Biodegradable porous scaffolds for tissue tissue scaffolds. Medical search. Frequent questions

Polymers have been widely chosen as tissue scaffolding material having a good combination of biodegradability, biocompatibility, and porous structure. (hindawi.com)
Metals that can degrade in physiological environment, namely, biodegradable metals, are proposed as potential materials for hard tissue scaffolding where biodegradable polymers are often considered as having poor mechanical properties. (hindawi.com)
Biodegradable polymers have been widely used and accepted as the most suitable materials for scaffolds due to their degradability, biocompatibility, and ease of processability [ 9 - 11 ]. (hindawi.com)
Synthetic biodegradable polymers such as poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and their copolymers have been used in many clinical applications [ 12 - 16 ]. (hindawi.com)
Biodegradable polymers degrade through hydrolysis process and are gradually absorbed by the human body thus allowing the supported tissue to gradually recover its functionality [ 8 , 17 ]. (hindawi.com)
Biodegradability can be imparted into polymers through molecular design with a controlled rate in concert with tissue regeneration [ 18 - 21 ]. (hindawi.com)
We created double-layered porous scaffolds composed of synthetic biodegradable polymers by combining freeze-drying and porogen leaching techniques to create tissue- engineered articular cartilage. (elsevierpure.com)
Biodegradable scaffolds made from polymers like polylactic acid (PLA), polyglycolic acid (PGA) or polycaprolactone may also be used as an alternative to metal implants. (hiltonpittmanphotography.com)
Natural and synthetic biodegradable polymers and hydrolysable metals make the main components for the creation of temporary medical implants [ 2 ] . (encyclopedia.pub)
Poly(lactides-co-glycolides) [PLGA] are broadly investigated biodegradable polymers and they are thoroughly used in a number of biomaterials apps and drug shipping and delivery devices. (ezblogz.com)
Polymers: Biodegradable synthetic polymers, like polylactic acid (PLA) and polyglycolic acid (PGA), are used to create porous scaffolds that promote bone cell attachment and growth. (credenceturbine.com)
Using biodegradable polymers such as poly (lactic-co-glycolic acid) (PLGA) and poly (ethylene glycol) (PEG), drug loaded films were fabricated onto FDA approved medical devices (the Glaucoma drainage device and the Surgical hernia mesh). (tulane.edu)
Especially, nanofibres of synthetic polymers PVDF, PAN and bio-compatible polymers such as Cellulose acetate(CA), poly-caprolactone and PVA(poly-vinyle alcohole) and polylactide(PLA) these are the biodegradable polymers used for fabrication of new materials for medical use and for tissue engineering application hence, produced by electrospinning technology have grate poential to produce advanced nanomaterialsfor high end applications. (textilesphere.com)
There are several types of local drug delivery systems for bone cancer treatment, including: Polymeric drug delivery systems: Polymeric drug delivery systems involve the use of biocompatible and biodegradable polymers that can encapsulate and release anticancer drugs in a controlled manner. (alliedacademies.org)
Biocompatible polymers are widely used in tissue engineering and biomedical device applications. (nature.com)
Synthetic polymers have been used in medical devices for more than five decades, and key recent advances have largely focused on the development of biodegradable (or resorbable) materials for tissue engineering 7 . (nature.com)

Scaffolds have been utilized in tissue regeneration to facilitate the formation and maturation of new tissues or organs where a balance between temporary mechanical support and mass transport (degradation and cell growth) is ideally achieved. (hindawi.com)
One of the most attractive subjects in tissue engineering is the development of a scaffold, a three-dimensional porous solid structure that plays a key role in assisting tissue regeneration [ 1 ]. (hindawi.com)
Its degradation rate should match the rate of new tissue regeneration in order to maintain the structural integrity and to provide a smooth transition of the load transfer from the scaffold to the tissue [ 3 ]. (hindawi.com)
The main challenge for large bone defect repair and regeneration remains the inadequate recruitment of mesenchymal stem cells (MSCs), reduced vascularization, and decreased growth factors stimulation within the scaffold construct to support cell viability and tissue growth. (frontiersin.org)
Consequently, enhancing the adhesion of MSCs, augmenting the release of growth factors, and promoting angiogenic potential of biomaterial scaffolds after implantation are pivotal for successful bone regeneration. (frontiersin.org)
The challenge of restoring patient's function that presented some loss of an organ or tissue encourages the Tissue Engineering and Biotechnology to develop materials that promote bone regeneration. (bvsalud.org)
guided tissue regeneration. (bvsalud.org)
Other procedures can be executed aiming to increase the bone volume, such as osteogenic distraction (surgical induction of the bone fracture and splitting into two fragments so that a new bone is formed between them), osteoinduction with growth factors and/or stem cells, osteoconduction by the use of substrates for cellular development (scaffolds) and guided tissue regeneration (GTR) with the aid of membranes 18 . (bvsalud.org)
9] Alessandri G, Emanueli C, Madeddu P. Genetically engineered stem cell therapy for tissue regeneration[J]. Ann N Y Acad Sci, 2004, 1015:271-284. (sdu.edu.cn)
Co-transplantation of neural stem cells and Schwann cells within poly (L-lactic-co-glycolic acid) scaffolds facilitates axonal regeneration in hemisected rat spinal cord[J]. Chin Med J, 2013, 126(5):909-917. (sdu.edu.cn)
Recently, carbon-modified biomaterials for bone tissue engineering have been extensively investigated to potentially revolutionize biomaterials for bone regeneration. (openorthopaedicsjournal.com)
This review summarizes the chemical and biophysical properties of carbon nanostructures and discusses their functionality in bone tissue regeneration. (openorthopaedicsjournal.com)
In the quest for alternative therapeutic strategies, research is focusing on the concept of tissue engineering to assist the progress of bone tissue regeneration. (openorthopaedicsjournal.com)
The results reveal the necessity of option of scaffold elements and computationally developed scaffolds to regulate tissue development and mechanical Qualities for wished-for bone tissue regeneration. (ezblogz.com)
Application of the CJS process as a highly efficient method of fabricating porous PLLA nanofiber is described for potential large-scale application for biodegradable tissue regeneration scaffolds. (rpi.edu)
Has excellent mechanical properties such as flexibility and elasticity and provides appropriate biodegradation time so that it can be used in manufacturing bio-degradable porous polymeric scaffolds suitable for regeneration of soft tissues such as skin and blood vessels, and medical materials such as medical matrix and wound coverings. (360ip.com)
In summary, our results showed that Gamat Hydrogel promoted burn wound repair via a complex mechanism involving stimulation of tissue regeneration and regulation of pro-inflammatory cytokines. (afpm.org.my)
Ceramic scaffolds can also promote bone regeneration, which is beneficial for patients with bone cancer. (alliedacademies.org)
Hydrogels can also promote tissue regeneration and reduce inflammation, which is beneficial for bone cancer patients. (alliedacademies.org)
Studying the influence of the designed alloy on reparative osteogenesis during experiment on rabbits has shown the positive dynamics of bone tissue regeneration without noticeable changes in its structure, which ensures reliable merging of elements in bones at osteosynthesis. (uran.ua)
In recent years, tissue engineering has evolved considerably, due to the problems in the biomedical area concerning tissue regeneration therapies. (bvsalud.org)
Moreover, sterilization strategies of scaffold are a crucial step for its application in tissue regeneration, however, the sterilization process have to maintain the structural and biochemical properties of the scaffold. (bvsalud.org)

Biomaterials can be variously permanent or biodegradable, naturally occurring or synthetic, but inevitably need to be biocompatible. (nanowerk.com)
Moreover, it is of great importance that they are totally biocompatible to not damage the surrounding tissues. (bvsalud.org)
These scaffolds should be biocompatible, biodegradable and porous and support the normal proliferation and functioning of the cells seeded on to it (Gnanaprakasam Thankam et al. (docksci.com)
Various medical applications of polyhydroxyalkanoates (PHAs), biodegradable and biocompatible materials have been reported, including tissue engineering scaffolds, patches for use in cardiovascular surgery, and other implants. (upt.ro)
Moreover, the histological response showed that the scaffolds are biocompatible and those sterilized by GR showed a more severe inflammatory response, accompanied with the presence of giant foreign body cells. (bvsalud.org)

Zhang and Ma have developed [ 25 ] a highly porous biodegradable polymer/apatite composite scaffold (95% porosity) through a thermally induced phase separation technique, which resulted in significant improvement in mechanical properties compared to polymer-only scaffold. (hindawi.com)
Low production cost, simple experimental procedure and easy processability together with the capability to produce highly porous scaffolds with controllable architecture justify the popularity of TIPS. (ibecbarcelona.eu)
These osteoconductive three dimensional constructs seeded with MSCs are highly porous, biodegradable and biomechanically stable scaffolds which do not evoke an immunogenic host cell response. (openorthopaedicsjournal.com)
The nanomaterial which is generated by this technology has a larger surface area and highly porous which makes it suitable for advanced applications. (textilesphere.com)

SBA-15 and MCM-41) and polymer/ceramics composite materials for application in bone and skin tissue engineering. (itsligo.ie)
Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering[J]. Biomaterials, 2006, 27(18):3413-3431. (sdu.edu.cn)
Biodegradable porous scaffolds are investigated in its place method of existing steel, ceramic, and polymer bone graft substitutes for lost or ruined bone tissues. (ezblogz.com)
The results suggest that the use of breath figure morphologies in biodegradable polymer films adds an additional level of control to drug release. (tulane.edu)
Ghalia MA, Dahman Y. ( 2017 ) Fabrication and enhanced mechanical properties of porous PLA/PEG copolymer reinforced with bacterial cellulose nanofibers for soft tissue engineering applications Polymer Testing . (academictree.org)
Ghalia MA, Dahman Y. ( 2017 ) Biodegradable poly(lactic acid)-based scaffolds: synthesis and biomedical applications Journal of Polymer Research . (academictree.org)
Nakhoda HM, Dahman Y. ( 2016 ) Mechanical properties and biodegradability of porous polyurethanes reinforced with green nanofibers for applications in tissue engineering Polymer Bulletin . (academictree.org)
I am a world-renowned leader in tissue engineering, my research involves the generation of new functional tissue using a combination of living cells and synthetic biodegradable polymer scaffolds. (artbots.org)

Ideally, a scaffold must be porous, bioactive, and biodegradable and possess adequate mechanical properties suited to the biological site. (hindawi.com)
In this review, we introduce the broad application of β-TCP in tissue engineering and discuss the different approaches that β-TCP scaffolds are customized, including physical modification (e.g., pore size, porosity and roughness) and the incorporation of metal ions, other materials (e.g., bioactive glass) and stem cells (e.g., mesenchymal stem cells). (frontiersin.org)
Also, they should be porous, because it is through the pores that the fluids, nutrients, oxygen, and bioactive substances for cellular growth are changed. (bvsalud.org)

A wide range of synthetic and natural biomaterials is being used to develop tissue-engineered bone. (openorthopaedicsjournal.com)
Such a scaffold can be made from synthetic and natural molecules or a combination of both, which can be effectively used for the ex vivo engineering of various organ parts. (docksci.com)
Currently, work has been focused on the synthesis and physicochemical characterization of poly lactic acid scaffolds, a synthetic polyester that has been extensively study for its excellent biocompatibility and biodegradability. (bvsalud.org)

Scientific advances in biomaterials, stem cells, growth and differentiation factors, and biomimetic environments have created unique opportunities to fabricate or improve existing tissues in the laboratory from combinations of engineered extracellular matrices ("scaffolds"), cells, and biologically active molecules. (wikipedia.org)
At the core of tissue engineering is the construction of three-dimensional scaffolds out of biomaterials to provide mechanical support and guide cell growth into new tissues or organs. (nanowerk.com)
It is one of a number of analysis and characterisation facilities within the Department, and is predominantly used by members of the Biomaterials and Tissue Engineering theme . (sheffield.ac.uk)

With further optimization in topologically ordered porosity design exploiting material property and fabrication technique, porous biodegradable metals could be the potential materials for making hard tissue scaffolds. (hindawi.com)
Sufficient porosity is needed to accommodate cell proliferation and differentiation, which will eventually enhance tissue formation [ 2 , 3 ]. (hindawi.com)
To create a favorable osteogenic environment, β-TCP scaffolds have been modified in a number of ways to boost bone healing, including modulating physical features (e.g., pore sizes, porosity and surface roughness), combining with ionic components, and the addition/delivery of growth factors. (frontiersin.org)
Porous polyester films were prepared by deposition from solutions with different porosity agents. (upt.ro)

The current promising fabrication technique for making scaffolds, such as computation-aided solid free-form method, can be easily applied to metals. (hindawi.com)
The recent advances in the fabrication of porous scaffolds through this technique, in terms of technology and material selection, have been reviewed. (ibecbarcelona.eu)
Fabrication and surface modification of macroporous poly(L-lactic acid) and poly(L-lactic-co-glycolic acid) (70/30) cell scaffolds for human skin fibroblast cell culture[J]. J Biomed Mater Res, 2002, 62(3):438-446. (sdu.edu.cn)
The first part of the dissertation work involves the fabrication of drug loaded breath figure thin films and its utilization as a controlled drug release carrier and biomaterial scaffold. (tulane.edu)
In a single fabrication step, single layer/multilayer porous thin films were designed and developed by combining the breath figure process and a modified spin or dip coating technique. (tulane.edu)

For instance, PLA could be combined with PGA to form poly(lactic- co -glycolic acid) (PLGA), which has degradation rate tailored with the tissue healing period and has been shown to support osteoblast cells attachment and growth in vitro and in vivo [ 22 - 24 ]. (hindawi.com)
Three-dimensional poly (1,8-octanediol-co-citrate) scaffold pore shape and permeability effects on sub-cutaneous in vivo chondrogenesis using primary chondrocytes. (ozhurnal.com)

The cytocompatibility of PLGA scaffolds coated with different concentration of chitosan with schwann cells in vitro[J]. Chin J Aesth Med, 2009, 18(11):1627- 1631. (sdu.edu.cn)
Histological Assessment discovered the fifty:50 PLGA scaffolds degraded but didn't maintain their architecture just after 4 weeks implantation. (ezblogz.com)
Mechanical Houses of the two PLLA and fifty:50 PLGA scaffolds lessened but PLLA scaffolds taken care of greater mechanical Houses than 50:fifty PLGA just after implantation. (ezblogz.com)
Some great benefits of localized biodegradable plga 50/50 therapy involve high, nearby antibiotic focus at the positioning of an infection, as well as, obviation of the need for elimination with the implant after therapy. (ezblogz.com)

To induce in vitro chondrogenesis, MSCs were seeded into MC solution retained within a porous polyurethane (PU) matrix. (nature.com)
Preliminary in vitro tests indicated that the scaffolds are suitable for cartilage tissue engineering, and that their potential applications can be extended to cartilage-bone interface tissue engineering. (unibo.it)
Preliminary in vitro tests show good osteoblast response in terms of proliferation and adhesion on all the scaffolds. (unibo.it)
Furthermore, the porous nature of the film was investigated as a biomaterial scaffold to construct three dimensional in vitro tissue model systems. (tulane.edu)
The breath figure film with interconnected pores facilitates cell infiltration and tissue remodelling in vitro, suggesting its high potential in regenerative medicine and tissue engineering applications. (tulane.edu)
Soft tissue engineering for both clinical use and as novel 3D in vitro models for improved laboratory studies. (sheffield.ac.uk)
Nobel Prize winner Alexis Carrel performed numerous experiments clearly showing that tissue explants, including connective tissue and heart tissue, could be cultured in vitro preserving their characteristics for prolonged periods of time [ 2 ] supporting the notion that entire organs could be cultured in vitro. (intechopen.com)

26 ] has shown that osteoblast survival and growth were significantly enhanced in the PLLA/HA composite scaffolds compared to the plain PLLA scaffolds. (hindawi.com)
Nevertheless, PLLA scaffolds preserved their architecture at each time details and showed enhanced bone ingrowth, which followed The inner architecture from the scaffolds. (ezblogz.com)

The biomaterial scaffold design should consider physicochemical properties, microstructure, and degradation in vivo . (openorthopaedicsjournal.com)

He proposed the joining of the terms tissue (in reference to the fundamental relationship between cells and organs) and engineering (in reference to the field of modification of said tissues). (wikipedia.org)
If damaged through injury or disease, most of our tissues and organs are unable to regenerate to their original state. (formlabs.com)
Tissue engineering refers to the development of technologies to grow replacement tissues and organs in the laboratory for use in treating injury and disease. (formlabs.com)
Methods of directly 3D printing with cells to form tissues and organs are being developed. (formlabs.com)
The ECM component of the tissues forms an insoluble scaffold, which determines the shape and dimension of the organs (Cox and Erler 2011). (docksci.com)

Films used as tissue engineering scaffolds must have several important performance features, including sufficient mechanical strength, biocompatibility, biodegradability and the ability to support cell attachment and proliferation. (upt.ro)

Moreover, the co-electrospinning technique was used to prepare nanofibrous scaffolds at variable content of gelatin and polylactic acid. (unibo.it)

Biodegradable metal scaffolds have showed interesting mechanical property that was close to that of human bone with tailored degradation behaviour. (hindawi.com)
A biodegradable scaffold allows the replacement of biological tissues via physiological extracellular components without leaving toxic degradation products. (hindawi.com)
Mechanically, the major challenge is to achieve adequate initial strength and stiffness and to maintain them during the stage of healing or neotissues generation throughout the scaffold degradation process [ 3 , 7 , 8 ]. (hindawi.com)
In comparison to non-porous films, the breath figure films showed an increased degradation and enhanced drug release. (tulane.edu)
This article reports a degradation study that was done on stent prototypes made of biodegradable Fe35Mn alloy in a simulated human coronary arterial condition. (afpm.org.my)
The aim of the present study was designed to analyze the effects of different sterilization techniques, i.e. ethylene oxide (ETO), gamma radiation (GR) and hydrogen peroxide- based plasma (H2O2) in biodegradable PLA scaffolds, and to determine the best sterilization technique to render a sterile product with minimal degradation and deformation, and good tissue response. (bvsalud.org)

Tissue engineering is a biomedical engineering discipline that uses a combination of cells, engineering, materials methods, and suitable biochemical and physicochemical factors to restore, maintain, improve, or replace different types of biological tissues. (wikipedia.org)
A suitable morphology on the implant s surface serves to guide cell adhesion, migration, and proliferation, and is a key to success in tissue engineering. (upt.ro)

A successful method was developed to prepare gelatin nanofibrous scaffolds electrospun from acetic acid/water solution and stabilized with a non-toxic crosslinking agent, genipin, able to preserve their original morphology after exposure to water. (unibo.it)

In the current study, novel polyethylene glycol interpenetrated cross-linked hydrogel scaffold based on a co-polysaccharide (PIAC) synthesized from two marine heteropolysaccharides, alginate and chitosan, was designed. (docksci.com)
The present hydrogel can form an ECM mimic and can form a potent candidate for various tissue engineering applications. (docksci.com)
Gamat Hydrogel markedly enhanced wound contraction and improved histological reorganization of the regenerating tissue. (afpm.org.my)
Response of orbital and auricular soft tissues to the developed hydrogel implant in rabbits]. (ozhurnal.com)

A variety of techniques have been developed to fabricate tissue engineering (TE) scaffolds, among them the most relevant is the thermally-induced phase separation (TIPS). (ibecbarcelona.eu)

Moreover, they need to provide an interface able to respond to local physiological and biological changes and to remodel the extracellular matrix (ECM) in order to integrate with the surrounding native tissue. (nanowerk.com)
Introduction The cells in a tissue are held together by colloidal extracellular matrix (ECM), which is gel like in consistency. (docksci.com)

The information acquired on the effect of crosslinking in different conditions was utilized to optimize the preparation procedure of electrospun and freeze-dried scaffolds. (unibo.it)

The development of iron as biodegradable material for bone implants has advanced significantly in the recent years. (jakajima.eu)
To substitute the metal implants for internal fracture fixation, numerous biodegradable materials (BMs) were developed. (encyclopedia.pub)
Biodegradable implants are increasingly used in regenerative medicine and sports medicine [ 1 ] . (encyclopedia.pub)
In an ideal scenario, these implants would break down as the wound healed, transferring load gradually to the healing tissue. (encyclopedia.pub)
There are several typical clinical indications for the use of biodegradable implants in orthopedics, which are mostly used for fractures stabilization, osteotomy procedures, bone grafts and fusions [ 6 ] [ 7 ] . (encyclopedia.pub)
The most common indications for biodegradable implants in orthopedics include anterior cruciate ligament reconstruction, meniscus repair, and ankle fracture treatment [ 9 ] . (encyclopedia.pub)
The occurrence of clinical indications for biodegradable implants is comprehensively demonstrated in Figure 1 . (encyclopedia.pub)
Current clinical applications of biodegradable implants. (encyclopedia.pub)
In the shoulder area, biodegradable implants are applied in fracture fixation of the glenoid fossa and in shoulder lesions repair [ 10 ] . (encyclopedia.pub)
It was established that the implants made from the designed alloy possess the necessary level of mechanical properties that match the mechanical properties of bone tissue. (uran.ua)
Biodegradable surgical implants based on magnesium alloys - A review of current research. (uran.ua)

While most definitions of tissue engineering cover a broad range of applications, in practice the term is closely associated with applications that repair or replace portions of or whole tissues (i.e. bone, cartilage, blood vessels, bladder, skin, muscle etc. (wikipedia.org)
Over the last few years, tremendous advances have been made towards producing tissue-engineered blood vessels, but researchers have only been able to construct simple straight tubes. (formlabs.com)
His research uses high-precision desktop stereolithography (SLA) 3D printing to enable the production of tissue-engineered blood vessels with a variety of geometries. (formlabs.com)
Dr Pashneh-Tala uses a hybrid approach, in which 3D printing enables the production of tissue-engineering scaffolds for growing blood vessels with unique geometries. (formlabs.com)
Prior to this, no tissue-engineered artificial blood vessels could withstand the high-pressure environment. (360ip.com)

For example, a tubular scaffold can be used to produce a blood vessel. (formlabs.com)

GTR is an alternative basically based on the installation of mechanical barriers to protect the area of neoformed tissue avoiding that other tissues, e.g., connective and clots, invade and jeopardize bone formation 10 ( figure 1 ). (bvsalud.org)
These connective tissues are made up of bundles of collagenous fibers arranged in parallel, slightly wavy or curved arrays. (asianarthroscopy.com)

Newer techniques using tissue engineering to regenerate musculoskeletal tissue by using biomimetic materials are now being studied. (openorthopaedicsjournal.com)
Biomimetic porous scaffolds for bone tissue engineering. (uran.ua)

PEG-penetrated chitosan-alginate co-polysaccharide-based partially and fully cross-linked hydrogels as ECM mimic for tissue engineering applications. (docksci.com)

For bone tissue engineering, a special subset of osteoinductive, osteoconductive, integrative and mechanically compatible materials are required. (nanowerk.com)
Usaid also fabricated osteoinductive porous scaffolds composed of well-known biopolymers (gelatin and chitosan) and hydroxyapatite (HA) by a simple freeze-drying method for bone tissue engineering applications. (itsligo.ie)

This PhD work was aimed to design, develop, and characterize gelatin-based scaffolds, for the repair of defects in the muscle-skeletal system. (unibo.it)
In this work, gelatin based scaffolds were prepared following three different strategies: films were prepared through the solvent casting method, electrospinning technique was applied for the preparation of porous mats, and 3D porous scaffolds were prepared through freeze-drying. (unibo.it)
Finally, 3D porous gelatin scaffolds, enriched with calcium phosphate, were prepared with the freeze-drying method. (unibo.it)

The purpose of this investigation was to acquire and characterize a biodegradable, implantable supply method containing ciprofloxacin hydrochloride (HCl) for your localized remedy of osteomyelitis and to study the extent of drug penetration from your web site of implantation to the bone. (ezblogz.com)

The ECM integrates molecular signals that synchronize the specific function of the tissues on responding to the physiological demands. (docksci.com)

It is also desirable for a scaffold to have high interconnectivities between pores for uniform cell seeding and distribution, and for the nutrients and metabolites exchange at the cell/scaffold construct [ 4 - 6 ]. (hindawi.com)

BB/D524983/1 - Imaging of 3D Engineered Tissues and BB/E012981/1 - Two Photon Imaging: From Polymeric Materials to Engineered Tissues. (sheffield.ac.uk)

Finally, as a mechanical support, a scaffold must possess adequate mechanical stability to withstand both the implantation procedure and the mechanical forces that are typically experienced at the scaffold-tissue interface and does not collapse during patient's normal activities [ 3 ]. (hindawi.com)
The loss of bone tissue resulting from lesions or other damages impacts the patient's life. (bvsalud.org)
They provide a scaffold for new bone growth and are gradually replaced by the patient's own bone tissue. (credenceturbine.com)

In conclusion, the results show that among sterilization techniques used in the preset study, the best results were observed with H2O2 sterilization, since it did not significantly modify the surface structure of the PLA fibers and their in vivo response did not cause an unfavorable tissue reaction. (bvsalud.org)

A rudimentary understanding of the inner workings of human tissues may date back further than most would expect. (wikipedia.org)
The goal is to manipulate and direct cell function in a variety of human tissues, including normal cells, cancer cells, and stem cells. (rpi.edu)

The term regenerative medicine is often used synonymously with tissue engineering, although those involved in regenerative medicine place more emphasis on the use of stem cells or progenitor cells to produce tissues. (wikipedia.org)
The growing importance of regenerative medicine and tissue engineering (TE) reflects the fact that bone metabolic and related diseases represent approximately 50% of all chronic diseases for people above the age of fifty. (encyclopedia.pub)
Today's regenerative medicine and tissue engineering are using a large portfolio of BMs, which are used largely as substitutes for damaged or missing hard tissue. (encyclopedia.pub)

The membranes should be hard enough to maintain the space and support the tissues of the surgical area. (bvsalud.org)
Traditional surgical intervention rarely restores the damaged tissue to its original biological state. (openorthopaedicsjournal.com)
This can cause an increase in bone loss, trauma to the surrounding tissue, and longer surgical time. (afpm.org.my)

Živčák, J. Biodegradable Materials for Tissue Engineering. (encyclopedia.pub)
Biodegradable Materials for Tissue Engineering" Encyclopedia , https://encyclopedia.pub/entry/45375 (accessed December 03, 2023). (encyclopedia.pub)
Gioffré, Michela (2013) Biodegradable systems for the development of functional materials , [Dissertation thesis], Alma Mater Studiorum Università di Bologna. (unibo.it)
These materials eventually degrade, leaving behind new bone tissue. (credenceturbine.com)

Nanofiber Scaffolds Sterilized by Different Techniques. (bvsalud.org)

This method aims to regenerate rather than repair skeletal tissue defects. (openorthopaedicsjournal.com)

The surface property of a biomaterial is known to affect its cell compatibility considerably, which is of particular importance for a medical implant, because the surface contacts directly with the host tissue. (upt.ro)

Amidst this, tissue engineering using stem cells has emerged as a hot topic of research and is a promising alternative to the traditional techniques of bone grafting. (openorthopaedicsjournal.com)

Whilst there have already been numerous experiments investigating the results of scaffold architecture on bone development, numerous of such scaffolds were fabricated applying regular procedures including salt leaching and phase separation, and ended up built with out designed architecture. (ezblogz.com)

Furthermore, they can be used in re-attachment of tendons, ligaments, meniscal cracks, and other tissue structures [ 8 ] . (encyclopedia.pub)

Anatomy1

Diseases1

Chemicals and Drugs11

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes3

Technology, Industry, Agriculture9

Polymers16

Regeneration22

Biocompatible5

Highly porous4

Polymer8

Bioactive3

Synthetic3

Biomaterials3

Porosity4

Fabrication5

Poly2

PLGA4

Vitro7

PLLA2

Biomaterial scaffold1

Organs5

Biodegradability1

Polylactic acid1

Degradation6

Suitable2

Nanofibrous scaffolds1

Hydrogel4

Thermally induced phase separation1

Extracellular2

Electrospun1

Implants11

Blood vessels5

Tubular1

Connective2

Biomimetic2

Mimic1

Osteoinductive2

Gelatin3

Characterize1

Physiological1

Construct1

Polymeric Materials1

Patient's3

Vivo1

Human tissues2

Regenerative3

Surgical3

Materials4

Nanofiber1

Defects1

Implant1

Stem cells1

Development1

Structures1