S-Phase Kinase-Associated ProteinsSKP Cullin F-Box Protein LigasesProtein BindingF-Box ProteinsMolecular Sequence DataCyclin-Dependent Kinase Inhibitor p27Cullin ProteinsBinding SitesAmino Acid SequenceCell Cycle ProteinsBase SequenceProtein Structure, TertiaryUbiquitin-Protein LigasesDNA-Binding ProteinsCell LineUbiquitin-Protein Ligase ComplexesUbiquitinModels, MolecularCarrier ProteinsMutationTranscription FactorsRecombinant Fusion ProteinsLigasesAnaphase-Promoting Complex-CyclosomeSequence Homology, Amino AcidRecombinant ProteinsUbiquitinsPromoter Regions, Geneticbeta-Transducin Repeat-Containing ProteinsKineticsHeLa CellsBinding, CompetitiveNuclear ProteinsTransfectionCell CycleUbiquitinationPeptide SynthasesProtein ConformationTwo-Hybrid System TechniquesDNAAmino Acid MotifsPhosphorylationCyclin ACDC2-CDC28 KinasesTumor Suppressor ProteinsEscherichia coliCell Line, TumorSignal TransductionSaccharomyces cerevisiae ProteinsRepressor ProteinsMutagenesis, Site-DirectedSequence AlignmentProteasome Endopeptidase ComplexCloning, MolecularCyclin-Dependent KinasesLigandsMultiprotein ComplexesCytoplasmCells, CulturedCell NucleusBacterial ProteinsCrystallography, X-RayRNA, MessengerSaccharomyces cerevisiaeDimerizationGene Expression RegulationMacromolecular SubstancesRNA-Binding ProteinsElectrophoresis, Polyacrylamide GelMembrane ProteinsMolecular ChaperonesCyclin-Dependent Kinase 2PlasmidsSubstrate SpecificityCOS CellsBlotting, WesternImmunoprecipitationModels, BiologicalPeriplasmPeptidesPeptide FragmentsProtein Processing, Post-TranslationalG1 PhaseDNA PrimersEscherichia coli ProteinsS PhaseProteinsTrans-ActivatorsRNA InterferenceCyclin EFungal ProteinsProtein Structure, SecondaryCell ProliferationCell MembraneIntracellular Signaling Peptides and ProteinsConserved SequenceSurface Plasmon ResonanceTumor Cells, CulturedImmunoblottingDown-Regulation