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  • ligand bindin
  • This structure is made up of an extracellular region or ectodomain or ligand binding region that contains approximately 620 amino acids, a single transmembrane-spanning region containing approximately 23 residues, and an intracellular cytoplasmic tyrosine kinase domain containing up to around 540 residues. (wikipedia.org)
  • insulin
  • Specific binding of 125I-labeled insulin and insulin-like growth factors-I and -II to early gestation cells was decreased only 15-18% at 10 microM BP, which indicates that loss of membrane receptors appears to be selective for EGF. (aspetjournals.org)
  • GRB7 has been shown to interact with: EPH receptor B1, Insulin receptor, PTK2, RET proto-oncogene, and Rnd1 Model organisms have been used in the study of GRB7 function. (wikipedia.org)
  • Evidence for an interaction between the insulin receptor and Grb7. (wikipedia.org)
  • putative
  • Using a reverse transcription-polymerase chain reaction approach, we also cloned and sequenced putative EGF-URO receptor ligand binding domain III from each cell type. (aspetjournals.org)
  • However, our data document that the distinct relative binding affinities for EGF-URO and TGF-alpha that can be observed in different cell types from the same species cannot be accounted for solely by the sequence of putative receptor ligand binding domain III. (aspetjournals.org)
  • found ADP-ribosylation factor (ARF) 4 is one of the putative target genes of Mir-221, and the direct binding relationship was further confirmed by dual-luciferase reporter assay. (nih.gov)
  • thus the receptor
  • Further, it appears that the structural requirements (and thus the receptor) related to the acid inhibitory activity differ from those related to the mitogenic activity of these polypeptides. (aspetjournals.org)
  • repeats
  • Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. (nih.gov)
  • The N-terminal domain of the LDL receptor, which is responsible for ligand binding, is composed of seven sequence repeats (~50% identical). (wikipedia.org)
  • Binding of ApoB requires repeats 2-7 while binding ApoE requires only repeat 5 (thought to be the ancestral repeat). (wikipedia.org)
  • Human CUGBP1 (hCUGBP1) had been previously identified by Timchenko and colleagues for its ability to bind to CUG repeats located in the DMPK 3'UTR. (wikipedia.org)
  • structural
  • The most prominent structural/functional features, which are common to both isoforms, include an amino-terminal EH ( E ps15 H omology) domain, a central region containing two adjacent proline-rich regions and a carboxy-terminal portion mediating the binding to RalBP1. (biomedcentral.com)
  • GO annotations related to this gene include binding and structural constituent of cytoskeleton . (genecards.org)
  • Furthermore, diverse structural alterations have been identified that cause ligand-independent firing of this receptor, doing so in the absence of receptor over-expression. (wikipedia.org)
  • epithelial cells
  • Several mutants were constructed and tested for their biological activity and their ability to bind to intestinal epithelial cells in culture. (wikipedia.org)
  • autophosphorylation
  • Evidence from cross-linking and autophosphorylation experiments confirmed that the Mr 170,000 binding protein was decreased in a dose-dependent manner following BP treatment. (aspetjournals.org)
  • In comparison, term placental cells exhibit a 26% loss of EGF receptor autophosphorylation without alteration in binding following exposure to 10 microM BP. (aspetjournals.org)
  • In early gestation cells, EGF binding and receptor autophosphorylation were measurably decreased at 10 microM concentrations of these polycyclic compounds, but to a lesser extent than observed with BP. (aspetjournals.org)
  • affinities
  • The reduced biological potencies of the shortened derivatives (EGF-URO 1-47) in fibroblasts are paralleled by reduced fibroblast receptor affinities, compared with the intact peptides. (aspetjournals.org)
  • In parallel, we measured the receptor binding affinities for epidermal growth factor-urogastrone (EGF-URO) and transforming growth factor-alpha (TGF-alpha) in cultured smooth muscle (GCM) and epithelial (GPC) cells derived from guinea pig intestine. (aspetjournals.org)
  • We conclude that the previously measured differences in biological potencies of EGF-URO and TGF-alpha in the contractile bioassay preparations are due to the distinct receptor binding affinities of EGF-URO and TGF-alpha that can be detected in different tissues. (aspetjournals.org)