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  • blue green
  • In 2005, a group of Japanese researchers surprised the scientific community by showing that the three proteins which make up the biological clock in blue green algae will establish a 24-hour cycle on their own when placed in a test tube with adenosine triphosphate (ATP), the chemical that powers biological reactions. (science20.com)
  • The study found that when the biological clocks of cyanobacteria (blue-green algae) were stopped in their daylight setting, the amount of several biomolecules that they were genetically altered to produce increased by as much as 700 percent when grown in constant light. (medindia.net)
  • oscillations
  • Within each bacterium, the genetic machinery responsible for the biological clock oscillations was tied to green fluorescent protein, which caused the bacteria to periodically fluoresce. (medgadget.com)
  • The homodimeric, growth-related and time-keeping constitutive hydroquinone oxidase ENOX1 of the eukaryotic cell surface capable of oxidizing extracellular NAD(P)H and intracellular hydroquinones exhibits properties of the ultradian driver of the biological 24-h circadian clock by exhibiting a complex 2 + 3 set of oscillations with a period length of 24 min (repeats 60 times over 24 h). (springer.com)
  • That the oscillations result from physical rather than chemical events accounts for the temperature independence of the period length of clock-related phenomena. (springer.com)
  • An opportunity to link the ultradian ENOX oscillation to downstream activation of clock genes may be provided by responses of transcriptional factors to levels of NADH and especially to NAD + generated by ENOX oscillations. (springer.com)
  • genes
  • We found that some 25 percent of the genes in our model organism appear to be under clock control. (redorbit.com)
  • The team's new discoveries about the extent of genes under the control of the biological clock and the utility of Computing Life came from studying genes in Neurospora crassa""bread mold. (redorbit.com)
  • Before the current research, only 16 clock-controlled genes had been discovered in Neurospora in more than 40 years of research. (redorbit.com)
  • Arnold's team uncovered a remarkable 295 genes that are influenced by the biological clock""and that number could be dramatically higher, given the conservative controls the researchers put on their work. (redorbit.com)
  • The UGA scientists discovered how three genes in Neurospora make such a clock tick at the molecular level. (redorbit.com)
  • These cells were genetically altered with two genes: an attached clock gene, which stimulates the cell's circadian rhythm, and a luciferase gene, which lights up when the biological clock was triggered (also seen in the glow of fireflies). (redorbit.com)
  • In the bees, the team has been able to monitor the switching on and off of several genes that control the circadian clock. (radionz.co.nz)
  • The NYU and London studies of fruit flies have allowed the identification of "clock genes" in mammals, which function in a similar manner in mammals as they do in a fly's clock. (phys.org)
  • In mammals, however, Cry assists in the 24-hour rhythmic expression of clock genes and has nothing to do with re-setting the clock. (phys.org)
  • We have shown that manipulating cyanobacteria's clock genes can increase its production of commercially valuable biomolecules," said Carl Johnson, Stevenson Professor of Biological Sciences at Vanderbilt University, who performed the study with collaborators at the J. Craig Venter Institute in Rockville, MD and Waseda University in Tokyo. (medindia.net)
  • In the current study, the researchers discovered that two components of the clock, KaiA and KaiC, act as switches that turn the cell's daytime and nighttime genes on and off. (medindia.net)
  • They found that the cells with the locked clocks produced 200 percent more hydrogenase, 500 percent more insulin and 700 percent more luciferase when grown in constant light than they did when the genes were inserted in cells with normally functioning clocks. (medindia.net)
  • body's
  • They govern the flow of hormones and regulate the body's response to sugar and many other important biological processes ( SN: 4/10/10, p. 22 ). (sciencenews.org)
  • The new insights about the body's central pacemaker might also, someday, advance efforts to treat diseases influenced by the internal clock, including cancer , Alzheimer's disease and mood disorders, said University of Michigan mathematician Daniel Forger. (psychcentral.com)
  • Ivanhoe Newswire) -- If you regularly experience the pangs of jet lag or a crazy work schedule, then you may not be the biggest fan of your body's biological clock. (redorbit.com)
  • clock's
  • Ribosome biogenesis is the process of making ribosomes, so knowledge that the process is under clock control adds a dramatic new dimension to the clock's inherent biological value as an adaptation. (redorbit.com)
  • The team has launched a clinical trial with kidney donor patients, essentially healthy people who are undergoing major surgery, to see whether light-producing masks can help reduce the biological clock's disruption. (radionz.co.nz)
  • Detailed knowledge of the clock's structure allowed them to determine how to switch the clock on and off. (medindia.net)
  • Fertility
  • We know that women have a biological time clock, with an increase in risk of miscarriage and producing children with trisomy-an extra chromosome, such as in Down's syndrome-as women age, and with a seemingly abrupt end of fertility around perimenopause," added Brenda Eskenazi, Ph.D., of the University of California at Berkeley School of Public Health, a co-author. (medpagetoday.com)
  • And lately I've been thinking about how ladies are basically required to find love and settle down and have a career at an earlier stage than guys are because their biological clocks mean that fertility/the chances of having healthy babies decline after the age of 35. (metafilter.com)
  • Biological clock may also pertain to female fertility wherein there is a gradual decrease of fertility from puberty to menopause. (biology-online.org)
  • simplest
  • Subsequent work mapped the entire clock mechanism in cyanobacteria, which is the simplest bioclock found in nature. (medindia.net)
  • Time
  • Our research suggests that men, too, have a biological time clock-only it is different," she added. (medpagetoday.com)
  • the reply would most certainly be "No." Clocks are complex instruments designed to accurately and repeatedly keep time to the millisecond. (apologeticspress.org)
  • As time passed, it also became clear that astronauts suffered bone loss and muscle wastage due, in part, to space travel s effects on their internal clocks, and air travelers began experiencing the clock-related ailment of jet lag. (innovations-report.com)
  • MorrĂ© spent time on other projects, but the biological clock never escaped his mind or efforts completely. (innovations-report.com)
  • The coolest part is that a simple biological machine can do such an astounding thing as keeping time," says Williams. (science20.com)
  • because they need to know along wat directions they are flying according to the position of the sun.therefore, they have to know at wat time wat position the sun would be found.this is done by using an internal clock. (biology-online.org)
  • cycles
  • Seasonal Affective Disorder, some types of depression, sleep disorders and problems adjusting to changes in work cycles all can occur when an individual's biological clock acts up. (science20.com)
  • genetically
  • As a result, all we have to do to lock the biological clock into its daylight configuration is to genetically upregulate the expression of KaiA, which is a simple manipulation in the genetically malleable cyanobacteria," Johnson said. (medindia.net)
  • cells
  • First Gene Therapy Successful Against Aging-Associated Decline: Mouse Lifespan Extended Up to 24% With a Single Treatment A new study consisting of inducing cells to express telomerase, the enzyme which -- metaphorically -- slows down the biological clock -- was successful. (metafilter.com)
  • The SCN contains both clock cells (which express a gene called per1) and non-clock cells. (psychcentral.com)
  • But Forger's British colleagues were able to separate clock cells from non-clock cells by zeroing in on the ones that expressed the per1 gene. (psychcentral.com)
  • Then they recorded electrical signals produced exclusively by those clock cells. (psychcentral.com)
  • The old theory was that the cells in the SCN which contain the clock are firing fast during the day but slow at night. (psychcentral.com)
  • But now we've shown that the cells that actually contain the clock mechanism are silent during the day, when everybody thought they were firing fast," Diekman said. (psychcentral.com)
  • The robot was programmed to isolate the molecules that showed the greatest effects on the cells' biological clocks. (redorbit.com)
  • To confirm that the protein was responsible not just for regulating growth but for all activities set by the biological clock, Pin-Ju Chueh, then a microbiology graduate student in Dorothy MorrĂ© s lab, isolated the gene which produced the protein within cells. (innovations-report.com)
  • research
  • The new research, just published in the Public Library of Science One, also shows how Arnold's team used a new methodology called Computing Life to yield these new discoveries about biological clocks. (redorbit.com)
  • internal clock
  • The finding is salient because the discovery may overturn a long-held theory about our internal clock. (psychcentral.com)
  • A traveler experiences jet lag when his or her internal clock becomes out of synch with the environment. (science20.com)
  • why do animals such as bee and pigeon have an internal clock in order to navigate using the sun as a compass? (biology-online.org)
  • dramatically
  • Tricking algae's biological clock to remain in its daytime setting can dramatically boost the amount of valuable compounds these simple marine plants can produce when grown in constant light. (medindia.net)
  • diseases
  • Kelsey Hubbard talks to the author about the role a man's biological clock plays in a child's risk for diseases and disorders. (wsj.com)
  • We have cracked the code, and the information could have a tremendous impact on all sorts of diseases that are affected by the clock. (psychcentral.com)