• Serum lipids profiles, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), apolipoprotein A-Ⅰ (apoA-Ⅰ), apolipoprotein B (apoB) and clinicopathologic data were analyzed. (researchsquare.com)
  • Variations of plasma lipids and lipoproteins have been observed in ovarian cancer patients. (researchsquare.com)
  • Hyperlipidemia comprises a heterogeneous group of disorders, characterized by high levels in one or more lipids and/or lipoproteins [atherogenic free fatty acids (FA), triglycerides (TG) (hypertriglyceridemia), small dense low-density lipoprotein cholesterol (LDL-C) (hypercholesterolemia), and apolipoprotein (apo) B], and/or low level in antiatherogenic high density lipoprotein cholesterol (HDL-C), in the circulation [ 1 - 3 ]. (hindawi.com)
  • He also coauthored several publications and patents on analytical aspects of measuring lipids and apolipoproteins, preparing reference and control sera, vial-to-vial variability of analyte concentrations, interactions of lipophilic anions and lipoproteins, clinical application of protease plasmasorption by using immobilized protease inhibitor, and using lipids in population studies of risk factors of atherosclerosis. (aacc.org)
  • I continued my post-doctoral research in Professor Griffiths lab (2009-2014) that involved isolation and characterisation of modified lipids in low density lipoproteins (LDL) in plasma from cardiovascular patients and Dementia patients. (j-alz.com)
  • 10). From the rural sample of the survey (n = 2,510), 495 people were selected for biochemical analysis (fasting plasma glucose and serum lipids) through systematic random sampling. (cdc.gov)
  • Does oxidized low-density lipoprotein occur in vivo? (portlandpress.com)
  • After secretion, LPL is carried across endothelial cells and presented into the capillary lumen by the protein glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1. (wikipedia.org)
  • Persons with low high-density lipoprotein (HDL) cholesterol levels, except those patients with a deficiency syndrome, have no symptoms specific to the condition. (medscape.com)
  • Persons with the common low high-density lipoprotein (HDL) syndromes have no specific physical findings. (medscape.com)
  • Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor? (medscape.com)
  • This finding of a low high-density lipoprotein (HDL) cholesterol level can be useful as an independent factor in assessing coronary artery disease (CAD) risk and further management. (medscape.com)
  • Reducing low-density lipoprotein (LDL) levels is the primary goal. (medscape.com)
  • 20%), the LDL goal is under 100 mg/dL, and the goal for non-HDL cholesterol (LDL plus very-low-density lipoprotein [VLDL]) is below 130 mg/dL. (medscape.com)
  • LDL: low-density lipoprotein. (figshare.com)
  • Miyagi, Y., Miwa, K. and Inoue, H. (1997) Inhibition of Human Low Density Lipoprotein Oxidation by Flavonoids in Red Wine and Grape Juice. (scirp.org)
  • 15] found that oxidized low-density lipoprotein (ox-LDL) in serum was higher in ovarian cancer patients than in control subjects, but total cholesterol (TC) and high-density lipoprotein (HDL) showed no such association. (researchsquare.com)
  • Increased waist circumference and blood pressures, elevated triglycerides and low High-Density Lipoprotein were the most frequent features of MS. The DAS28 was significantly lower in the reevaluation (p = 0.006). (scirp.org)
  • Patients with RA, especially those with an active disease, have shown a tendency to present abnormal lipid profile with low levels of high-density lipoprotein cholesterol (HDL) and high levels of triglycerides, as well as less insulin sensitivity. (scirp.org)
  • In the men taking regular exercise serum cholesterol concentrations increased 26% more in the high density lipoprotein subfraction two (HDL2) and decreased 31% more in the subfraction three (HDL3) and 9% more in the low density lipoprotein fraction than in the control group. (nih.gov)
  • Gonzalez, M.S., Rimoldi, O. and Brenner, R. (1995) Studies on Very-High-Density Lipoprotein of Triatoma infestans Hemolymph in Relation to Its Function as Free Fatty Acid Carrier. (scirp.org)
  • Transport of Phospholipids, Free Acids and Triacylglycerols as the Major Lipid Classes by a High-Density Lipoprotein Fraction Isolated from Plasma of Polybetes pythagoricus. (scirp.org)
  • In addition, some research has supported the association of very low-, low- and high-density lipoprotein (VLDL HDL) particle diameters with components of the metabolic syndrome (MetS), although this has been the focus of less research. (biomedcentral.com)
  • Under his supervision, the department standardized and developed quality-control steps for measuring total and high-density lipoprotein cholesterol, triglycerides, apolipoproteins, and electrolytes. (aacc.org)
  • Possible mechanisms for steatosis include reduced synthesis of very low density lipoprotein (VLDL) and increased hepatic triglyceride synthesis (possibly due to decreased oxidation of fatty acids or increased free fatty acids being delivered to the liver). (msdmanuals.com)
  • Our study also identified the clinical risk factors for hypertension, such as, total cholesterol, triglycerol, low density lipoprotein-cholesterol, and high density lipoprotein-cholesterol Inels, which were significantly higher in patients compared to controls (P (bvsalud.org)
  • These fatty acids are transported to the liver, where they are used for triglyceride synthesis and are exported as very-low-density lipoprotein (VLDL), which is elevated in these patients. (medscape.com)
  • While it is well established that the fatty acid composition of dietary fat is important in determining plasma lipoprotein cholesterol concentrations, the effects of changing the absolute quantities of the individual fatty acids are less clear. (cambridge.org)
  • Serum lipoprotein concentrations have been compared in samples taken at different times after the incident. (bmj.com)
  • We further aimed to examine the distribution of the MetS, and its individual components across these groupings, and assess whether any association between group and IR help when controlling for overall lipoprotein concentrations. (biomedcentral.com)
  • This latter step was conducted to ascertain whether any association between MetS features and lipoprotein diameter occurs independently of lipoprotein concentrations, which has been the focus of much previous research. (biomedcentral.com)
  • It is a water-soluble enzyme that hydrolyzes triglycerides in lipoproteins, such as those found in chylomicrons and very low-density lipoproteins (VLDL), into two free fatty acids and one monoacylglycerol molecule: triacylglycerol + H2O = diacylglycerol + a carboxylate It is also involved in promoting the cellular uptake of chylomicron remnants, cholesterol-rich lipoproteins, and free fatty acids. (wikipedia.org)
  • We aimed to explore the relationship of VLDL, LDL and HDL diameters to MetS and its features, and by clustering individuals by their diameters of VLDL, LDL and HDL particles, to capture information across all three fractions of lipoprotein into a unified phenotype. (biomedcentral.com)
  • Our first aim was to report how the diameters correlate across VLDL, LDL and HDL particles and confirm the association between the diameter of each fraction of lipoprotein and features of the MetS. (biomedcentral.com)
  • TS-containing diets did not increase the cholesterol content of any of the major lipoprotein fractions. (cambridge.org)
  • Correlation analysis of individual variation of controls and index case relatives indicates a substantial level of independence between the major lipoprotein fractions. (bmj.com)
  • Cunningham, M., Gonzalez, A. and Pollero, R.J. (2000) Characterization of Lipoproteins Isolated from the Hemolymph of the Spider Latrodectus mirabilis. (scirp.org)
  • Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. (wikipedia.org)
  • These effects on lipoprotein metabolism may be exerted through specific modulation of the expression of the LDL receptor and apolipoprotein B genes. (cambridge.org)
  • In order to fulfill the increased biochemical demands that accompany increased proliferation, lipid metabolism is often dysregulated in cancer [12]. (researchsquare.com)
  • [ 1 ] which is an autosomal recessive abnormality of lipoprotein metabolism resulting in ataxia combined with acanthocytosis. (medscape.com)
  • Despite these associations, how the diameters covary across the three fractions is poorly understood, and, as yet, information on all three fractions of lipoprotein diameter has not been captured into a single phenotype and examined for its relationship to disease. (biomedcentral.com)
  • Our second aim was to capture the relationship between all three fractions into a single trait, by clustering individuals into groups according to their similarities across all three fractions of lipoprotein simultaneously. (biomedcentral.com)
  • The evidence for genetic variation in serum lipoprotein is based on the polygenic model and the analysis of the correlation between parents and offspring and the correlation between sibs. (bmj.com)
  • Our data suggest that mild regular physical exercise favourably influences cholesterol distribution in serum lipoproteins in healthy middle aged men and may have beneficial effects on circulating metabolites of arachidonic acid. (nih.gov)
  • Lee, R.F. and Puppione, D.L. (1978) Serum Lipoproteins in the Spiny Lobster, Panulirus interruptus. (scirp.org)
  • Clinical, biochemical, and anthropometric evaluations were conducted. (scirp.org)
  • We are an industry leading manufacturer of high quality biochemical products used in a wide range of applications, from biopharmaceuticals to cell culture media, clinical diagnostic manufacturing and life science research around the world. (leebio.com)
  • Clinical and biochemical variables were measured to assess the associated riskfactors. (bvsalud.org)
  • More recently we have begun a programme to test the effect of antioxidant compounds on biochemical markers of heart disease in both animal and human trials. (otago.ac.nz)
  • Our objective was to evaluate the effect of chronic gestational treatment and post-breast feeding with purple grape juice on the biochemical parameters in offspring of dams. (scirp.org)
  • When considering the post-breast feeding factor, grape juice resulted in an improvement in HDL-C. We concluded that purple grape juice was able to produce a beneficial effect on certain biochemical parameters in offspring. (scirp.org)
  • PTE treatment maintained calcium and phosphorus homeostasis and improved other blood biochemical parameters to various degrees. (researchgate.net)
  • A study was conducted to evaluate the organ weights and biochemical indices of broiler chickens fed diets containing varying levels of Saccharomyces cerevisiae. (ajol.info)
  • Sociodemographic and lifestyle characteristics, comorbidity, anthropometry and biochemical indices were measured. (who.int)
  • Ozone disrupts the integrity of the bacterial cell envelope through oxidation of the phospholipids and lipoproteins. (silvermedicine.org)
  • Using biochemical assays, colorimetry and mass spectrometry techniques, I have shown that LDL isolated from patients with hypercholesterolemia has higher level of lipid and protein oxidation and these lipid affect neuronal cell viability and processing of amyloid beta protein in a neuronal cell line via a redox driven mechanism. (j-alz.com)
  • LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. (wikipedia.org)
  • Plasminogen receptors promote lipoprotein(a) uptake by enhancing surface binding and facilitating macropinocytosis. (otago.ac.nz)
  • Upon binding to ApoC-II and lipid in the lipoprotein, the C-terminal domain presents the lipid substrate to the lid region. (wikipedia.org)
  • Lipid-poor HDL precursors mature by obtaining cholesterol and phospholipids from cell membranes or triglyceride-rich lipoproteins. (jci.org)
  • Lipoproteins, as the name suggests, are a class of biochemical compounds formed by a protein component and a lipid component. (medindia.net)
  • Chris is currently pursuing a PhD in Nutritional Sciences with a concentration in Biochemical and Molecular Nutrition at the University of Connecticut. (thehealthyskeptic.org)
  • It is characterized by orofacial dyskinesia, hyporeflexia, seizures, aberrant behavior, atrophy of the caudate nucleus and putamen and acanthocytes in the blood with a normal concentration of lipoproteins. (neurologyindia.com)
  • Lung and Blood Institute in 2009 de- interviews, anthropometric and blood days to provide fasting blood samples fined it as 3 or more of the following: pressure measurements, and assess- for biochemical analysis. (who.int)
  • Anthropometric measurements (height and weight) and biochemical estimation (hemoglobin level in blood) were done to evaluate nutritional status. (who.int)
  • Dioguardi N, Vergani C. [Familial alpha lipoprotein deficiency. (medscape.com)
  • Here we recruited 60 longevity families and investigated the blood biochemical indexes of family members to seek candidate factors associated with familial longevity. (nature.com)
  • Using latent class analysis, the sample was grouped by the diameter of their fasting lipoproteins, and mixed effects models tested whether the distribution of MetS components varied across the groups. (biomedcentral.com)
  • Glycogen-storage disease type I (subtypes Ia and Ib) is one of the few genetic-biochemical causes of hypoglycemia in newborns. (medscape.com)
  • Sociodemographic variables and maternal biochemical profile without statistical differences in the comparison of the mothers of the initial sample with those who completed the follow-up. (bvsalud.org)
  • Biochemical characteristics of the study population. (figshare.com)
  • Body weight, blood biochemical indicators, relative organ coefficients, femoral bone mineral density (BMD), bone biomechanical properties, and bone microarchitecture were examined and analyzed. (researchgate.net)
  • Routine biochemical tests and blood cell count were within normal limits. (neurologyindia.com)
  • We are also investigating the variation in lipoprotein-associated genes in families with various dyslipidaemias. (otago.ac.nz)
  • It is estimated that up to forty LPL dimers may act simultaneously on a single lipoprotein. (wikipedia.org)
  • We are currently studying the regulation of lipoprotein levels and composition to identify therapeutic targets for their manipulation with a particular interest in the Lp(a) and HDL lipoproteins which have opposing risk associations with heart disease. (otago.ac.nz)
  • At the end of the feeding trial (day 56), two birds were randomly picked from each replication for carcass evaluation and another two birds were randomly selected from each pen and 5mlblood was collected f from the wing vein using sterile disposable syringe for biochemical analysis. (ajol.info)
  • Dr. Malakhov's investigations also included developing data management methods for findings of multicenter population-based biochemical studies, which could take into account the real values of analytical errors. (aacc.org)
  • Similarities and differences are found when it is compared to lipoproteins of only the three species of spiders studied. (scirp.org)
  • To study the effects of physical exercise on biochemical risk factors for ischaemic heart disease 31 healthy middle aged men undertook regular physical exercise for two months and 29 served as controls in a randomised trial. (nih.gov)
  • Dr. Malakhov's research took a turn in 1979 when he became head of the newly founded Department of Standardization of Biochemical Methods of the Institute for Preventive Cardiology (today known as the National Research Center for Preventive Medicine of the Ministry of Health). (aacc.org)
  • When it was originally described, it was also frequently compared with Bassen-Kornzweig disease in that both combined neurologic abnormalities with acanthocytosis, but the Levine-Critchley syndrome had normal lipoproteins as well as a later age of onset. (medscape.com)
  • Soulages, J.L. and Wells, M.A. (1994) Effect of Diacylglycerol Content on Some Physicochemical Properties of the Insect Lipoprotein, Lipophorin. (scirp.org)
  • In this longitudinal study we used an existing database of 233 individuals who had complete nutritional and biochemical data at baseline and after 12-month follow-up. (frontiersin.org)