• 3. Research on bioactive molecules: For the study of certain bioactive molecules, such as proteins, enzymes, etc., the chelation effect of EDTA may affect their activity or stability. (hbdsbio.com)
  • Our ready-to-use ChemScene compound libraries consist of over 4000 small molecules with validated biological and pharmacological activities. (chemscene.com)
  • Display our full list of chromogenic substrates . (megazyme.com)
  • New chromogenic substrates for the assay of alpha-amylase and (1→4)-β-D-glucanase. (megazyme.com)
  • Previous studies showed that different plant-derived flavonoid compounds could stimulate osteoblasts function, and inhibit osteoclasts functions either alone or in combination. (biomedcentral.com)
  • The use of plant-derived bioactive compounds has gained significant popularity due to their potential benefits such as weight loss, stress relief, and revitalization. (laboratoire-cellmade.fr)
  • Moreover, a selective analytical method based on high performance liquid chromatography with fluorescence detection (HPLC-FLD) for the simultaneous identification and quantification of thirteen compounds including bisphenol analogues (BPA, BPB, BPC, BPE, BPF, BPG) and BADGEs (BADGE, BADGE. (academic-accelerator.com)
  • The present invention relates generally to the synthesis of fluorescent compounds that are analogues of cyanine dyes. (justia.com)
  • H-D-Phe-Pip- Arg -pNA dihydrochloride, a chromogenic substrate, mimics the N-terminal fragment of the A alpha chain of fib. (targetmol.com)
  • Screening of a collection of 450 compounds as inhibitors revealed a structure-activity relationship that mimics in part that of mammalian DPP9. (inra.fr)
  • Indole is an aromatic, heterocyclic, organic compound with the formula C8H7N. (wikipedia.org)
  • OBJECTIVES To apply a combined metabolomic fingerprinting approach by nuclear magnetic resonance (NMR) and gas chromatography-mass spectrometry (GC-MS) to common dandelion, corn poppy and stinging nettles to obtain simultaneous identification and quantitation of the major classes of organic compounds. (academic-accelerator.com)
  • Current material science, pharmaceutical, and organic chemistry compound synthesis reaction pathway determination has been implemented with various computational chemistry methods. (asdrp.org)
  • Bioassay guided fractionation on each extract establishes for exploring S. jamaicensis leaves active compounds. (bvsalud.org)
  • The extract of fresh and HPD dried drumstick powder contained 50 major bioactive compounds such as 2,6-Dihydroxybenzoic acid 3TMS derivative, Butanal 2-ethyl-3-methyl-, etc, these bioactive compounds act as various nutraceuticals and therapeutic values. (arccjournals.com)
  • The company also notes that the extract is highly bioactive with a 20 to1 concentration ratio, meaning 20 kg of Chaga produces 1 kg of extract. (nutritioninsight.com)
  • To ensure their optimal effectiveness, it is necessary to extract and concentrate bioactive compounds using advanced technological processes that allow them to reach the desired plasma concentrations. (laboratoire-cellmade.fr)
  • She is currently focusing on small molecule synthesis but is also venturing into natural products and metal-based bioactive compounds. (monash.edu)
  • MCE owns a unique collection of 17212 compounds with confirmed biological activities and clear targets. (chemscene.com)
  • These compounds generally penetrate cell membranes, act on specific target proteins in cells, regulate intracellular signaling pathways, and cause some changes in cell phenotype. (chemscene.com)
  • Evaluation of a chromogenic medium for total coliforms andEscherichia coli determination in ready-to-eat foods. (potravinarstvo.com)
  • HPD dried drumstick powder at 55°C was found maximum drying characteristics and higher retention of bioactive compounds with special reference to high powder recovery (97.22%), excellent flowability and better functional characteristics. (arccjournals.com)
  • Ligand fishing is a suitable approach for the highly selective screening of bioactive substances in complex mixtures. (bvsalud.org)
  • Bioactive compounds are a general term for a class of substances that can cause certain biological effects in the body, which are the main source of small molecule drugs. (chemscene.com)
  • 2. Specific anticoagulants: For drug analysis or bioactive molecule research, specific anticoagulants in the experiment can be selected to ensure the stability and accuracy of the sample. (hbdsbio.com)
  • Compound libraries are useful professional tools for drug discovery and new indication research. (chemscene.com)
  • Therefore, these natural compounds may be of interest to be used to supplement oral healthcare products. (biomedcentral.com)
  • Considering the highly concentrated nature of these compounds, it is crucial to assess their efficacy, quality, and potential toxicity in order to safeguard human health. (laboratoire-cellmade.fr)
  • Cyanine dyes that are highly charged, such as those including multiple sulfonate, alkylsulfonate, carboxylate and/or alkylcarboxylate moieties are examples of cyanine dyes of use in the compounds of the invention. (justia.com)
  • Dipivefrin hydrochloride (Dipivefrine hydrochloride) is an antiglaucoma proagent that is hydrolyzed to the active compound, epinephrine, by esterases in the cornea. (medchemexpress.com)
  • Expertly extracted in alignment with the wisdom of traditional Siberian herbalists and then freeze dried to capture and secure the valuable chromogenic complex compounds that chaga's powerful immune boosting & numerous adaptogenic properties are revered for. (primalalchemy.co.uk)
  • designed an HPD dryer, which resulted in the retention of bioactive compounds in dried products. (arccjournals.com)
  • Other indolic compounds include the plant hormone auxin (indolyl-3-acetic acid, IAA), tryptophol, the anti-inflammatory drug indomethacin, and the betablocker pindolol. (wikipedia.org)
  • This integrated approach, supported by a robust dataset, expedites the discovery and development of safe and effective bioactive compounds. (laboratoire-cellmade.fr)
  • it plays a key role in the maintenance of GSH homeostasis, detoxification of xenobiotic compounds, and metabolism of endogenous biomolecules. (hindawi.com)
  • 16. A competitive chromogenic assay to study the functional interaction of urokinase-type plasminogen activator with its receptor. (nih.gov)
  • tomentosum exhibited PAI-1 inhibitory activity, and identified Toddalolactone as the main active component that inhibited the activity of recombinant human PAI-1 with IC50 value of 37.31 ± 3.23 μM, as determined by chromogenic assay, and the effect was further confirmed by clot lysis assay. (chemfaces.com)
  • Among them, phenolic acids and flavonoids are the main compound classes that show pharmacological activities in Toxicodendron plants both in vitro and in vivo. (bvsalud.org)
  • Cannabis leaves contain a diverse range of antioxidants, including cannabinoids, flavonoids, and phenolic compounds, which offer significant health benefits. (mdpi.com)
  • Other indolic compounds include the plant hormone auxin (indolyl-3-acetic acid, IAA), tryptophol, the anti-inflammatory drug indomethacin, and the betablocker pindolol. (wikipedia.org)
  • Background: The anti-inflammatory activity of magnolol and related compounds is currently a focus of interest. (iiarjournals.org)
  • Native Brazilian flora is an important source of bioactive natural products, including antimicrobial and anti-inflammatory substances [ 43 ]. (biomedcentral.com)
  • Mechanistic Studies of the TRIP Catalyzed Allylation with Organozinc Reagents 3,3-Bis(2,4,6-triisopropylphenyl)-1,1-binaphthyl-2,2-diyl hydrogenphosphate (TRIP) catalyzes the uneven allylation of aldehydes with organozinc compounds leading to extraordinarily worthwhile structural motifs, like precursors to lignan pure merchandise. (tissue-cell-culture.com)
  • Substituted indoles are structural elements of (and for some compounds, the synthetic precursors for) the tryptophan-derived tryptamine alkaloids, which includes the neurotransmitter serotonin and the hormone melatonin, as well as the naturally occurring psychedelic drugs dimethyltryptamine and psilocybin. (wikipedia.org)
  • Biomolecules & Therapeutics (Biomolecules & Therapeutics) (Print ISSN 1976-9148, Online ISSN 2005-4483) is an international, peer-reviewed, open access journal that covers pharmacological and toxicological fields related to bioactive molecules and therapeutics. (koreascience.kr)
  • The screening of medicinal plants used locally for the treatment of infectious diseases, can provide a reliable option in the discovery of potent therapeutic compounds. (biomedcentral.com)
  • The prodrugs, except compound 5, exhibited very potent activity similar to that of araC ( $ED_{50}$ about $0.12{\mu}g/mι$ ) when evaluated against another human DNA virus, cytomegarovirus. (koreascience.kr)
  • Among the compounds, emodin addressed to the ethanol-induced cytotoxicity more effectively compared to the chrysophanol. (hindawi.com)
  • PAH compounds are not estrogenic, and indeed, stomach and small intestine digestions of 62.5 nmol naphthalene, phenanthrene, pyrene, and benzo( a )pyrene showed no estrogenic effects in the human estrogen receptor bioassay. (nih.gov)
  • 5. Herbal compound triptolide synergistically enhanced antitumor activity of amino-terminal fragment of urokinase. (nih.gov)
  • In the present study, the inhibitory effects of these compounds on cyclooxygenase (COX-2) expression and nuclear factor-kappa B (NF-κB) activation were investigated in RAW264.7 macrophage-like cells stimulated with the fimbriae of Porphyromonas gingivalis, an oral anaerobe. (iiarjournals.org)
  • A study in Clinical Cancer Research has shown that the new drug NUC-7738, developed by NuCana, has a up to 40 times greater potency for killing cancer cells than its parent compound, with limited toxic side effects. (ox.ac.uk)
  • Expertly extracted in alignment with the wisdom of traditional Siberian herbalists and then freeze dried to capture and secure the valuable chromogenic complex compounds that chaga's powerful immune boosting & numerous adaptogenic properties are revered for. (primalalchemy.co.uk)
  • Ethanol-induced HepG2/CYP2E1 cells were treated with the compounds at various concentrations, and the results showed that there was a dose-dependent decrease of gamma-glutamyl transpeptidase (GGT) activity and increase of glutathione (GSH) in the culture media with an increase in cell viability. (hindawi.com)
  • Screening of a collection of 450 compounds as inhibitors revealed a structure-activity relationship that mimics in part that of mammalian DPP9. (inra.fr)
  • The regulatory effect of these compounds on the expression of COX-2 mRNA, stimulated by exposure to the fimbriae was investigated by real-time polymerase chain reaction (PCR). (iiarjournals.org)
  • The Bestmann-Ohira Reagent and Related Diazo Compounds for the Synthesis of Azaheterocycles Azaheterocycles are one of the crucial prevalent programs of compounds present in fairly a number of bioactive compounds, pure merchandise, and agrochemicals, and undoubtedly, new methods to entry them are on a regular basis in extreme demand. (tissue-cell-culture.com)
  • Cordyceps sinensis has had potential applications in cancer treatment for hundreds of years, but the limitations of its bioactive compound Cordycepin has prevented its development into approved chemotherapy drugs. (ox.ac.uk)
  • Hence, if microbial PAH bio-transformation in the human colon is possible, the susceptibility of the colon epithelium to bioactive PAH metabolites may increase the health risks that are associated with non-absorbed PAHs that reach the colon. (nih.gov)