, with algorithms such as WGCNA and lmQCM having been developed to detect co-expressed modules. (biomedcentral.com)
In this paper, we propose a novel module detection algorithm based on topology potential and spectral clustering algorithm to detect co-expressed modules in gene co-expression networks. (biomedcentral.com)
Moreover, this method is designed not only for gene co-expression networks but can also be applied to any general fully connected weighted network. (biomedcentral.com)
Among these biomedical networks, gene co-expression network is one of the most widely studied. (biomedcentral.com)
Gene co-expression networks are constructed by gene expression profiles and in which each gene is represented by a node and the relationship between a pair of gene is represented by a connected edge. (biomedcentral.com)
The strength of the relationship between genes is usually quantified by the correlation between the expression of two genes. (biomedcentral.com)
Gene co-expression networks are divided into weighted and unweighted networks. (biomedcentral.com)
An unweighted gene co-expression network is a traditional binary network, which only keeps relationships between genes above a specified cutoff, while a weighted network is a fully connected network and keeps all relationships as a continuous measurement. (biomedcentral.com)
Because setting a cutoff will cause the information loss, weighted gene co-expression networks are commonly used in biomedical analysis [ 12 ]. (biomedcentral.com)
To get biologically relevant information, it is necessary to perform module (or community) detection in gene co-expression networks. (biomedcentral.com)
Unfortunately, the existing WGCNA and lmQCM can only detect gene co-expression modules without the ability to incorporate such prior knowledge. (biomedcentral.com)
A Finnish study group has investigated how listening to classical music affected the gene expression profiles of both musically experienced and inexperienced participants. (sciencedaily.com)
In a previous study , Blau and his colleagues found that rhythms in expression of a potassium channel (Ir) helps link the biological clock to the activity of pacemaker neurons. (nyu.edu)
With increased electrical activity in the evening, when clock neurons are normally fairly inactive, the researchers found that clock neurons have a circadian gene-expression profile more typically found in morning hours. (nyu.edu)
In contrast, by diminishing electrical activity in the morning, gene expression was shifted to look more like it does in the evening. (nyu.edu)
In other words, the electrical state of a clock neuron can dramatically affect circadian gene expression in clock neurons. (nyu.edu)
What was striking about these results was the coordination between the firing of neurons and gene expression," observed Blau. (nyu.edu)
One of these motifs binds the well-known set of factors that regulate gene expression in neurons involved in learning and memory. (nyu.edu)
Furthermore, stable viral gene expression was done in cells and subsequently verified by immunoblotting technique. (news-medical.net)
Therefore, this study aimed to compare the fidelity of blood to substantia nigra (SN) tissue gene expression from PD patients to provide a systematic approach to predict role of the key genes of PD pathobiology. (bvsalud.org)

Earlier studies of "clock genes" in fruit flies allowed the identification of similarly functioning genes in humans. (nyu.edu)
Besides enabling the potential development of drugs to treat cocaine addiction, this research holds out the prospect that so-called "clock" genes -- which are involved in setting and maintaining the body's internal clock -- might have other, as yet undiscovered, roles in the body and brain. (sciencedaily.com)

By integrating these two datasets, 16 overlapped genes were detected, including downregulated lncRNA‑NEAT1 and upregulated TF‑ETV5. (spandidos-publications.com)

Autism 'Risk Genes' Can Be Mapped By Function: What Genetic Behaviors Cause ASD? (medicaldaily.com)
Investigators at the University of California, Los Angeles say they've mapped risk genes for autism spectrum disorder across the brain, by function. (medicaldaily.com)
Now, investigators from the University of California, Los Angeles, say they've developed a map describing genetic variants - "risk genes" - associated with the development of autism spectrum disorder (ASD), in addition to those implicated in neural disturbances unrelated to the disorder. (medicaldaily.com)
Although sharing common risk genes, the disorder and the more generalized "intellectual disability" develop distinctly as genes express themselves, copying data from DNA to RNA, says Daniel Geschwind, a neurologist at UCLA. (medicaldaily.com)
For their study , Geschwind and his colleagues became the first to report mapping groups of autism-risk genes by function, and to identify behavioral roles in early brain development. (medicaldaily.com)
Parikshak emphasized that ASD should be considered distinct on the molecular level from intellectual disability, even though they share common risk genes. (medicaldaily.com)
Genetic association studies have also uncovered several PDB predisposing risk genes contributing to the disease pathology and severity. (bvsalud.org)

The pathways that are probably regulated by the identified plant phytoconstituents were analyzed using Kyoto encyclopedia of genes and genomes. (ijpsonline.com)
Kyoto encyclopedia of genes and genomes pathway identified eight pathways that are directly related to cognitive impairment. (ijpsonline.com)
Blau added that the findings may offer new pathways for exploring treatments to sleep disorders because the research highlights the parts of our biological clock that "may be particularly responsive to treatment or changes at different times of the day. (nyu.edu)
It was also demonstrated that USF1 directly binds to the promoter region of 2,492 genes, which may be involved in the viral progression and cell proliferation pathways. (spandidos-publications.com)
Genetics researchers have long been able to manipulate genes in fruit flies for investigations of nervous system pathways. (sciencedaily.com)

To find the mechanism, Blau's lab brought in the computational expertise of Gunsalus' lab at NYU to identify regulatory DNA motifs in genes that respond to neuronal activity in clock neurons. (nyu.edu)
A total of 4,761 perfect and 6,583 imperfect SSRs were present in 3,781 genes (14.11% of the total), corresponding to an overall density across the gene space of 32,5 and 44,9 SSRs/Mbp for perfect and imperfect motifs, respectively. (researchgate.net)

Calcium-induced activation of calmodulin regulates and modulates the function of cardiac ion channels. (nih.gov)

Transcriptional targeting in the airway using novel gene regulatory elements. (nih.gov)
Using the bioinformatics tool MAGICTRICKS and reversible pharmacological inhibition, we found that primed genes required the transcriptional activities of NF-κB. (frontiersin.org)

In terms of the distribution of identified genes in a specific category relative to the whole genome, only the categories of PE/PPE and conserved hypotheticals have statistical significance. (hindawi.com)
A) SARS-CoV-2 genome annotation, predicting 29 virus gene products. (news-medical.net)
An extensive literature documenting physiological and ecological diversity make Daphnia an ideal model to study the genetic architecture of phenotypic variation in natural populations and the evolution of genome structure/function relationships in aquatic environments. (biomedcentral.com)

Inferring horizontal gene transfer through computational identification of HGT events relies upon the investigation of sequence composition or evolutionary history of genes. (wikipedia.org)
Sequence composition-based ("parametric") methods search for deviations from the genomic average whereas evolutionary history-based ("phylogenetic") approaches identify genes whose evolutionary history significantly differs from that of the host species. (wikipedia.org)
By sequence analysis, Zhang et al identified a recurrent mutation 2272C→T (R758X) of the CYLD gene in the affected familial persons that had been previously identified in other ethnic kindreds with familial cylindromatosis. (medscape.com)
The mutation occurred by two codon changes within the vip3Aa19 coding sequence when this gene was introduced in the maize event MIR162. (cbd.int)

Circular RNAs (circRNAs) are closed, long, non-coding RNAs that are formed via direct reverse splicing of precursor mRNA that function by regulating RNA transcription and protein production, as well as sponging miRNAs ( 4 ). (spandidos-publications.com)

The Wnt genes encode secreted glycoprotein ligands that regulate a wide range of developmental processes, including axis elongation and segmentation. (biomedcentral.com)
The WT1 protein mediates the mesenchymal-epithelial transition and differentiation during morphogenesis of the kidney and gonad by repressing genes that encode cell proliferation factors and by activating genes that encode markers of epithelial cell differentiation. (medscape.com)

Epigenetic modifications of genes involved in bone remodelling and regulation, including RANKL, OPG, HDAC2, DNMT1, and SQSTM1, have been implicated in the development and progression of Paget's disease of bone, providing insight into the molecular basis of the disease and potential targets for therapeutic intervention. (bvsalud.org)

A missense mutation in this gene is associated with Van der Woude syndrome 2. (nih.gov)
Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.A missense mutation in the CALM1 gene has been associated with ventricular tachycardia. (nih.gov)

We carried out a series of bioinformatics studies with the phytoconstituents of Amaranthus tricolor to elicit their possible molecular functions in cognitive disorders including Alzheimer's disease. (ijpsonline.com)

Despite variable phenotypic expressions of a predominant tumor in BSS, the gene responsible for multiple cylindromas, CYLD , is localized to band 16q12-q13. (medscape.com)

To further validate the results pathway study was performed to identify the involvement of the coding genes in type II diabetes. (researchgate.net)

In exploring this mechanism, the researchers examined the biological, or circadian, clocks of Drosophila fruit flies, which are commonly used for research in this area. (nyu.edu)

The researchers theorize that myocilin could perform a similar function in the eye. (nih.gov)
Researchers have noted an MYB-NFIB gene fusion, which provides a new genetic link between dermal cylindroma and adenoid cystic carcinoma. (medscape.com)

As the capacity for generating large-scale molecular profiling data continues to grow, the ability to extract meaningful biological knowledge from it remains a limitation. (imperial.ac.uk)
Our study was limited to computer simulations and calls for wet lab validation of the predicted molecular functions. (ijpsonline.com)
Upstream transcription factor 1 (USF1) is a canonical transcription factor (TF) and is associated with the pathogenesis of several cancers, but its biological functions and molecular targets in HCC remain unclear. (spandidos-publications.com)

therefore the flies can be used as a tool to study the complex biological processes underlying drug abuse. (sciencedaily.com)
We need to figure out where genetic changes appear in the brain, at what stages during development, and which biological processes they disrupt. (medicaldaily.com)
Genes linked to intellectual disability influence many biological processes in the body," he added. (medicaldaily.com)

Alternative splicing of this gene results in multiple transcript variants. (nih.gov)
Identifying gene variants that boost risk is only the first step of unraveling a disease," Geschwind said in a statement . (medicaldaily.com)
Investigator Neelroop Parikshak said that the team found gene variants expressing themselves in the developing brain as cells that determined their future roles in the neural circuitry. (medicaldaily.com)

Investigation of hub genes for the development of potential therapeutic targets and candidate biomarkers is warranted. (nature.com)

In these minor intron-containing genes (MIGs), the majority of introns are usually spliced by the major spliceosome, with only one or two introns being spliced by the minor spliceosome. (biomedcentral.com)
For example, the current Ensembl version proposes a Chiss ortholog of BLU31 (gene responsible for their characteristic blue skin), but further investigation concluded that the "gene" lacks possible introns and thus cannot produce any resemblance of a protein in wookiee. (ubc.ca)

Six among the 42 genes identified in this study are on the list of the top 100 persistence targets selected by the TB Structural Genomics Consortium. (hindawi.com)
Given that the minor spliceosome is ubiquitously expressed, we hypothesized that these restricted phenotypes might be caused by the tissue-specific regulation of the minor spliceosome targets, i.e. minor intron-containing genes (MIGs). (biomedcentral.com)
The biological complexity of PD is yet to reveal potential targets for intervention or to slow the disease severity. (bvsalud.org)

Cognitive impairment is a complex disorder of old age people characterized by changes in cognitive functions like trouble in remembering, concentrating, learning and decision making. (ijpsonline.com)
The Parkinson disease (PD) is the second most common neurodegenerative disorder affecting the central nervous system and motor functions. (bvsalud.org)

He and his team published their results in the Journal of Biological Chemistry. (nih.gov)

This GLABR gene was further characterized by a conditional knockout experiment as well as an in situ hybridization on sectioned epithelial cells in order to better determine its function. (ubc.ca)

Our study identified 9 key genes associated with oxidative stress and immune reaction in AD pathogenesis. (nature.com)

One of the most up-regulated genes, synuclein-alpha (SNCA) is a known risk gene for Parkinson's disease that is located in the strongest linkage region of musical aptitude. (sciencedaily.com)

These studies also hold hope for discovering common biological abnormalities underlying sleep/wake disturbances and mood disorders. (sciencedaily.com)

However, the efficacy of using pyroptosis-related genes (PRGs) in predicting the prognosis of pancreatic adenocarcinoma (PAAD) patients is unknown. (hindawi.com)

Consistent with a cell-cycle regulatory function, CYLD localizes to microtubules in interphase and the midbody during telophase CYLD 's protein levels decrease as cells exit from mitosis. (medscape.com)

Daphnia is a versatile model system to investigate fundamental mechanisms of inheritance and development, cellular function, physiological systems, immunity response, disease, macromolecular structure/function relationships and the genetic basis of complex phenotypic traits. (biomedcentral.com)
PDB has a complex genetic basis involving multiple genes, with SQSTM1 being the gene most frequently associated with its development. (bvsalud.org)

We present evidence for the de novo origin of the Wookiee wookiee protein-coding gene GLABR since their divergence from humans. (ubc.ca)
The up-regulation of several genes that are known to be responsible for song learning and singing in songbirds suggest a shared evolutionary background of sound perception between vocalizing birds and humans," says Dr. Irma Järvelä, the leader of the study. (sciencedaily.com)

Horizontal or lateral gene transfer (HGT or LGT) is the transmission of portions of genomic DNA between organisms through a process decoupled from vertical inheritance. (wikipedia.org)

Many of these genes are related to stress responses. (hindawi.com)

We obtained 66 immune-related DEOSGs by intersecting turquoise module with the DEOSGs and identified 15 hub genes through PPI analysis. (nature.com)

27 gene modules were obtained through WGCNA and turquoise module was the most relevant module. (nature.com)

Since U4atac snRNA is ubiquitously expressed, mutation in this gene is expected to result in systemic inhibition of the minor spliceosome. (biomedcentral.com)

ASXL1 MT are further associated with de novo accessibility of distal enhancers binding ETS transcription factors, targeting important leukemogenic driver genes. (nature.com)
Finally, we constructed the drug, transcription factors (TFs), and microRNA network of the diagnostic genes. (nature.com)

The diagnostic value of hub genes was assessed by receiver operating characteristic analysis and validated in GSE1297. (nature.com)

In contrast to sporadic cylindromas, according to one study, the fusion of MYB-NFIB genes was absent for CYLD -defective tumors in inherited disorders. (medscape.com)
Many of the studies indicate that pesticide physiology, pharmacology, epidemiology, soci- toms such as respiratory problems, memory exposure is associated with deficits in cogni- ological studies, and the emerging area of disorders, dermatologic conditions, cancer, tive function. (cdc.gov)

NYU biologists have uncovered new ways our biological clock's neurons use electrical activity to help keep behavioral rhythms in order. (nyu.edu)
Changes made in the genes influence the brain's wiring by altering the synapse, and shaping how neurons transmit signals to each other. (medicaldaily.com)

We investigated the relationship of the microbiome with the neuroanatomy and cognitive function of 281 healthy children in a cross-sectional analysis and demonstrated that differences in gut microbial taxa and gene functions are associated with the size of brain regions and with overall cognitive function. (biorxiv.org)
Many species, including Eubacterium eligens and Roseburia hominis , were associated with higher cognitive function, while some species such as Ruminococcus gnavus was more commonly found in children with low cognitive scores. (biorxiv.org)
Microbial enzymes involved in the metabolism of neuroactive compounds such as glutamate and GABA, were also associated with structure of the brain, including the first brain regions to develop such as the cerebellum, and with overall cognitive function. (biorxiv.org)
Listening to music represents a complex cognitive function of the human brain, which is known to induce several neuronal and physiological changes. (sciencedaily.com)

Splicing at the second alternative site (exon 9) is thought to have a great biological importance and results in the inclusion or exclusion of 3 amino acids, lysine, threonine, and serine (KTS), yielding the KTS-positive isoform when the amino acids are included and KTS-negative isoform when excluded. (medscape.com)
Our WES findings revealed a rare heterozygous gain-of-function variant (R496W) in the exon 9 of the PCSK9 gene as a causal factor for FH in this family. (bvsalud.org)

Our results show that the GLABR gene is responsible for robust hair growth in Wookiees, and that inactivation of this gene results in reduced androgenic hair growth or hairless phenotype. (ubc.ca)
Downregulation of the Ppo5 gene results in reduced susceptibility to black spot bruise development. (cbd.int)

Because of their complementary approaches-and often non-overlapping sets of HGT candidates-combining predictions from parametric and phylogenetic methods can yield a more comprehensive set of HGT candidate genes. (wikipedia.org)
Several bioinformatic approaches were used to analyze the biological functions of DEPRGs and to identify prognostic DERPGs. (hindawi.com)

Phylogenetic methods examine evolutionary histories of genes involved and identify conflicting phylogenies. (wikipedia.org)
At New Order Laboratories, we aim to identify the biological mechanism responsible for W. wookiee hairiness. (ubc.ca)
A gene regulatory network has been formed with the top ranked coding genes to identify their role in causing diabetes. (researchgate.net)

Our study has identified 42 genes specifically induced by capreomycin and PA-824. (hindawi.com)
The genes obtained from this study showed a significant involvement in causing the disease, which may be used as a potential drug target. (researchgate.net)
According to a new study, listening to classical music enhanced the activity of genes involved in dopamine secretion and transport, synaptic neurotransmission, learning and memory, and down-regulated the genes mediating neurodegeneration. (sciencedaily.com)
This study opens up the field of drug studies to thinking how a totally unexpected set of genes functions in response to drugs," says Jay Hirsh, professor of biology at U.Va. and senior author of the report. (sciencedaily.com)

Phylogenetic methods tend to be applied to genes or protein sequences as basic evolutionary units, which limits their ability to detect HGT in regions outside or across gene boundaries. (wikipedia.org)
But genes tied to autism tend to affect specific functions, such as the connections between brain regions that are essential to many human-specific behaviors, such as speech and language. (medicaldaily.com)

Anatomy17

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