Binds human chlamydia trachomatis. Medical search. Frequent questions

Microtiter wells as a solid phase are coated with inactivated Elementary Bodies Chlamydia trachomatis antigen. (globaldiagnosticsb.com)
Another serious human pathogen, Bacillus anthracis, causative of anthrax , has well-developed virulence mechanisms involving the secretion of three proteins, one of which, protective antigen (PA), binds host cell receptors to effect entry of either lethal factor (LF) or edema factor (EF). (immunology.org)
Diagnostic Automation offers a OneStep Chlamydia RapiCard InstaTest is a rapid immunoassay for direct qualitative detection of Chlamydia trachomatis antigen endocervical or endourethral swab specimens. (rapidtest.com)
The OneStep Chlamydia Rapid Test utilizes the chemical extraction of a carbohydrate antigen from Chlamydia followed by the utilization of migratory color immunoassay technology for the qualitative detection of Chlamydia trachomatis. (rapidtest.com)
If Chlamydia trachomatis antigen is present, the labeled antibody dye conjugate bind to it, forming an antibody antigen complex. (rapidtest.com)

A common sexually transmitted infection caused by the bacterium Chlamydia trachomatis . (hivedmonton.com)
3,4 Altered protein expression and variation of genetic makeup of SP-D has been shown in a number of extra-pulmonary pathologies, such as rheumatoid disease, problems of organs such as the skin, intestines and the renal system etc. 3,4 Human SP-D also appears to play distinct roles in controlling generalised infection, allergy and inflammation. (org.pk)
Novel Recombinant 15-kDa Polypeptide and Use of Same in Detecting Human Infection with Bartonella henselae. (genesisbiotechgroup.com)
Chlamydia trachomatis is the leading cause of both bacterial sexually transmitted infection and infection-derived blindness world-wide. (plos.org)
Related to erythromycin, azithromycin is considered by many to be the treatment of choice for Chlamydia trachomatis genitourinary infection because it may be administered in a single dose, which improves adherence to treatment. (medscape.com)
Chronic infections, particularly those which are primarily characterized by an asymptomatic intracellular life cycle, e.g., latent Mycobacterium tuberculosis infection (LTBI), hepatitis B virus (HBV) infection, Chlamydia trachomatis infection, cytomegalovirus (CMV) or Epstein-Barr virus (EBV) infections, present a unique premise to decipher the fine balance between protective host immune responses, immunopathology and full-fledged clinical disease. (frontiersin.org)
Here, we systematically assessed the importance of the microtubule cytoskeleton for infection by Chlamydiae, which are obligate intracellular bacteria that are of great importance for human health. (bvsalud.org)
The elimination of microtubules in human HEp-2 cells prior to C. pneumoniae infection profoundly attenuated the infection efficiency, demonstrating the need for microtubules for the early infection processes. (bvsalud.org)
In patients with APS, antibiotics are used for treatment of presumptive C trachomatis and U urealyticum infection. (medscape.com)
The Chlamydia Rapid Test is a meaningful test for point-of-care diagnosis of a chlamydia infection. (rapidtest.com)
Subsequently meat, dairy products and water serve as key vehicles in the transmission of MAP infection to humans (from farm to fork) who have a genetic predisposition, thus leading to the development of CD. (wjgnet.com)

Other organisms include genital mycoplasmas, Chlamydia trachomatis and Neisseria gonorrhoeae . (aafp.org)
It is also effective against most isolates of ocular pathogens like Chlamydia pneumoniae, Chlamydia trachomatis, Moraxella catarrhalis, Mycoplasma hominis, Mycoplasma pneumoniae & Neisseria gonorrhoeae. (aristopharma.com)

Chlamydia trachomatis is an obligate intracellular human pathogen that exhibits stage-specific gene transcription throughout a biphasic developmental cycle. (plos.org)
We report that chlamydiae, which are obligate intracellular bacterial pathogens, can inhibit interferon (IFN)-γ-inducible major histocompatibility complex (MHC) class II expression. (silverchair.com)
Chlamydia is an obligate intracellular bacterial pathogen ( 19 ) and the causative agent of many important human diseases ( 20 , 21 ). (silverchair.com)

Mammalian host cells have also evolved an array of pattern recognition receptors for microbes or microbial factors, such as the Toll-like receptors (TLRs), which when bound, trigger intracellular signalling cascade(s) with antimicrobial effects. (immunology.org)
These results reveal a novel immune evasion strategy used by the intracellular bacterial pathogen chlamydia that improves our understanding of the molecular basis of pathogenesis. (silverchair.com)
Liang P, Rosas-Lemus M, Patel D, Fang X, Tuz K, Juárez O (2017) Dynamic Energy Dependency of Chlamydia trachomatis on Host Cell Metabolism during Different Stages of Intracellular Growth: Possible role of Sodium -based energetics in Chlamydial ATP generation. (iit.edu)

This article is confined to human microbial pathogens, although plant and animal pathogens are also widespread in nature. (immunology.org)
Chlamydia trachomatis is one of the most common sexually transmitted pathogens. (rapidtest.com)

Azithromycin binds to the 50S subunit of the 70S bacterial ribosomes, and therefore inhibits RNA-dependent protein synthesis in bacterial cells. (illumina.com)
This study provides evidence that a switch-protein kinase regulatory network controls availability of σ 66 , the main sigma subunit for transcription in Chlamydia . (plos.org)
Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. (nih.gov)
It binds to the 50S ribosomal subunit of the bacteria, thereby inhibiting bacterial protein synthesis. (medscape.com)
The B subunit portion of cholera toxin (CTB) is a safe and effective oral immunizing agent in humans, affording protection against both cholera and diarrhoea caused by enterotoxigenic Escherichia coli producing heat-labile toxin (LT) (Clemens et al. (curehunter.com)
Inhibits bacterial protein synthesis by inhibiting peptide chain initiation at the bacterial ribosome where it binds preferentially to the 50S ribosomal subunit, causing bacterial growth inhibition. (medscape.com)
The antibiotic binds preferentially to the 50S ribosomal subunit and affects the process of peptide chain initiation. (theodora.com)
Strickland M, Juárez O, Neehaul Y, Cook DA, Barquera B, Hellwig P. (2014) The conformational changes induced by ubiquinone binding in the Na+-pumping NADH:ubiquinone oxidoreductase (Na+-NQR) are kinetically controlled by conserved glycines 140 and 141 of the NqrB subunit. (iit.edu)
Shea ME, Juárez O, Cho J, Barquera B. (2013) Aspartic acid 397 in subunit B of the Na+-pumping NADH:quinone oxidoreductase from Vibrio cholerae forms part of a sodium-binding site, is involved in cation selectivity, and affects cation-binding site cooperativity. (iit.edu)
Juárez O, Neehaul Y, Turk E, Chaubon N, Hellwig P and Barquera B. (2012) The role of Glycine residues 140 and 141 of NqrB subunit in the ubiquinone binding site of the sodium -dependent NADH dehydrogenase. (iit.edu)
It acts by binding to the 50S ribosomal subunit of susceptible microorganisms and interfering with microbial protein synthesis. (aristopharma.com)
by binding to the 50S subunit of the ribosome, they inhibit bacterial protein synthesis. (msdmanuals.com)

Prevalence and persistence of Chlamydia trachomatis-specific antibodies after occasional and recurrent infections. (ppshp.fi)
This mode of growth is known as persistence and how C . trachomatis senses stress and responds in this manner is an important area of research. (plos.org)

Erythromycin acts by inhibition of protein synthesis by binding 50S ribosomal subunits of susceptible organisms. (nih.gov)
Antibiotic coverage for Bacteroides, group B and A streptococci, Enterobacteriaceae organisms, and Chlamydia trachomatis in endometritis is suggested. (medscape.com)

Expression of glycosaminoglycan-binding proteins depends on growth and culture conditions in bacteria, and differs in various phases of parasite development. (microbiologyresearch.org)
Whether or not glycosaminoglycan-binding proteins mediate invasion of epithelial cells is a matter of controversy. (microbiologyresearch.org)
Erythromycin is largely bound to plasma proteins. (nih.gov)
Tetracyclines are readily absorbed and are bound to plasma proteins in varying degree. (nih.gov)
Ampicillin binds to penicillin-binding proteins, which inhibit bacterial cell wall synthesis by inhibiting the final transpeptidation step of peptoglycan synthesis in bacterial cell wall. (medscape.com)
It binds to penicillin-binding proteins, thereby inhibiting bacterial cell wall growth. (medscape.com)
Targeted capture of Chinese hamster ovary host cell proteins: Peptide ligand binding by proteomic analysis. (ncsu.edu)

Doxycycline, a well-absorbed tetracycline derivative, is the second drug of choice for genital chlamydia infections. (medscape.com)
In addition to being a passage for sperm, menstruum, and the baby, the human vagina and its microbiota can influence conception, pregnancy, the mode and timing of delivery, and the risk of acquiring sexually transmitted infections. (frontiersin.org)
Vibramycin I.V. ( doxycycline hyclate) is a tetracycline antibiotic used to treat many different bacterial infections such as urinary tract infections acne gonorrhea and chlamydia periodontitis (gum disease) and others. (rxlist.com)
In 1985, CDC published Policy Guidelines for Prevention and Control of Chlamydia trachomatis infections (1). (cdc.gov)
Those guidelines highlighted the prevalence and morbidity of chlamydial infections and stressed the need to include antibiotics effective against chlamydia when treating patients for urethritis, mucopurulent cervicitis, and pelvic inflammatory disease. (cdc.gov)
Because chlamydial infections are common among adolescents and young adults throughout the United States, health-care providers and other agencies serving these groups should become more involved if a sufficiently large proportion of the chlamydia-infected population is to be reached. (cdc.gov)
Chlamydia trachomatis infections are common in sexually active adolescents and young adults in the United States (CDC, unpublished review). (cdc.gov)

Chlamydia pneumoniae is a respiratory tract pathogen but can also infect the central nervous system (CNS). (bvsalud.org)
Chlamydia pneumoniae (Cpn) has been reported to be involved in the pathogenesis of early atherosclerosis by inducing macrophage-derived foam cell formation in the presence of low-density lipoprotein (LDL). (bvsalud.org)

During incubation Chlamydia trachomatis-specific antibodies of high-analyte specimens and controls are bound to the immobilized antigens. (globaldiagnosticsb.com)
After a washing step to remove unbound sample and control material horseradish peroxidase conjugated anti-human IgA antibodies are dispensed into the wells. (globaldiagnosticsb.com)
During a second incubation this anti-IgA conjugate binds specifically to IgA antibodies resulting in the formation of enzyme-linked immune complexes. (globaldiagnosticsb.com)

The intensity of this color is directly proportional to the amount of Chlamydia trachomatis-specific IgA antibody in the sample specimen. (globaldiagnosticsb.com)
Sustained Cross-Reactive Antibody Responses After Human Papillomavirus Vaccinations: Up To 12 Years Follow-Up In The Finnish Maternity Cohort. (ppshp.fi)
When loaded with immune complexes (IC), consisting of tumor antigens bound to antitumor antibody, BMDC induce powerful antitumor immunity in mice. (stanford.edu)

Serum protein binding is variable in the concentration range approximating human exposure, decreasing from 51% at 0.02 µg/mL to 7% at 2 µg/mL. (illumina.com)
It is highly stable in normal human serum. (nih.gov)

When a pathogenic microorganism ( bacterium , viru s or protozoal parasite ) infects the human body, a battle ensues between the host's innate & adaptive immune systems and the pathogen's assorted virulence mechanisms and factors . (immunology.org)

The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. (curehunter.com)

Human PGLYRP4 is directly bactericidal for both Gram-positive (Bacillus subtilis, Bacillus licheniformis, Bacillus cereus, Lactobacillus acidophilus, Listeria monocytogenes, Staphylococcus aureus) and Gram-negative (Escherichia coli, Proteus vulgaris, Salmonella enterica) bacteria and is also active against Chlamydia trachomatis. (wikipedia.org)
In Gram-positive bacteria, human PGLYRP4 binds to the separation sites of the newly formed daughter cells, created by bacterial peptidoglycan-lytic endopeptidases, LytE and LytF in B. subtilis, which separate the daughter cells after cell division. (wikipedia.org)
The identification of specific binding to different glycosaminoglycan molecules by bacteria (e.g. (microbiologyresearch.org)
To sustain their virulence mechanisms, many bacteria can sequester free iron in the mammalian host, through the elaboration of iron-binding siderophores. (immunology.org)
Doxycycline binds to the 30S and, possibly, 50S ribosomal subunits of the bacteria, thereby inhibiting bacterial protein synthesis. (medscape.com)
Inhibits protein synthesis and thus bacterial growth by binding to 30S and possibly 50S ribosomal subunits of susceptible bacteria. (medscape.com)

Genomics of Ocular Chlamydia trachomatis after 5 years of SAFE interventions for trachoma in Amhara, Ethiopia. (cdc.gov)

Our lab conducts biomedical research directed to establish the metabolic strategies and host- pathogen relationship in bacterial pathogenic species, such as Chlamydia trachomatis , the most prevalent sexually transmitted disease in the world, and Vibrio cholerae , which produces severe gastrointestinal disease to millions of people in developing countries. (iit.edu)

Azithromycin, a semisynthetic antibiotic belonging to the macrolide subgroup of azalides, is used to treat STDs due to chlamydia and gonorrhea, community-acquired pneumonia, pelvic inflammatory disease, pediatric otitis media and pharyngitis, and Mycobacterium avium complex (MAC) in patients with advanced HIV disease. (illumina.com)
Penetrates prostate well and is effective against N gonorrhea and C trachomatis . (medscape.com)

Detection of Penicillin Tolerance in Group B Streptococcus: Single Nucleotide Polymorphisms in Penicillin Binding Protein 4. (genesisbiotechgroup.com)
The main advantages of this technique are to reduce the number of inadequate smears and to provide enough cells for the detection of infectious agents such as human papillomavirus (HPV) through molecular biology techniques [ 1 - 3 ]. (cytojournal.com)
The primary method for detection of Chlamydia is growth of the organism in cell culture. (rapidtest.com)

Many members of the human microbiome belong to phyla from which no isolates have been cultured owing to their unknown growth requirements, resulting in the widespread application of cultivation-independent methods to characterize the composition and function of the microbiome. (biomedcentral.com)
Whole genome sequencing of Plasmodium vivax isolates reveals frequent sequence and structural polymorphisms in erythrocyte binding genes. (cdc.gov)

To establish whether human-to-human transmission of influenza A H5N1 occurred in the healthcare setting in Vietnam, we conducted a cross-sectional seroprevalence survey among hospital employees exposed to 4 confirmed and 1 probable H5N1 case-patients or their clinical specimens. (cdc.gov)

Doxycycline has a high degree of lipoid solubility and a low affinity for calcium binding. (nih.gov)

Researchers at the Research Institute of the McGill University Health Centre (RI-MUHC) will embark on 31 new projects designed to accelerate discoveries of benefit to human health, thanks to the Canadian Institutes of Health Research (CIHR) Fall 2022 Project Grants Competition . (rimuhc.ca)

It is not known whether Azithromycin is excreted in human milk. (aristopharma.com)

Helicobacter pylori, Bordetella pertussis and Chlamydia trachomatis ), viruses (e.g., herpes simplex and dengue virus), and protozoa (e.g. (microbiologyresearch.org)
Trichomonas vaginalis, Chlamydia trachomatis , N. gonorrhoeae, Candida albicans, and Herpes simplex virus should be ruled out. (theodora.com)

Collectively, these data implicate TARP in signaling to the actin cytoskeleton remodeling machinery, demonstrating a mechanism by which C.trachomatis invades non-phagocytic cells. (elsevierpure.com)
Our results suggest a mechanism by which Chlamydia can tailor its growth rate to the conditions within the host cell. (plos.org)
These effects extend to human cancers and other murine cancer models, implicating a conserved systemic mechanism by which malignancies spread to distant organs. (stanford.edu)

Structural characterization of muropeptides from Chlamydia trachomatis peptid. (invivogen.com)

Chlamydia trachomatis and respiratory disease in infants. (medscape.com)
If transmitted to infants during birth, Chlamydia can cause conjunctivitis and pneumonia. (rapidtest.com)

CPn0443 bound and bundled microtubules in vitro and co-localized partially with microtubules in vivo in yeast and human cells. (bvsalud.org)

PGLYRP4 binds peptidoglycan, a polymer of β(1-4)-linked N-acetylglucosamine (GlcNAc) and N-acetylmuramic acid (MurNAc) cross-linked by short peptides, the main component of bacterial cell wall. (wikipedia.org)

Chlamydia trachomatis attachment to cells induces the secretion of the elementary body-associated protein TARP (Translocated Actin Recruiting Protein). (elsevierpure.com)

Drug becomes concentrated within macrophages and polymorphonucleocytes giving it good activity against Chlamydia trachomatis. (illumina.com)
The present study showed that in LDL-treated THP-1-derived macrophages, Cpn not only upregulated the expression of scavenger receptor A1 (SR-A1) and acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1), but it also downregulated the expression of ATP binding cassette transporters (ABCA1 and ABCG1) at both the mRNA and protein levels. (bvsalud.org)

It inhibits viral replication at the pyrophosphate-binding site on virus-specific DNA polymerases. (medscape.com)

Thus to protect itself from such virulence mechanisms, the host cell fights back by synthesising siderocalin receptors which competitively bind iron. (immunology.org)

Methods and Compositions for Detecting Serotypes of Chlamydia trachomatis Capable of Causing Lymphogranuloma Venereum. (genesisbiotechgroup.com)
Our report characterizes a complete signaling module, the Rsb network, that is capable of controlling the growth rate or infectivity of Chlamydia . (plos.org)

Long-term follow-up of human papillomavirus type replacement among young pregnant Finnish females before and after a community-randomised HPV vaccination trial with moderate coverage. (ppshp.fi)

An analog of the human albumin N-terminus (Asp- Ala-His-Lys) prevents formation of copper-induced reactive oxygen species. (ac.ir)

Passage of antimicrobial agents across the placenta and into fetal circulation is affected by the duration of the pregnancy and the protein-binding capacity of the drug. (aafp.org)

The DRG Chlamydia trachomatis IgA ELISA kit is a solid phase enzyme-linkedimmunosorbent assay (ELISA). (globaldiagnosticsb.com)

A model is proposed where the relative levels of active antagonist (RsbV1) and switch-protein anti-sigma factor (RsbW) control the availability of σ 66 and subsequently act as a molecular 'throttle' for Chlamydia growth and development. (plos.org)
The active ingredient, dihydrotestosterone is present in anabolic steroids due to the fact that high-molecular weight compounds, often referred to as steroids, are bound to the inactive end molecules of this hormone, anabolic steroids side effects medscape. (honeydrewmedia.com)

Recent advances in genome sequencing of single microbial cells enable the assignment of functional roles to members of the human microbiome that cannot currently be cultured. (biomedcentral.com)
Directed differentiation of human iPSC into insulin producing cells is improv. (invivogen.com)
Thus, diminished CIITA expression as a result of USF-1 degradation may account for the suppression of the IFN-γ-inducible MHC class II in chlamydia-infected cells. (silverchair.com)

Peptidoglycan recognition protein 4 (PGLYRP4, formerly PGRP-Iβ) is an antibacterial and anti-inflammatory innate immunity protein that in humans is encoded by the PGLYRP4 gene. (wikipedia.org)

Adolescents and young adults are at substantial risk of becoming infected with chlamydia. (cdc.gov)

Microbial binding of heparin may interfere with heparin-dependent growth factors. (microbiologyresearch.org)

Subsequently, the Human Genome Organization Gene Nomenclature Committee changed the gene symbols of PGRP-S, PGRP-L, PGRP-Iα, and PGRP-Iβ to PGLYRP1 (peptidoglycan recognition protein 1), PGLYRP2 (peptidoglycan recognition protein 2), PGLYRP3 (peptidoglycan recognition protein 3), and PGLYRP4 (peptidoglycan recognition protein 4), respectively, and this nomenclature is currently also used for other mammalian PGRPs. (wikipedia.org)
PGLYRP4, similar to PGLYRP3, has two peptidoglycan-binding type 2 amidase domains (also known as PGRP domains), which are not identical (have 34% amino acid identity in humans) and do not have amidase enzymatic activity. (wikipedia.org)
The C-terminal peptidoglycan-binding domain of human PGLYRP4 has been crystallized and its structure solved (in a free form and in a complex with peptidoglycan fragment, disaccharide-pentapeptide) and is similar to human PGLYRP1 and PGLYRP3. (wikipedia.org)
Thus, PGLYRP4 C-terminal PGRP domain has a preference for binding peptidoglycan fragments from Gram-positive cocci. (wikipedia.org)
These cell-separating endopeptidases likely expose PGLYRP4-binding muramyl peptides, as shown by co-localization of PGLYRP4 and LytE and LytF at the cell-separation sites, and no binding of PGLYRP4 to other regions of the cell wall with highly cross-linked peptidoglycan. (wikipedia.org)

No vaccine has proven protective to date in humans. (plos.org)

Recent advances in genetic manipulation of Chlamydia were employed to inactivate rsbV1 , as well as to increase the expression levels of rsbW or rsbV1 , in vivo . (plos.org)

Such an effort is now possible because of a) expanding educational efforts stimulated by the epidemic of acquired immunodeficiency syndrome and other sexually transmitted diseases, and b) the availability of chlamydia tests that are easy to use, economical, and accurate, thereby allowing health-care providers to diagnose and treat infected persons and their sex partners. (cdc.gov)
Objective-- This report presents national estimates of the percentage and number of This report is intended to provide persons in the U.S. population aged 15-44 who report behaviors that place them at reliable national estimates of some basic increased risk for acquiring or transmitting human immunodeficiency virus, or HIV. (cdc.gov)

The drug is excreted in human milk. (nih.gov)

Anatomy13

Organisms13

Diseases44

Chemicals and Drugs17

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Psychiatry and Psychology2

Phenomena and Processes6

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science4

Named Groups2

Health Care6

Geographicals1

Antigen5

Infection11

Neisseria2

Obligate intracellular3

Intracellular3

Pathogens2

Subunit12

Persistence2

Organisms2

Proteins7

Infections7

Pneumoniae2

Antibodies3

Antibody3

Serum2

Bacterium1

Epithelial cells1

Bacteria6

Genomics1

Prevalent1

Gonorrhea2

Detection3

Isolates2

Specimens1

Doxycycline1

20221

Azithromycin1

Herpes2

Mechanism3

Characterization1

Infants2

Vitro1

Bacterial cell wall1

Secretion1

Macrophages2

Inhibits1

Receptors1

Capable2

Papillomavirus1

Species1

Antimicrobial1

Enzyme1

Molecular2

Cells3

Innate1

Adults1

Microbial1

Peptidoglycan5

Protective1

Genetic1

Immunodeficiency2

Excreted in human milk1