Binds pathways. Medical search. Frequent questions

Here we show that 14-3-3 proteins bind to Pim kinase-phosphorylated Ser166 and Ser186 on the human E3 ubiquitin ligase mouse double minute 2 (Mdm2), but not protein kinase B (PKB)/Akt-phosphorylated Ser166 and Ser188. (dundee.ac.uk)
Structure is probed with vibrational spectroscopic tools that are capable of determining the Raman and IR spectra of bound substrates and specific protein molecular moieties embedded in large proteins. (elsevierpure.com)
Here we outline the current status of the viral evasion mechanism underlying the regulation of the cGAS-STING pathway, focusing on how post-transcriptional modifications, viral proteins, and non-coding RNAs involve innate immunity during viral infection, attempting to inspire new targets discovery and uncover potential clinical antiviral treatments. (frontiersin.org)
The pathway may also be deactivated downstream by directly inhibiting adenylyl cyclase or dephosphorylating the proteins phosphorylated by PKA. (wikipedia.org)
Sterol regulatory element binding proteins (SREBP) control transcription of cholesterol synthesis by regulating the transcription of 3-hydroxy-3-methyl- glutaryl coenzyme A (HMGCoA) reductase, an enzyme responsible for controllinglevels of cholesterol in the body, regulates LDL receptor which supplies cholesterol through receptor-mediated endocytosis, and also adjusts transcription of genes encoding enzymes of fatty acid synthesis and uptake. (readabstracts.com)
Ferric binding proteins: Identification and role in the rion acquisition pathways of the pasteurellaceae and neissericaceae (Doctoral thesis, University of Calgary, Calgary, Canada). (ucalgary.ca)
Yet not all nuclear proteins interact with importins, necessitating the identification of a general importin-independent nuclear import pathway. (ox.ac.uk)
AR-containing proteins (ARPs) with a hydrophobic residue at the 13th position of two consecutive ARs bind RanGDP efficiently, and consequently enter the nucleus. (ox.ac.uk)
For a few pathogens, the microbial binding protein responsible for the top connection of FHL-1/reconectin as LY2811376 well as for element H have already been determined, like the sialylated porin or lipooligosaccharide, the main outer membrane proteins of (33, 34), the M proteins for (35), the Hic proteins for (16), and gp120 aswell as gp41 from human being immunodeficiency disease (41). (abic2004.org)
SUMOylation is a post-translational modification of proteins that has been found to play a major role in the Wnt/β-catenin signaling pathway. (frontiersin.org)
Proteins associated with the Wnt/β-catenin pathway have been identified as SUMOylated substrates, and evidences suggested that the initiation and progression of cancers depended on the function of the SUMOylation ( 23 ). (frontiersin.org)

A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. (nih.gov)
The relationship between NAFLD and retinol-binding protein 4 - an updated systematic review and meta-analysis. (nih.gov)
Positive Expression of Retinol-Binding Protein 4 Is Related to the Malignant Clinical Features Leading to Poor Prognosis of Glioblastoma. (nih.gov)
Interplay of retinol binding protein 4 with obesity and associated chronic alterations (Review). (nih.gov)
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. (nih.gov)
ATP-Binding Cassette Transporter Family C Protein 10 Participates in the Synthesis and Efflux of Hexosylceramides in Liver Cells. (nih.gov)
In the closed conformation, HEAT/ARM core domains shield the GTPase-activating protein-related domain (GRD) so that Ras binding is sterically inhibited. (nature.com)
We showed that by adding the protein we enhance the sensitization pathways, making it much brighter," Abergel said. (sciencedaily.com)
In the field of molecular biology, the cAMP-dependent pathway, also known as the adenylyl cyclase pathway, is a G protein-coupled receptor-triggered signaling cascade used in cell communication. (wikipedia.org)
Each GPCR binds to and is activated by a specific ligand stimulus that ranges in size from small molecule catecholamines, lipids, or neurotransmitters to large protein hormones. (wikipedia.org)
This leads to an increase in adenylyl cyclase activity, thereby increasing cAMP levels, which can lead to an increase in insulin and therefore hypoglycemia The Gs alpha subunit slowly catalyzes the hydrolysis of GTP to GDP, which in turn deactivates the Gs protein, shutting off the cAMP pathway. (wikipedia.org)
Molecules that inhibit the cAMP pathway include: cAMP phosphodiesterase converts cAMP into AMP by breaking the phosphodiester bond, in turn reducing the cAMP levels Gi protein, which is a G protein that inhibits adenylyl cyclase, reducing cAMP levels. (wikipedia.org)
These data implicate a single mechanism for the pleiotropic effects of DJ-1 in different model systems, namely that the protein binds multiple RNA targets in an oxidation-dependent manner. (houstonmethodist.org)
Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway. (bvsalud.org)
The hexosamine biosynthetic pathway (HBP) generates uridine diphosphate N-acetylglucosamine ( UDP -GlcNAc) for glycan synthesis and O-linked GlcNAc (O-GlcNAc) protein modifications. (bvsalud.org)
Here, we show that spliced X-box binding protein 1 (Xbp1s), the most conserved signal transducer of the unfolded protein response (UPR), is a direct transcriptional activator of the HBP. (bvsalud.org)
RGD-independent cell adhesion to tTG-FN does not require transamidating activity, is mediated by the binding of tTG to cell-surface heparan sulfate chains, is dependent on the function of protein kinase Cα (PKCα) and leads to activation of the cell survival focal adhesion kinase (FAK). (ntu.ac.uk)
Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer. (ox.ac.uk)
Circulating levels of insulin-like growth factor I (IGF-I) and its main binding protein, IGF binding protein 3 (IGFBP-3), have been associated with risk of several types of cancer. (ox.ac.uk)
abstract = "The RNA-binding protein human antigen R (HuR) has been implicated in apoptosis in multiple ways. (edu.sa)
Von Roretz, C & Gallouzi, IE 2010, ' Protein kinase RNA/FADD/caspase-8 pathway mediates the proapoptotic activity of the RNA-binding protein human antigen R (HuR) ', Journal of Biological Chemistry , vol. 285, no. 22, pp. 16806-16813. (edu.sa)
One technique of microorganisms which has lately attracted particular curiosity is the capability to acquire web host fluid-phase go with regulatory protein of the choice pathway. (abic2004.org)
Both central individual fluid-phase go with regulators of the choice pathway are FHL-1/reconectin and aspect H. Both protein are related structurally, and their transcripts are produced by alternative digesting of the nuclear RNA transcript, LY2811376 which comes from a single human being gene (11, 47). (abic2004.org)
Binding experiments using either endogenous p21 mRNA or in vitro-labeled p21 transcripts revealed a specific PGA 2 -dependent association of the p21 mRNA with the RNA-binding protein HuR. (johnshopkins.edu)
The hippo/yap/taz pathway and pdac The transcriptional co-activators yes-associated protein (YAP)10 and its paralog WW-domain-containing Transcriptional co-Activator with a PDZ-binding motif (TAZ)11 are attracting intense Buparvaquone attention as fundamental points of convergence and intersection of many signal transduction pathways that are implicated in the regulation of development, metabolism, organ-size, positional sensing, tissue regeneration and tumorigenesis12C14. (kidztrainer.com)
The RNA-binding protein, polypyrimidine tract-binding protein 1 (PTBP1), also named hnRNP I, acts as a critical mediator of insulin biosynthesis through binding to the pyrimidine-rich region in the 3'-untranslated region (UTR) of insulin mRNA. (molcells.org)
KIN17, which is known as a DNA and RNA binding protein, is highly expressed in numerous types of human cancers and was discovered to participate in several vital cell behaviors, including DNA replication, damage repair, regulation of cell cycle and RNA processing. (spandidos-publications.com)
Signaling is initiated when the Wnt ligand binds to the Frizzled receptor on the cell membrane and the LDL receptor-associated protein 5/6 (LRP5/6) co-receptor. (frontiersin.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)
FV810-1492 is an artificial FV-Short variant that cannot synergize with protein S as TFPIα cofactor even though it contains AR2 and binds TFPIα. (lu.se)
A microtiter-based assay tested binding between FV-Short variants, protein S, and TFPIα. (lu.se)
None of the FV-Short variants bound directly to protein S. The combination of TFPIα and preAR2-containing FV-Short variants bound protein S, whereas TFPIα together with the preAR2-minus variants did not. (lu.se)
Protein S potentiated TFPIα-binding to the preAR2-containing variants and binding between TFPIα and protein S was stimulated only by the preAR2-containing variants. (lu.se)
ODE induced significant NOD2 mRNA and protein expression at 24 and 48 h, respectively, which was mediated via a NF-KB signaling pathway as opposed to a TNF-a autocrine/paracrine mechanism. (cdc.gov)
it occurs when mannose-binding lectin (MBL), a serum protein, binds to mannose, fucose, or N -acetylglucosamine groups on bacterial cell walls, yeast walls, or viruses. (msdmanuals.com)
However, although Michael acceptors are reactive, the Michael addition is reversible and it can be assumed that also other parts of the molecules will moderate the binding to and the release from any given nucleophilic site in a protein, and thereby moderate a specific biological activity. (lu.se)

Gene knockdown showed caspase-8 to be the apical caspase in the AIM2- and NLRP3-dependent apoptotic pathways, with little or no requirement for caspase-9. (nih.gov)
NF-KB is important in immune, inflammatory, and apoptotic pathways. (medscape.com)

The kinetics of ligand binding/release will be probed here. (elsevierpure.com)
This altered selectivity is explained by altered surface receptor-ligand binding kinetics and can be quantitatively predicted using a multivalent binding model. (biorxiv.org)
The cytokine family operates through a common theme of binding private receptors for each ligand before engaging the common γ c receptor to induce signaling. (biorxiv.org)

On the process side, Generalized-Reactions describe both individual biochemical reactions, and biochemical pathways. (ecocyc.org)

LYTGOBI covalently binds to FGFR2 and inhibits the signaling pathway. (biospace.com)
Vamorolone is a structurally unique steroidal anti-inflammatory drug that potently inhibits proinflammatory NFkB pathways via high-affinity binding to the glucocorticoid receptor. (medscape.com)

While recent work has emphasized the importance of mitochondrial oxidative phosphorylation, the role of the glycolytic pathway in axon morphogenesis and maintenance remains minimally understood. (jneurosci.org)

C4BP controls the classical pathway of complement activation. (lu.se)

The cAMP pathway is studied through loss of function (inhibition) and gain of function (increase) of cAMP. (wikipedia.org)
Interestingly, although inhibition of the ERK pathway did not prevent the PGA 2 -triggered increase in cytoplasmic HuR, it did impair the formation of endogenous and in vitro [HuR-p21 mRNA] complexes and further prevented the PGA 2 -mediated stabilization of the p21 mRNA, suggesting that ERK-mediated events were required for binding HuR to the p21 mRNA and preventing its decay. (johnshopkins.edu)
Specifically, NF-KB translocation increased rapidly following ODE stimulation as demonstrated by EMSA, and inhibition of the NF-KB pathway significantly reduced ODE-induced NOD2 expression. (cdc.gov)

This leads to the activation of the cAMP-dependent pathway. (wikipedia.org)
Additionally, we observed that these HuR-CPs are sufficient to trigger cell death in the absence of activation of the PKR pathway. (edu.sa)
Activation of other pathways by additional mutations, including mutations in tumor suppressor genes, such as and/or environmental stimuli (obesity, type 2 diabetes mellitus) are required for the promotion of invasive PDAC. (kidztrainer.com)
Abnormal activation of this pathway plays an essential role in chemoradiotherapy resistance ( 12 ). (frontiersin.org)
Alternate pathway activation occurs when components of microbial cell surfaces (eg, yeast walls, bacterial cell wall lipopolysaccharide [endotoxin]) or immunoglobulin (eg, nephritic factor, aggregated IgA) cleave small amounts of C3. (msdmanuals.com)

The investigation of signal transduction pathways is critical to the basic understanding of cellular processes as these pathways function to regulate diverse processes in both eukaryotes and prokaryotes. (umd.edu)

Translocation and structure switch of STING provides the prerequisite for TANK-binding kinase 1 (TBK1) recruitment and auto-phosphorylation. (frontiersin.org)
Other signaling mechanisms, such as the MAP/SAP kinase or Ras pathways, although potentially important for transmission of some of the TGF-beta signals, will not be described. (nih.gov)

Classical pathway components are labeled with a C and a number (eg, C1, C3), based on the order in which they were identified. (msdmanuals.com)
This pathway otherwise resembles the classical pathway structurally and functionally. (msdmanuals.com)

In a cAMP-dependent pathway, the activated Gs alpha subunit binds to and activates an enzyme called adenylyl cyclase, which, in turn, catalyzes the conversion of ATP into cyclic adenosine monophosphate (cAMP). (wikipedia.org)
Molecules that activate cAMP pathway include: cholera toxin - increases cAMP levels forskolin - a diterpene natural product that activates adenylyl cyclase caffeine and theophylline inhibit cAMP phosphodiesterase, which degrades cAMP - thus enabling higher levels of cAMP than would otherwise be had. (wikipedia.org)
Surprisingly, although in response to the apoptotic inducer staurosporine PKR itself is not phosphorylated, PKR triggers the cleavage of HuR via its downstream effector FADD that in turn activates the caspase-8/caspase-3 pathway. (edu.sa)
Therefore, our results support a model whereby in response to lethal stress, PKR, without being phosphorylated, activates the FADD/caspase-8/caspase-3 pathway to trigger HuR cleavage, and the HuR-CPs are then capable of promoting apoptosis. (edu.sa)

Wnt/β-catenin signaling is a delicate and complex signal transduction pathway mediated by multiple signaling molecules, which plays a significant role in regulating human physiology and pathology. (frontiersin.org)

The implications of these findings for regulation of the p53 pathway, oncogenesis and drug discovery are discussed. (dundee.ac.uk)
Furthermore, KIN17 is associated with cancer cell proliferation, migration, invasion and cell cycle regulation by regulating pathways including the p38 MAPK, NF‑κB‑Snail and TGF‑β/Smad2 signaling pathways. (spandidos-publications.com)
Studies have shown that the Wnt/β-catenin signaling pathway controls cell fate and function through the transcriptional and post-translational regulation of omics networks. (frontiersin.org)

This pathway can activate enzymes and regulate gene expression. (wikipedia.org)
Furthermore, the Wnt/β-catenin can crosstalk with other signaling pathways including Notch, FGF, Hedgehog, and TGF-β/BMP signaling cascades to form a signaling network to regulate the survival and progression of cancer cells ( 14 - 16 ). (frontiersin.org)
Organic dust augments nucleotide-binding oligomerization domain expression via an NF-kB pathway to negatively regulate inflammatory responses. (cdc.gov)

The current research described in PNAS identifies a new pathway for the intracellular delivery of the radioactive toxic metal ions, and thus a possible new target for treatment strategies. (sciencedaily.com)
We then implement the pathway in a photosynthetic organism Synechococcus elongates PCC7942, and show that it increases the intracellular acetyl-CoA pool and enhances bicarbonate assimilation by roughly 2-fold. (osti.gov)
1994). High-res- belongs to the family of intracellular lipid bind- olution crystal structures (Sacchetti ni et al. (lu.se)

Insulin receptors are embedded in the outer membrane surrounding the cell, where they attach (bind) to insulin circulating in the bloodstream. (medlineplus.gov)
Subsequently, Lats1/2 phosphorylates TAZ and YAP, two main downstream effectors from the Hippo pathway and book receptors from the glycolytic and mevalonate pathways13, 22, 23. (kidztrainer.com)
Arsenite binds specifically to thiol group-containing hormone receptors, a process that prevents the binding of steroids [Lopez et al. (cdc.gov)

It binds as a cofactor to C3b/C4b inactivator (C3bina), which then hydrolyzes the complement fragment C4b. (lu.se)

We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis binding sites and target genes, in breast cancer cells. (nature.com)
The cyclic GMP-AMP synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway is a critical defender to sense various pathogens and trigger innate immunity of mammalian cells. (frontiersin.org)
Heritable factors explain up to 60% of the variation in IGF-I and IGFBP-3 in studies of adult twins.We systematically examined common genetic variation in 18 genes in the IGF signaling pathway for associations with circulating levels of IGF-I and IGFBP-3. (ox.ac.uk)

Figure 3: Estrogen receptor and RNA PolII binding relative to specific gene targets. (nature.com)

The classical, lectin, and alternative pathways converge into a final common pathway when C3 convertase (C3 con) cleaves C3 into C3a and C3b. (msdmanuals.com)

Some individuals with MS and other CNS inflammatory syndromes also may experience homonymous visual field defects caused by lesions in retrochiasmal or retrogeniculate (posterior) regions of the afferent visual pathway. (medscape.com)

Further, we show that DJ-1 binds RNA but dissociates after oxidative stress. (houstonmethodist.org)

These data indicate that the glycolytic pathway is operative in distal axons and contributes to the rate of axon extension and growth cone dynamics in the presence of NGF and that, in the absence of NGF, the axonal glycolytic pathway is required for axon maintenance. (jneurosci.org)
The data reveal that the glycolytic pathway is required for normal sensory axon extension in the presence of NGF, while in the absence of NGF the glycolytic pathway is required for axon maintenance. (jneurosci.org)

Glycolysis is a pathway consisting of 10 enzymes and separated into preparatory and payoff phases, the latter producing ATP. (jneurosci.org)

Here, we report that glucose induces the expression of PTBP1 via the insulin receptor (IR) signaling pathway in β cells. (molcells.org)
It is hypothesized that arsenic's diabetogenic effect may be related to its ability to bind and inhibit the insulin receptor [Rossman 2007]. (cdc.gov)

This lactone ring is a Michael acceptor that is known to affect biological processes such as cell proliferation, death/apoptosis, and cell migration, by interfering with nucleophilic sites in cell signalling pathways. (lu.se)

The motion(s) of TIM's catalytically important mobile loop in releasing bound ligands and the time course of TIM-substrate to TIM-product inner complex conversion will be investigated by laser induced T-jump relaxation spectroscopy over our time range. (elsevierpure.com)

We first functionally demonstrate the design of the MCG pathway in vitro and in Escherichia coli. (osti.gov)

It specifically negatively regulates the PI3K-AKT signaling pathway to induce cell cycle arrest. (medscape.com)

Consequently, mutated Nf1 shows altered Ras-GAP activity and leads to uncontrolled signalling in multiple cell signalling pathways. (nature.com)
Figure 7: Assessment of estrogen receptor binding properties in different cell systems. (nature.com)
Association of tTG with its binding site on the 70 kda aminoterminal FN fragment does not support this cell adhesion process, which seems to involve the entire FN molecule. (ntu.ac.uk)
We propose a novel RGD-independent cell adhesion mechanism that promotes cell survival when the anti-apoptotic role mediated by RGD-dependent integrin function is reduced as in tissue injury, which is consistent with the externalisation and binding of tTG to fibronectin following cell damage/stress. (ntu.ac.uk)

Nucleotide-binding oligomerization domain 2 (NOD2) is involved in innate immune responses to peptidoglycan degradation products. (cdc.gov)

1493-1537) that binds tissue factor pathway inhibitor alpha (TFPIα). (lu.se)

In the first project, I examined the nucleotide binding reaction of CheA using the fluorescent nucleotide analogue, TNP-ATP [2'(3')-O-(2,4,6-trinitrophenyl)adenosine 5'-triphosphate]. (umd.edu)
Figure 1: Summary of estrogen receptor and RNA PolII binding sites and correlation with nucleotide and gene number. (nature.com)

Figure 4: Identification of enriched motifs within the estrogen receptor binding sites and validation of transcription factor binding. (nature.com)
Figure 5: Involvement of cooperating transcription factors at estrogen receptor binding sites. (nature.com)

In the second project, I focused on elucidating the binding mechanism that underlies formation of the CheA:TNP-ATP complex. (umd.edu)
This has led to an improved understanding of the multilayered mechanisms of this pathway transduction proceeds as well as the molecular mechanism regulating this pathway ( 28 ). (frontiersin.org)

This pathway converts a C3 metabolite to two acetyl-CoA by fixation of one additional CO2 equivalent, or assimilates glyoxylate, a photorespiration intermediate, to produce acetyl-CoA without net carbon loss. (osti.gov)

This pathway can also be activated downstream by directly activating adenylyl cyclase or PKA. (wikipedia.org)

Figure 2: Estrogen-mediated transcript changes and correlation with estrogen receptor binding. (nature.com)
In the version of this article initially published online, the estrogen receptor and RNA PolII binding data were aligned incorrectly in the top panel of Figure 3, which represents estrogen receptor binding at the ESR1 gene region. (nature.com)
2004). Phytoestrogens are capable of estrogen-receptor binding (Cornwell et al. (cdc.gov)

Many CRASPs bind both individual immune system regulators at their C-terminal ends. (abic2004.org)
Cytokines that bind to the common γ-chain (γ c ) receptor, including interleukin (IL)-2, 4, 7, 9, 15, and 21, are a critical hub in modulating both innate and adaptive immune responses ( 1 ) . (biorxiv.org)

Procaspase-8 localised to ASC inflammasome 'specks' in cells, and bound directly to the pyrin domain of ASC. (nih.gov)
Abnormally activated Wnt/β-catenin signaling pathway plays a crucial role in promoting malignant tumor occurrence, development, recurrence, and metastasis, particularly in cancer stem cells. (frontiersin.org)
This suggests the possibility that strictly regulated self-renewal mediated by Wnt signaling in cancer cells may be disturbed by the SUMOylation pathway to allow more malignant proliferation. (frontiersin.org)

In the third project, I turned my attention to studying the CheY phosphorylation and binding reactions using fluorescently labeled versions of CheY. (umd.edu)

A 563-bp fragment encoding antigenic ( 19 , 20 ) and receptor-binding ( 21 ) sites of the HA1 domain is shown, with the sequences aligned to A/Brevig Mission/1/1918 (BREVIG18) ( 15 ). (cdc.gov)

Some studies in arsenic metabolism suggest that methylation of inorganic arsenic may be a toxification, rather than a detoxification pathway and that trivalent methylated arsenic metabolites, particularly monomethylarsonous acid and dimethylarsinous acid, have a great deal of biological activity [Kitchin 2001]. (cdc.gov)

By monitoring the fluorescence of TNP-ATP when it bound to CheA, I examined the affinity of the binding interaction and discovered that the two ATP binding sites of each CheA dimer exhibited negative cooperativity in their interactions with TNP-ATP. (umd.edu)
The majority of nuclear import pathways are mediated by importin-cargo interactions. (ox.ac.uk)

If cAMP-dependent pathway is not controlled, it can ultimately lead to hyper-proliferation, which may contribute to the development and/or progression of cancer. (wikipedia.org)

A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway. (ox.ac.uk)

The RaDAR (RanGDP/AR) pathway represents a general importin-independent nuclear import pathway and is frequently used by AR-containing transcriptional regulators, especially those regulating NF-κB/p53. (ox.ac.uk)

Safety against go with by binding of FHL-1/reconectin and/or go with element H continues to be demonstrated elsewhere for a number of human being pathogens: (10), (33, 34), (35), (17, 19, 31), (30), (6), as well as the human being immunodeficiency disease (41). (abic2004.org)

Pim-mediated phosphorylation of Ser186 blocks phosphorylation of Ser188 by PKB, indicating potential interplay between the Pim and PKB signaling pathways in regulating Mdm2. (dundee.ac.uk)

It is believed that there are likely to be multiple evolutionary pathways that would increase mammalian transmissibility of avian influenza viruses, including HPAI H5N1 viruses. (cdc.gov)

Genetic variation in the ATP binding cassette transporter ABCC10 is associated with neutropenia for docetaxel in Japanese lung cancer patients cohort. (nih.gov)

Wood, NT, Meek, DW & MacKintosh, C 2009, ' 14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2-Potential interplay with the PKB/Akt pathway and p14(ARF) ', FEBS Letters , vol. 583, no. 4, pp. 615-620. (dundee.ac.uk)

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cAMP binds to the regulatory sub-units. (wikipedia.org)

All variants bound to TFPIα. (lu.se)

Instance frames describe specific biological objects, such as a specific gene or a specific metabolic pathway. (ecocyc.org)

This dissertation focuses on understanding some of the biochemical events that take place in the chemotaxis signal transduction pathway of bacteria. (umd.edu)

Anatomy22

Organisms17

Chemicals and Drugs99

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Phenomena and Processes80

Information Science3

Health Care1

Proteins11

Protein36

Apoptotic pathways2

Ligand3

Biochemical pathways1

Inhibits2

Mitochondrial1

Complement activation1

Inhibition3

Activation5

Cellular1

Kinase2

Classical pathway2

Activates4

Molecules1

Regulation3

Regulate3

Intracellular3

Receptors3

Cofactor1

Genes3

Targets1

Convertase1

Inflammatory1

Oxidative1

Glycolytic2

Enzymes1

Insulin receptor2

Apoptosis1

Ligands1

Functionally1

Regulates1

Cell4

DEGRADATION1

Tissue1

Nucleotide2

Transcription2

Mechanism2

Converts1

Downstream1

Estrogen receptor3

Immune2

Cells3

Reactions1

Fragment1

Metabolism1

Interactions2

Proliferation1

Defines1

Transcriptional1

Pathogens1

Phosphorylation1

Viruses1

Cancer1

Interplay1

Transform2

Regulatory1

Variants1

Specific gene1

Signal1