• These data suggest that CREB proteins are involved in the regulation of granulopoiesis via C/EBPβ upregulation. (harvard.edu)
  • Results DIM, but not I3C, increased adipocyte differentiation through upregulation of peroxisome proliferator‐activated receptor γ and CCAAT/enhancer‐binding protein α. (researchgate.net)
  • C/EBPβ can interact with CREB, NF-κB, and other proteins, leading to a trans-activation potential. (wikipedia.org)
  • In addition, the transcripts of CRE binding (CREB) family proteins were readily detected in hematopoietic stem/progenitor cells. (harvard.edu)
  • CREB was upregulated, phosphorylated and bound to the CREs in response to GM-CSF stimulation. (harvard.edu)
  • Mounting evidence suggests that alterations in the ratio of the C/EBPβ-liver-enriched inhibitory protein isoform and the C/EBPβ-liver-enriched activating protein isoform may play a role in the development of breast cancer. (johnshopkins.edu)
  • Zahnow, CA 2002, ' CCAAT/enhancer binding proteins in normal mammary development and breast cancer ', Breast Cancer Research , vol. 4, no. 3, pp. 113-121. (johnshopkins.edu)
  • We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis binding sites and target genes, in breast cancer cells. (nature.com)
  • Gene deletion of individual C/EBP family members has demonstrated an essential role for C/EBPβ in normal mammary development, while transgenic and overexpression studies provide evidence that the dominant-negative C/EBPβ-liver-enriched inhibitory protein isoform induces proliferation in mammary epithelial cells. (johnshopkins.edu)
  • C/EBP proteins interact with the CCAAT (cytosine-cytosine-adenosine-adenosine-thymidine) box motif, which is present in several gene promoters. (wikipedia.org)
  • p30C/EBP alpha binds to the C/EBP sites within and activates reporter gene expression driven by the 422(aP2) and C/EBP alpha gene promoters. (duke.edu)
  • Figure 1: Summary of estrogen receptor and RNA PolII binding sites and correlation with nucleotide and gene number. (nature.com)
  • Figure 3: Estrogen receptor and RNA PolII binding relative to specific gene targets. (nature.com)
  • In the version of this article initially published online, the estrogen receptor and RNA PolII binding data were aligned incorrectly in the top panel of Figure 3, which represents estrogen receptor binding at the ESR1 gene region. (nature.com)
  • To demonstrate the flexibility and modular nature of the liposome system, 10 recombinant surface antigens representing distinct influenza virus strains were bound simultaneously to generate a highly multivalent protein particle that with 5 ng individual antigen dosing induced antibodies in mice that specifically recognized the constituent immunogens and conferred protection against heterologous H5N1 influenza virus challenge. (cdc.gov)
  • The molecular composition and binding epitopes of the immunoglobulin G (IgG) antibodies that circulate in blood plasma following SARS-CoV-2 infection are unknown. (cdc.gov)
  • C/EBP proteins also contain activation domains at the N-terminus and regulatory domains. (wikipedia.org)
  • All six members of this family exhibit a high sequence similarity in their C-terminal DNA binding domain and a more diverge regulatory N-terminus [ 1 , 2 ]. (biomedcentral.com)
  • Sterol regulatory element binding protein (SREBP)-1 is a transcription factor with important roles in the control of fatty acid metabolism and adipogenesis. (diabetesjournals.org)
  • C/EBP proteins are involved in different cellular responses, such as in the control of cellular proliferation, growth and differentiation, in metabolism, and in immunity. (wikipedia.org)
  • This protein is expressed in the mammalian nervous system and plays a significant role in the development and function of nerve cells. (wikipedia.org)
  • In contrast to the definitive role of the transcription factor, CCAAT/Enhancer binding protein α (C/EBPα), in steady-state granulopoiesis, previous findings have suggested that granulopoiesis during emergency situations, such as infection, is dependent on C/EBPβ. (harvard.edu)
  • It has been shown that C/EBPβ plays an important role in the consolidation of long-term memory, suggesting a very important role for this protein in the hippocampus [ 10 , 11 ] and Menard et al . (biomedcentral.com)
  • Intracellular zinc homeostasis regulated by a complex of EVER proteins and zinc transporter proteins may play a role in inhibiting EV-HPV expression. (medscape.com)
  • AMPK pathways inhibit biosynthetic pathways with energy consumption, such as protein, fatty acid and glycogen synthesis. (springer.com)
  • Multiple protein isoforms, including truncated, dominant negatives, are generated by translation of the C/EBPβ transcript or via proteolytic cleavage of the full-length C/EBPβ protein. (johnshopkins.edu)
  • Full-length (42 kDa) CCAAT/enhancer binding protein alpha (C/EBP alpha) (p42) has been implicated in the transcriptional activation of adipocyte genes including the 422(aP2) and C/EBP alpha genes during differentiation of 3T3-L1 preadipocytes. (duke.edu)
  • Scholars@Duke publication: A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity. (duke.edu)
  • ZnT-1/EVER has been found to bind the E5 protein, resulting in increased concentrations of free zinc in keratinocytes. (medscape.com)
  • 80%) against epitopes residing outside the receptor-binding domain (RBD). (cdc.gov)
  • The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is a candidate vaccine antigen that binds angiotensin-converting enzyme 2(ACE2), leading to virus entry. (cdc.gov)
  • Figure 4: Identification of enriched motifs within the estrogen receptor binding sites and validation of transcription factor binding. (nature.com)
  • Bae KM, Wang H, Jiang G, Chen MG, Lu L, Xiao L. Protein kinase C epsilon is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner. (famri.org)
  • Exposure of isolated human adipocytes to tumor necrosis factor-α (TNF-α) produced a marked and specific decrease in the mRNA encoding the SREBP1c isoform and completely blocked the insulin-induced cleavage of SREBP1 protein. (diabetesjournals.org)
  • The CEBPA gene provides instructions for making a protein called CCAAT enhancer-binding protein alpha. (medlineplus.gov)
  • This shortened protein is produced from one copy of the CEBPA gene in each cell, and it is believed to interfere with the tumor suppressor function of the normal protein produced from the second copy of the gene. (medlineplus.gov)
  • The somatic CEBPA gene mutations that have been identified in leukemia cells generally decrease the DNA-binding ability of CCAAT enhancer-binding protein alpha. (medlineplus.gov)
  • This RNA binds to DNMT1 and prevents CEBPA gene locus methylation. (nih.gov)
  • Domain organization of RNA polymerase alpha subunit: C-terminal 85 amino acids constitute a domain capable of dimerization and DNA binding. (nature.com)
  • The synthesis of fatty acids and cholesterol, the building blocks of membranes, is regulated by three membrane-bound transcription factors: sterol regulatory element-binding proteins (SREBP)-1a, -1c, and -2. (nih.gov)
  • This process is mediated by the major thermogenic factor uncoupling protein-1 and can be activated by certain stimuli, such as cold exposure, adrenergic compounds or genetic alterations. (degruyter.com)
  • HSF1 granule formation only requires the DNA binding competence and the trimerization of the factor. (rupress.org)
  • El FACTOR DE UNIÓN A CCAAT es estructuralmente un tipo distinto de proteína de unión aumentadora a CCAAT que consta de un trímero de tres subunidades diferentes. (bvsalud.org)
  • CCAAT-BINDING FACTOR is structurally distinct type of CCAAT-enhancer binding protein consisting of a trimer of three different subunits. (bvsalud.org)
  • B3 Ku binds to the C-terminal region of DNA-PK (amino acids 3002-3850) near the protein kinase domain (Jin et al. (nih.gov)
  • B7 The SH3 domain of c-Abl binds to the C-terminal region of DNA-PK (amino acids 3414-3850) and may compete with Ku for binding to the same region (Jin et al. (nih.gov)
  • The other type of mutation blocks the DNA-binding ability of CCAAT enhancer-binding protein alpha. (medlineplus.gov)
  • The luciferase assay confirmed that miR-155 can bind to the 3′ untranslated region of SMAD5 mRNA. (hindawi.com)
  • miR-155 transfection significantly decreased the expression of SMAD5 protein and mRNA in MC3T3-E1 cells under control media and the p-SMAD5 protein level during osteogenesis. (hindawi.com)
  • It is worth noting that ISL can strongly inhibit the mRNA and protein expression of Mincle (macrophage-induced c-type lectin) in BMDM and UUO. (scienceopen.com)
  • B10 HMG1 or 2 compete with Ku for binding to DNA-PK and stimulate DNA-dependent kinase activity in vitro in the absence of Ku (Yumoto et al. (nih.gov)
  • Absence of the tumor suppressor function of CCAAT enhancer-binding protein alpha is believed to disrupt the regulation of blood cell production, leading to the uncontrolled production of abnormal cells that occurs in acute myeloid leukemia. (medlineplus.gov)
  • One type leads to production of an abnormally short protein that interferes with the tumor suppressor function of normal versions of CCAAT enhancer-binding protein alpha. (medlineplus.gov)
  • C/EBP proteins are involved in different cellular responses, such as in the control of cellular proliferation, growth and differentiation, in metabolism, and in immunity. (wikipedia.org)
  • CCAAT enhancer-binding protein alpha is involved in the maturation (differentiation) of certain blood cells. (medlineplus.gov)
  • This protein is expressed in the mammalian nervous system and plays a significant role in the development and function of nerve cells. (wikipedia.org)
  • Only 1-2% of the mammalian genome is translated into proteins. (frontiersin.org)
  • Within this locus, HSF1 binds through direct DNA-protein interaction with a nucleosome-containing subclass of satellite III repeats. (rupress.org)
  • C9orf72-derived dipeptide repeats (DPRs) proteins have been regarded as the pathogenic cause of neurodegeneration in amyotrophic lateral sclerosis and frontotemporal dementia (C9-ALS/FTD). (bvsalud.org)
  • Genome-wide sequencing approaches have lead to the discovery of non-coding RNAs (ncRNAs), which account for approximately 98% of the entire genome output, compared to the remaining 2% corresponding to protein-coding transcripts ( 14 ). (frontiersin.org)
  • Insulin obviously upregulated hepcidin expression in HepG2 cells and enhanced signal transducer and activator of transcription 3 protein synthesis and DNA binding activity. (diabetesjournals.org)
  • A third recognition element in bacterial promoters: DNA binding by the alpha subunit of RNA polymerase. (nature.com)
  • The efficacy of macrophage-mediated inflammatory responses relies on the coordinated expression of key proteins involved in macrophage activation and polarization processes, whose expression is finely regulated at both transcriptional and post-transcriptional levels ( 4 - 9 ). (frontiersin.org)
  • In this study, we found that miR-155 expression was downregulated in a time-dependent manner in cells of the preosteoblast cell line MC3T3-E1 after osteogenic induction using bone morphogenetic protein 2 (BMP2). (hindawi.com)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • More interestingly, when dealing with TDB, a ligand of Mincle, it revealed significant reversal of protein expression levels as that observed with ISL. (scienceopen.com)
  • Treatment with DpdtpA attenuated the increase in the expression of NF-κB and production of inflammatory cytokines, IL-1ß, IL-6 and IL-10, in rat microglial cells induced by expression of human tau40 proteins. (bvsalud.org)
  • The isoprenoids are lipid moieties that are added to various proteins, including Ras, Rho, and Rac of small G proteins during posttranslational modification (prenylation), and anchor these proteins to the cell membrane ( 2 ). (aacrjournals.org)
  • This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. (cancerindex.org)
  • Moreover, we found that (PR)50 induces mdm2 mistranslocation from the nucleus to the cytoplasm and competitively binds to p53, reducing mdm2-p53 interactions in the nucleus in two different (PR)50 transfected cells. (bvsalud.org)
  • 1993) and has helicase activity, but ssb-bound Ku does not activate DNA-PK (Smider et al. (nih.gov)
  • The mutations result in a shorter version of CCAAT enhancer-binding protein alpha. (medlineplus.gov)
  • It can also form heterodimers with the related protein CEBP-alpha. (nih.gov)
  • Mutations that alter the ability of the Escherichia coli cyclic AMP receptor protein to activate transcription. (nature.com)
  • Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. (cancerindex.org)
  • Osteogenesis was induced by adding 200 ng/mL bone morphogenetic protein 2 (BMP2) into the complete media for cell culture for 14 days [ 12 ]. (hindawi.com)
  • The CERM contains a variant E2F-recognition element, and binds a complex (termed CERC) consisting of E2F4, DP1, and either p130 or p107, as well as an unidentified necessary component. (nih.gov)
  • Li, M., Moyle, H. & Susskind, M. M. Target of the transcriptional activating function of phage lambda cl protein. (nature.com)
  • Location, structure and function of the target of a transcription activator protein. (nature.com)
  • Chen, Y., Ebright, Y. W. & Ebright, R. H. Identification of the target of a transcription activator protein by protein-protein photocrosslinking. (nature.com)
  • DNA-PK does not bind detectably to Ku in the absence of DNA. (nih.gov)
  • A class of proteins that were originally identified by their ability to bind the DNA sequence CCAAT. (bvsalud.org)
  • Tau protein hyperphosphorylation and formation of intracellular neurofibrillary tangles (NFTs) are one of the histopathological hallmarks of Alzheimer's disease (AD) and positively correlated with the severity of AD symptoms. (bvsalud.org)
  • BAT, in contrast to WAT, dissipates energy through a process called uncoupled respiration mediated by uncoupling protein-1 (UCP1), resulting in increased fatty acid oxidation and heat production (thermogenesis) [7, 8]. (degruyter.com)