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  • genomic
  • The goal of this review is to consider progress in delineating factors in gene regulation that need to be considered as we endeavor to elucidate the mechanisms involved in genetic and genomic diseases to facilitate molecular diagnoses, provide counseling and to improve management and treatment. (frontiersin.org)
  • sequences
  • MiRNAs are a novel group of gene regulators wherein their 5' seed sequences bind to complementary sequences in the 3' untranslated region (UTR) of their target mRNAs, whereupon they induce negative regulation. (jcancer.org)
  • MammaPrint
  • The 70-gene signature (MammaPrint™) has been developed on retrospective series of breast cancer patients to predict the risk of breast cancer distant metastases. (agendia.com)
  • Background: The MINDACT (Microarray In Node-negative and 1-3 node positive Disease may Avoid ChemoTherapy) trial investigates the clinical utility of the 70-gene profile (MammaPrint) for the selection of breast cancer patients for adjuvant chemotherapy (CT) together with standard clinicopathological criteria. (agendia.com)
  • Objective: To evaluate the cost-effectiveness of 70-gene MammaPrint signature (Agendia Inc, Huntington Beach, CA) vs Adjuvant! (agendia.com)
  • receptor
  • However, treated tumors frequently become resistant to therapy, prompting the search for new ways to block receptor function. (cshlpress.com)
  • knockout
  • Our partner EdiGene has developed an innovative and highly efficient CRISPR/Cas9 approach to design, perform and validate gene knockout in most commonly used human cells such as HEK293T, HeLa, HCT116, HepG2, A549 and Jurkat to speed up your research and save research money. (biocat.com)
  • To validate gene knockout, the target region of each Edi-G KO Cell Line is sequenced twice to ensure each allele of the target gene has an insertion/deletion mutation but not an in-frame mutation. (biocat.com)
  • promoter
  • Each vector contains the shRNA under control of the U1 promoter and either the GFP gene, for the enrichment of transiently transfected cells, or the neomycin or puromycin resistance genes, for the selection of stably transfected cells. (sabiosciences.com)
  • regulate
  • Our data indicate that the cold-sensitive lines can up-regulate known cold-responsive genes comparable to that of cold-hardy lines. (biomedcentral.com)
  • Horizontal Gene Tra
  • Horizontal gene transfer of PIB-type ATPases among bacteria isolated from radionuclide- and metal-contaminated subsurface soils. (semanticscholar.org)
  • The contribution of interspecies horizontal gene transfer (HGT) to the evolution and virulence of Mycobacterium tuberculosis, the agent of tuberculosis in humans, has been barely investigated. (semanticscholar.org)
  • fruit flies
  • To support their findings about the clock's workings, the researchers studied genetically altered mice cells and fruit flies that lacked the JARID1a gene. (scienceblog.com)
  • biology
  • Satchidananda Panda , an associate professor in Salk's Regulatory Biology Laboratory, who led the research along with Luciano DiTacchio, a post-doctoral research associate and their colleagues have identified a new component of the biological clock, a gene -KDM5A- responsible for starting the clock from its restful state every morning. (laboratory-journal.com)
  • EZH2 is part of a structure called the Polycomb Repressive Complex 2, which silences target genes," says Jeannie T. Lee, MD, PhD,of the MGH Department of Molecular Biology, senior author of the report. (phys.org)
  • pathway
  • After the bags were removed, nearly all structural and regulatory genes, such as UDP-glucose: flavonoid-3- O -glucosyltransferase (UFGT), MYB, basic helix-loop-helix (bHLH), and WD40, involved in the anthocyanin biosynthetic pathway were upregulated. (frontiersin.org)
  • The included parental control enables disease-related gene function and pathway analysis in isogenic cell lines. (biocat.com)
  • molecules
  • High angular resolution diffusion imaging data is the observed characteristic function for the local diffusion of water molecules in tissue. (imperial.ac.uk)
  • characteristic
  • Non-parametric scalar measures are proposed to summarize such data, and to locally characterize spatial features of the diffusion probability density function (PDF), relying on the geometry of the characteristic function. (imperial.ac.uk)
  • novel
  • Of particular interest, we propose to test the appealing notion that PWS may represent a novel example of the growing list of ribosomal diseases, i.e. diseases caused by abnormalities in ribosome synthesis and/or function. (fpwr.org)
  • Biological function of a novel gene overexpressed in human hepatocellular carcinoma. (semanticscholar.org)
  • gene's
  • The interpretation of PC2 and PC3 as measures of a gene's plasticity is compatible with the observation that genes with high values of these PCs tend to be expressed in a condition- or tissue-specific manner. (royalsocietypublishing.org)
  • complementary
  • However, integration of cis-regulatory elements shows that 46% of the gene coexpression neighborhoods are enriched for one or more motifs, providing a valuable complementary source to functionally annotate genes. (plantphysiol.org)
  • identify
  • To identify which genes change in response to specific conditions (e.g. cancer), we must filter or process the dataset to remove genes which are not informative. (genomespace.org)
  • response
  • We have shown, for the first time, that EZH2 can act outside of the PRC2 complex to activate genes through another mechanism-in this case by cleaving the B2 RNA molecule, which then activates stress response genes. (phys.org)
  • found a positive correlation between multistimuli response genes and cis-element density in upstream regions. (plantphysiol.org)
  • specific
  • Future studies will investigate the specific mechanism by which EZH2 is attracted to stress genes and how it cleaves the B2 RNA molecule. (phys.org)
  • Pre-designed shRNA Plasmids include four tubes each containing individual shRNA Plasmids specific for the same gene. (sabiosciences.com)
  • The forms of sequencing most frequently carried out for clinical diagnostic purposes include targeted sequencing of specific genes and whole exome sequencing. (frontiersin.org)
  • tissue
  • Genes which are expressed in one condition, such as cancer tissue, are said to be differentially expressed when compared to normal conditions. (genomespace.org)
  • clock
  • With age, for instance, the biological clock seems to decline, often causing older people to suffer from difficulty sleeping. (scienceblog.com)
  • The biological clock also appears important to the development of disease, most likely due to its daily influence over metabolic cycles. (scienceblog.com)