Binds adapter proteins. Medical search. Frequent questions

Adaptor proteins, such as the sequestosome 1/p62-like receptors, which directly bind to cargos, contribute to specific molecular targeting. (nature.com)
Reelin receptors and intracellular adaptor protein Dab1 were found to be necessary for formation of the aggregates. (jneurosci.org)
Secreted IFN-α/β and IFN-λ bind to their specific receptors (IFNAR and IFNLR) in infected and neighboring cells. (cdc.gov)
Proteins that enhance gene expression when associated with ligand bound activated NUCLEAR RECEPTORS. (bvsalud.org)
Alternatively nuclear receptor coactivators can function as adaptor proteins that bring nuclear receptors into close proximity with transcriptional complexes. (bvsalud.org)
Arrestins are best known for their role in homologous desensitization of G protein-coupled receptors (GPCRs). (bvsalud.org)
G protein-coupled receptor kinases (GRKs) and arrestins terminate signaling by G protein-coupled receptors exerting a powerful influence on receptor functions. (bvsalud.org)
Chemokine secretion was reduced upon inhibition of NF-kappaB, as predicted by upstream regulator analysis of the transcriptomics data, and Toll-like receptors (TLRs) and their adaptor molecule, MyD88 were shown to be important for CCL5 secretion. (cdc.gov)

Adaptor proteins, GRB2 and SOS, are then sequentially recruited to stimulate the release of GDP from KRAS which permits binding of GTP to activate KRAS. (hindawi.com)
The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. (joplink.net)
GRB2 (growth factor receptor-bound protein 2), an adaptor protein involved in signal transduction, contains a central SH2 domain flanked by two SH3 domains. (rndsystems.com)
Tyrosine phosphorylation of GRB2 SH3 domains reduces binding to Sos and negatively regulates downstream signaling pathways including Ras, JNK and MAPK. (rndsystems.com)
Phosphorylation of EGFR at Y1086 specifically allows binding of the adaptor protein GRB2, leading to activation of the MAPK pathway. (thermofisher.com)

BRAF is a protein kinase and part of the MAP kinase signalling cascade which involves transduction of a growth signal from the cell membrane to the nucleus via a chain of protein kinases and is responsible for cellular proliferation and survival. (hindawi.com)
It is an integral component of the MAP (mitogen-activated protein) kinase cascade. (hindawi.com)
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. (joplink.net)
TANK-binding kinase 1 (TBK1) serves prominent innate immune functions via complex interactions with adaptor proteins to affect phosphorylation of NF-κB (NF-κB). (bioworld.com)
The signaling complex which is composed of a transmembrane receptor, histidine protein kinase CheA and adaptor protein CheW plays an important role in chemotaxis signaling pathway. (ucsb.edu)

Here, we define a phosphorylation-dependent binding site on the receptor that mediates agrin-induced clustering. (jneurosci.org)
Phosphorylation of the AChR β subunit is correlated with increased rapsyn/AChR binding, suggesting that the effect of βY390 phosphorylation on clustering is mediated by rapsyn. (jneurosci.org)
Indeed, we found that rapsyn associated with CD4-β loop chimeras in a phosphorylation-dependent manner, and that agrin increased the ratio of rapsyn binding to wild type AChR but not to AChR-β 3F/3F , which lacks β loop tyrosine phosphorylation sites. (jneurosci.org)
Together, these findings suggest that agrin-induced phosphorylation of the β subunit motif increases the stoichiometry of rapsyn binding to the AChR, thereby helping to stably cluster the receptor and anchor it at high density in the postsynaptic membrane. (jneurosci.org)
Here we want to investigate the interaction between the CheA and receptor protein by using mutagenesis and phosphorylation assay. (ucsb.edu)
The chemotaxis system in prokaryotes is composed of membrane-embedded receptor proteins that, upon signal reception, trigger a cascade resulting in the phosphorylation of a protein termed CheY. (esrf.fr)
The phosphorylation of CheY leads to small conformational changes within the protein that increase its affinity towards a switch complex on the cytoplasmic face of the flagellum. (esrf.fr)
By a broad mass spectrometry based approach on whole cells we are in the process of identifying additional such proteins and their phosphorylation status. (lu.se)

These proteins are involved in signal transduction from ectoderm to mesenchyme during development of the fetus and are indispensable for the differentiation of ectoderm-derived structures such as eccrine sweat glands, teeth, hair, skin, and/or nails. (springer.com)
Within the last 10 years significant progress has been made in understanding the pathogenesis of HED and this is mainly due to the discovery of unknown proteins and the elucidation of their function in signal transduction via the TNFα-related pathway. (springer.com)
The downstream signal transduction toward Eda-A1 involves the canonical Wnt/β-catenin pathway (Clevers 2006 ) and requires lymphoid enhancer-binding factor-1 (Lef-1) for activation of the Ed1 ( Ta ) expression (Durmowicz et al. (springer.com)
This signal transduction pathway is initiated by epidermal growth factor ligands binding to and activating receptor tyrosine kinases (RTK) at the cell membrane. (hindawi.com)

Most naïve T cells do not express surface CTLA4 because of its binding to AP50, a subunit of the clathrin adaptor AP-2 protein ( 2 ). (snmjournals.org)

The autophagophore membrane then elongates and encloses the molecules to be degraded forming an autophagosome, which occurs in two separate conjugation reactions catalyzed by autophagy-related proteins (ATGs). (hindawi.com)
AP2A2 has direct interactions with proteins and molecules. (creativebiomart.net)
We selected proteins and molecules interacted with AP2A2 here. (creativebiomart.net)
Together these proteins shorten the end of the mRNAs, preparing the molecules for degradation. (elifesciences.org)
The LDL particles are bound to long receptor molecules on the cell surface, which then associate with adaptor proteins and clathrin on the inner side of the membrane. (rcsb.org)
It provides a dominant negative signaling to T cells on binding to the costimulatory molecules CD80 (B7.1) and CD86 (B7.2) expressed on the surface of antigen-presenting cells ( 1 ). (snmjournals.org)
The structural model revealed that two molecules of CheY-P bind to one CheF dimer ( Figure 2 ). (esrf.fr)
Homophilic binding between CD229 molecules is mediated by the N-terminal Ig‑like domain (7). (rndsystems.com)

The insulin receptor substrate p53 (IRSp53), an Src homology 3 (SH3) adapter protein and regulator of the actin cytoskeleton, was identified as an espin-binding protein in yeast two-hybrid screens. (northwestern.edu)
All NSP proteins contain an NH 2 -terminal SH2 (Src homology domain 2) domain, a central proline/serine-rich domain, and a COOH-terminal domain with modest homology to Ras subfamily GDP-exchange factors (GEFs). (molvis.org)

Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is an intracellular pattern recognition receptor that recognizes bacterial peptidoglycan (PG) containing meso-diaminopimelic acid (mesoDAP) and activates the innate immune system. (amrita.edu)
Using chimeric proteins in which CD4 is fused to the large intracellular loop of each of the AChR subunits we found that agrin induced clustering of only chimeras containing the β subunit loop. (jneurosci.org)
Each subunit has a large intracellular loop between the third and fourth transmembrane domains that is the likely site for regulated interactions with postsynaptic scaffolding proteins. (jneurosci.org)
Autophagy is a cellular catabolic process that eliminates damaged cell organelles, unfolded proteins, and various intracellular pathogens through lysosomal degradation. (hindawi.com)
In general, autophagy degrades long-lived damaged intracellular proteins, in contrast to the ubiquitin-proteasome system, which controls the degradation of short-lived proteins [ 2 ]. (hindawi.com)

How NLRP7-a component of the CATERPILLAR family of proteins involved in innate immunity and apoptosis-causes these specific DNA methylation and trophoblast defects is unknown. (nih.gov)
EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. (thermofisher.com)

We structurally resolve the interface with PRMT5 and show via genetic perturbation that it is required for methylation of adaptor-recruited substrates including the spliceosome, histones, and ribosomal complexes. (rcsb.org)

The mechanism by which MuSK signaling regulates the interaction of the AChR with scaffolding proteins that localize it in the postsynaptic membrane, however, remain unknown. (jneurosci.org)
The present study aimed to investigate the effects of changes in heat shock protein (HSP)90β expression and verify whether HSP90β regulates EAAT2 expression in a cerebral ischemia‑reperfusion injury model. (spandidos-publications.com)
As a molecular chaperone, HSP90 regulates the conformational maturation and functional stability of many signaling proteins in cells, serves important roles in cell growth, differentiation, apoptosis and tumor development and is an important antitumor target ( 8 , 9 ). (spandidos-publications.com)
BACKGROUND AND PURPOSE: The cannabinoid CB(1) receptor is primarily thought to be functionally coupled to the G(i) form of G proteins, through which it negatively regulates cAMP accumulation. (bvsalud.org)

PRMT5 uses adaptor proteins for substrate recruitment through a previously undefined mechanism. (rcsb.org)
We demonstrate that PRMT5 uses modular adaptor proteins containing a common binding motif for substrate recruitment, comparable with other enzyme classes such as kinases and E3 ligases. (rcsb.org)
Genetic disruption of the PRMT5-substrate adaptor interface impairs growth of MTAP-null tumor cells and is thus a site for development of therapeutic inhibitors of PRMT5. (rcsb.org)

PML-RARA-regulated adapter molecule 1 is a protein that in humans is encoded by the PRAM1 gene. (wikipedia.org)
When a cell needs to make a particular protein, it first copies the instructions from the matching gene into a molecule known as a messenger RNA (or an mRNA for short). (elifesciences.org)
Upon binding of dsDNA, cGAS produces a cyclic di-nucleotide molecule, cGAMP. (monash.edu)

Because rodents lack NLRP7, we used human embryonic stem cells to study its function and demonstrate that NLRP7 interacts with YY1, an important chromatin-binding factor. (nih.gov)

AND-34/BCAR3 (Breast Cancer Anti-Estrogen Resistance 3) associates with the focal adhesion adaptor protein, p130CAS/BCAR1. (molvis.org)
Regulation of cell migration by focal adhesion adapter proteins and their role in cancer cell metastasis. (upstate.edu)

After the degradation of damaged proteins and lipids, amino acids and fatty acids are released into the cytoplasm and recycled for new biosynthesis of cellular components or energy production [ 4 ]. (hindawi.com)

Recent advances in understanding the molecular events underlying hypohidrotic ectodermal dysplasia (HED) caused by mutations of the genes encoding proteins of the tumor necrosis factor α (TNFα)-related signaling pathway have been presented. (springer.com)
My lab uses a multi-faceted approach combining biochemistry, cell and molecular biology and various high-end microscopy techniques along with mouse knockout and tumor models to determine the molecular organization of the proteins that are involved in cell adhesion and thereby understand how they each contribute to cell behavior in vivo. (upstate.edu)
We are particularly interested in characterizing the function of the molecular scaffold/adapter proteins Paxillin and it's close relative Hic-5 during tumor cell migration and invasion. (upstate.edu)
However, insights into the molecular details of CheY-P binding to the archaellum and the mechanism of how rotational switching is achieved in the archaellum were still critically lacking. (esrf.fr)
This highly complex 'protein biogenesis' process is assisted by a diverse network of folding catalysts and protein-modifying enzymes and is scrutinized by molecular chaperones and other 'quality control' factors which ensure that only correctly folded and assembled proteins exit the ER and proceed to distal compartments of the secretory pathway. (stanford.edu)

SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)

In contrast to the flagellum, where CheY-P directly binds to the switch complex at the cytoplasmic face, an adaptor protein termed CheF has been identified to be present in all motile archaea [5] . (esrf.fr)
Arrestin-2-(1-380) action depends on tBID: at physiological concentrations, arrestin-2-(1-380) directly binds tBID and doubles tBID-induced cytochrome C release from isolated mitochondria. (bvsalud.org)

In this work, we have revealed that early viral protein UBCv1, the only known conjugating enzyme encoded by a virus, modulates innate immune and inflammatory signaling. (mdpi.com)

5] C1q is a member of the collectin family, which also includes surfactant A, surfactant D, and mannose-binding lectin (MBL). (medscape.com)

Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. (joplink.net)
The SH2 domain binds to phosphotyrosine residues in RTKs such as PDGF and EGF, non-RTKs such as Bcr/Abl and FAK, and docking proteins such as FRS-2 and Gab1. (rndsystems.com)
EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. (thermofisher.com)

Once bound to the mRNA HuR is recognized by adapter proteins which then facilitate nuclear export of the complex. (uncg.edu)
The more mRNA copies it makes, the more protein it can produce. (elifesciences.org)
A simple way to control protein production is to raise or lower the number of these mRNA messages, and living cells have lots of ways to make this happen. (elifesciences.org)
RNA binding proteins recognize these sequences and assemble with their mRNA target into mRNPs. (europa.eu)
Mutations affecting zipcodes, RBPs or motor-proteins required for neuronal mRNA localization were shown to lead to severe neurodegenerative diseases as ALS, FXTAS and FXS (7), underlining the need to understand the mechanisms that drive neuronal mRNA transport. (europa.eu)
Dendritic localisation of CaMKIIa-mRNA requires its 3'UTR harbouring binding sites for RBPs as FMRP and Staufen2, which are required for its correct localisation. (europa.eu)
Inhibiting the localisation of this mRNA leads to a significant reduction of CamKIIa protein at postsynaptic densities and a strong reduction of cognitive abilities in animal models (12). (europa.eu)
Also in this specific case, it is not understood how RBPs, potential adaptors and motor proteins, which are essential for the transport of CaMKIIa-mRNA are mechanistically contributing to its correct localisation. (europa.eu)

These proteins are novel isoforms of the actin-bundling protein espin that arise through the use of a unique site for transcriptional initiation and differential splicing. (northwestern.edu)
Significant obstacles for the sequencing of tRNA include the presence of numerous post-transcriptional modifications and its stable and extensive secondary structure, which interfere with cDNA synthesis and adapter ligation. (cdc.gov)

The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), which is an adaptor protein involved in T cell receptor mediated signaling. (wikipedia.org)
The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). (wikipedia.org)
The BRAF (v-raf murine sarcoma viral oncogene homolog B) gene encodes a protein that belongs to the Raf family of serine/threonine protein kinases. (hindawi.com)
Mutations in the EGFR gene are associated with lung cancer and multiple alternatively spliced transcript variants encode different protein isoforms of EGFR have been found. (thermofisher.com)

Thus, the PC espins exhibit the properties of modular actin-bundling proteins with the potential to influence the organization and dynamics of the actin cytoskeleton in PC dendritic spines and to participate in multiprotein complexes involving SH3 domain-containing proteins, such as IRSp53. (northwestern.edu)

At the neuromuscular junction, the acetylcholine receptor (AChR) is specifically clustered in the postsynaptic membrane via interactions with rapsyn and other scaffolding proteins. (jneurosci.org)
Membrane proteins must be threaded co-translocationally into the lipid bilayer to become membrane-integrated, often with complex topologies and typically form hetero- or homo- oligomers. (stanford.edu)

The accumulation of both Cyclin and CKI proteins is tightly regulated at the level of transcription. (intechopen.com)

ED1 , encoding a ligand-ectodysplasinA-A1 (EDA-A1), EDAR , coding for ectodysplasinA-A1 receptor, EDARADD , programming the structure of EDAR-associated death domain protein and NEMO whose protein product, NFκB essential modulator (NEMO), is necessary for an indirect activation of nuclear factor κB (NFκB). (springer.com)
Using in vitro RNA gel shifts we have demonstrated that the C/EBPÃŸ message is a ligand for HuR and that the single binding site is an adenylate-uridylate rich element in the 3'untranslated region. (uncg.edu)

We have found that these multi-domain proteins bind numerous structural and signaling proteins including kinases, phosphatases and Rho family GTPase regulators and effectors. (upstate.edu)

Two tyrosines in the cytoplasmic domain are required for association of CD229 with the adaptor proteins AP-2 (μ2 chain) and GRB-2 and both are required for CD229 internalization (8, 9). (rndsystems.com)

RNA viruses may escape acquired humoral and cellular immune responses by mutations in protective antigenic epitopes (e.g., avian influenza viruses), while accessory nonstructural proteins or multifunctional structural proteins interfere with the interferon system (e.g. (imperial.ac.uk)

Hermansky-Pudlak syndrome type 5 (HPS-5) results from a deficiency of the HPS-5 protein, a component of BLOC-2. (medscape.com)

This Antibody was verified by Independent antibody to ensure that the antibody binds to the antigen stated. (thermofisher.com)
antibody responses to polysaccharide antigens are decreased and antibody responses to protein antigens are slightly reduced. (medscape.com)

Novel data were reviewed and discussed on the structure and functions of the components of TNFα-related signaling pathway, the consequences of mutations of the genes encoding these proteins, and the prospect for further investigations, which might elucidate the origin of HED. (springer.com)
Also, other proteins which involved in the same pathway with AP2A2 were listed below. (creativebiomart.net)
Recently, one important pathway for ROS regulation has been discovered, mediated by the signaling protein p66Shc. (nature.com)
The vast majority of proteins entering the secretory pathway are synthesized on ribosomes docked at ER translocons and are co-transationally translocated into the ER lumen. (stanford.edu)
Our goal is to elucidate the functional networks that coordinate protein synthesis and quality control in the early secretory pathway. (stanford.edu)

Computational studies to elucidate how SWCNTs may interact with TLR4 in the absence of a protein corona suggested that binding is guided mainly by hydrophobic interactions. (cdc.gov)

The impaired function of specific organelles indicates that the causative genes encode proteins operative in the formation of lysosomes and vesicles. (medscape.com)

In humans, the multisubunit complex cohesin is made up of SMC1, SMC3, RAD21 and a STAG protein. (nih.gov)

Chemoattractants or chemorepellents bind to the transmembrane receptor transmitted a signal to CheW and CheA. (ucsb.edu)

Estrogen Effects on Actin Cytoskeletal and Endocytic Proteins Associated With Tubulobulbar Complex Disruption in Rat Testes. (creativebiomart.net)

The SH3 domains associate with proline rich motifs on the guanine nucleotide releasing factor, Sos, stimulating GTP binding to Ras, which in turn activates MAPK and other signaling pathways. (rndsystems.com)

The place of the deletion is at the very C-terminal's end, preventing a complete loss of the HPS2 protein. (medscape.com)

We identified a group of actin-binding-bundling proteins that are expressed in cerebellar Purkinje cells (PCs) but are not detected in other neurons of the CNS. (northwestern.edu)
The PC espins efficiently bound and bundled actin filaments in vitro, and these activities were not inhibited by Ca 2+ . (northwestern.edu)
This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins. (embl.de)

Phosphoryl CheY binds to the flagella motor and rotates the flagella motor to clockwise. (ucsb.edu)
This structure made it possible to map and characterise the binding interface between CheF and CheY-P and advised the construction of a fusion protein of the CTD of CheF and CheY. (esrf.fr)
CheY-P binding induces conformational changes at CheF. (esrf.fr)
Left: Structure of apo CheF (grey) superposed with the CheF-CTD (red) bound to CheY-P (green). (esrf.fr)
Slight conformational changes between the apo and CheY-P-bound states of CheF can be observed. (esrf.fr)
Furthermore, small conformational changes were observed within CheF in the CheY-P bound structure ( Figure 2 ). (esrf.fr)
However, with the structure of the archaeal switch complex still unknown, future studies need to unveil this connection and the implications of CheY-P binding. (esrf.fr)
Taken together, this study delivers the mechanistic basis of how CheY-P binds to the adaptor protein CheF and suggests a model of how rotational switching of the archaellum might be achieved. (esrf.fr)

However, it remains unclear where these proteins bind on the AChR and how the interactions are regulated. (jneurosci.org)

Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)

Its primary goal was to identify small chemical compounds which target the particular sites of the proteins important in regulating the tumor cell growth and aggressiveness. (worldcommunitygrid.org)

RNA-binding proteins contribute to specificity by interacting with both Ccr4-Not and target mRNAs, but this is not fully understood. (elifesciences.org)
The test-tube system confirmed previous suggestions that a protein called Puf3 forms a bridge between Ccr4-Not and mRNAs. (elifesciences.org)
It is still not known which RBPs or adaptor proteins are essential to recruit microtubule-binding motor proteins to mRNPs and to which extend this varies between different transported mRNAs. (europa.eu)
Patients with schizophrenia, but not schizoaffective disorder, displayed a reduced concentration of arrestin and GRK mRNAs and GRK3 protein. (bvsalud.org)

Anatomy33

Organisms8

Chemicals and Drugs142

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes47

Information Science3

Receptors8

GRB25

Kinase5

Phosphorylation8

Signal transduction4

Clathrin adaptor1

Molecules8

Homology2

Intracellular5

Family of proteins2

Substrates1

Regulates4

Substrate3

Molecule3

Chromatin1

Focal adhesion2

Amino acids1

Molecular5

Structural Classifi1

Directly binds2

Innate1

Mannose bindin1

Residues3

MRNA8

Transcriptional2

Gene4

Cytoskeleton1

Membrane2

Transcription1

Ligand2

Kinases1

Cytoplasmic1

Immune1

Deficiency1

Antibody2

Pathway5

TLR41

Encode1

Humans1

Transmembrane receptor1

Cytoskeletal1

Turn activates1

Deletion1

Actin3

CheY8

Interactions1

Nuclear1

Tumor cell1

MRNAs4