ras GTPase-Activating Proteinsras Proteinsp120 GTPase Activating ProteinMyeloproliferative DisordersMyelodysplastic-Myeloproliferative DiseasesGTPase-Activating ProteinsMyelodysplastic SyndromesLeukemia, MyeloidProto-Oncogene Proteins p21(ras)GTP PhosphohydrolasesMutationNeurofibromin 1Point MutationMutation, MissenseLeukemia, Myeloid, AcuteLeukemia, Myelomonocytic, ChronicHematologic NeoplasmsGenes, rasMolecular Sequence DataProteinsAmino Acid SequenceSignal TransductionBlood Platelet DisordersChromosomes, Human, Pair 20Metabolic Networks and PathwaysBase SequenceCore Binding Factor Alpha 2 SubunitFrameshift MutationDNA-Binding ProteinsChromosomes, Human, Pair 5Leukemia, Myelomonocytic, JuvenileDNA Mutational AnalysisModels, BiologicalBiochemical ProcessesProto-Oncogene ProteinsPrimary MyelofibrosisGerm-Line MutationBiochemistryKaryotypingOncogene Protein p21(ras)Chromosomes, Human, Pair 21Proto-Oncogene Proteins c-cblTranscription FactorsChromosome DeletionCell LineMyeloid CellsBiosynthetic PathwaysLeukemiaPhenotypeProtein BindingPedigreeProtein Structure, TertiaryCell Transformation, NeoplasticEscherichia coliChromosomes, Human, Pair 11Chromosomes, Human, Pair 7NeoplasmsTransplantation, HomologousHematopoietic Stem CellsBiochemical PhenomenaSequence Homology, Amino AcidMetabolomicsSequence Analysis, DNAGuanosine TriphosphateKineticsIn Situ Hybridization, FluorescenceLeukemia, Myelogenous, Chronic, BCR-ABL PositivePrognosisModels, MolecularHistocompatibility TestingTransplantation ConditioningAmino Acid SubstitutionMice, Inbred C57BLGene Expression ProfilingAcute DiseaseMembrane ProteinsPolymerase Chain ReactionBinding SitesRecombinant ProteinsMutation RateGraft vs Host DiseaseHematopoietic Stem Cell TransplantationTranslocation, GeneticExonsMetabolomeEnzymesEnzyme ActivationCloning, MolecularRNA, MessengerPhosphorylationMutagenesis, Site-DirectedSaccharomyces cerevisiaeHeterozygoteOncogene Proteins, FusionComputational BiologySequence AlignmentTransfectionCells, Culturedrho GTP-Binding ProteinsChromosome Aberrations