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  • long-chain
  • FABP1 is primarily expressed in the liver where it is involved in the binding, transport and metabolism of long-chain fatty acids (LCFAs), endocannabinoids, phytocannabinoids (and less so for synthetic cannabinoid receptor (CBR) agonists and antagonists) and other hydrophobic molecules. (wikipedia.org)
  • They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. (wikipedia.org)
  • FABP
  • To the Editor We read with interest the systematic review and meta-analysis by Bruins Slot et al concerning early diagnosis of myocardial infarction (MI) using heart-type fatty acid-binding protein (H-FABP). (bmj.com)
  • Human
  • FABP1 is expressed abundantly in the human liver where it accounts for 7-11% of the total cytosolic protein, and can also be found in the intestine, kidney, pancreas stomach and lung. (wikipedia.org)
  • form
  • The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. (nih.gov)
  • cell
  • This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. (nih.gov)
  • regulation
  • Current research suggests that the protein is associated with regulation of the GH supply in the circulatory system as well as GH receptor function. (wikipedia.org)
  • Baritaki S, Katsman A, Chatterjee D, Yeung K, Spandidos D, Bonavida B. Regulation of tumor cell sensitivity to TRAIL-induced apoptosis by the metastatic suppressor Raf kinase inhibitor protein via Yin Yang 1 inhibition and death receptor 5 up-regulation. (labome.org)
  • Recent results suggest that novel CBP-mediated post-translational N-glycosylation activity alters the conformation of CBP-interacting proteins, leading to regulation of gene expression, cell growth and differentiation, Homeodomain interacting protein kinase 2 (HIPK2) phosphorylates several regions of CBP close to the N-terminal and close to the C-terminal region as well. (wikipedia.org)
  • structures
  • Serre L, Pereira de Jesus K, Zelwer C, Bureaud N, Schoentgen F, Benedetti H. Crystal structures of YBHB and YBCL from Escherichia coli, two bacterial homologues to a Raf kinase inhibitor protein. (labome.org)
  • This family are an example of type 2 periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. (ebi.ac.uk)
  • Comparison of the structures of the liganded and unliganded forms of MBP has shown that the binding of maltose induces a major conformational change that closes the groove by a rigid motion of the two domains around the linking polypeptide hinge. (wikipedia.org)
  • These proteins are important in bending arrays of nucleosomes and arranging them into the larger structures that form chromosomes. (wikipedia.org)
  • PEBP
  • Other PEBP-like proteins that show strong structural homology to PEBP include Escherichia coli YBHB and YBCL, the Rattus norvegicus (Rat) neuropeptide HCNP, and Antirrhinum majus (Garden snapdragon) protein centroradialis (CEN). (ebi.ac.uk)
  • Nonetheless, mPEBP-2 is seen to be very similar in structure to other PEBP proteins from human, bovine and plant sources. (labome.org)
  • ligand
  • This extracellular domain physically binds GH in the receptor-ligand interaction. (wikipedia.org)
  • Assays estimate that growth hormone and growth hormone binding protein form a natural complex at a 1:1 ratio for transport and preservation of the ligand through the bloodstream. (wikipedia.org)
  • When the cysteine amino acids in GHBP are mutated and the disulfide bridges are disrupted, the stability of the ligand to bind to the active site of the GHBP is significantly lessened. (wikipedia.org)
  • The clearance rate, or the rate at which the carrier protein is broken down, for GHBP alone is much faster than when it is bound to its ligand. (wikipedia.org)
  • Additionally, current literature provides evidence that the carrier-protein prolongs the half-life of growth hormone through its binding with the ligand. (wikipedia.org)
  • Yet this could be confounded by the fact that GH binding to GHBP prevents the ligand from binding to GHR and ultimately proteolytic activity. (wikipedia.org)
  • These two regions form part of the ligand-binding site, which can accommodate various anionic groups. (ebi.ac.uk)
  • bZIP domain Comparison of nucleic acid simulation software DNA-binding domain Helix-loop-helix Helix-turn-helix HMG-box Leucine zipper Lexitropsin (a semi-synthetic DNA-binding ligand) Single-strand binding protein Zinc finger Created from PDB 1LMB Created from PDB 1RVA Travers, A. A. (1993). (wikipedia.org)
  • interaction
  • The interaction with apoptotic and necrotic cells is mediated by the Gla domain of protein S and does not affect the ability of C4BP to inhibit complement. (wikipedia.org)
  • As the DNA bends, its contact with TBP increases, thus enhancing the DNA-protein interaction. (wikipedia.org)
  • The CREB protein carries out its function by activating transcription, where interaction with transcription factors is managed by one or more CREB domains: the nuclear receptor interaction domain (RID), the KIX domain (CREB and MYB interaction domain), the cysteine/histidine regions (TAZ1/CH1 and TAZ2/CH3) and the interferon response binding domain (IBiD). (wikipedia.org)
  • amino-acid
  • When TBP binds to a TATA box within the DNA, it distorts the DNA by inserting amino acid side-chains between base pairs, partially unwinding the helix, and doubly kinking it. (wikipedia.org)
  • This specificity is most likely due to the lack of conformational flexibility of the binding fragment of E3BP and the complementary amino acid match with the E3 interface. (wikipedia.org)
  • double-stranded
  • TRFs are double-stranded proteins which are known to induce bending, looping, and pairing of DNA which aids in the formation of T-loops. (wikipedia.org)
  • Telomere-binding proteins not present may cause the exposed telomeres to undergo a DNA repair response, having mistakenly identified the ends as a double-stranded break. (wikipedia.org)
  • transcription
  • In humans, GHBP is formed by post-translational modification after the complete transcription and translation of the growth hormone receptor (GHR) gene into the cell-surface receptor protein. (wikipedia.org)
  • A feature of the SREBP pathway is the proteolytic release of a membrane-bound transcription factor, SREBP. (wikipedia.org)
  • This region modulates the DNA binding activity of the C-terminus, and modulation of DNA-binding affects the rate of transcription complex formation and initiation of transcription. (wikipedia.org)
  • Binding of TFIID to the TATA box in the promoter region of the gene initiates the recruitment of other factors required for RNA Pol II to begin transcription. (wikipedia.org)
  • The TATA-box binding protein (TBP) is required for the initiation of transcription by RNA polymerases I, II and III, from promoters with or without a TATA box. (wikipedia.org)
  • Transcription activation requires the binding of adenosine triphosphate (ATP) and maltotriose to MalT and the binding of cyclic AMP to the dimer of CRP. (wikipedia.org)
  • Alternatively, transcription factors can bind enzymes that modify the histones at the promoter. (wikipedia.org)
  • RKIP
  • Our results suggest that H. pylori utilizes a tumor suppressor protein, RKIP, to promote apoptosis in gastric cancer cells. (labome.org)
  • sequences
  • The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. (nih.gov)
  • There include: TRF1 TRF2 POT1 TIN2 RAP1 TPP1 Both TRF1 and TRF2 bind the telomeric repeat sequences in the duplex region of the genome in vivo. (wikipedia.org)
  • lipids
  • The exclusion of certain lipids in particular regions drive to processes such as membrane binding or signaling. (wikipedia.org)
  • contrast
  • However, in contrast to E-box-binding HLH proteins, an arginine residue is replaced with tyrosine making them capable of recognizing StREs and thereby regulating membrane biosynthesis. (wikipedia.org)
  • bovine
  • Retinol-binding proteins have been identified within the uterus, embryo, and extraembryonic tissue of the bovine, ovine, and porcine, clearly indicating that RBP plays a role in proper retinol exposure to the embryo and successful transport at the maternal-fetal interface. (wikipedia.org)
  • complex
  • The protein encoded by the human PDHX gene, also known as E3 binding protein (E3BP), is part of the pyruvate dehydrogenase complex, a required complex for cellular respiration that catalyzes the dehydration of pyruvate to Acetyl-CoA. (wikipedia.org)
  • The composition of E2.E3BP was thought to be 60 E2 plus approximately 12 E3BP, however, equilibrium sedimentation and small angle x-ray scattering studies showed that the E3BP/E2 binding complex has a lower mass than the E2 subunit alone. (wikipedia.org)
  • This protein tethers E3 dimers to the E2 core of the PDH complex. (wikipedia.org)
  • Other than core splicesome complex, RBPs also bind to the sites of Cis-acting RNA elements that influence exons inclusion or exclusion during splicing. (wikipedia.org)
  • coli
  • Sulfate and thiosulfate transport in Escherichia coli K-12: evidence for a functional overlapping of sulfate- and thiosulfate-binding proteins. (ebi.ac.uk)
  • Maltose-binding protein (MBP) is a part of the maltose/maltodextrin system of Escherichia coli, which is responsible for the uptake and efficient catabolism of maltodextrins. (wikipedia.org)
  • MBP is used to increase the solubility of recombinant proteins expressed in E. coli. (wikipedia.org)
  • Cellular
  • Apart from one whole day focused on the fascinating roles played by calmodulin in cellular activities, the other sessions were devoted to calmodulin-related calcium binding proteins in muscle and non- muscle tissues and to some selected biological systems such as mitochondria, secretory cells or sarcoplasmic reticulum in which calcium also plays a crucial role. (springer.com)
  • CRBP I/II, cellular-binding proteins involved in transport of retinol and metabolites into retinyl esters for storage or into retinoic acid. (wikipedia.org)
  • human
  • Blood levels of both these proteins are controlled by human growth hormone (hGH), a hormone that's produced by the pituitary gland, a pea-sized gland in the brain that works with the endocrine system. (kidshealth.org)
  • It is only present in some human proteins. (wikipedia.org)
  • The main form of C4BP in human blood is composed of 7 identical alpha-chains and one unique beta-chain, which in turn binds anticoagulant, vitamin K-dependent protein S. C4BP is a large glycoprotein (500 kDa) with an estimated plasma concentration of 200 micrograms/mL synthesized mainly in the liver. (wikipedia.org)
  • Prakash B, Praefcke GJ, Renault L, Wittinghofer A, Herrmann C. Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins. (wikipedia.org)
  • vitro
  • The resulting antibody-drug conjugates fully retained their antigen binding capability and proved to be internalized and trafficked to the lysosome, which released the payload with a favorable efficacy in vitro and in vivo. (mdpi.com)
  • In this way, large libraries of proteins can be screened and amplified in a process called in vitro selection, which is analogous to natural selection. (wikipedia.org)
  • Phage display is also a widely used method for in vitro protein evolution (also called protein engineering). (wikipedia.org)
  • novel
  • Furthermore, we identified a novel subunit of the ADA complex, termed Ahc2, and characterized Sgf29 as an ADA family protein present in all Gcn5 histone acetyltransferase complexes. (embopress.org)
  • In this study, we developed and applied a novel method utilizing biochemistry, quantitative proteomics and computational approaches in order to characterize the organization of proteins in a complex. (embopress.org)
  • insulin
  • In the pancreas these genes influence expression of, among others, the genes for insulin, the principal glucose transporter (GLUT2), and several proteins involved in glucose and mitochondrial metabolism. (wikipedia.org)
  • domain
  • Interestingly, 3hyn is structurally most similar to nucleotide binding proteins, not to the TIR domain (DALI top hit, 3ehd, belongs to the nucleoside 2-deoxyribosyl transferase family PF05014). (burnham.org)
  • Both the cyclooxygenase and the peroxidase active sites are located in the catalytic domain, which accounts for approximately 80% of the protein. (wikipedia.org)
  • function
  • Background Cardiac stress may trigger production of the 40\kDa peptide fragment produced from the amino terminus from the cardiac myosin\binding protein C. function, cell viability, hypertrophy, or possibility of success. (biomasswars.com)
  • DasSarma's recent research (2010's) on an Antarctic halophilic microorganism, Halorubrum lacusprofundi, resulted in further refinement in understanding of protein function in high salinity and cold conditions. (wikipedia.org)
  • genetic
  • The key of our method is the systematic purification of several tagged components of the protein complex in multiple genetic deletion strains, which serve to compromise the integrity of the complex. (embopress.org)
  • Phage display is a laboratory technique for the study of protein-protein, protein-peptide, and protein-DNA interactions that uses bacteriophages (viruses that infect bacteria) to connect proteins with the genetic information that encodes them. (wikipedia.org)
  • laboratory
  • This technology was further developed and improved by groups at the Laboratory of Molecular Biology with Greg Winter and John McCafferty, The Scripps Research Institute with Lerner and Barbas and the German Cancer Research Center with Breitling and Dübel for display of proteins such as antibodies for therapeutic protein engineering. (wikipedia.org)
  • Cell
  • They bind to DnaA-ADP and DnaA-ATP with equal affinities and are bound by DnaA throughout most of the cell cycle and forms a scaffold on which rest of the orisome assembles. (wikipedia.org)
  • promotes
  • It is hypothesized that DNA stretching by DnaA bound to the origin promotes strand separation which allows more DnaA to bind to the unwound region. (wikipedia.org)
  • highly
  • The 3D atomic structure of a protein provides highly valuable information to understand the intimate details of its mechanism of action. (wikipedia.org)
  • Crystal
  • Crystal structure of Putative signal transduction protein (YP_002936568.1) from Eubacterium rectale at 1.20 A resolution. (burnham.org)
  • target
  • a href='/help/protein_existence' target='_top'>More. (uniprot.org)
  • By immobilizing a relevant DNA or protein target(s) to the surface of a microtiter plate well, a phage that displays a protein that binds to one of those targets on its surface will remain while others are removed by washing. (wikipedia.org)