CD137: When this molecule, also called 4-1BB, is bound by CD137 ligand, the result is T-cell proliferation. (wikipedia.org)
Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. (genscript.com)
OX40-OX40 Ligand signaling is involved in allergic airway inflammation, graft-versus-host disease and autoimmune disease. (genscript.com)
PF-04518600 (Ivuxolimab) is an activating monoclonal antibody to TNFRSF4 (OX40, CD134), which mimics the binding of the ligand, TNFSF4 (OX40L, CD252), to stimulate proliferation of T-cells and enhance an anti-tumor response (Journal of Clinical Oncology 34, no. 15_suppl (May 20 2016) 3079-3079). (jax.org)
The CD134 binds to CD134 ligand (CD252) to provide a costimulatory signal that is independent of CD28. (abeomics.com)
CD134 functions as a T cell costimulatory receptor when bound by OX40 Ligand/TNFSF4 that is expressed by antigen presenting cells. (bdbiosciences.com)
OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand. (absoluteantibody.com)
CD1344
The ACT35 monoclonal antibody specifically binds to CD134 which is also known as OX40. (bdbiosciences.com)
OX40 was clustered as CD134 in the Sixth International Workshop on Human Leukocyte Differentiation Antigens. (bdbiosciences.com)
This antibody recognises murine OX40 (CD134), a cell surface antigen expressed only by activated T lymphocytes. (absoluteantibody.com)
Binding curve of anti-CD134 antibody OX86 (Ab00110-23.0) to mouse CD134-Fc fusion protein ELISA Plate coated with mouse CD134-Fc fusion protein (Pr00154-1.9) at a concentration of 5 µg/ml. (absoluteantibody.com)
Receptor5
Four stimulatory checkpoint molecules are members of the tumor necrosis factor (TNF) receptor superfamily-CD27, CD40, OX40, GITR and CD137. (wikipedia.org)
OX40 is a T cell co-stimulatory molecule of the TNF receptor superfamily that coordinates with other co-stimulators (CD28, CD40, CD30, CD27 and 4-1BB) to manage the activation of the immune response. (genscript.com)
IMG-007 is a humanized IgG1 monoclonal antibody (mAb) that specifically binds to the OX40 receptor. (vietnamnews.net)
IMG-007 is a humanized IgG1 mAb specifically binds to OX40, a co-stimulatory receptor that is present primarily on activated T cells. (vietnamnews.net)
SIRPα-Fc-CD40L bound CD47 and CD40 with high affinity and activated CD40 signaling in the absence of Fc receptor cross-linking. (aacrjournals.org)
Antigen4
The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. (acrobiosystems.com)
A membrane-bound tumor necrosis family member that is expressed on activated antigen-presenting cells such as B-LYMPHOCYTES and MACROPHAGES. (bvsalud.org)
The human OX40 homolog: cDNA structure, expression and chromosomal assignment of the ACT35 antigen. (bdbiosciences.com)
Antibodies of the IgG sub-class are bi-functional molecules, possessing a F(ab) domain, variable in sequence and responsible for the binding of antigen, and an Fc domain, constant in sequence and responsible for mediating a range of antibody effector functions [ 1 ]. (bmj.com)
OX86 antibody, in its original rat IgG1 format, acts as an OX40 agonist in an Fc-dependent manner and has been widely used in studies investigating the role of OX40 in tumor inhibition (Hirschhorn-Cymerman et al. (absoluteantibody.com)
Antibody6
Setting the corresponding isotype control antibody to detect non-specific binding can reduce the generation of false positive results and evaluate the possible influencing factors accurately in the drug development process. (acrobiosystems.com)
Disrupting the binding of CD47 to SIRPα has emerged as a promising immunotherapeutic strategy for advanced cancers by potentiating antibody-dependent cellular phagocytosis (ADCP) of targeted antibodies. (aacrjournals.org)
HFB200301 is a first-in-class agonistic anti-TNFR2 antibody that binds potently and selectively to TNFR2 and induces the activation and proliferation of CD4 and CD8 T-cells and NK cells. (hifibio.com)
This antibody was raised against the recombinant mouse OX40 protein. (absoluteantibody.com)
IHC: OX86 antibody was utilised in immunohistochemistry staining of gut tissue (Peyer's patches and lamina propria samples) in order to identify OX40-positive cells in colitic mice (Higgins et al. (absoluteantibody.com)
Most of these immunomodulatory antibodies are of IgG isotypes that have low, or no, binding to the Fc gamma receptors (FcγRs) that trigger cell-mediated cytotoxic effector functions such as antibody dependent cellular cytotoxicity (ADCC) and phagocytosis (ADCP). (bmj.com)
Recombinant1
Here, we report rational engineering of an immune-activating recombinant MVA (rMVA, MVA∆E5R-Flt3L-OX40L) with deletion of the vaccinia E5R gene (encoding an inhibitor of the DNA sensor cyclic GMP-AMP synthase, cGAS) and expression of two membrane-anchored transgenes, Flt3L and OX40L. (bvsalud.org)
Protein2
Streptavidin is a tetrameric protein providing 4 high-affinity biotin binding sites. (acrobiosystems.com)
We also determined that γδT cells can bind MSP protein. (bvsalud.org)
Effector2
Like CD27, OX40 promotes the expansion of effector and memory T cells, however it is also noted for its ability to suppress the differentiation and activity of T-regulatory cells, and also for its regulation of cytokine production. (wikipedia.org)
OX40 has also shown to decrease the cells' immunosuppressive activity on effector T cells. (genscript.com)
Agonist1
and MEDI6383, an OX40 agonist GITR: short for Glucocorticoid-Induced TNFR family Related gene, prompts T cell expansion, including Treg expansion. (wikipedia.org)
Potently1
In nonclinical studies, IMG-007 potently and completely blocks signaling between OX40 and OX40L. (vietnamnews.net)
Proliferation1
OX40 is constitutively expressed on Tregs and enhances the sensitivity of Tregs to IL-2, thus promoting Treg proliferation. (genscript.com)
Antitumor1
Intratumoral (IT) delivery of rMVA (MVA∆E5R-Flt3L-OX40L) generates potent antitumor immunity, dependent on CD8+ T cells, the cGAS/STING-mediated cytosolic DNA-sensing pathway, and type I IFN signaling. (bvsalud.org)
Interaction4
In this article, we report that the interaction between OX40L and OX40 is of critical importance for both induction and progression of acute GVHD (aGVHD) driven by human T cells. (aai.org)
Mechanistically, blocking OX40L-OX40 interaction with an anti-hOX40L reduces infiltration of human T cells in target organs, including liver, gut, lung, and skin. (aai.org)
Therapeutic strategies that can efficiently interrupt OX40L-OX40 interaction in patients might have potential to provide patients with an improved clinical benefit. (aai.org)
Remarkably, IT rMVA (MVA∆E5R-Flt3L-OX40L) depletes OX40hi regulatory T cells via OX40L/OX40 interaction and IFNAR signaling. (bvsalud.org)
Signaling pathway1
We are continuing our evaluations of IMG-007's potential in other diseases where OX40 signaling pathway plays an important pathogenic role. (vietnamnews.net)
Isotype1
Each IgG isotype has a different binding profile to the various FcγRs, and each FcγR has a different cellular expression pattern. (bmj.com)
CD861
Binding with its two ligands are CD80 and CD86, expressed on dendritic cells, prompts T cell expansion. (wikipedia.org)
Therapeutic1
Anti-human OX40L mAb (hOX40L) treatment could thus effectively reduce the disease severity in a xenogeneic-aGVHD model in both preventative and therapeutic modes. (aai.org)
Necrosis1
Miembro de la familia de necrosis tumoral unido a la membrana que se expresda en las células presentadoras de antígeno activadas tales como los LINFOCITOS B y los MACRÓFAGOS. (bvsalud.org)
Cells3
Data from this study indicate that OX40L-OX40 interactions play a central role in the pathogenesis of aGVHD induced by human T cells. (aai.org)
3 In resting cells, the NF-κB dimer is inactive and is sequestered in the cytoplasm by binding to members of the κB inhibitory factor (IκB) family. (xiahepublishing.com)
In resting cells, the binding of members of the IκB family, such as the prototypical IκB member IκBα, to classical NF-κB complexes, particularly NF-κB1 p50-RelA and NF-κB1 p50-c-Rel dimers, inhibit the nuclear translocation of NF-κB complexes. (xiahepublishing.com)
Cell1
OX40-OX40L axis is important in T cell activation, expansion, and survival, thereby having an important role in the pathogenesis of a spectrum of immunological and inflammatory diseases. (vietnamnews.net)
ADCC1
The lead compound, IMG-007, a unique OX40 antagonist mAb with an extended half-life and a silenced ADCC function, is in two global POC clinical trials. (vietnamnews.net)
Human2
Immobilized OX40 His, human at 2 μg/mL (100 μL/well) can bind Biotin-OX40L His, Human with a linear range of 1.22-19.53 ng/mL. (genscript.com)
Immobilized OX40 His, human at 2.0 μg/ml (100 µl/well) can bind Biotin-OX40L His, Human when detected by Streptavidin-HRP. (genscript.com)
Target1
2 , 3 These NF-κB subunits form various homodimers or heterodimers that bind to κB enhancers of target genes and regulate their transcription. (xiahepublishing.com)
Antibodies1
Anti-OX40 monoclonal antibodies have been shown to have clinical utility in advanced cancer. (wikipedia.org)