Binds 2 calcium ions s100 calcium binding protein g. Medical search. Frequent questions

S100 genes include at least 19 members which are located as a cluster on chromosome 1q21. (wikipedia.org)
Candidate genes showing distinctive expression patterns in response to ethanol were clustered by pattern and further analyzed for related function, pathway membership and common transcription factor binding within and across clusters. (biomedcentral.com)
Thus, stress response studies during these growth stages reveal novel differentially regulated genes or proteins with important functions in plant stress adaptation. (intechopen.com)

Furthermore, SRI was overexpressed, while intracellular calcium concentration was decreased, in chemoresistant cancer cells. (biomedcentral.com)
To restore intracellular calcium homeostasis and overcome chemoresistance, we developed lipid-coated albumin-PTX nanoparticles loaded with SRI-siRNA (LANP-PTX-siSRI) for PTX and SRI-siRNA co-delivery. (biomedcentral.com)
The LANP-PTX-siSRI inhibited the expression of SRI and enhanced intracellular calcium, leading to the induction of apoptosis and the inhibition of the growth of PTX-resistant cancer cells in vitro and in vivo. (biomedcentral.com)
In conclusion, our data unveil that restoring intracellular calcium ion homeostasis via reducing SRI expression can reverse chemoresistance. (biomedcentral.com)
In intestinal ENTEROCYTES it mediates intracellular calcium transport from apical to basolateral membranes via calcium binding at two EF-HAND MOTIFS. (lookformedical.com)
Immature calcium handling in immature myocardium raises intracellular calcium concentrations after ischemia and reperfusion. (medscape.com)

S100A1 contains 4 EF-hand calcium-binding motifs in its dimerized form, and can exist as either a hetero or homodimer. (wikipedia.org)
Today, recognition and classification of sequence motifs and protein folds is a mature field, thanks to the availability of numerous comprehensive and easy to use software packages and web-based services. (biomedcentral.com)
In this paper, we describe an extension of DeepView/Swiss-PdbViewer through which structural motifs may be defined and searched for in large protein structure databases, and we show that common structural motifs involved in stabilizing protein folds are present in evolutionarily and structurally unrelated proteins, also in deeply buried locations which are not obviously related to protein function. (biomedcentral.com)
The possibility to define custom motifs and search for their occurrence in other proteins permits the identification of recurrent arrangements of residues that could have structural implications. (biomedcentral.com)
The main reason for our interest in general ( i.e. , sequentially non-contiguous) structural motifs, is the crucial role played by side-chains in the correct packing of proteins. (biomedcentral.com)
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. (cancerindex.org)
Calbindins possess a variable number of EF-HAND MOTIFS which contain calcium-binding sites. (lookformedical.com)
Calcium-binding motifs composed of two helices (E and F) joined by a loop. (lookformedical.com)
These motifs are found in many proteins that are regulated by calcium. (lookformedical.com)

We identified 231 proteins released from actomyosin contraction-dependent blebs and apoptotic bodies by adapted SILAC (stable isotope labeling with amino acids in cell culture) combined with mass spectrometry analysis. (nature.com)

The most enriched proteins released were the nucleosomal histones, which have previously been identified as damage-associated molecular pattern proteins (DAMPs) that can initiate sterile inflammatory responses. (nature.com)
2) Lysine acetylation in histones and various other proteins is certainly effected with the active interplay of acetyltransferase (HAT) and deacetylase (HDAC) enzymes, which is certainly analogous towards the regulation of serine, threonine, and tyrosine phosphorylation by kinases and phosphatases. (smartrailexpo-europe.com)
Bromodomains certainly are a category of conserved 110 amino acidity modules that bind selectively to acetylated lysines within protein, notably histones,(3) and so are thereby considered to take part in deciphering the histone code. (smartrailexpo-europe.com)
13) The introduction of little molecule inhibitors of bromodomain binding to histones and various other acetyl-lysine-containing proteins is within its infancy. (smartrailexpo-europe.com)
It contains most of the cell's genetic material, organized as multiple long linear DNA molecules in complex with a large variety of proteins, such as histones, to form chromosomes. (absoluteastronomy.com)

Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. (enquirebio.com)
Weakly powerful little molecule ligands from the cAMP response element-binding proteins (CREB) binding proteins (CREBBP) bromodomain, uncovered by NMR testing of acetyl-lysine (KAc) mimics, have already been proven to modulate p53 balance and function in response to DNA harm in cells. (smartrailexpo-europe.com)

This antibody reacts with alpha and beta subunits of human S-100 protein (21-24 kD). (abcam.cn)
We noticed elevated immunofluorescence strength from the 18 antibody staining, which can be specific to triggered -catenin conformation under tensile stress, in ZO-1,-2 DKO cells (Supplementary Fig.?S1a, b). (aboutsciencenow.info)

S100A1 has been shown to interact with the PEVK region of Titin in a calcium-dependent manner, and its binding reduces the force in an in vitro motility assay, suggesting that S100A may modulate Titin-based passive tension prior to systole. (wikipedia.org)

Prognostic values of S100 family members in ovarian cancer patients. (cancerindex.org)
While the prognostic value of each individual S100 in ovarian cancer is still elusive. (cancerindex.org)
In current study, we investigated the prognostic value of S100 family members in the ovarian cancer. (cancerindex.org)
Sorcin (SRI) is a soluble resistance-related calcium-binding protein involved in chemoresistant processes and is overexpressed in many chemoresistant cancer cells, including paclitaxel (PTX)-resistant ovarian cancer. (biomedcentral.com)
Human epididymis protein 4 in association with Annexin II promotes invasion and metastasis of ovarian cancer cells. (gzsys.org.cn)

S100A1 is a member of the S100 family of proteins expressed in cardiac muscle, skeletal muscle and brain, with highest density at Z-lines and sarcoplasmic reticulum. (wikipedia.org)

A calbindin protein that is differentially expressed in distinct populations of NEURONS throughout the vertebrate and invertebrate NERVOUS SYSTEM, and modulates intrinsic neuronal excitability and influences LONG-TERM POTENTIATION. (lookformedical.com)
Right here, we propose a molecular system where AJC scaffolding proteins control apical cell contractility by differentially recruiting MAGI-1 and MAGI-3 to apical AZD-3965 junctions. (aboutsciencenow.info)

Increased SRI can reduce the concentration of calcium ions in the cytosol and mitochondria and the decrease of calcium ion concentration prevents the occurrence of apoptosis. (biomedcentral.com)
The increased expression of SRI can induce the accumulation of calcium ions in the endoplasmic reticulum and reduce the concentration of calcium ions in the cytosol and mitochondria [ 16 ]. (biomedcentral.com)

S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility. (gzsys.org.cn)

A calcium-binding protein that mediates calcium HOMEOSTASIS in KIDNEYS, BRAIN, and other tissues. (lookformedical.com)
Therefore, we exposed the MAGIs are crucial regulators of Par polarity proteins that are central towards the rules of pressure distribution in epithelial cells homeostasis. (aboutsciencenow.info)

S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (wikipedia.org)
This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. (microarraystation.com)
Roy A, Mondal S, Kordower JH, Pahan K. Attenuation of microglial RANTES by NEMO-binding domain peptide inhibits the infiltration of CD8(+) T cells in the nigra of hemiparkinsonian monkey. (rush.edu)
The lactic acid produced from fermentation broth usually contains numerous impurities such as bacterial cells, residual carbohydrates, proteins, vitamins, and phenolic compounds. (springeropen.com)
Dying cells have been defined as apoptotic by distinguishing features, including cell contraction, nuclear fragmentation, blebbing, apoptotic body formation and maintenance of intact cellular membranes to prevent massive protein release and consequent inflammation. (nature.com)
In this scholarly study, we present proof that MAGI proteins, structural the different parts of AJC whose function continued to be unclear, regulate apical constriction of epithelial cells through the Par polarity proteins. (aboutsciencenow.info)
Throughout our analysis, we noted higher irregularity in form and size from the apical area in ZO-1 and ZO-2 dual knockout (ZO-1,-2 DKO) cells in comparison to parental (WT) EpH4 cells (Fig.?1a). (aboutsciencenow.info)
In the meantime, the ZO-1,-2 DKO monolayer was an admixture of smaller sized and bigger cells relatively, each with cell junctions that demonstrated high variability within their measures. (aboutsciencenow.info)
These observations recommended to us that apical cell junctions of cells in the ZO-1,-2 DKO cell sheet had been AZD-3965 put through unbalanced tensile stress from encircling cells. (aboutsciencenow.info)
Furthermore, intercellular spaces had been noticed at tricellular get AZD-3965 in touch with sites in ZO-1 regularly, dKO cells -2, indicating dysregulation and more than contractile activity throughout apical junctions (Supplementary Fig.?S1a, insets). (aboutsciencenow.info)
To get this, we discovered that perijunctional myosin II activation was prominent in ZO-1,-2 DKO however, not in parental (WT) EpH4 cells (Fig.?1b, c). (aboutsciencenow.info)
Open up in another windowpane Fig. 1 Lack of ZO proteins dysregulates ROCK-dependent contractility to improve apical morphology.a Consultant immunofluorescence pictures of ZO-1 and WT, dKO cells stained for activated -catenin -2. (aboutsciencenow.info)
Scale pub, 20?m. b Representative immunofluorescence pictures of the co-culture of ZO-1 and WT,-2 Cldn5 DKO cells stained for phosphorylated MLC (pMLC, magenta) and ZO-1 (green). (aboutsciencenow.info)
Size pub, 10?m. c Cross-junctional range scans (pMLC) from immunofluorescence pictures of WT and ZO-1,-2 DKO cells stained for pMLC and triggered -catenin. (aboutsciencenow.info)

They can act as transport proteins, regulator proteins, or activator proteins. (lookformedical.com)

Calcium-binding proteins that are found in DISTAL KIDNEY TUBULES, INTESTINES, BRAIN, and other tissues where they bind, buffer and transport cytoplasmic calcium. (lookformedical.com)
Identification and Comparison of Differentiation-Related Proteins in Hepatocellular Carcinoma Tissues by Proteomics. (gzsys.org.cn)

Helix 3, 4, and the hinge region are the most divergent areas between individual S100 proteins, and so it is likely that the sequence of these regions is pivotal in fine-tuning calcium-dependent target binding by S100 proteins. (wikipedia.org)
Exhibiting high consistence in sequence and structure, S100 family members are interchangeable in function and they show a wide spectrum of biological processes, including proliferation, apoptosis, migration, inflammation and differentiation and the like. (cancerindex.org)

Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. (enquirebio.com)
May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. (enquirebio.com)

This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. (wikipedia.org)

In a rat model of myocardial infarction, intracoronary S100A1 adenoviral gene transfer restored sarcoplasmic reticular calcium transients and load, normalized intracellular sodium concentrations, reversed the pathologic expression of the fetal gene program, restored energy supply, normalized contractile function, preserved inotropic reserve, and reduced cardiac hypertrophy 1 week post-myocardial infarction. (wikipedia.org)

These results indicate that limited membrane permeabilization occurs in blebs and apoptotic bodies before secondary necrosis, leading to acute and localized release of immunomodulatory proteins during the early phase of active apoptotic membrane blebbing. (nature.com)

Calcium-Binding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)

In this process, astrocytes proliferate to fill gaps and undergo a typical morphological change: a large cytoplasmic mass, long and branched processes, and increased expression of intermediate filaments such as glial fibrillary acidic protein (GFAP). (jneurosci.org)

A novel Anxa2-interacting protein Ebp1 inhibits cancer proliferation and invasion by suppressing Anxa2 protein level. (gzsys.org.cn)

Low molecular weight, calcium binding muscle proteins. (lookformedical.com)
These strategies involve rearrangements at the molecular level starting from transcription, regulation of mRNA processing, translation, and protein modification or its turnover. (intechopen.com)

Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. (abcam.cn)
[ 3 , 4 ] Further refinements in CPB hardware and techniques, perfusion methods, myocardial and brain protection over the past 2 decades contributed to improved outcomes of surgical treatment of CHD. (medscape.com)
All of these factors affect the way in which the immature heart handles calcium, which, in turn, contributes to the myocardial dysfunction observed after CPB. (medscape.com)
Protein to protein interaction network analysis showed glycolytic enzymes, such as isoform alpha-enolase of alpha-enolase, isoform 1 of triosephosphate isomerase and glyceraldehyde-3-phosphate dehydrogenase, had more connections than other proteins in myocardial metabolism during ischemia. (biomedcentral.com)
It is the first time to use effluents of human perfused heart to study the proteins released during myocardial ischemia by HPLC-Chip-MS system. (biomedcentral.com)

19) This work demonstrates the feasibility of inhibiting KAc binding to bromodomains with little molecules that occupy the well-defined KAc-binding pocket. (smartrailexpo-europe.com)
Lipocalin 2 (lcn2) is a member of the lipocalin family that binds to small hydrophobic molecules. (jneurosci.org)

Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. (abcam.cn)
E3 ligases are also key players in cell cycle control, mediating the degradation of cyclins, as well as cyclin dependent kinase inhibitor proteins. (e3ligasesignal.com)

Furthermore, little molecule inhibition of bromodomainCprotein connections might elicit subtly different pharmacological replies towards the inhibition from the catalytic site from the same proteins. (smartrailexpo-europe.com)

The most accurate high-resolution solution structure of human apo-S100A1 protein (PDB accession code: 2L0P) has been determined by means of NMR spectroscopy in 2011. (wikipedia.org)
with Pubmed ID, gene symbol/accession number and viral interacting protein. (polygenicpathways.co.uk)

Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. (lookformedical.com)
This is because there are many highly abundant proteins present in the serum or plasma, which will mask biomarkers, presumably the less abundant proteins. (biomedcentral.com)

Steroid hormones can be grouped into five groups by the receptors to which they bind: glucocorticoids, mineralocorticoids, androgens, estrogens, and progestogens. (absoluteastronomy.com)

DEL1 protects against chondrocyte apoptosis through integrin binding. (uchicago.edu)
We now show that during early apoptosis limited membrane permeabilization occurs in blebs and apoptotic bodies, which allows release of proteins that may affect the proximal microenvironment before the catastrophic loss of membrane integrity during secondary necrosis. (nature.com)
Blebbing, apoptotic body formation and protein release during early apoptosis are dependent on ROCK and myosin ATPase activity to drive actomyosin contraction. (nature.com)
2 , 3 A key feature of apoptosis has been defined as the maintenance of an intact cellular membrane (detectable as exclusion of impermeable dyes such as propidium iodide, PI) throughout the apoptotic program to prevent intracellular protein release and subsequent immunological activation. (nature.com)

Results Lack of ZO proteins highly perturbs Par-3 localization and alters apical morphology We previously demonstrated that depletion of ZO proteins in the mouse mammary epithelial cell range, EpH4, delays the forming of the contractile belt-like AJ18, recommending that ZO proteins are necessary for epithelial polarization. (aboutsciencenow.info)

This protein may function in exocytosis and endocytosis. (cancerindex.org)
Analysis showed function-based networks, shared transcription factor binding sites and signaling pathways for members of the clusters. (biomedcentral.com)
MAGIs further localize a range of scaffolding and signaling proteins that recruit and control Par-3 function to modulate contractility from the AJC-linked actomyosin network. (aboutsciencenow.info)

Specifically, S100A1 increases the gain of excitation-contraction coupling and decreases calcium spark frequency in cardiomyocytes. (wikipedia.org)
In mice with ablation of the S100A1 gene (S100A1-/-), cardiac reserve upon beta adrenergic stimulation was impaired, showing reduced contraction rate and relaxation rate, as well as reduced calcium sensitivity. (wikipedia.org)

SRI can not only bind calcium ions but also can interact with the calcium channel proteins and regulate the sodium-calcium pump located in the endoplasmic reticulum and serosal membrane [ 13 ]. (biomedcentral.com)

12) Another BET-family protein, the testis-specific BRDT, is vital for male germ cell differentiation in selective domain knockout mice which were practical but sterile. (smartrailexpo-europe.com)

The amount of sarcoplasmic reticulum and its ability to sequester calcium similarly increase in early development. (medscape.com)

These proteins were L-lactate dehydrogenase B(LDHB), glyceraldehyde-3-phosphate dehydrogenase, glucose-6-phosphate isomerase (GPI), phosphoglycerate mutase 2 (PGAM2), gelsolin and isoform 8 of titin. (biomedcentral.com)

It is found in well-defined populations of NEURONS and is involved in CALCIUM SIGNALING and NEURONAL PLASTICITY. (lookformedical.com)
2. Zhu J K, Abiotic Stress Signaling and Responses in Plants. (sustech.edu.cn)

107 proteins were identified at the beginning of ischemia, 174 and 175 proteins at ischemic 30 min and ischemic 60 min, respectively. (biomedcentral.com)

These biophysical properties seem to be well conserved across the S100 family of proteins. (wikipedia.org)

S100A1 overexpression via adenoviral gene transfer in adult rabbit cardiomyocytes or a cardiac-restricted S100A1 murine transgenic enhanced cardiac contractile performance by increasing sarcoplasmic reticular calcium transients and uptake, altering the calcium sensitivity and cooperativity of myofibrils, enhancing SERCA2A activity and enhancing calcium-induced calcium release. (wikipedia.org)
Forced expression of lcn2 or treatment with LCN2 protein increased the sensitivity of astrocytes to cytotoxic stimuli. (jneurosci.org)

Scope includes mutations and abnormal protein expression. (cancerindex.org)

Finally, the activity of Na + /K + adenosine triphosphatase (ATPase) increases with maturation, and this affects the sodium-calcium exchange mechanism. (medscape.com)

BST2 bone marrow stromal cell antigen 2 (Tetherin): Candida albicans enhanced the production of the CCR5-interacting chemokines CCL3, CCL4, and CCL5, and stimulates the production of interferon-a and the restriction factors APOBEC3G, APOBEC3F, and tetherin (BST2) in macrophages Rodriguez et al, 2013 . (polygenicpathways.co.uk)
1) Additionally, latest proteomics studies have got demonstrated that lysine acetylation occurs in more than 1750 cellular protein involved with diverse roles such as for example cell routine, splicing, nuclear transportation, and actin nucleation. (smartrailexpo-europe.com)
Protein targeting or protein sorting is the mechanism by which a cell transports proteins to the appropriate positions in the cell or outside of it. (absoluteastronomy.com)
Iron and BIM (Bcl-2-interacting mediator of cell death) proteins were involved in the cytotoxic sensitization process. (jneurosci.org)
LCN2 protein induced upregulation of glial fibrillary acidic protein (GFAP), cell migration, and morphological changes similar to characteristic phenotypic changes termed reactive astrocytosis. (jneurosci.org)
By coupling the adhesion equipment towards the polarity proteins to modify mobile contractility, we suggest that MAGIs play important and central tasks in maintaining stable state intercellular pressure through the entire epithelial cell sheet. (aboutsciencenow.info)

In response to a brain injury, astrocytes proliferate and become hypertrophic with an increased expression of intermediate filament proteins. (jneurosci.org)

This conformational change exposes a large hydrophobic pocket between helix 3, 4, and the hinge region of S100A1 that is involved in virtually all calcium-dependent target protein interactions. (wikipedia.org)

Anatomy10

Organisms9

Chemicals and Drugs91

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Phenomena and Processes37

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science4

Health Care1

Genes3

Intracellular calcium6

Motifs9

Amino-acids1

Histones5

Weakly2

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S100A1

Ovarian cancer5

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Annexin1

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Receptors1

Apoptosis4

Apical1

Function3

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Sarcoplasmic reticulum1

Titin1

SIGNALING2

Ischemia1

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Scope1

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Expression1

Target1