• Clonidine hydrochloride tablets act relatively rapidly. (nih.gov)
  • Clonidine hydrochloride tablets must be adjusted according to the patient's individual blood pressure response. (wikidoc.org)
  • The pharmacokinetics of clonidine is dose-proportional in the range of 100 to 600 mcg. (nih.gov)
  • Neither food nor the race of the patient influences the pharmacokinetics of clonidine. (nih.gov)
  • While it is also used as a high blood pressure medication, clonidine can treat opioid withdrawal and is often used during the early stages of withdrawal to help a patient through their symptoms. (drugaddiction.org)
  • Clonidine is the "most commonly used medication" to treat opioid withdrawal and "primarily reduces anxiety, agitation, muscle aches, sweating, runny nose, and cramping" ( NLM ). (drugaddiction.org)
  • Following intravenous administration, clonidine displays biphasic disposition with a distribution half-life of about 20 minutes and an elimination half-life ranging from 12 to 16 hours. (nih.gov)
  • The United States Food and Drug Administration (FDA) has approved Clonidine to treat attention deficit hyperactivity disorder, under Kapvay alone or with stimulants in 2010, for pediatric patients between 6 and 17 years. (scopeheal.com)
  • KAPVAY® (clonidine hydrochloride) extended-release is indicated for the treatment of attention deficit hyperactivity disorder (ADHD) as monotherapy and as adjunctive therapy to stimulant medications. (pillintrip.com)
  • Due to the lack of controlled clinical trial data and differing pharmacokinetic profiles, substitution of KAPVAY for other clonidine products on a mg-per-mg basis is not recommended. (pillintrip.com)
  • KAPVAY is contraindicated in patients with a history of a hypersensitivity reaction to clonidine. (pillintrip.com)
  • Clonidine stimulates alpha-adrenoreceptors in the brain stem. (nih.gov)
  • Clonidine acutely stimulates growth hormone release in both children and adults, but does not produce a chronic elevation of growth hormone with long-term use. (nih.gov)
  • Clonidine uniquely stimulates α 2 receptors, yet affects the heart rate which is normally affected by beta receptors. (proprofs.com)
  • Clonidine hydrochloride, USP is a centrally acting alpha-agonist hypotensive agent available as tablets for oral administration in three dosage strengths: 0.1 mg, 0.2 mg and 0.3 mg. (nih.gov)
  • Hypertension treatment with clonidine can be administered orally (tablets) or by transdermal patches. (wikidoc.org)
  • Do not crush, chew, or break tablets because this will increase the rate of clonidine release. (pillintrip.com)
  • Clonidine crosses the placental barrier. (nih.gov)
  • Clonidine hydrochloride is an odorless, bitter, white, crystalline substance soluble in water and alcohol. (nih.gov)
  • Clonidine can be used to relieve the withdrawal and containment symptoms associated with the use of long-term narcotics and alcohol, such as benzodiazepines and nicotine (smoking). (scopeheal.com)
  • If the two drugs are coadministered, the β-blocker should be withdrawn several days before discontinuing clonidine. (com.bd)
  • Higher opium doses were required by 40% of infants in the placebo group versus 20% in the clonidine group. (medscape.com)
  • Slowing of the pulse rate has been observed in most patients given clonidine, but the drug does not alter normal hemodynamic response to exercise. (nih.gov)
  • The risk of hemodynamic instability, especially hypotension and bradycardia, from epidural clonidine may be unacceptable in these patients. (wikidoc.org)
  • If someone starts out being treated with clonidine in morphine rehab, it will likely just be in the beginning, especially if they are dealing with severe withdrawal symptoms. (drugaddiction.org)
  • [ 47 ] Each infant received oral diluted tincture of opium (dosage according to standardized algorithm) and either oral clonidine (1 mcg/kg q4h) or placebo. (medscape.com)
  • Clonidine 0.1-0.2 mg every 4-8 hours also decreases the severity of symptoms. (medscape.com)
  • Clonidine has been shown to be an effective and safe second-line medication for the treatment of NAS symptoms refractory to opioid therapy. (medscape.com)
  • The food and drug administration approved Clonidine in September 1974. (scopeheal.com)
  • The Therapeutic Goods Administration (Clonidine) is an accepted but not approved use for attention deficit hyperactivity disorder in Australia. (scopeheal.com)
  • If replacing clonidine by β-blocker therapy, the introduction of β-blockers should be delayed for several days after clonidine administration has stopped (see also prescribing information for clonidine). (com.bd)
  • Agthe et al studied 80 infants exposed in utero to methadone or heroin and subsequently had NAS to determine if oral clonidine, an alpha2-adrenergic receptor agonist, would reduce the duration of opioid detoxification. (medscape.com)
  • Switching to an alternative formulation of the same drug may involve a change in dose due to differing bioavailability of the active drug. (medscape.com)
  • Clonidine is a central alpha-2 adrenergic agonist that is FDA approved for the treatment of hypertension . (wikidoc.org)
  • The contiguous Clonidine with methylphenidate has been studied for attention deficit hyperactivity disorder medication and treatment. (scopeheal.com)
  • Clonidine has also been suggested as a treatment for rare cases of dexmedetomidine withdrawal. (scopeheal.com)
  • Clonidine is very beneficial, however, and many doctors start with it in the treatment of opioid dependence, sometimes even in the case of abuse. (drugaddiction.org)
  • Seven infants in the clonidine group required restarting opium after initial discontinuation, versus none in the placebo group, although total length of treatment was significantly less in the clonidine group. (medscape.com)
  • Treatment failures occurred in 12.5% of the infants in the placebo group versus none in the clonidine group. (medscape.com)
  • The exact relationship of these pharmacologic actions to the antihypertensive effect of clonidine has not been fully elucidated. (nih.gov)
  • The effect of Quercetin was observed on clonidine-induced hypothermia (noradrenaline mediated behavior), haloperidol-induced catalepsy (dopamine mediated behavior). (biomedjournal.com)
  • Clonidine is able to affect the heart rate by stimulating α2 receptors instead of β receptors because it has the ability to cross the blood-brain barrier. (proprofs.com)
  • By binding to α2 receptors in the CNS, clonidine can modulate the release of norepinephrine, resulting in a decrease in sympathetic outflow and ultimately leading to a decrease in heart rate. (proprofs.com)
  • The NLM states that clonidine "works by decreasing your heart rate and relaxing the blood vessels so that blood can flow more easily through the body. (drugaddiction.org)
  • Peak plasma clonidine levels are attained in approximately 1 to 3 hours. (nih.gov)
  • Patients receiving epidural clonidine from a continuous infusion device should be closely monitored for the first few days to assess their response. (wikidoc.org)
  • Acute studies with clonidine hydrochloride in humans have demonstrated a moderate reduction (15% to 20%) of cardiac output in the supine position with no change in the peripheral resistance: at a 45° tilt there is a smaller reduction in cardiac output and a decrease of peripheral resistance. (nih.gov)
  • Some studies show that Clonidine is more sedating than guanfacine, which can be better when lying down with a stimulant in the morning. (scopeheal.com)
  • Clonidine can be used to treat Tourette syndrome (precisely to control or decrease tics). (scopeheal.com)
  • Clonidine has also been used to treat diarrhea associated with irritable bowel syndrome, fecal incontinence, diabetes, diarrhea associated with withdrawal, intestinal insufficiency, neuroendocrine tumors, and cholera. (scopeheal.com)
  • Clonidine is the most commonly prescribed medication to treat opioid addiction. (drugaddiction.org)
  • Clonidine can help with these issues, but then another medication will need to be used altogether to treat the person's morphine addiction. (drugaddiction.org)
  • Results showed that the median length of therapy was 27% shorter in the clonidine group (11 d) versus placebo (15 d). (medscape.com)
  • The addition of clonidine to standard opioid therapy reduced the duration of pharmacotherapy for NAS. (medscape.com)
  • Clonidine hydrochloride injection (epidural clonidine) is not recommended for obstetrical, postpartum, or perioperative pain management. (wikidoc.org)