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  • enzyme
  • Although each disorder results from different gene mutations that translate into a deficiency in enzyme activity, they all share a common biochemical characteristic - all lysosomal disorders originate from an abnormal accumulation of substances inside the lysosome. (wikipedia.org)
  • Biochemistry
  • Long before a deeper understanding of their numerous biological functions, the plant lectins, also known as phytohemagglutinins, were noted for their particular high specificity for foreign glycoconjugates (e.g. those of fungi, invertebrates, and animals) and used in biomedicine for blood cell testing and in biochemistry for fractionation. (wikipedia.org)
  • reactions
  • Yet another nontrivial prediction of the IsoRes hypothesis is that at ≈250-350 ppm deuterium content, the terrestrial resonance becomes "perfect", and the rates of biochemical reactions and growth of terrestrial organisms further increase. (wikipedia.org)
  • techniques
  • His greatest achievements were in developing histochemical techniques for studying the structure and functions of cells and their organelles. (wikipedia.org)
  • This is due to the optimization of enrichment protocols for phosphoproteins and phosphopeptides, better fractionation techniques using chromatography, and improvement of methods to selectively visualize phosphorylated residues using mass spectrometry. (wikipedia.org)
  • He later pioneered the application of cell biological techniques to the nervous system. (wikipedia.org)
  • 1993
  • Zanvil Alexander Cohn (November 16, 1926 - June 28, 1993) was a cell biologist and immunologist who upon his death was described by the New York Times as being "in the forefront of current studies of the body's defenses against infection. (wikipedia.org)
  • interferon
  • Prior to the discovery of cGAS, it was known that interferon beta was produced in the presence of cytosolic dsDNA and that STING-deficient cells were unable to produce interferon in the presence of dsDNA. (wikipedia.org)
  • spectroscopy
  • We have combined somatic gene targeting with fluorescence correlation spectroscopy (FCS) [a method successfully applied to the analysis of fluorescent particles in solution ( 5 ) or within cells ( 6 )] to directly measure the diffusion of EGFP-tagged Brca2 expressed natively in the nucleoplasm of living cells. (pnas.org)
  • tissues
  • In most cells from the vegetative tissues of the plant body, the central vacuole occupies much of the volume and is essential for much of the physiology of the organism. (plantcell.org)
  • In some cell types, defense or signal compounds are stored in the vacuole, particularly within specialized cells located in strategically favorable tissues such as the leaf epidermis. (plantcell.org)
  • Tissues - A collection of interconnected cells that perform a similar function within an organism. (wikipedia.org)
  • Dendritic Cells
  • Concurrent Delivery of Tumor Antigens and Activation Signals to Dendritic Cells by Irradiated CD40 Ligand-transfected Tumor Cells Resulted in Efficient Activation of Specific CD8+ T Cells Cancer Gene Therapy. (jove.com)
  • Although Cohn never won the Nobel Prize, Ralph M. Steinman, with whom he ran a laboratory at Rockefeller University for many years, was named in 2011, eighteen years after Cohn's death, to win the Nobel Prize in Physiology and Medicine for the work on dendritic cells done in their lab. (wikipedia.org)
  • epidermal cells
  • As early as last century, it was observed that many pigments (e.g., anthocyanins) are localized in the vacuoles of epidermal cells from flowers, leaves, and stems. (plantcell.org)
  • fetal calf serum
  • The story of receptor-mediated endocytosis begins in 1973 when the two of us discovered that cultured fibroblasts from normal humans supply themselves with cholesterol through the action of a cell surface receptor that binds cholesterol-carrying low density lipoprotein ( LDL ), a constituent of the fetal calf serum in which cells are grown. (wenxuecity.com)
  • He first realised that the addition of bovine fetal calf serum (FCS) to Swiss 3T3 cells increased the polymerisation of actin and assembly of stress fibres. (wikipedia.org)
  • 2016
  • The Latin America Cell Fractionation Market was worth USD 189 million in 2016 and estimated to be growing at a CAGR of 10.2%, to reach USD 307 million by 2021. (emailwire.com)
  • functional
  • Plant cell vacuoles are widely diverse in form, size, content, and functional dynamics, and a single cell may contain more than one kind of vacuole. (plantcell.org)
  • Replacement of Endogenous Brca2 with a Functional GFP-Tagged Form by Gene Targeting in DT40 Cells. (pnas.org)
  • Cell - The structural and functional unit of all known living organisms. (wikipedia.org)
  • organelles
  • The vacuoles of plant cells are multifunctional organelles that are central to cellular strategies of plant development. (plantcell.org)
  • Alex Benjamin Novikoff (28 February 1913 - 9 January 1987) was a Ukrainian-born American biologist who is recognized for his pioneering works in the discoveries of cell organelles. (wikipedia.org)
  • Using this he had separated cell fractions and identified six cell organelles, along with two unidentified fractions. (wikipedia.org)
  • In addition, the number of individual organelles of each type found in a given cell varies depending upon the function of that cell. (wikipedia.org)
  • gene
  • David L. Spector (born (1952-12-06)December 6, 1952, in New York City) is a cell and molecular biologist best recognized for his research on gene expression and nuclear dynamics. (wikipedia.org)
  • Further DNA testing showed that the transforming sequences in the two cancer cell lines were the same, and the gene was later characterised as N-ras, a member of the Ras gene family. (wikipedia.org)
  • organisms
  • Cell theory - The scientific theory which states that all organisms are composed of one or more cells. (wikipedia.org)
  • Unicellular - Organisms which are composed of only one cell. (wikipedia.org)
  • citation needed] While most cell biologists consider the term organelle to be synonymous with "cell compartment", other cell biologists choose to limit the term organelle to include only those that are containing deoxyribonucleic acid (DNA), having originated from formerly autonomous microscopic organisms acquired via endosymbiosis. (wikipedia.org)
  • growth
  • In the vegetative organs of the plant, they act in combination with the cell wall to generate turgor, the driving force for hydraulic stiffness and growth. (plantcell.org)
  • The presence of the cation channel, AtCNGC10, in root cap meristem cells, cell plate, and gravity-sensing columella cells, combined with the previously reported antisense phenotypes of decreased gravitropic and cell enlargement responses, suggest roles of AtCNGC10 in modulating cation balance required for root gravitropism, cell division and growth. (biomedcentral.com)
  • Cells are stimulated with factor of interest (e.g. growth factor, hormone). (wikipedia.org)
  • In one study design, cells are exposed to SILAC labelling and then stimulated by a specific growth factor. (wikipedia.org)
  • functions
  • They offered mechanistic accounts that explained cellular phenomena by identifying the relevant parts of cells, the biochemical operations they performed, and the way in which these parts and operations were organised to accomplish important functions. (cambridge.org)
  • Vital functions of an organism occur within cells. (wikipedia.org)
  • All cells come from preexisting cells and contain the hereditary information necessary for regulating cell functions and for transmitting information to the next generation of cells. (wikipedia.org)
  • plant
  • Plant cell vacuoles were discovered with the early microscope and, as indicated in the etymology of the word, originally defined as a cell space empty of cytoplasmic matter. (plantcell.org)
  • For example, pectinase which digests middle lamella among plant cells. (wikipedia.org)