Binds motor activity. Medical search. Frequent questions

They allow cells to configure protein networks locally and exclude proteins from locations where their activity is harmful. (europa.eu)
RNA binding proteins recognize these sequences and assemble with their mRNA target into mRNPs. (europa.eu)
It is thought that motor or adaptor proteins recognise different features on the surface of mRNPs with different affinities. (europa.eu)
It is still not known which RBPs or adaptor proteins are essential to recruit microtubule-binding motor proteins to mRNPs and to which extend this varies between different transported mRNAs. (europa.eu)
Mutations affecting zipcodes, RBPs or motor-proteins required for neuronal mRNA localization were shown to lead to severe neurodegenerative diseases as ALS, FXTAS and FXS (7), underlining the need to understand the mechanisms that drive neuronal mRNA transport. (europa.eu)
Also in this specific case, it is not understood how RBPs, potential adaptors and motor proteins, which are essential for the transport of CaMKIIa-mRNA are mechanistically contributing to its correct localisation. (europa.eu)
Residue I384 of Tsr receptor is important for binding to the proteins. (ucsb.edu)
We further demonstrate that the activity of Kermit in PCP differentially relies on the motor proteins: the microtubule-based dynein and kinesin motors and the actin-based myosin VI. (nih.gov)
Our results place Kermit as a potential transducer of Go, linking Vang with motor proteins for its delivery to dedicated cellular compartments during PCP establishment. (nih.gov)
Dyneins are a family of cytoskeletal motor proteins that move along microtubules in cells . (wikipedia.org)
In contrast, most kinesin motor proteins move toward the microtubules' plus-end, in what is called anterograde transport . (wikipedia.org)
The protein attaches (binds) to a group of proteins called the dynein complex, turning it on (activating it) and helping it bind to other cellular materials for transport. (medlineplus.gov)
Overactivity of the BICD2 protein changes its ability to bind with the dynein complex, leading to reduced movement of proteins, synaptic vesicles, and other materials within cells. (medlineplus.gov)
Such proteins, which resist mechanical forces in some regions while being flexible in others, transmit signals from one region of the protein to another (action at a distance) in response to binding of ligands (oxygen, ATP or other small molecules). (preprints.org)
NQO1 displays a remarkable functional chemistry, capable of binding different functional ligands that modulate its activity, stability and interaction with proteins and nucleic acids. (preprints.org)

[1] Additionally, dynein motor is also responsible for the transport of degradative endosomes retrogradely in the dendrites. (wikipedia.org)
While a postdoctoral student at MIT, Tomomi Kiyomitsu discovered how dynein has a role as a motor protein in aligning the chromosomes in the middle of the cell during the metaphase of mitosis. (wikipedia.org)
[12] This suggests that proline-rich sequences may be a major binding site that co-opts dynein. (wikipedia.org)
Shown is the order of regions of interest for human cytoplasmic dynein 2 motor domains as they occur from the linker to C-terminal. (wikipedia.org)
transport is driven by the microtubule motor protein cytoplasmic dynein, with motor activity regulated by a sequential series of adaptors. (bvsalud.org)
GTP-bound ARF6 promotes formation of the JIP3/4-dynein-dynactin complex. (bvsalud.org)
Either knockdown or overexpression of RAB10 stalls transport, suggesting that this GTPase is also required to coordinate the opposing activities of bound dynein and kinesin motors. (bvsalud.org)

To connect microscopic dynamics to macroscale behaviors we measured the phase diagram of a new system of microtubule filaments and end-accumulating kinesin molecular motors. (aps.org)

While it is clear, that RNA distribution patterns in neurons are created by active transport processes of mRNPs along microtubules, the essential enzymatic activities required are not known. (europa.eu)
The growing family of myosin motors and their role in neurons and sensory cells. (embl.de)
Decreased synaptic vesicle transport in neurons that control muscle movement (motor neurons), leading to impaired growth of neurons, is thought to contribute to the muscle weakness and atrophy experienced by people with SMA-LED. (medlineplus.gov)
The active transport of membrane-bound organelles such as mitochondria along the cytoskeleton is essential in most eukaryotic cells, but is especially important in neurons. (upenn.edu)
Neurons are highly polarized cells, with axons that can extend up to one meter, making them uniquely dependent on motor-driven transport. (upenn.edu)
In this animal, the motor neurons of the brain and spinal cord deteriorate at 3-4 months of age and the mouse becomes paralyzed. (utoledo.edu)
and protects motor neurons from microglial toxicity, all of which activities would benefit CNS tissue afflicted by ALS. (utoledo.edu)
When glutamate delivers a signal between two neurons that haven't spoken before, the activity primes the pump. (additudemag.com)
When this protein is misfolded, it creates toxic aggregates, causing progressive degeneration of motor neurons in the brain, brainstem, and spinal cord. (business-politika.net)
These findings highlight the complex coordination of motor regulation during organelle transport in neurons. (bvsalud.org)

Conservation within the myosin motor domain: implications for structure and function. (embl.de)
The myosin motor domain, the light chain binding neck and the tail domain of the heavy chain are indicated. (elifesciences.org)

The cadherin cytoplasmic tail binds β-catenin (Armadillo [Arm]), that links to α-catenin (α-cat), which binds F-actin. (rupress.org)
Here we define the precise Rab29 binding region of the LRRK2 Armadillo domain between residues 360-450 and show that this domain, termed 'Site #1', can also bind additional LRRK2 substrates, Rab8A and Rab10. (stanford.edu)

The thyrotropin-releasing hormone (TRH) analog taltirelin is of high pre-clinical interest given its neuronal-stimulant properties, minimal endocrine activity, tongue muscle activation following microperfusion into the hypoglossal motor nucleus (HMN) or systemic delivery, and high TRH receptor expression at the HMN compared to rest of the brain. (nature.com)
Findings also identify that a muscarinic receptor mechanism mediates the strong hypoglossal motor inhibition in rapid eye movement (REM) sleep 16 . (nature.com)
Chemoattractants or chemorepellents bind to the transmembrane receptor transmitted a signal to CheW and CheA. (ucsb.edu)
Previously, research showed that CheA interacts with a transmembrane receptor, but how CheA and receptor interact with each other and activate kinase activity are unknown. (ucsb.edu)
Our results indicated that Tsr receptor mutant, I384A, interfered with the binding sites of the ternary complex. (ucsb.edu)
conformational changes, energy-driven molecular motors, and receptor-triggered infection machines. (mdpi.com)
develops when toxin produced by Clostridium botulinum spores irreversibly binds to a specific receptor (synaptotagmin II) on the presynaptic terminal cholinergic nerve endings. (msdmanuals.com)

Predicted to enable ATP binding activity and MAP kinase activity. (wormbase.org)

This signaling complex regulates CheA phosphorylation activity. (ucsb.edu)
Work done using smooth muscle myosin and mammalian non-muscle myosin have demonstrated that phosphorylation of the RLC at conserved Serine and Threonine sites ( Figure 1B , Serine-19 and Threonine-18) activates myosin motor activity, enhances the affinity of myosin for actin, and promotes myosin filament assembly ( Heissler and Sellers, 2016 ). (elifesciences.org)
However, it has not been biochemically demonstrated that Drosophila myosin motor activity and filament assembly is regulated by RLC phosphorylation or whether the extent of activation is similar to that of mammalian systems. (elifesciences.org)

This has revealed remarkably poor overall conservation at the site thought to be involved in actin binding, but several highly conserved residues have been identified that may be functionally important. (embl.de)
The vacuolar ATPase (V-ATPase) is a highly conserved rotary motor proton pump that plays an essential role in cellular housekeeping functions. (upstate.edu)

The structure of myosin is known, but the actin-binding site is not well defined, and the mechanisms by which actin activates ATP hydrolysis by myosin, and myosin moves relative to the actin filament, developing force, are not fully understood. (embl.de)
Conserved residues in the motor domain have been positioned within the framework provided by the recent crystal structures, thus helping to define those residues involved in actin and ATP binding, in hydrolysis and in conformational change. (embl.de)
The motor domain catalyzes the hydrolysis of ATP to power the translocation of actin filaments, a function referred to as motor activity. (elifesciences.org)
V-ATPase is made of two subcomplexes: a cytosolic V 1 that carries out ATP hydrolysis, and a membrane bound V o that is responsible for proton translocation. (upstate.edu)
Unlike reversible disassembly, which requires ATP hydrolysis on V 1 to break protein-protein interactions, Oxr1p mediated disassembly of V-ATPase is ATP independent and therefore a novel mode of activity regulation. (upstate.edu)

It prepares and encourages nerve cells to bind to one another, which is the cellular basis for learning new information. (additudemag.com)

We show that NQO1apo has a minimally stable folded core holding the protein dimer and with FAD and dicoumarol ligand binding sites populating binding non-competent conformations. (preprints.org)
Our work provides an experimental perspective into the communication of stability effects through the NQO1 dimer, valuable to understand at the molecular level the effects of disease-associated variants, post-translation modifications and ligand binding cooperativity in NQO1. (preprints.org)

Myosin XVA is a large actin-based motor protein. (hindawi.com)

The model with DNA suggests that the beta-hairpin partly blocks the active site, and in vivo activity assays show that the nuclease domain is not functional in the absence of the ATPase domain. (rcsb.org)
Here we test the hypothesis that taltirelin increases HMN activity and/or responsivity to excitatory stimuli applied across sleep-wake states in-vivo. (nature.com)
Three comparisons were made between in vitro binding and in vivo exposure data, namely: 1) mouse brain-to-plasma exposure versus unbound plasma-to-unbound brain fraction ratio (fu plasma /fu brain ), 2) cerebrospinal fluid-to-brain exposure versus unbound brain fraction (fu brain ), and 3) cerebrospinal fluid-to-plasma exposure versus unbound plasma fraction (fu plasma ). (aspetjournals.org)
[11] Not much is known about virus' motor-specific binding sites, but it is known that some viruses contain proline-rich sequences (that diverge between viruses) which, when removed, reduces dynactin binding, axon transport (in culture), and neuroinvasion in vivo. (wikipedia.org)
Here, combining the biochemical analysis of enzymatic and motile properties for purified myosin mutants with in vivo measurements of apical constriction for the same mutants, we show that in vivo constriction rate scales with myosin motor activity. (elifesciences.org)

Gain-of-function mutations in the LRRK2 gene cause Parkinson's disease (PD), characterized by debilitating motor and non-motor symptoms. (bvsalud.org)

Although, the non-muscle myosin II holoenzyme (myosin) is a molecular motor that powers contraction of actin cytoskeleton networks, recent studies have questioned the importance of myosin motor activity cell and tissue shape changes. (elifesciences.org)
We study cell biology within the Perelman School of Medicine at the University of Pennsylvania , researching molecular motors and the cytoskeleton, autophagy and mitophagy, the cell biology of the neuron, and neurodegeneration. (upenn.edu)
The chemi- appear to interact with the structural elements of the cell, cal analysis was assessed at DATA CHEM Laboratories using plasma- with apparent binding to the cytoskeleton [Porter et al. (cdc.gov)

An un-biased screen identified additional targets of high interest to modulate hypoglossal activity for potential OSA pharmacotherapy, and provided a database of them with FDA-approved drugs 10 . (nature.com)

The encoded protein contains an N-terminal motor domain which includes nucleotide-binding and microtubule-interacting regions, a stalk domain containing a predicted coiled coil motif and a C-terminal tail domain. (nih.gov)

Not surprisingly, V-ATPase activity (or loss thereof) has been linked to several disease states including renal tubular acidosis, osteoporosis, neurodegeneration, and cancer. (upstate.edu)
A recent study from the Wilkens lab in collaboration with Seoul National University uncovered a novel mechanism of yeast V-ATPase regulation based on biochemical experiments and cryo electron microscopy (cryo-EM) structures of holo V-ATPase and Oxr1 bound V 1 subcomplex. (upstate.edu)
Biochemical experiments showed that Oxr1p binds and promotes V-ATPase disassembly. (upstate.edu)

molecular motor. (embl.de)
Forces that shape cells and tissues can be produced by the contraction of actin filament (F-actin) meshworks by the molecular motor Myosin II (myosin). (nature.com)

Continuing, The Forebrain: Development, Physiology and Functions aims to show the existence of specific neuronal populations in basal forebrain linking with specific sensory, motor and prefrontal cortices. (novapublishers.com)
These are called fine motor, gross motor, and sensory skills - and they all make up an important part of your child's development. (first5california.com)
The rest are sensory in nature, although the largest sensory receptors, the neuromuscular spindles, have a motor supply of their own. (medscape.com)

This spiral-bound, travel-friendly tablet features 32 wipe-clean pages and an included dry-erase pen to help children master handwriting skills and letter recognition. (michaels.com)
This take-along, spiral-bound book includes four connect-the-dots challenges, scenes to color, and search-and-find activities for each scene. (hobbyexpressinc.com)

This nuclease activity is tightly regulated as the enzyme is inactive for the duration of DNA translocation. (rcsb.org)

This course examines dynamic properties of macromolecules, their interactions, catalytic activities, and methods for analyzing their behavior. (yale.edu)

This change and the other BICD2 gene mutations increase the activity of the BICD2 protein. (medlineplus.gov)

In the low-moderate activity regime, we identify the sequences of bifurcations leading to the development of steady and periodic coherent flows. (aps.org)

What other molecules might bind CRMP2? (utoledo.edu)

The defect in the myosin motor activity in these mutants is evident in developing Drosophila embryos where tissue recoil following laser ablation is decreased compared to wild-type tissue. (elifesciences.org)
Overall, our data highlights that myosin activity is required for rapid cell contraction and tissue folding in developing Drosophila embryos. (elifesciences.org)

BACKGROUND: Myosins are motors that use energy supplied by ATP to travel along actin filaments. (embl.de)
Extensive efforts over the past few years have focused on understanding the non-equilibrium macroscale behaviors of filamentous biopolymers such as microtubules and actin filaments that are driven by associated molecular motors. (aps.org)
The motor domain at the N-terminus of the myosin heavy chain binds actin filaments in an ATP-dependent manner. (elifesciences.org)
RhoA activity results in the assembly of myosin II and anti-parallel actin filaments into the structure of the contractile ring. (jove.com)

When mediated by nutrient levels, the process is reversible and catalytic-activity dependent. (upstate.edu)

Pharyngeal muscle activity and responsiveness are key pathophysiological traits in human obstructive sleep apnea (OSA) and strong contributors to improvements with pharmacotherapy. (nature.com)

Nerve Chemical-Warfare Agents Nerve agents are chemical-warfare agents that act directly at nerve synapses, typically increasing the activity of acetylcholine. (msdmanuals.com)
Only 60% of the axons in the nerve to a given muscle are motor to the muscle fibers that make up the bulk of the muscle. (medscape.com)

Here, we propose that the nuclease activity is regulated by movement of the beta-hairpin, altering active site access and the orientation of catalytically essential residues. (rcsb.org)

About 80 percent of the signaling in the brain is carried out by two neurotransmitters that balance each other's effect: Glutamate stirs up activity to begin the signaling cascade, and gamma aminobutyric acid (GABA) clamps down on activity. (additudemag.com)

One mechanism of contraction involves myosin motor activity. (jove.com)

A motor unit comprises a motor neuron in the spinal cord or brainstem together with the squad of muscle fibers it innervates. (medscape.com)

Contributes to microtubule motor activity. (wormbase.org)

however, relatively less is known about the determinants of tissue binding. (aspetjournals.org)
However, many of the critical pharmacokinetic implications can be derived from information regarding the overall extent of tissue binding estimated nonspecifically. (aspetjournals.org)
With relatively few assumptions, qualitative insight into the extent of tissue binding is easily obtained by pairing distribution measures with unbound plasma fraction. (aspetjournals.org)
Each muscle fascicle represents a group of muscle fibers bound together by a layer of connective tissue termed the perimysium. (medscape.com)

A key component of OSA pathogenesis is the impact of sleep mechanisms on pharyngeal muscle tone and compensatory motor responses. (nature.com)
We explore the molecular mechanisms that lead to the coordinated activity of molecular motors during long-distance transport. (upenn.edu)

Organophosphate Poisoning and Carbamate Poisoning Organophosphates and carbamates are common insecticide ingredients that inhibit cholinesterase activity, causing acute muscarinic manifestations (eg, salivation, lacrimation, urination, diarrhea. (msdmanuals.com)

To date, less is known on the effects of gross motor movements that do not fall into the category of sports-related aerobic or anaerobic exercise. (frontiersin.org)
Less is known on the effects of gross motor movements on the cognitive system that do not fall into the categorization of aerobic or anaerobic exercise. (frontiersin.org)

Neuroinflammation is a specific type of innate immune response that occurs in the brain during many, perhaps all, neurodegenerative diseases (including Alzheimer's disease, Parkinson's disease, Huntington's disease and various motor neuron diseases). (utoledo.edu)
Background: Parkinson's disease (PD) is the most prevalent neurodegenerative motor disorder. (lu.se)

the activity of "driving" and collecting (pull, release, crawl) benefits large muscle groups and coordination, too. (albeebaby.com)
ALS (Amyotrophic Lateral Sclerosis) is a devastating neurodegenerative disease that affects the body's ability to control muscle activity. (business-politika.net)
Motor points have been identified for all major muscle groups for the purpose of functional electrical stimulation by physical therapists, in order to increase muscle power. (medscape.com)
The axons supply single motor endplates placed about halfway along the muscle fibers. (medscape.com)
In large muscles (eg, the flexors of the hip or knee), each motor unit contains 1200 or more muscle fibers. (medscape.com)

Dicoumarol binding further stabilizes all three functional sites, a result not previously anticipated by available crystallographic models. (preprints.org)

Current research demonstrates beneficial effects of physical activity on brain functions and cognitive performance. (frontiersin.org)
In previous studies, we found beneficial effects of dynamic working environments, i.e., environments that encourage movements during cognitive task performance, on cognitive performance and corresponding brain activity. (frontiersin.org)
In previous studies, we investigated the effects of dynamic sitting on brain activity and cognitive performance. (frontiersin.org)
Disentangling Inhibition-based and Retrieval-based After-Effects of Distractors: Cognitive versus Motor Processes. (uni-trier.de)

Other systemic symptoms may include mydriasis, dry mouth, constipation, urinary retention, and tachycardia due to unopposed sympathetic nervous system activity (anticholinergic syndrome). (msdmanuals.com)

Feldman peppered LeAlcala with questions on how the fingerprints were gathered, who had access to the motor home, what steps were taken to avoid contaminating the evidence, and on her experience level and education all in an apparent quest to call into question the believability of the evidence. (freerepublic.com)

This differential effect on tonic motor activity versus responsivity informs human studies of the potential beneficial effects of taltirelin on pharyngeal motor control and OSA pharmacotherapy. (nature.com)

Binding Abstract Concepts. (uni-trier.de)

In closing, the authors discuss the putative involvement of Reelin signal in motor-related impairments observed in neurological diseases, including lissencephaly, psychiatric disorders and brain injuries. (novapublishers.com)

From another aspect, 17β-Estradiol, melatonin, metformin, rapamycin, coenzyme Q10, N-acetyl cysteine, and vitamin C were the most studied agents, while the main protective mechanism was through telomerase activity enhancement or oxidative damage ablation. (magiran.com)

EEG oscillatory patterns indicate beneficial effects of dynamic office environments on attentional and vigilance performance that are mediated by increased motor activity. (frontiersin.org)
It's that simple but very beneficial to enhance those motor skills. (teachingexpertise.com)
This one might be a bit more challenging for students than the first few, but it will be highly beneficial to motor strength development. (teachingexpertise.com)
Using a tray for different cutting activities is really beneficial, not only to your kiddos but also to you! (teachingexpertise.com)

These group activities are designed with the non-trainer in mind. (reviewing.co.uk)

Repeated MDMA ("Ecstasy") exposure in adolescent male rats alters temperature regulation, spontaneous motor activity, attention, and serotonin transporter binding. (umassmed.edu)
Effects of a short-course MDMA binge on dopamine transporter binding and on levels of dopamine and its metabolites in adult male rats. (umassmed.edu)

This super simple scissor skill activity literally only involves a piece of paper and a little bit of time. (teachingexpertise.com)

Dendritic localisation of CaMKIIa-mRNA requires its 3'UTR harbouring binding sites for RBPs as FMRP and Staufen2, which are required for its correct localisation. (europa.eu)
Binding of FAD significantly decreases protein dynamics and stabilizes the FAD and dicoumarol binding sites as well as the monomer:monomer interface. (preprints.org)

Anatomy60

Organisms11

Diseases18

Chemicals and Drugs60

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Psychiatry and Psychology24

Phenomena and Processes62

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science5

Health Care1

Proteins15

Dynein7

Kinesin1

Neurons10

Myosin motor domain2

Armadillo2

Receptor7

Kinase activity1

Phosphorylation3

Highly conserved2

Hydrolysis5

Cellular1

Ligand2

Actin-based1

Vivo5

LRRK21

Cytoskeleton3

Modulate1

Tail1

ATPase3

Molecular motor2

Sensory3

Spiral-bound2

Enzyme1

Behavior1

Mutations1

Sequences1

Molecules1

Drosophila2

Filaments4

Catalytic1

Responsiveness1

Nerve2

Residues1

Glutamate1

Contraction1

Spinal1

Contributes1

Tissue4

Mechanisms2

Muscarinic1

Gross motor2

Parkinson's2

Muscle5

Functional1

Cognitive4

Systemic1

Apparent1

Versus1

Abstract1

Diseases1

Mechanism1

Beneficial4

Group1

Rats2

Involves1

Sites2