SiglecSIGLECsImmunoglobulin superfamilyReceptorAntibodyAntigenMoleculeRecombinantELISAGlycoproteinCD22PhosphatasesAntibodiesConformationalKinaseHigh-affinityMembrane proteinAmino acidRecognizesMigratesExtracellularDomainAdhesionEndothelialHydrophobicJunction proteinConcentrationOrganicHumanDegreesImmune cellsInteractionsMolecularHumansFunctionTumorMoleculesAssayRegionCarriesBiologicalContributeCells
Siglec8
- Sialic acid-binding Ig-like lectin 12, or Siglec-XII, is a protein that in humans, is encoded by the SIGLEC12 gene. (wikipedia.org)
- The Siglec-XII protein has been identified as a possible promoter of human carcinoma progression in research by Ajit Varki and Nissi Varki at the University of California San Diego School of Medicine. (wikipedia.org)
- CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. (creativebiolabs.net)
- CD22 molecule is a transmembrane protein from SIGLEC (Sialic acid-binding immunoglobulin-type lectins) family. (biomedcentral.com)
- Siglec-15 is a DAP12-associated immunoreceptor, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. (transcriptionfactor.org)
- Siglec-15 consisting of immunoglobulin (Ig)-like domains, transmembrane domain and a short cytoplasmic tail. (transcriptionfactor.org)
- Human CD33 / Siglec-3 cDNA encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N--terminal Ig--like V--type domain, one Ig--like C2--type domains, a transmembrane region and a cytoplasmic tail. (biovisi.com)
- Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. (cusabio.com)
SIGLECs3
- Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. (wikipedia.org)
- Siglecs are cell surface proteins that bind sialic acid. (transcriptionfactor.org)
- Myeloid cell surface antigen CD33 also known as SIGLEC3, Siglecs (sialic acid binding Ig-like lectins) and GP67, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. (biovisi.com)
Immunoglobulin superfamily1
- The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. (creativebiolabs.net)
Receptor8
- It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. (wikipedia.org)
- Explore our comprehensive collection of recombinant Fc receptor proteins! (acrobiosystems.com)
- gamma-aminobutyric acid type A receptor. (gsea-msigdb.org)
- Immunoglobulin molecules that form a receptor protein on the outer surface of B-cells . (anthropogeny.org)
- G protein-coupled receptor kina. (gsea-msigdb.org)
- Although monoclonal antibodies to the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are known, B-cell receptor repertoire and its change in patients during coronavirus disease-2019 (COVID-19) progression is underreported. (bvsalud.org)
- The most common example of this type of fusion protein combines the hinge and Fc regions of an immunoglobulin (Ig) with domains of a cell-surface receptor that recognizes a specific ligand (Box 1). (coek.info)
- Immunoadhesin structure The majority of immunoadhesins combine the hinge and Fc regions of an IgGl heavy chain with the extracellular domain (ECU) of a type I transmembrane protein, usually a receptor or an adhesion molecule (Fig. 1). (coek.info)
Antibody14
- Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation. (creativebiolabs.net)
- Setting the corresponding isotype control antibody to detect non-specific binding can reduce the generation of false positive results and evaluate the possible influencing factors accurately in the drug development process. (acrobiosystems.com)
- The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. (acrobiosystems.com)
- BCRs allow the B-cell to bind to a specific antigen , against which it will initiate an antibody response. (anthropogeny.org)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human AE Binding Protein 1 (AEBP1) in tissue homogenates, cell lysates and other biological fluids. (kits-elisa.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human AE Binding Protein 1 (AEBP1) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (kits-elisa.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Heat Shock Protein 47 (HSP47) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (lipidx.org)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Protein C Inhibitor (PCI) in plasma. (envite.org)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Protein C Inhibitor (PCI) in samples from plasma with no significant corss-reactivity with analogues from other species. (envite.org)
- Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Protein C Inhibitor (PCI) in Plasma. (envite.org)
- IGH rearrangement usage showed no apparent relation to anti-SARS-CoV-2 antibody titers. (bvsalud.org)
- is to generate an antibody-like molecule by combining framework sequences from a human mAb with sequences from a human protein that carries a target-recognition function. (coek.info)
- Tuning Monoclonal Antibody Galactosylation utilizing Raman Spectroscopy-Managed Lactic Acid Feeding A key side of large-scale manufacturing of biotherapeutics is a well-designed and consistently-executed upstream cell tradition course of. (tuberculosistest.net)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Plasminogen Activator Inhibitor 2 (PAI2) in Plasma. (jsce-ip.com)
Antigen2
- They exist in pentameric form (IgM), dimeric form (IgA) or single form (IgG, IgE, IgD), which consist of Y-shaped units that each have two antigen-binding pockets on one side and a region recognized by immune cells on the opposite. (anthropogeny.org)
- Some patients demonstrated mono/oligoclonal populations carrying highly mutated IGHV rearrangements indicating antigen experience at some of the time points tested, including even before anti-SARS-CoV-2 antibodies were detected. (bvsalud.org)
Molecule2
- Single Molecule Protein Detection with Attomolar Sensitivity Utilizing Droplet Digital Enzyme-Linked Immunosorbent Assay Many proteins are current at low concentrations in organic samples, and subsequently, methods for ultrasensitive protein detection are mandatory. (elisareagents.com)
- Kinetics of homophilic binding by embryonic and adult forms of the neural cell adhesion molecule. (academicinfluence.com)
Recombinant2
- SARS-CoV-2 Mutant (L452R, T478K)Alternates names: N/ATaglines: Recombinant Spike RBD mutant of the SARS-CoV-2. (transcriptionfactor.org)
- In this review, we summarize the many examples of immunoadhesins in the literature, and discuss some essential structural and functional features of this expanding fanuly of recombinant proteins. (coek.info)
ELISA12
- Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. (biovisi.com)
- Description: A sandwich quantitative ELISA assay kit for detection of Human AE Binding Protein 1 (AEBP1) in samples from tissue homogenates, cell lysates or other biological fluids. (kits-elisa.com)
- Description: A sandwich ELISA kit for detection of AE Binding Protein 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (kits-elisa.com)
- Description: A sandwich ELISA kit for detection of High Mobility Group AT Hook Protein 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (lipidx.org)
- Description: A sandwich quantitative ELISA assay kit for detection of Human High Mobility Group AT Hook Protein 1 (HMGA1) in samples from tissue homogenates, cell lysates or other biological fluids. (lipidx.org)
- Description: A sandwich quantitative ELISA assay kit for detection of Human Protein C Inhibitor (PCI) in samples from plasma. (envite.org)
- Description: Quantitativesandwich ELISA kit for measuring Human phospholipid transfer protein(PLTP) in samples from serum, plasma, tissue homogenates. (elisareagents.com)
- Description: A competitive ELISA for quantitative measurement of Human Translationally controlled tumor protein(TPT1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (allelisakits.com)
- Description: A sandwich ELISA kit for detection of Secreted Phosphoprotein 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (myelisakit.com)
- Description: Quantitativesandwich ELISA kit for measuring Human Secreted phosphoprotein 2 (SPP2/SPP24) in samples from serum, plasma, tissue homogenates. (myelisakit.com)
- Description: A sandwich quantitative ELISA assay kit for detection of Human Plasminogen Activator Inhibitor 2 (PAI2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (jsce-ip.com)
- Description: A sandwich quantitative ELISA assay kit for detection of Mouse Plasminogen Activator Inhibitor 2 (PAI2) in samples from plasma. (jsce-ip.com)
Glycoprotein1
- Transmembrane glycoprotein that controls innate and adoptive immune response. (transcriptionfactor.org)
CD221
- CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. (creativebiolabs.net)
Phosphatases3
- The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. (wikipedia.org)
- It mediates negative impact on BCR signaling pathway by dephosphorylating the associated cascade components via protein tyrosine phosphatases [ 67 , 68 , 69 ] (Fig. 1 ). (biomedcentral.com)
- These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. (cusabio.com)
Antibodies2
- The clumping of cells due to the interaction of antibodies (or other proteins ) and specific molecules on the surface of cells. (anthropogeny.org)
- Complete Evaluation of the Antigenic Influence of Human Papillomavirus Lineage Variation on Recognition by Neutralizing Monoclonal Antibodies Raised Towards Lineage A Main Capsid Proteins of Vaccine-Associated Genotypes Human papillomavirus (HPV) is the causative agent of cervical and different epithelial cancers. (tuberculosistest.net)
Conformational1
- Fluorescent probes for conformational states of proteins. (academicinfluence.com)
Kinase8
- A-kinase anchoring protein 9 [Source:HG. (gsea-msigdb.org)
- death associated protein kinase 1 [Sour. (gsea-msigdb.org)
- Long-term activation of protein kinase c causes chronic Na/H antiporter stimulation in cultured proximal tubule cells. (jci.org)
- To examine the role of protein kinase C as a chronic regulator of proximal tubule Na/H antiporter activity, the effect of phorbol 12-myristate 13-acetate (PMA) on the Na/H antiporter was studied in cultured proximal tubule cells. (jci.org)
- Short-term activation of protein kinase C by 5 min exposure to PMA caused an acute increase in Na/H antiporter activity that was not prevented by cycloheximide or actinomycin D and did not persist 24 h later. (jci.org)
- Long-term activation of protein kinase C by 2 h exposure to PMA caused a dose-dependent increase in Na/H antiporter activity 24 h later. (jci.org)
- This latter effect was due to protein kinase C activation in that it was inhibited by sphingosine and was not seen with 4 alpha-PMA, an inactive analogue. (jci.org)
- In conclusion, short-term activation of protein kinase C leads to a transient increase in Na/H antiporter activity that is independent of transcription and translation, whereas long-term activation of protein kinase C causes a persistent increase in antiporter activity that is dependent on transcription and translation and is associated with increased mRNANa/H abundance. (jci.org)
High-affinity2
- Streptavidin is a tetrameric protein providing 4 high-affinity biotin binding sites. (acrobiosystems.com)
- B cell-specific deletion of STIM proteins decreased the number of high-affinity B cells in the late phase of GC formation. (bvsalud.org)
Membrane protein1
- ER membrane protein complex sub. (gsea-msigdb.org)
Amino acid1
- The amino acid region from 165 to 205 in BAP31 plays an important role in regulating the glycosylation of EpCAM. (bvsalud.org)
Recognizes1
- Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans. (cusabio.com)
Migrates2
- The protein migrates as 33-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. (transcriptionfactor.org)
- Protein migrates as 40-45 kDa in reduced SDS-PAGE. (biovisi.com)
Extracellular1
- Cytotactin, an extracellular matrix protein of neural and non-neural tissues that mediates glia-neuron interaction. (academicinfluence.com)
Domain7
- Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest. (creativebiolabs.net)
- It has three parts: (i) V-type Ig domain with sia -binding site, (ii) C1-type Ig domain, (iii) C2-type Ig domain. (biomedcentral.com)
- The tyrosine residues of the ITIMs become phosphorylated with the ligand binding, which leads to activation of SHP-1 ( Src homology region 2 domain-containing phosphatase-1), SHP-2 ( Src homology region 2 domain-containing phosphatase-2), SHIP-1 (( Src homology region 2 domain-containing inositol 5′ polyphosphatase-1). (biomedcentral.com)
- MIA SH3 domain ER export factor 2 [Sour. (gsea-msigdb.org)
- dysbindin domain containing 2 [Source:H. (gsea-msigdb.org)
- C-type lectin domain containing. (gsea-msigdb.org)
- 2~). In the absence of light chains, deletion of the C,,l domain improves assembly and secretion of immunoadhesins by the host cell. (coek.info)
Adhesion2
- Measured by the ability of the immobilized protein to support the adhesion of human red blood cells. (biovisi.com)
- Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein. (academicinfluence.com)
Endothelial1
- We explored whether LPL affects (a) lipoprotein transport across bovine aortic endothelial cells or (b) lipoprotein binding to subendothelial cell matrix (retention). (jci.org)
Hydrophobic1
- I. Mechanism of fluorescence of 2-p-toluidinylnaphthalene-6-sulfonate, a hydrophobic probe. (academicinfluence.com)
Junction protein1
- gap junction protein delta 2 [Source:HG. (gsea-msigdb.org)
Concentration1
- Reconstitute in sterile deionized water to the desired protein concentration. (transcriptionfactor.org)
Organic1
- Organic compounds that are the building blocks of proteins and participate in a number of processes such as neurotransmitter transport and biosynthesis. (anthropogeny.org)
Human1
- Human-specific polymorphic pseudogenization of SIGLEC12 protects against advanced cancer progression, FASEB BioAdvances, 3:69-82, 2021 Jones, Asher, "Rogue" Protein Could Contribute to Humans' High Cancer Rates, The Scientist, April 1, 2021 Maruyama K, Sugano S (1994). (wikipedia.org)
Degrees1
- However, the combination of Ab1 and Ab2 (preincubated for 2 h at 22 degrees C) binds to platelets in a saturation-dependent manner at an optimum ratio range of 10-20:1. (jci.org)
Immune cells1
- They are found primarily on the surface of immune cells and are a subset of the I-type lectins. (transcriptionfactor.org)
Interactions3
- They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. (wikipedia.org)
- The study of protein structures and interactions is critical to understand their function. (tuberculosistest.net)
- Chemical cross-linking of proteins with mass spectrometry (XL-MS) is a rapidly developing structural biology technique able to provide valuable insight into protein conformations and interactions, even as they exist within their native cellular environment. (tuberculosistest.net)
Molecular1
- Whether it is for protein electrophoresis or western blot, our pre-stained protein markers help you quickly determine the molecular weight of the target protein or evaluate the transfer efficiency. (acrobiosystems.com)
Humans1
- Approximately seventy percent of humans have a mutation that inactivates the protein, but those without the mutation may suffer an inordinate number of carcinomas when compared to other primates. (wikipedia.org)
Function1
- Alu elements were considered to be a part of what has been called "junk DNA" because they do not code for the production of proteins, however they may serve some yet unknown function and definitely contribute to genomic plasticity, evolution, and disease. (anthropogeny.org)
Tumor1
- We analyzed the relationship of BAP31 with 84 kinds of tumor-associated antigens and found that BAP31 is positively correlated with the protein level of EpCAM. (bvsalud.org)
Molecules1
- Neural factors are a class of protein molecules with neurotrophic activity that can promote the survival and regeneration of nerve cells. (acrobiosystems.com)
Assay1
- The 3′UTR luciferase reporter assay confirmed that miR-183 directly regulated PDCD4 by binding to sequences in the 3′UTR of PDCD4. (molcells.org)
Region1
- We used immunoglobulin heavy chain (IGH) variable region (IGHV) spectratyping and next-generation sequencing of peripheral blood B-cell genomic DNA collected at multiple time points during disease evolution to study B-cell response to SARS-CoV-2 infection in 14 individuals with acute COVID-19. (bvsalud.org)
Carries1
- This protein carries a polyhistidine tag at the C-terminus. (transcriptionfactor.org)
Biological1
- Protein markers are an essential component in biological research and drug development. (acrobiosystems.com)
Contribute1
- We suggest that the anti-HIV-1gp120 antiidiotype-like complex contributes to the markedly elevated platelet Ig and C3 level of HIV-1-ITP patients and propose that this may contribute to their thrombocytopenia. (jci.org)
Cells1
- Proximal tubule cells exposed to PMA for 2 h demonstrated a two- to threefold increase in Na/H antiporter mRNA (mRNANa/H) abundance 4 h later. (jci.org)