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  • receptor
  • We developed a novel model to describe the non-uniform dielectric function of the GluA2 receptor, evaluating the binding energy of the GluA2-glutamate system accordingly and comparing the results with those obtained using a fixed dielectric function. (rsc.org)
  • Panel of Six New Anti-Glutamate Receptor Antibodies From AbboMax and Their Function in the Central Nervous System and Other Organs. (biochemist.org)
  • novel
  • Inhibitors of glutamate racemase could act as novel antibiotics against a target to which there are no current antibiotics, and thus no known resistance. (illinois.edu)
  • conformational
  • Previous studies have suggested that the conformational heterogeneity of the critical glutamate residue, Glu ex , could explain the transport cycle of CLC-type Cl − /H + antiporters. (pnas.org)
  • In this study, we report four new crystal structures of human GGT1 (hGGT1) that show conformational changes within the active site as the enzyme progresses from the free enzyme to inhibitor-bound tetrahedral transition states and finally to the glutamate-bound structure prior to the release of this final product of the reaction. (osti.gov)
  • catalytic
  • These structures are the first structures for any eukaryotic GGT that include a molecule in the active site covalently bound to the catalytic Thr-381. (osti.gov)
  • Expression
  • The increases in mRNA expression of gdh1a and Gdh amination activity would probably lead to an increase in glutamate production in support of increased glutamine synthesis for the purpose of ammonia detoxification or cell volume regulation under these two different environmental conditions. (frontiersin.org)
  • sequence
  • We obtained a cDNA sequence of glutamate dehydrogenase ( gdh ), which consisted of a 133-bp 5′ UTR, a complete coding sequence region spanning 1629 bp and a 3′ UTR of approximately 717 bp, from the liver, intestine, and brain of M. albus . (frontiersin.org)
  • sites
  • Molecularly imprinted polymers are artificial networks designed to have many selective binding sites that are suitable for various applications. (dartmouth.edu)
  • results
  • The results of the second two projects then feed back into our in silico methods in order to improve our capacity to predict small molecule binders of glutamate racemase. (illinois.edu)
  • critical
  • Structural studies have shown that the critical glutamate residue, Glu ex , in the CLC antiporter can take 3 conformations, each of which occupies a different position along the anion transport pathway. (pnas.org)
  • active
  • Spies, M. A. In silico optimization of a fragment-based hit yields biologically active, high-efficiency inhibitors for glutamate racemase. (illinois.edu)
  • known
  • Here, we provide evidence for a structural intermediate and an extra anion binding site above the known external binding site. (pnas.org)
  • high
  • We also found that an extra anion can be located above the external Cl − -binding site in the E148D mutant when the anion concentration is high. (pnas.org)
  • work
  • Biochemistry senior, Angelica Lackey attended the 2017 American Epilepsy Society in Washington, DC this week where she presented her work with Dr. Kossoff on Ketogenic Diet Second Opinion Clinics. (stevenson.edu)
  • free
  • We also demonstrate that a free carboxylate can occupy the central Cl − -binding site with a short carboxylate, bromoacetate. (pnas.org)
  • central
  • Moreover, we observed that a carboxylate in solution can occupy either the external or central Cl − -binding site in the ungated E148A mutant using an anomalously detectable short carboxylic acid, bromoacetate. (pnas.org)