Biological cell derived microparticles. Medical search. Frequent questions

Exosomes are small lipid bilayer-surrounded extracellular vesicles released from cells into the extracellular space or biological fluids ( 1 , 2 ). (spandidos-publications.com)
MPs are extremely small vesicles generated via off-budding from a parent cell. (unityhealth.to)
100nm) which are pre-formed vesicles stored in multi-vessicular compartments and secreted from the cell. (unityhealth.to)
The cells secrete extracellular vesicles (EV) that may have an endosomal origin, or from evaginations of the plasma membrane. (frontiersin.org)
The exosome vesicles are a type of extracellular vesicles (EV), which are defined as lipid-bilayer spheroid structures, without replicating capacity, that are released from cells, including both prokaryotes and eukaryotes. (frontiersin.org)
Small extracellular vesicles are non-replicating, nano-sized (70-150 nm) lipid bilayer-enclosed vesicles, which have shown remarkable biological activities in various physiological and pathophysiological contexts. (explorationpub.com)
When administered post-stroke, mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) induce neuroprotection, promote brain remodeling and plasticity, and enhance neurological recovery in rodents and non-human primates via mechanisms that involve immunomodulation and anti-inflammation. (explorationpub.com)
Recently, mesenchymal stromal cell (MSC)-derived small extracellular vesicles (EVs) have emerged as a potential new therapeutic agent for stroke treatment. (explorationpub.com)
Various cells release lipid-enclosed particles known as extracellular vesicles (EVs), which are rich in bioactive substances. (biomedcentral.com)
Several aspects of MSC function have been attributed to the paracrine effects of MSC derived extracellular vesicles (EVs). (frontiersin.org)
In the present work, we have isolated and characterized the extracellular vesicles from human AD-MSC to investigate their role in the chondroprotective actions of these cells. (karger.com)
Within the past decade, extracellular vesicles have emerged as important mediators of intercellular communication, being involved in the transmission of biological signals between cells in both prokaryotes and higher eukaryotes to regulate a diverse range of biological processes. (nature.com)
Figure 1: Biogenesis of extracellular vesicles and their interactions with recipient cells. (nature.com)
2009) define exosomes as 40 -100 nm diameter membrane vesicles of endocytic origin that are released by most cell types upon fusion of multivesicular bodies with the plasma membrane, presumably as a vehicle for cell-free intercellular communication. (malvernpanalytical.com)
2013) focused on the role of cellular exocytic vesiculation in health, disease, and transfusion medicine, recognizing that microparticles (MPs), small membrane-derived vesicles which are derived from many cell types and released into the circulation under shear stress, complement activation, proapoptotic stimulation, cellular damage, or agonist interaction with cell surface receptors. (malvernpanalytical.com)
Our lab is also interested in extracellular vesicles such as exosomes and microvesicles as vehicles for the transfer of misfolded proteins between cells. (edu.au)
Extracellular vesicles (EV) are released by cells and include exosomes, microvesicles and microparticles. (edu.au)
We are interested in investigating the mechanisms, of how these proteins are packaged into these vesicles and also how they transfer their contents between cells. (edu.au)
The technology behind our work involves detecting a disease signature of RNA molecules called microRNA which can be isolated from small biological vesicles called 'exosomes' that travel in the bloodstream. (edu.au)
Extracellular vesicles act as a cell's transfer signals - these nanoparticles, which contain protein, sugars, and other biological materials, communicate with adjacent cells and tissues to transmit messages, such as whether a cell is healthy or in distress. (corning.com)
In conclusion, we provide evidence that proinflammatory polarization of macrophages does not lead to enhanced procoagulatory function, whereas alternative polarization of macrophages leads to an increased expression of TF and increased production of TF bearing extracellular vesicles by these cells suggesting a procoagulatory phenotype of alternatively polarized macrophages. (haematologica.org)

The profound roles of exosomes in homeostasis, stress and several pathological conditions, in conjunction with their selective and cell‑specific composition/function, allude to their use as promising circulating clinical biomarkers of systemic stress and specific pathologic states, and as biocompatible vehicles of therapeutic cargo. (spandidos-publications.com)
Exosomes, via their cargo or surface composition, are signals/mediators of systemic homeostasis and stress for specific cell-to-cell or tissue-to-tissue communication ( 5 ). (spandidos-publications.com)
Microparticles (MPs) are a type of extracellular vesicle (EV) distinct from exosomes (which are smaller and generated inside vesicular bodies prior to secretion through the open cannicular system) and apoptotic bodies (larger fragments of late-stage apoptotic cells carrying fragmented DNA and protein). (unityhealth.to)
Therefore, research on exosomes produced by MSC has been intensified for use in cell-free regenerative medicine. (frontiersin.org)
EVs, including exosomes (or cardiosomes), were described to be released from all major heart cell types in vitro , suggesting that they play an important role in the cardiovascular system. (trillium.de)
Studies have shown that exosomes microRNAs from different cells or tissue sources play an important role in cardiovascular diseases including PH and is expected to become a new way to treat PH. (imrpress.com)
The study of exosomes and other cell-derived microvesicles is an area of rapidly growing importance and the subject of intense interest and research. (malvernpanalytical.com)
Extracellular vesicular bodies such as microvesicles and exosomes are currently under intense investigation due to their apparently ubiquitous presence in a broad range of prokaryotic and eukaryotic organisms and the wide role they appear to play, at a fundamental level, in many biological processes, both physiological and pathological. (malvernpanalytical.com)
Chen J, Wang S, Jia S, Ding G, Jiang G, Cao L. Integrated Analysis of Long Non-Coding RNA and mRNA Expression Profile in Pancreatic Cancer Derived Exosomes Treated Dendritic Cells by Microarray Analysis. (jcancer.org)
However, few studies have investigated the role of pancreatic cancer-derived exosomes (PEXs) in DC-meditated immune escape. (jcancer.org)
For example, exosomes and nanovesicles secreted by living cells serve as intercellular couriers of mRNA, microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and proteins and have thus garnered considerable interest [ 3 ]. (jcancer.org)
We are also using high-resolution cryo-electron microscopy to study the structure of exosomes isolated from neuronal cells and characterise their protein and RNA content using high throughput sequencing and proteomics techniques. (edu.au)

Phagocytosis (from Ancient Greek φαγεῖν (phagein) 'to eat', and κύτος (kytos) 'cell') is the process by which a cell uses its plasma membrane to engulf a large particle (≥ 0.5 μm), giving rise to an internal compartment called the phagosome. (wikipedia.org)
As such they have a plasma membrane bilayer and biological molecule endowment derived from a parent cell. (unityhealth.to)
Microparticles are plasma membrane vesicle fragments (between 0.1 and 1 μm in size) released from various cell types during activation by agonists or physical or chemical stress, including apoptosis [ 6 , 7 ]. (ersjournals.com)
Upon activation, platelets release plasma-membrane derived microparticles (PMPs) exposing phosphatidylserine (PS) on their surface. (lu.se)

Patients with PH exhibited higher circulating levels of microparticles compared to control subjects and in vitro or in vivo generated microparticles can induce endothelial dysfunction, interfere with coagulation pathways or modulate inflammatory phenomenon. (ersjournals.com)
The involvement of MPs in tumor progression and aggressiveness will be evaluated by in vitro proliferation, migration and invasion assays using two human breast tumor cell lines overexpressing Her2 and a human breast tumor cell line that doesn't express Her2. (fapesp.br)
Also, the supposed relation of MPs with angiogenesis will be investigated by in vitro capillary-like tube-formation assays on human umbilical vein endothelial cells. (fapesp.br)
In vitro analysis using human adipose derived stem cells (hADSCs) showed that mTNs effectively scavenged reactive oxygen species (ROS) and enhanced osteogenesis of hADSCs by inducing secretion of alkaline phosphatase. (springeropen.com)
The majority of available protocols and data are focused on EVs isolated from cell culture conditioned media or body fluid [4, 5], however, transferability of EV secretion studies in vitro to a disease-dependent condition in vivo is limited [7]. (trillium.de)
The biological activity of Exo-Gel was evaluated in vitro, and the therapeutic effect of Exo-Gel on STOA was evaluated in vivo. (allergy-link.com)
At this time I also began working with mouse and human embryonic stem cells resulting in the publication of some of the first papers describing the osteogenic differentiation of mouse ES and human cells in vitro and in vivo . (nottingham.ac.uk)
Aim of the present study was to investigate if the pre-coating of MWCNTs with pulmonary surfactant has an influence on potential adverse effects, upon both (i) human monocyte derived macrophages (MDM) monocultures, and (ii) a sophisticated in vitro model of the human epithelial airway barrier. (biomedcentral.com)
In vitro cell culture systems are instrumental in the development of therapeutic targets. (cdc.gov)
A robust in vitro cell culture system supporting HBV and HDV infections (HBV/HDV) is a critical prerequisite to studying HBV/HDV pathogenesis, the complete life cycle of HBV/HDV infections, and consequently identifying new therapeutics. (cdc.gov)
In vitro cell culture models have evolved with significant improvements over several decades. (cdc.gov)

Microvesicles have a diameter ranging from 100 nm to 1 µm and are released by cell membrane budding. (spandidos-publications.com)
Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. (nature.com)

Microparticles/Microvessicles (~100-1000nm) are one of the more commonly studied populations and are typically induced following activation or inflammatory stimuli from many cell types including platelets, macrophages/monocytes, T-cells, B-cells, progenitor cells (EPCs, MSCs, etc.), cancer cells, endothelial and epithelial cells among many others. (unityhealth.to)
The tyrosine kinase receptors Tyro3, Axl and Mer (TAMs) and their ligands protein S and Gas6 are involved in the uptake of PS-exposing apoptotic cells in macrophages and dendritic cells. (lu.se)
The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
Macrophages are versatile cells that can be polarized by the tissue environment to fulfill required needs. (haematologica.org)
To understand if polarization of macrophages can lead to a procoagulant macrophage subset we polarized human monocyte derived macrophages to a proinflammatory and an alternative activation state. (haematologica.org)
Macrophages are cells of the innate immune system which play numerous and vastly different functions within the body. (haematologica.org)
2 Upon inflammation, the pool of resident macrophages gets quickly replaced by macrophages derived from circulating monocytes. (haematologica.org)
6 In addition, these cells are present during early wound healing and proinflammatory macrophages are characterized by a pronounced ability to degrade tissue. (haematologica.org)

Their multi‑functional cargo have been indicated to regulate a vast number of biological pathways in target cells. (spandidos-publications.com)
MPs roles are related to the biological contexts that determine their content and the cellular pathways that trigger their synthesis. (fapesp.br)
After attaching to target cells, EVs can change the physiological state of recipient cells through various pathways. (biomedcentral.com)
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate several gene expressions, pathways, and complex biological networks at the cellular level acting either exclusively or together with other miRNAs. (justia.com)
Furthermore, we analyzed differential gene expression profiles related to each vaccine delivery group and found that tissue stress, T cell receptor signaling, and NFB signaling pathways were activated in all groups. (cdc.gov)

Likewise, they have the ability to activate the angiogenesis, proliferation, migration, and differentiation of the main cell types involved in skin regeneration. (frontiersin.org)
MPs arise from many cell types, such as endothelial cells, leukocytes, stem-cells and tumor cells and are produced during many cell processes such as, cell differentiation, stress, senescence and others. (fapesp.br)
However, when employing MSC transplantation to treat tissue defects, the research found that: less than one percent of MSCs could home and colonize in the tissue defect area, continuously promoting tissue regeneration, and the paracrine mechanism of MSCs plays a more important role than the replacement of damaged cells by differentiation [ 13 ]. (biomedcentral.com)
Many existing tissue-engineering approaches focus on delivery of selected proteins (growth factors, transcription factors etc.) or nucleic acids to host or implanted stem cells to achieve lineage specific differentiation. (frontiersin.org)
The posterior download drawing made easy dragons fantasy unleash your of self-containing die in reading beobachten stem and andere with Organ-derived Periodontal differentiation. (it-dresden.net)
The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
It maintains normal hematopoietic function by interacting with hematopoietic stem cells (HSCs) to control their proliferation and differentiation ( Morrison and Scadden, 2014 ). (techscience.com)
Exo released from Exo-Gel continuously for 28 days could promote the proliferation and migration of mouse bone mesenchymal stem cells (mBMSCs) and chondrocytes, at the same time enhance the chondrogenic differentiation of mBMSCs, and inhibit inflammation-induced chondrocyte degeneration. (allergy-link.com)

These well-regulated processes to transfer information between cells occur through direct cell-cell contact, various soluble bioactive factors and through cellular microparticles [ 6 , 7 ]. (ersjournals.com)
In this process, MSCs can release varieties of bioactive molecules (such as growth factors, cytokines, chemokines, etc.) through the paracrine mechanism, which has a crucial impact on the control of biological processes. (biomedcentral.com)

CD3 for T-cell MPs, etc) and carry a complement of surface proteins, enzymes, signaling proteins, second messengers and RNA species known to regulate the function of host/target cells. (unityhealth.to)
In particular, it is believed that MVs/MPs often are enriched for proteins and biological molecules that are concentrated in lipid rafts. (unityhealth.to)
They can carry mRNAs, microRNAs and proteins that can be delivered to nearby cells, or even to distant tissues. (fapesp.br)
EVs are a natural carrier system that can transfer nucleic acids, proteins, and lipids between donor and recipient cells in an autocrine, paracrine, and endocrine manner. (imrpress.com)
In cystic fibrosis proteins that normally allow chloride to pass across cell membranes are not normal. (cdadc.com)

Thus, it may refer to the "exosome complex ," being a proteic (enzymatic) macromolecular machinery, present in archaea and eukaryotic cells, being involved in RNA degradation. (frontiersin.org)
On the other hand, the "exosome vesicle " is an extracellular particle released from the endosomal compartment of most eukaryotic cells. (frontiersin.org)
Exosome/microvesicle-mediated epigenetic reprogramming of cells. (nature.com)
Lai, R. C., Chen, T. S. & Lim, S. K. Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease. (nature.com)
This project will also investigate the role of modifiers in exosome biogenesis by altering their expression with RNAi, using a lentiviral delivery system in neuronal cells. (edu.au)

Apoptosis was measured by Hoechst 33258/propidium iodide double staining of nuclear chromatin and the formation of gaps into the lymphendothelial barrier in a three-dimensional co-culture model consisting of MCF-7 tumour cell spheroids and human lymphendothelial monolayers. (nature.com)
In HL-60 leukaemia cells, di-GA activated caspase 3 and dose-dependently induced apoptosis. (nature.com)
These data show that di-GA exhibits three distinct anticancer activities: induction of apoptosis, cell-cycle arrest and disruption of cancer cell-induced lymphendothelial disintegration. (nature.com)
During the first two hours after the injury, which is called the acute phase 4 , glial cells and neurons at the site of the lesion die via necrosis (inflammatory cell death) or by apoptosis (programmed cell death) 5 . (anova-irm.com)
In vivo experiments confirmed that Exo-Gel increased the local retention of Exo, inhibited the apoptosis and hypertrophy of chondrocytes, enhanced their proliferation, and potentially played the role in stem cell recruitment to delay the development of STOA. (allergy-link.com)

BACKGROUND: Many older patients with acute myeloid leukaemia die or cannot undergo allogeneic haematopoietic stem-cell transplantation (HSCT) due to toxicity caused by intensive chemotherapy. (bvsalud.org)
Therefore, our work establishes a locoregional treatment strategy for priming cancer stem cell-specific tumoricidal immunity with broad application in patients suffering from recurrent malignancies. (nih.gov)
Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction. (nature.com)
Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium. (nature.com)
The combination of Stem Cell Therapy with neuromuscular feedback training with HAL may advance success rates in patients with Spinal Cord Injury. (anova-irm.com)
While still subject of ongoing research, any of the ingredients of the mesenchymal stem cell secretome and their specific activities have been identified. (anova-irm.com)
32, 33 All of these factors are potent ingredients of stem cell secretome. (anova-irm.com)

These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
Adipose tissue-derived mesenchymal stem cells (AD-MSC) show great potential to treat inflammatory and degradative processes in OA and have demonstrated paracrine effects in chondrocytes. (karger.com)
GO and pathway analysis revealed differentially expressed mRNAs involved in many critical biological processes and molecular functions. (jcancer.org)
Target contrast ultrasound combines ultrasound with novel molecular targeted contrast agent to assess biological processes at molecular level. (hindawi.com)

100% whey protein retains the valuable biological microparticles of the whey protein (glycomacropeptides, immunoglobulins, lactoferrin and lactoperoxidase) on nature's own terms. (sonunutritions.com)
These tiny natural components of the whey protein have been shown to efficiently support the immune system and trigger the building process of the muscle cells. (sonunutritions.com)
100% Whey Protein is a Norwegian, high quality, whey protein derived from grass-fed cows. (nortechnutrition.com)

By performing local transplants, other non-periodontal-derived MSCs such as dental pulp stem cells (DPSCs), bone marrow stem cells (BMSCs), and adipose tissue-derived stem cells (ADSCs) also aid in the regeneration of periodontal tissue [ 12 ]. (biomedcentral.com)
Human mesenchymal stem cells (HMSCs) are multipotent somatic stem cells that can be isolated from a variety of tissues such as the bone marrow, adipose tissue, and dental pulp. (frontiersin.org)

Dendritic cells also reside in tissues and ingest pathogens by phagocytosis. (wikipedia.org)
Dendritic cells (DCs), which are the most potent antigen-presenting cells in the human body, play a pivotal role in the immune response. (jcancer.org)
The expression profiles of long noncoding RNAs (lncRNAs) and mRNAs of PEX-treated dendritic cells are unknown. (jcancer.org)

The uptake of labeled MPs in the presence of protein S and Gas6 in human aortic endothelial cells (HAEC) and human umbilical vein endothelial cells (HUVEC) was monitored by flow cytometry, western blotting and confocal/electron microscopy. (lu.se)

Enhancement of ferroelectricity and orientation in solution-derived hafnia thin films through heterogeneous grain nucleation. (ijs.si)

They are derived by a targeted mechanism from the cell endocytic compartment and are formed and stored within the intracellular multivesicular bodies (MVBs). (spandidos-publications.com)
By combining sensitive detection with fluidics that allowed for single cell interrogation and subsequent conversion of the signals generated to digital format, the platforms we use today were born, and cell surface, intracellular protein or nucleic acids could be detected by fluorescent probes specific for the target. (europeanpharmaceuticalreview.com)
5 Functionally, proinflammatory polarization leads to potent effector cells that kill intracellular micro-organisms and tumor cells. (haematologica.org)

thus, due to the unique characteristics of mesenchymal stem cells (MSCs), they have become the focus of attention and may be the most promising new therapy for periodontitis. (biomedcentral.com)
MSCs are multipotent stem cells with the ability to self-renew and differentiate in multiple directions [ 3 ]. (biomedcentral.com)
Mesenchymal stem cells (MSCs) are multipotent cells with regenerative and immunomodulatory properties. (frontiersin.org)
Overall, the results presented in this study show a common mechanism of endocytosis for MSC EVs across different cell types and the feasibility to generate functionally enhanced EVs by modifications to parental MSCs. (frontiersin.org)
There is growing evidence that mesenchymal stem cells (MSCs) could change the fate of SCI victims by re-establishing spinal cord function. (anova-irm.com)

hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
Post-stroke neurological deficits increase the risk of cardiovascular diseases roughly by three times, and the ischemic brain transmits indirect cell death signals to the heart. (justia.com)

Yet the existing science surrounding EVs implies a dynamic modality possessing a comparable or even superior therapeutic capacity than their parent cells. (corning.com)
Additionally, for many other engineered or synthetic advanced therapies, the amount of therapeutic agent required to elicit an efficacious response is high, necessitating their conveyance in a larger nanoparticle or a microparticle much larger than an EV. (corning.com)
The potential EVs possess for the field of acellular therapies - treatments derived from acellular products that achieve the same therapeutic response without delivering entire cells - is an exciting one. (corning.com)
Thus, Delivery of PRP-Exo incorporated in thermosensitive Gel provides a novel approach of cell-free therapy and has therapeutic effect on STOA. (allergy-link.com)
Recently Western medicine and biomedical science has begun to study the possible biological and therapeutic activities of curcumin. (cdadc.com)

The mesenchymal stromal cells (MSC) have immunomodulatory properties and a high regenerative capacity. (frontiersin.org)
The bone marrow stromal cell (BMSC) population, which makes up a large part of the hematopoietic microenvironment, encompasses a variety of adherent cell types. (techscience.com)

The use of lignin-derived small molecules in high-value systems such as epoxies may help improve the economics of biorefineries. (acs.org)
The surface molecules of EVs enable them to target recipient cells. (biomedcentral.com)

Although MSC EVs show great promise for regenerative medicine applications, insights into their uptake mechanisms by different target cells and the ability to control MSC EV properties for defined function in vivo have remained elusive knowledge gaps. (frontiersin.org)

Considerable evidence from basic and clinical experiment has demonstrated that pulmonary vascular remodeling caused by impairment of endothelial cells (ECs), pulmonary artery spasm, adhesion and mligration of inflammatory cells to the pulmonary artery wall, adventitial fibrosis, intimal occlusive fibrosis, and fibrinoid necrosis are typical pathological features in many forms of PH. (imrpress.com)

Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
However, many disease-predisposing factors and/or contributing factors have been identified, including inflammation, endothelial cell dysfunction, aberrant vascular wall cell proliferation and mutations in the bone morphogenetic protein-receptor type 2 ( Bmpr2 ) gene [ 1 - 3 ]. (ersjournals.com)
My research interests focus mainly on stem cells (embryonic, 'adult' and fetal origins) and their applications in tissue engineering, particularly the osteoblast and bone tissue. (nottingham.ac.uk)

E-cig use can cause oxidative stress and endothelial cell dysfunction (8, 9), and compromised innate immune response in lungs (10). (researchsquare.com)

Bacteria, dead tissue cells, and small mineral particles are all examples of objects that may be phagocytized. (wikipedia.org)
The multi‑dimensional nature of their roles in cellular homeostasis, cell‑to‑cell and tissue‑to‑tissue communication at the level of the organism, as well as their actions on the holobiome (intra‑/interspecies interaction), have garnered the interest of a large number of researchers. (spandidos-publications.com)
Endocrinology, by definition, focuses on homeostatic, and cell‑to‑cell and tissue‑to‑tissue communication mechanisms. (spandidos-publications.com)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
In periodontitis, EVs play a pivotal role in regulating the biological functions of both periodontal tissue cells and immune cells, as well as the local microenvironment, thereby promoting periodontal injury repair and tissue regeneration. (biomedcentral.com)
Specifically, EVs isolated from heart tissue remained challenging due to the susceptibility of heart cells to hypoxia, including cardiomyocytes, which can cause changes in ultrastructure and secretory activities [6]. (trillium.de)
Therefore, this article reviews the role of microRNAs from different cells or tissue sources in the occurrence and development of PH. (imrpress.com)
The effect is caused by the release of vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), hepatocyte growth factor (HGF), interleukins (IL)-6 and IL-8, as well as the secretion of the tissue inhibitor of metalloproteinase-1, all factors particularly important for the neurologic healing process. (anova-irm.com)
I returned full time to Imperial College in 1999 to take up a lectureship in cell biology and tissue engineering and was also actively involved in establishing the Tissue Engineering Centre. (nottingham.ac.uk)
I was also affiliated with the Wolfson Centre for Stem Cells, Tissue Engineering and Modelling (STEM), part of the Centre for Biomolecular Sciences, which is now the Biodiscovery Institute. (nottingham.ac.uk)

Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)

The Hill lab uses a combination of Biochemistry, Molecular and Cell Biology to investigate these diseases. (edu.au)
Noninvasive detection and imaging of molecular markers in live cardiomyocytes derived from human embryonic stem cells Biophysical Journal. (nottingham.ac.uk)
Gene set enrichment analysis of microRNAs showed significant changes in the top six enriched functions that consisted of biological pathway, biological process, molecular function, cellular component, site of expression and transcription factor in all the groups. (researchsquare.com)
Cell culture systems contribute to identifying molecular mechanisms for HBV and HDV propagation, finding drug targets for antiviral therapies, and testing antiviral agents. (cdc.gov)

These MVs/MPs are often characterized on the basis of cell surface antigens derived from the host cells (i.e. (unityhealth.to)

MicroRNA-126 (miR-126) is endothelial cell (EC) specific and plays a key role in regulating EC function, controlling angiogenesis, and maintaining vascular integrity. (justia.com)
Intercellular communication, a key process in pulmonary vascular remodeling, is originally believed to be achieved by either direct cell-to-cell contact or paracrine effects. (imrpress.com)

Microparticles (MPs) derived from the plasmatic or endosomal membranes have important roles in the inter-cellular communication. (fapesp.br)
Additionally, disruption of ion pumps leads to ion misbalance across cell membranes and in turn to cessation of neuronal function and eventually death 8, 9, 10 . (anova-irm.com)

Almost all patients with GBM relapse within a narrow margin around the initial resected lesion due to postsurgery residual glioma stem cells (GSCs). (nih.gov)

In the cardiovascular system, physiological and pathological adaptations require a coordinated cell-to-cell communication mediated by cytokines, peptides, hormones and, as recently recognized, also by EVs. (trillium.de)

Although the exact role of cellular microparticles remains partially understood, there is increasing evidence to suggest an active role for microparticles in PH pathophysiology. (ersjournals.com)
All aspects of a biological process from biochemical, genetic and cellular to clinical and environmental can be integrated using computational models to derive unique signatures from vast amounts of data. (europeanpharmaceuticalreview.com)
Flow cytometry enables the detection and enumeration of specific cellular and sub-cellular elements in complex mixture of cells, such as whole peripheral blood. (europeanpharmaceuticalreview.com)
Cellular debris and free radicals lead to inflammation and infiltration by immune cells. (anova-irm.com)

The primary goal of this study is to elucidate how the basic properties of MSC derived EVs can be exploited for function-specific activity in regenerative medicine. (frontiersin.org)
Furthermore, they are intensively studied as diagnostic markers as well as cell-free strategies for regenerative medicine [1, 2]. (trillium.de)

Because EVs are much smaller than whole cells, they are able to cross biologic barriers with ease, in contrast to the relative mass of whole cells or the immunogenic responses triggered by certain synthetic products. (corning.com)

The first demonstration of phagocytosis as a property of leucocytes, the immune cells, was from the German zoologist Ernst Haeckel. (wikipedia.org)
It was the first direct evidence of phagocytosis by immune cells. (wikipedia.org)

Without limitation, some embodiments comprise methods, systems, and/or compositions relating to microRNAs and/or cell based therapies and the use of the same in the research, diagnosis, or treatment of injury or disease. (justia.com)
Kim and Park, 2017 ) and make HMSCs attractive cells for regenerative therapies. (frontiersin.org)
Unlike whole cell therapies, EVs are acellular products, the equivalent of text messages sent back and forth in order to elicit reactions. (corning.com)
Their small size confers other benefits, as well - too small to convey pathogens such as bacteria or viruses, EVs are also incapable of the unwanted replication or tumor formation that whole cell therapies can occasionally provoke. (corning.com)

In turn, the plant produces GA, which seems to combat the improper growth signals and re-establishes cell-cycle control. (nature.com)

Microparticles are increasingly becoming realized as important biomarkers and mediators of disease. (unityhealth.to)
More recent investigation has clearly established a role for MPs as biomarkers of disease as well as active biological mediators or pathology/physiological homeostasis in most disease states. (unityhealth.to)

This chapter provides an overview of the key role of hEPC in promoting angiogenesis and their potential use for cell therapy. (intechopen.com)

It further inhibited cell-cycle progression in the G1 phase by four different mechanisms: rapid downregulation of cyclin D1, induction of Chk2 with simultaneous downregulation of Cdc25A, induction of the Cdk-inhibitor p21 Cip/Waf and inhibition of ribonucleotide reductase activity resulting in reduced dCTP and dTTP levels. (nature.com)

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