Biogenesis and degradation. Medical search. Frequent questions

Probable ribosome biogenesis protein RLP24 is a protein that in humans is encoded by the RSL24D1 gene. (wikipedia.org)
The ribosome biogenesis factor Las1 is an essential endoribonuclease that is well-conserved across eukaryotes and a newly established member of the higher eukaryotes and prokaryotes nucleotide-binding (HEPN) domain-containing nuclease family. (nih.gov)
ribosome biogenesis factor. (nih.gov)
Dr. Figueiredo seeks to understand how ribosome biogenesis and ribosome degradation is regulated in myofibers, the muscle cells and how those cellular processes impact on ribosome homeostasis/turnover, muscle protein synthesis and muscle size. (oakland.edu)
Genetic and epigenetic regulation of skeletal muscle ribosome biogenesis with exercise. (oakland.edu)
2021). Targeting cancer via ribosome biogenesis: the cachexia perspective. (oakland.edu)
Ribosome biogenesis and degradation regulate translational capacity during muscle disuse and reloading. (oakland.edu)
2019). Regulation of Ribosome Biogenesis in Skeletal Muscle Hypertrophy. (oakland.edu)
Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. (nih.gov)
Among these effects, growth-defective 60S mutants increased synthesis of proteins involved in proteasome-mediated degradation, whereas 40S mutants accumulated mature 60S subunits and increased translation of ribosome biogenesis genes. (broadinstitute.org)

Overexpressing β-catenin restored hyperammonemia-induced perturbations in signaling responses that regulate ribosomal biogenesis. (nih.gov)
A new study by IMBB researchers shows that molecular condensates that store or degrade mRNA tightly associate with mitochondria to regulate their biogenesis and function. (forth.gr)
MicroRNAs (miRNAs) are a class of short non-coding RNAs that primarily regulate protein synthesis through reversible translational repression or mRNA degradation. (uzh.ch)
MicroRNAs (miRNA) are small noncoding RNAs, preserved throughout the evolution, able to regulate gene expression through repression of translation or degradation of target molecules of messenger RNA. (bvsalud.org)

The proteostasis network (PN) is an assembly of distinct dynamic molecular pathways that control the functionality of the proteome (proteome homeodynamics) during protein synthesis, folding, trafficking, and degradation. (hindawi.com)
Skeletal muscle mass is primarily dictated by the balance between protein synthesis and degradation. (oakland.edu)

In yeast, the glucose-induced degradation-deficient (GID) E3 ligase selectively degrades superfluous gluconeogenic enzymes. (elifesciences.org)
Particularly in yeast, an organism where gluconeogenesis and glycolytic activity are intermittently coordinated, the multi-subunit GID E3 ligase complex specifically targets the surplus of gluconeogenic enzymes, including the conserved Fructose-1,6-bisphosphatase 1 (Fbp1), for proteasomal degradation. (elifesciences.org)
The ides of MARCH5: The E3 ligase essential for peroxisome degradation by pexophagy. (ruhr-uni-bochum.de)
p53 is regulated by human double minute 2 (MDM2), an E3 ubiquitin ligase that targets and binds to p53 promoting ubiquitination and degradation of the protein [6,7]. (nanoker-society.org)

Cysteine-specific ubiquitination protects the peroxisomal import receptor Pex5p against proteasomal degradation. (ruhr-uni-bochum.de)

Consistent with this, qRT-PCR confirmed that the expression of multiple genes involved in cilia biogenesis was significantly downregulated by diacetyl and 2,3-pentanedione in NHBE cells. (nature.com)
Genes required for degradation of and growth on the carbon source pectin were down-regulated, whereas transcripts involved in redox processes were up-regulated. (frontiersin.org)

Cellular proteostasis involves the coordinated and compensatory action of pathways that control biogenesis, folding, trafficking and breakdown of proteins allowing the cell to adapt to physiological or pathological environmental changes. (elifesciences.org)
Together, our results suggest that the EMC engages with DENV polyproteins to ensure proper biogenesis of the NS4A-NS4B region, and provide further evidence for the cellular function of the EMC in the stable expression of TM proteins. (biorxiv.org)
The contributors examine how proteins enter the ER, the biogenesis of membrane proteins, and the role of the ER in protein sorting and quality control. (cshlpress.com)
UBIQUITIN-like modifier proteins that function in CYTOPLASM to VACUOLE transport (Cvt), vesicle transport within the GOLGI APPARATUS, and AUTOPHAGOSOME biogenesis. (bvsalud.org)

The work supports a role for chemical modification in the recognition and subsequent degradation of a key protein subunit of PSII by a bacterial-type protease, suggesting that tryptophan oxidation of components of the photosynthetic apparatus after high light stress plays a critical role in initiating the PSII repair system. (elifesciences.org)
In particular, I will discuss how cargo receptors and the autophagy machinery act sequentially during cargo condensation, membrane nucleation and elongation to mediate the specific sequestration and subsequent degradation of cellular material. (tigem.it)

Under normal conditions, Keap1 promotes ubiquitination and eventual degradation of Nrf2. (springer.com)

For instance, the association of mitochondria with the endoplasmic reticulum (ER), in a juxtaposition known as Mitochondria-Associated Membrane (MAM), has an important role in controlling mitochondria biogenesis, Ca 2+ release, and lipid synthesis and apoptosis [ 10 , 11 ]. (hindawi.com)
Additionally, they found a rapid degradation of spike protein following its synthesis when ZDHHC enzymes were silenced. (news-medical.net)

This review summarizes recent data exemplifying the known roles of miRNAs in memory formation in different model organisms, and describes how neuronal plasticity regulates miRNA biogenesis, activity and degradation. (uzh.ch)
This study performs a literature review of miRNA, focusing on aspects related to biogenesis, mechanisms of action and potential role of these small RNAs in oral carcinogenesis. (bvsalud.org)

Increased ribosomal biogenesis occurs during tissue hypertrophy, but whether ribosomal biogenesis is impaired during atrophy is not known. (nih.gov)
Decreased ribosomal content was accompanied by decreased expression of cMYC, a positive regulator of ribosomal biogenesis, as well as reduced expression and activity of β-catenin, a transcriptional activator of cMYC. (nih.gov)

In peroxisomal biogenesis disorders, abnormal accumulation of VLCFAs (C24, C26) is the hallmark of peroxisomal disorders. (medscape.com)

IRE1 regulates this activation through the nonconventional splicing of XBP1 mRNA and the degradation of a large pool of cytoplasmic mRNAs in the regulated‐IRE1 dependent decay (RIDD) pathway [ 9 , 14 ]. (biomedcentral.com)
MicroRNAs (miRNAs) are small, noncoding RNAs that bind to the 3' UTR of target mRNAs, and silence gene expression by inducing degradation of target mRNAs or inhibition of protein translation [ 10 ]. (cdc.gov)

Biogenesis and classification of extracellular vesicles. (spandidos-publications.com)

However, unlike the canonical regulation of β-catenin via glycogen synthase kinase 3β (GSK3β)-dependent degradation, GSK3β expression and phosphorylation were unaltered during hyperammonemia, and depletion of GSK3β did not prevent ammonia-induced degradation of β-catenin. (nih.gov)

They are also required for selective autophagic degradation of the nucleus (nucleophagy) and MITOPHAGY. (bvsalud.org)

Autophagy is an intracellular lysosomal bulk degradation pathway that ensures cellular homeostasis by the removal of damaged and dangerous material from the cytoplasm. (tigem.it)
Autophagy stimulus-dependent role of the small GTPase Ras2 in peroxisome degradation. (ruhr-uni-bochum.de)

Du, T. & Zamore, P. D. microPrimer: the biogenesis and function of microRNA. (nature.com)
Furthermore, their biogenesis, composition and function have been associated with viruses, an entirely different domain of life. (spandidos-publications.com)

Lastly, we showed a physical interaction between the EMC and DENV NS4B protein post-cleavage and rapid degradation of processed NS4B in the absence of EMC. (biorxiv.org)

Here, we show that an oxidative post-translational modification of Trp residue at the N-terminal tail of D1 is correlated with D1 degradation by FtsH during high-light stress. (elifesciences.org)

While this system is well known to cope with photoinhibition, the actual oxidation within the D1 polypeptide and its association to degradation remained elusive. (elifesciences.org)

Further characterization of Trp-14 using chloroplast transformation in Chlamydomonas indicated that substitution of D1 Trp-14 to Phe, mimicking Trp oxidation enhanced FtsH-mediated D1 degradation under high light, although the substitution did not affect protein stability and PSII activity. (elifesciences.org)

Probable ribosome biogenesis protein RLP24 is a protein that in humans is encoded by the RSL24D1 gene. (wikipedia.org)
Trapped proteins are delivered by autophagosome fusion to the lysosome where protein and polysaccharide degradation permit amino acids and sugars to be recycled. (nih.gov)
Misfolded proteins activate the unfolded protein response (UPR), which increases the protein folding capacity of the ER and induces ER-associated degradation. (db-engine.de)
Recent genetic and biochemical studies have revealed an extraordinary diversity of protein complexes involved in the biogenesis of cilia during each cell cycle. (nih.gov)
These ciliary TGL domains appear to have originated from prokaryotic TGL domains that act as peptidases, either in a prokaryotic protein degradation system with the MoxR AAA+ ATPase, the precursor of eukaryotic dyneins and midasins, or in a peptide-ligase system with an ATP-grasp enzyme comparable to tubulin-modifying TTL proteins. (nih.gov)
NSF is a member of the ATPases associated with various cellular activities family (AAA+ ATPase), which is essential for many cellular functions such as DNA replication and protein degradation, membrane fusion, microtubule severing, peroxisome biogenesis, signal transduction, and the regulation of gene expression . (news-medical.net)
Escherichia coli periplasmic Zn-metallopeptidase BepA contributes to the maintenance of OM integrity through its involvement in the biogenesis and degradation of LptD, a β-barrel protein component of the lipopolysaccharide translocon. (elifesciences.org)
Mitochondria have circular DNA (mitochondrial DNA, mtDNA), and mitochondrial biogenesis (mitobiogenesis) involves the replication, transcription, and translation of mtDNA-encoded genes, the interorganelle transport of phospholipids, and the import of nuclear-encoded proteins into mitochondria through the protein translocation machinery of the outer and inner membranes [ 14 ]. (biomedcentral.com)
Chloroplast ATP synthase biogenesis requires peripheral stalk subunits AtpF and ATPG and stabilization of atpE mRNA by OPR protein MDE1 - 2023 - Plant J. Epub ahead of print. (ibpc.fr)
Autophagy is a highly conserved metabolic process that plays a key role in maintaining cellular homeostasis through lysosome-mediated protein degradation, amino acid recycling, and protein biogenesis. (nih.gov)
The contributors examine how proteins enter the ER, the biogenesis of membrane proteins, and the role of the ER in protein sorting and quality control. (cshlpress.com)
Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. (nih.gov)
Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). (nih.gov)
Cellular responses to stress generally lead to the activation of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. (nih.gov)
A key host factor in ERAD is the valosin-containing protein (VCP), an ATPase which ushers ubiquitin-tagged proteins to degradation by the proteasome. (nih.gov)

MicroRNAs (miRNAs) are a class of non-coding endogenous RNA molecules that are involved in post-transcriptional gene silencing via binding to their target messenger RNA, leading to mRNA degradation or translational repression. (intechopen.com)
MicroRNAs or miRNAs are a class of small non-coding RNA approximately 21-25 nucleotides that modulate on gene expression post-transcriptionally via binding to the 3′ untranslated region (3′-UTR) of the target messenger RNA (mRNA), resulting in mRNA degradation or translational repression. (intechopen.com)
Does not play a role in replication-dependent histone mRNA degradation. (innatedb.com)

Celecoxib-primed TAFs showed a reduced EGFR degradation after EGF challenge. (oncotarget.com)

The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. (ucsc.edu)
Defects in this gene are a cause of Zellweger syndrome (ZWS), as well as peroxisome biogenesis disorder complementation group 14 (PBD-CG14), which is also known as PBD-CGJ. (ucsc.edu)
ZWS is a fatal peroxisome biogenesis disorder characterized by dysmorphic facial features, hepatomegaly, ocular abnormalities, renal cysts, hearing impairment, profound psychomotor retardation, severe hypotonia and neonatal seizures. (ucsc.edu)

They showed that hRGCs are efficient in maintaining mitochondrial homeostasis through rapid degradation and biogenesis of mitochondria under acute damage. (wms-site.com)
Activation of mitochondrial biogenesis through pharmacological inhibition of the Tank binding kinase 1 (TBK1) restores energy homeostasis, mitigates mitochondrial swelling with neuroprotection against acute mitochondrial damage for glaucomatous E50K hRGCs, revealing a novel neuroprotection mechanism. (wms-site.com)

This gene is necessary for early peroxisomal biogenesis. (ucsc.edu)

2012) Architecture of the Atg17 complex as a scaffold for autophagosome biogenesis. (nih.gov)
2014) The beginning of the end: How scaffolds and coalescing vesicles nucleate autophagosome biogenesis. (nih.gov)
UBIQUITIN -like modifier proteins that function in CYTOPLASM to VACUOLE transport (Cvt), vesicle transport within the GOLGI APPARATUS , and AUTOPHAGOSOME biogenesis. (bvsalud.org)

A key finding in support of this was the discovery that expression of lysosomal genes changes in response to nutrient status, revealing that cells monitor lysosomal function and respond to degradation requirements and environmental conditions. (nih.gov)
In contrast, autophagic flux provides direct evidence of lysosomal substrate degradation. (nih.gov)
Transcription factor EB (TFEB) is known as a master regulator of lysosomal biogenesis and, here, we reveal that aspirin, one of the most widely used medications in the world, upregulates TFEB and increases lysosomal biogenesis in brain cells. (nih.gov)
This study reveals a new function of aspirin in stimulating lysosomal biogenesis via PPARα and suggests that low-dose aspirin maybe used in lowering storage materials in Alzheimer's disease and lysosomal storage disorders. (nih.gov)

3. CRL3IBTK Regulates the Tumor Suppressor Pdcd4 through Ubiquitylation Coupled to Proteasomal Degradation. (nih.gov)
7. S100A4 negatively regulates β-catenin by inducing the Egr-1-PTEN-Akt-GSK3β degradation pathway. (nih.gov)
11. Insulin receptor substrate 1/2 (IRS1/2) regulates Wnt/β-catenin signaling through blocking autophagic degradation of dishevelled2. (nih.gov)
To answer these questions, we investigate three related processes: (1) ER membrane biogenesis, which enables organelle expansion and remodeling, (2) ER-phagy, which mediates autophagic organelle degradation, and (3) SHRED, which regulates proteasomal degradation of misfolded cytosolic and ER membrane proteins. (db-engine.de)

They are also required for selective autophagic degradation of the nucleus (nucleophagy) and MITOPHAGY . (bvsalud.org)

substrate proteins to degradation might be influenced by purified endopeptidases (chymotrypsin and trypsin). (123dok.net)

In the 5' to 3' pathway, this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts. (kegg.jp)

M y scientific interests range from cell-cell interactions within tissues to cellular differentiation during gametogenesis, biogenesis of subcellular organelles, phospholipid signaling, membrane trafficking, cytoskeletal organization, and post-transcriptional regulation of long noncoding and messenger RNAs. (ascb.org)
Mitochondrial mass and quality are tightly regulated by two essential and opposing mechanisms, mitochondrial biogenesis (mitobiogenesis) and mitophagy, in response to cellular energy needs and other cellular and environmental cues. (biomedcentral.com)

Peroxisome Degradation and Its Molecular Machinery Peroxisomes: Biogenesis, Function, and Role in Human Disease Part I, Chapter 3(2019). (kyoto-u.ac.jp)

Related mechanisms cooperate with the UPR to clear troublesome proteins, including proteasome biogenesis ( Schmidt et al, 2019 ). (db-engine.de)
From NCBI Gene: Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). (nih.gov)
An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. (nih.gov)

Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. (innatedb.com)
Uridylated pre- let-7 miRNAs fail to be processed by Dicer and undergo degradation. (innatedb.com)
Leaf microarray studies showed that many genes involved in microRNAs (miRNAs) and trans-acting siRNAs (tasiRNAs) biogenesis were significantly changed in the fast-growing lines. (biomedcentral.com)
Significant changes of leaf microarray data in genes for miRNAs (a) and tasiRNAs (b) biogenesis. (biomedcentral.com)

The sources of dsRNAs that trigger siRNAs biogenesis could be exogenous (e.g., viral replication) or endogenous. (biomedcentral.com)

VCP exhibits different proviral activities, such as engaging in the biogenesis of viral replication organelles. (nih.gov)

The molecular chaperone DnaK, a bacterial Hsp70 homologue, promotes curli biogenesis via unknown mechanism(s). (nature.com)
Full Professor of Biology, Director of The International Institute of Molecular Mechanisms and Machines Polish Academy of Sciences (IMol PAS) where she heads the Laboratory of Mitochondrial Biogenesis. (fnp.org.pl)

Novel nucleases, helicases and RNA binding proteins have been identified in piRNA biology, and while we are starting to understand some mechanisms of piRNA biogenesis and function, this diverse and prolific class of small RNAs remains full of surprises. (nih.gov)

Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. (ucsc.edu)

To investigate the coordinated biogenesis of this complex, we isolated novel ATP synthase mutants in the green alga Chlamydomonas reinhardtii by screening for high light sensitivity. (ibpc.fr)

Genetic studies have indicated that malfunctioning degradation pathways contribute to the pathogenesis of PD. (biomedcentral.com)

16. GSK3β-dependent cyclin D1 and cyclin E1 degradation is indispensable for NVP-BEZ235 induced G0/G1 arrest in neuroblastoma cells. (nih.gov)
The main scientific areas of interest include (1) exRNA biogenesis, (2) exRNA biodistribution, (3) uptake of exRNA by target cells, and (4) the physiological impact of delivered exRNA in target cells and tissues. (nih.gov)
Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. (innatedb.com)

This includes biogenesis, transport and degradation of mitochondrial proteins and their failure resulting in pathologies. (fnp.org.pl)

Anatomy44

Organisms10

Diseases3

Chemicals and Drugs99

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes71

Information Science4

Health Care2

Ribosome biogenesis10

Regulate4

Protein synthesis2

Ligase4

Proteasomal degradation1

Genes2

Proteins4

Subsequent degradation2

Ubiquitination1

Synthesis2

MiRNA2

Ribosomal2

Peroxisomal1

MRNAs2

Vesicles1

Regulation1

Mitophagy1

Autophagy2

Function2

Rapid1

Stress1

Association1

Activity1

Protein15

MRNA3

Reduced EGFR degradation1

Peroxisome biogenesis3

Homeostasis2

Peroxisomal biogenesis1

Autophagosome3

Lysosomal4

Regulates4

Autophagic degradation1

Proteins to degradation1

PATHWAY1

Cellular2

Peroxisomes1

Proteasome3

MiRNAs4

Exogenous1

Viral replication1

Molecular2

Mechanisms1

Nucleus1

Investigate1

Genetic1

Cells3

Transport1