Binds preferentially. Medical search. Frequent questions

This subgroup corresponds to the RRM1 of hnRNP M, a pre-mRNA binding protein that may play an important role in the pre-mRNA processing. (nih.gov)
Also, they share a similar protein architecture based on an N-terminal ssDNA binding domain of ~180 amino acids and a C-terminal extension that in the case of RAD52 is required for homologous recombination (HR) through specific protein-protein interactions 6 . (nature.com)
Both Int and IHF bind to attP and form an intasome , a DNA-protein-complex designed for site-specific recombination of the phage and host DNA. (wikidoc.org)
1) Various complex formation of Histone methyltransferases for repressive chromatin and the molecular basis of their formation, 2) Relationship between heterochromatin formation and repressive histone modification on inactive X chromosome, 3) Involvement of an HP1 binding protein in pathway choice for repairing double-strand breaks. (nii.ac.jp)
When bound to phage GA coat protein, the bulged adenine loops out of the helix and occupies a binding pocket on the surface of the protein, forming a nucleation complex for phage assembly. (rcsb.org)
The coat protein can bind helices with bulged adenines at either position, but the 3'-proximal site binds with greater affinity. (rcsb.org)
We have studied this RNA motif in a 21 nucleotide hairpin containing a GA coat protein-binding site whose four nucleotide loop has been replaced by a more stable loop from the related phage Ms2. (rcsb.org)
CABs increase safety because the drug is activated when it preferentially binds directly to its intended target protein in the area of disease. (prnewswire.com)
In this example, the CAB does not effectively bind to the same protein located in healthy tissue or other part of the body that otherwise results in undesirable toxicity. (prnewswire.com)
The binding of 12-hr-old and 84-hr-old extracts to CPD- and 6-4PPs under various concentration of NaCl supported the possibility that different damage-recognition protein were expressed in zebrafish according to their developmental condition. (ncl.edu.tw)
The DNA damage-recognition problem in human and other eukaryotic cell: the XPA damage binding protein. (ncl.edu.tw)
Characterization of DNA recognition by the human UV-damaged DNA-binding protein. (ncl.edu.tw)
The cryo-EM analysis also revealed a population of free V 1 bound to Oxidation Resistance 1 (Oxr1p), a poorly characterized protein that has been implicated in protecting cells from oxidative stress. (upstate.edu)
The purine-rich element binding (Pur) protein family protein consists PURalpha/beta/gamma in humans. (embl-heidelberg.de)
Pur-alpha is a highly conserved, sequence-specific DNA- and RNA-binding protein involved in diverse cellular and viral functions including transcription, replication, and cell growth. (embl-heidelberg.de)
Association of human Pur alpha with the retinoblastoma protein, Rb,regulates binding to the single-stranded DNA Pur alpha recognitionelement. (embl-heidelberg.de)
The retinoblastoma protein, Rb, is detected in extracts of monkey CV-1cells complexed with Pur alpha, a sequence-specific single-strandedDNA-binding protein implicated in control of gene transcription and DNAreplication. (embl-heidelberg.de)
Human Pur alpha, expressed as a glutathioneS-transferase fusion protein, specifically binds to the hypophosphorylatedform of Rb with an affinity as high as that of SV40 large T-antigen. (embl-heidelberg.de)
Inthe absence of DNA, glutathione S-transferase-Pur alpha binds to p56RB, anNH2-terminal-truncated Rb protein purified from Escherichia coli,containing the T-antigen binding domain, to form multimeric complexes. (embl-heidelberg.de)
Sequence of cDNA comprising the human pur gene and sequence-specificsingle-stranded-DNA-binding properties of the encoded protein. (embl-heidelberg.de)
PCBP1 is a single-stranded nucleic acid binding protein that binds preferentially to oligo dC. (prospecbio.com)
PCBP1 along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. (prospecbio.com)
The principal means by which blood is used to transport oxygen involves the specific binding protein hemoglobin. (pharmacology2000.com)
When the ligand attaches (binds), the PDGFRA receptor protein is turned on (activated), which leads to activation of a series of proteins in multiple signaling pathways. (medlineplus.gov)
However, the fusion protein does not require ligand binding to be activated. (medlineplus.gov)
Similarly, point mutations in the PDGFRA gene can result in a PDGFRA protein that is activated without ligand binding. (medlineplus.gov)
The basis of hapten- molecular mechanisms of the sensitization pro- protein binding work is the hypothesis that upon cess will result in novel opportunities for the skin absorption, only protein-reactive chemicals development of alternative methods for assessing (or those that can be metabolically or chemically skin sensitization hazard and relative potency of converted to protein-reactive species) are able to chemicals. (cdc.gov)

The kinetics of binding to TIR1 are contrasted to those for the herbicide picloram, which shows the opposite receptor preference as it binds to AFB5 with far greater affinity than to TIR1. (whiterose.ac.uk)
Catecholamines inhibited ligand binding in the potency order adrenaline NA isoprenaline, corresponding to peripheral a-receptor activation. (erowid.org)
Donepezil's long half-life provides a long duration of drug availability for binding at the receptor sites. (medscape.com)
In addition, hnRNP M and another splicing factor Nova-1 work together as dopamine D2 receptor (D2R) pre-mRNA-binding proteins. (nih.gov)
Bacteriophage Lambda binds to the target E. coli cell, the tail tip binding to a maltose receptor. (wikidoc.org)
The virus enters human cells via endocytosis by binding the ACE2 receptor and releasing its positive-sense RNA genome. (news-medical.net)
These viruses infect by binding host transferrin receptor type-1 (TfR), but also hemagglutinate erythrocytes. (nih.gov)
Research indicates, however, that high-frequency TENS analgesia is not reversed by naloxone, implicating a naloxone-resistant, dynorphin-binding receptor. (medscape.com)
Other possible mechanisms are a decrease in binding affinity between a drug and receptor and a decrease in the number of receptors. (msdmanuals.com)

Improved affinity for TIR1 and the preference for binding to TIR1 was maintained for 4- and 6-chloroindole-3-tetrazoles, coupled with improved efficacy in vivo. (whiterose.ac.uk)
p-Hydroxylation or N methylation increased the affinity for CD-binding sites. (erowid.org)
They are weak ssDNA binding proteins with no affinity for double-stranded (ds) DNA. (nature.com)
Here, we demonstrate that βSyn and γSyn have a reduced affinity towards membranes compared to αSyn, and that direct interaction of βSyn or γSyn with αSyn results in reduced membrane binding of αSyn. (biorxiv.org)

Recent studies have shown that cisplatin noncompetitively inhibits an archetypal, membrane-bound mechanosensitive sodium-hydrogen ion transporter known as NHE-1. (wikipedia.org)
V-ATPase is made of two subcomplexes: a cytosolic V 1 that carries out ATP hydrolysis, and a membrane bound V o that is responsible for proton translocation. (upstate.edu)
Our data suggest that proteolytic maturation of HIV-1 not only assembles the viral capsid surrounding the genome but also repurposes the membrane-bound MA lattice for an entry or postentry function and results in the partial removal of up to 2500 lipids from the viral membrane. (bvsalud.org)
While many studies have been focused on the membrane structure, the dynamics of such systems are crucial for the function of the membrane including membrane bound proteins. (lu.se)

The antibiotic binds preferentially to the 50S ribosomal subunit and affects the process of peptide chain initiation. (theodora.com)

As opposed to single strand (ss) DNA binding proteins such as SSB and RPA, which protect and occlude ssDNA from recombination, RAD52/Redβ SSAPs promote recombination and share several biochemical similarities. (nature.com)
This study showed several sides of structure and function of heterochromatin through analysis of HP1 and its binding proteins, as follows. (nii.ac.jp)
Although studies suggest that αSyn and its missense mutant, A53T, preferentially accumulate in the mitochondria, the mechanisms by which αSyn and mitochondrial proteins regulate each other to trigger mitochondrial and neuronal toxicity are poorly understood. (springer.com)
The binding activity expressed in embryos was apparently unrelated to human DNA repair damage-recognition proteins XPA、RPA-70 and RPA-32, since those polypeptides recognized by an anti-human XPA、RPA-70 and RPA-32 antibody were detected only in 84-h-old zebrafish extracts. (ncl.edu.tw)
DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria. (embl-heidelberg.de)

The human Pur factor binds strongly to a sequence element repeated withinzones of initiation of DNA replication in several eukaryotic cells. (embl-heidelberg.de)

The binding of αSyn to ClpP further promotes a distribution of ClpP from soluble to insoluble cellular fraction in vitro and in vivo, leading to reduced solubility of ClpP. (springer.com)
Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. (thermofisher.com)

These StaRs and structures can be used to select and design compounds with specific pharmacologies, such as inverse agonist, partial agonist or full agonist, based on their ability to bind differentially to the agonist and antagonist StaRs. (science20.com)

αSyn functions in neurotransmitter release via binding to and clustering synaptic vesicles and chaperoning of SNARE-complex assembly. (biorxiv.org)
Our data suggest that all three synucleins affect synapse function, but only αSyn mediates the downstream function of vesicle clustering and SNARE-complex assembly, while βSyn and γSyn modulate the activity of αSyn through regulating its binding to synaptic vesicles. (biorxiv.org)

Cro binds to OR3 preventing access to the RM promoter preventing transcription and production of cI. (wikidoc.org)
Dynamic binding of transcription factors to DNA elements specifies gene expression and cell fate, in both normal physiology and disease. (nih.gov)
To date, our understanding of mammalian gene regulation has been hampered by the difficulty of directly measuring in vivo binding of large numbers of transcription factors to DNA. (nih.gov)
We apply iChIP to reconstruct the physical regulatory landscape of a mammalian cell, by building genome-wide binding maps for 29 transcription factors (TFs) and chromatin marks at four time points following stimulation of primary dendritic cells (DCs) with pathogen components. (nih.gov)
Our data demonstrates that transcription factors vary substantially in their binding dynamics, genomic localization, number of binding events, and degree of interaction with other factors. (nih.gov)
To investigate the effects of selection in the shaping of transcriptional networks, we derive transcriptional logic from a combinatorially powerful yet tractable model of the binding between DNA and transcription factors. (lu.se)
Furthermore, we find that transcription factors act preferentially as either activators or repressors, both when binding multiple sites for a single target gene and globally in the transcriptional networks. (lu.se)

hnRNP M contains three RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), and an unusual hexapeptide-repeat region rich in methionine and arginine residues (MR repeat motif). (nih.gov)
The R3H motif: a domain that binds single-stranded nucleic acids. (embl-heidelberg.de)
Binding of Pur alpha top56RB, the COOH-terminal portion of Rb, is inhibited by a syntheticpeptide containing the T-antigen Rb-binding motif. (embl-heidelberg.de)

A third set consists of TF that bind mainly after the stimuli and target specific gene functions. (nih.gov)
The electrical stimuli on the skin preferentially activate low-threshold, myelinated nerve fibers. (medscape.com)

Binding of tumor CD47 to SIRPα on macrophages and dendritic cells triggers a 'don't eat me' signal that inhibits phagocytosis and allows escape from innate immune surveillance. (bmj.com)
AO-176 not only blocks the CD47/SIRPα interaction and induces phagocytosis of tumor cells, but it also has a direct killing mechanism (via PCDIII) and induction of immunogenic cell death, leveraged by preferential binding to tumor versus normal cell CD47. (bmj.com)
Results Previously, we described that the preferential binding of AO-176 to tumor versus normal cells was due to its interaction with CD47 molecules that were pre-complexed to β1 integrin. (bmj.com)
In addition, we show that AO-176 is able to bind and occupy CD47/β1 integrin complexes to a greater extent at acidic versus physiologic pH such as would be found in tumor microenvironments, an observation that also contributes to the enhanced targeting of AO-176 to tumor cells. (bmj.com)
Taken together, these findings add further insight into the preferential binding of AO-176 to tumor versus normal cells. (bmj.com)
Tumors can become resistant if a mutation develops that confers resistance to an anticancer drug and that anticancer drug is used repeatedly, preferentially eliminating nonresistant tumor cells. (msdmanuals.com)

The expanded amelogenin polyproline region preferentially binds to apatite versus carbonate and promotes apatite crystal elongation. (rochester.edu)
Biochemical experiments showed that Oxr1p binds and promotes V-ATPase disassembly. (upstate.edu)
PCBP1 and PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promotes poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. (prospecbio.com)

As with penicillins, inhibits third and final stage of bacterial cell wall synthesis by preferentially binding to specific PBPs located inside the bacterial cell wall. (medscape.com)

Because the neurobiological substrate of cariprazine has remained elusive, we took advantage of PharmacoSTORM to provide in vivo evidence that cariprazine predominantly binds to D 3 dopamine receptors on Islands of Calleja granule cell axons but avoids dopaminergic terminals. (nature.com)
Thus, the conserved Neu5Gc-binding preference of these viruses likely plays a role in the natural history of the virus in vivo. (nih.gov)

Functionally, the TFs are organized in a hierarchy of different types: Cell differentiation factors bind most of the genes and remain largely unchanged during the stimulation. (nih.gov)
A second set of TFs bind already in the un-stimulated and preferentially target induced genes. (nih.gov)

A recent study from the Wilkens lab in collaboration with Seoul National University uncovered a novel mechanism of yeast V-ATPase regulation based on biochemical experiments and cryo electron microscopy (cryo-EM) structures of holo V-ATPase and Oxr1 bound V 1 subcomplex. (upstate.edu)

Unlike the embryonic extract, the extracts of 84-h-old larvae produced only low-shifting binding complexes when incubated with a CPD-specific probe. (ncl.edu.tw)
An efficient tool for investigating a target binding sites on the DNA double helix structure, sequence preference, DNA secondary structure, and the structural variations in DNA-drug complexes is an infrared spectroscopic study. (databasefootball.com)

It works in part by binding to DNA and inhibiting its replication. (wikipedia.org)

6-OHDA reduced NA levels by 80%, NA uptake by 67% and reduced ligand binding. (erowid.org)
A ligand fixation into DNA structure can be performed by electrostatic binding between a positively charged guest and negatively charged DNA host by binding to the major and minor groove of DNA and by intercalation, meaning the insertion of the ligand molecule between DNA base pairs. (databasefootball.com)

To date, HPAI A(H5N1) viruses currently circulating in birds and poultry, with spillover to mammals, and those that have caused human infections do not have the ability to easily bind to receptors that predominate in the human upper respiratory tract. (cdc.gov)

A competitive binding assay indicated that both CPDs and 6-4PPs were recognized by the same binding activity expressed in 12-h-old zebrafish. (ncl.edu.tw)

Such approach corresponded very well with an electrochemical study based on preferential TP binding to guanine moiety. (databasefootball.com)

The positively charged hydrogen atom remains bound to the imine group, causing the color change. (sciencedaily.com)

Either adenine may act as the branch-point residue in mammals, but the 3'-proximal adenine does so preferentially. (rcsb.org)
In the case of TP binding to adenine moiety, the complex might be formed by only one possible concept with significantly lower constant of stability. (databasefootball.com)

The ototoxicity of both the aminoglycosides and cisplatin may be related to their ability to bind to melanin in the stria vascularis of the inner ear or the generation of reactive oxygen species. (wikipedia.org)
CO preferentially binds haemoglobin, which displaces oxygen and adversely affects the delivery of oxygen to the tissues. (cdc.gov)

Unlike the decision systems, the circadian clocks show strong cooperative binding and negative regulation, which achieves tight temporal control of gene expression. (lu.se)

After TP binding, the absorption bands of DNA nucleobases strongly diminished, which confirmed the DNA-TP interaction as well as the changes in DNA double helix structure. (databasefootball.com)

It also preferentially binds to poly(G) and poly(U) RNA homopolymers. (nih.gov)

The expression of distorted DNA-binding factors was studied in developing zebrafish using UV-damaged DNA as the binding target. (ncl.edu.tw)

Our method, which allowed us to map routinely temporal binding profiles of dozens of TFs, provides a foundation for future understanding of the mammalian regulatory code. (nih.gov)

Small molecules readily penetrate tissue preparations and bind their targets with known stoichiometry. (nature.com)

Binding was highest in the cerebral cortex and lowest in the cerebellum. (erowid.org)

N binds to the two Nut sites, one in the N gene, and one in the cro gene. (wikidoc.org)

Rb binding involves a Pur alpha region with limited homologyto the Rb-binding region of SV40 large T-antigen. (embl-heidelberg.de)

UV-binding factors found in 12-h-old zebrafish embryos may be involved in processing developmental stage-specific DNA structures similar to UV-damage DNA. (ncl.edu.tw)

In the presence of water, the water molecules will preferentially bind to the imine groups. (sciencedaily.com)
If more ozone than water is present (or the ozone-laden air is fully dry), the excess ozone binds to the imine groups and splits them. (sciencedaily.com)
In water, methoxychlor preferentially binds to sediments and organic matter, although some methoxychlor may remain dissolved in water. (cdc.gov)
Cover bare soil with a lead-binding layer of compost followed by heavy, water-permeable landscape cloth. (cleanwater.org)

Interacts preferentially with IKK-beta but also able to interact with IKK-alpha, IKAP, TAX, RIP and MAP3k14/NIK. (lu.se)

Ehrlichia chaffeensis is a small, gram negative, obligately intracellular bacterium that preferentially infects mononuclear phagocytes. (frontiersin.org)
Lead binds preferentially to the small soil particles that are picked up by a strong breeze. (cleanwater.org)

Both crystal structures revealed that the N-terminal domain of ~200 amino acids forms a mushroom-shaped undecameric ring with an external groove lined with positive charges, which probably binds the phosphodiester backbone of ssDNA. (nature.com)

Binds to one or more PBPs, which, in turn, inhibit cell wall synthesis and result in bactericidal activity. (medscape.com)
Binds to T-cell leukemia virus type I TAX oncoprotein. (lu.se)

A strong and high-shifting binding activity was detected in the extracts of zebrafish embryo (12 h after fertilization), and the expression of the activity dramatically decreased in 60 to 84-h-old zebrafish. (ncl.edu.tw)
Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. (thermofisher.com)

Identification of one 50.2 and one 29-kDa UV-damage-DNA binding factor in 12-hr-old zebrafish extracts by EMSA linked to SDS-PAGE and determined by MALDI TOF analysis, indicated that the 29-kDa and 50.2-kDa polypeptides are high homologous to zebrafish fast skeletal muscle troponin T and vitellogenin. (ncl.edu.tw)
Analysis with a seriesof mutated oligonucleotides defines a minimal single-stranded DNAPur-binding element. (embl-heidelberg.de)

Theprotein binds preferentially to the purine-rich single strand of thiselement, PUR. (embl-heidelberg.de)

The N bound in the L and R open reading frames extends the reading frames. (wikidoc.org)
In mature HIV-1, a lipid extends out of the membrane to bind with a pocket in MA. (bvsalud.org)

Anatomy22

Organisms17

Chemicals and Drugs99

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Phenomena and Processes80

Information Science3

Health Care1

Protein27

Receptor9

Affinity4

Membrane-bound4

Subunit1

Proteins5

Eukaryotic1

Vitro2

Agonist and Antagonist1

Synaptic2

Transcription7

Motif3

Stimuli2

Tumor6

Promotes3

Bacterial1

Vivo2

Genes2

Biochemical1

Complexes2

Replication1

Ligand2

Predominate1

Assay1

Preferential1

Positively charged1

Adenine2

Oxygen2

Control of gene1

Strongly1

Poly1

Target1

Temporal1

Tissue1

Cerebral1

Sites1

Involves1

Developmental1

Water4

Interact1

Small2

Groove1

Cell2

Activity2

Analysis2

Single1

Extends2