Binding and protein protein interaction. Medical search. Frequent questions

P59 (FK506 binding protein 59) interaction with heat shock proteins is highly conserved and may involve proteins other than steroid receptors. (broadinstitute.org)
P59 [also known as FK506 binding protein 59 (FKBP59) or heat shock protein 56 (hsp56)] and heat shock proteins 90 and 70 (hsp90 and hsp70) associate with steroid receptors and are believed to maintain the receptors in an inactive state. (broadinstitute.org)
Here we provide evidence that rabbit uterine p59 also binds FK506 and rapamycin and that p59 or its homologue is associated with nontransformed progesterone receptors of rabbit uterus and chicken oviduct. (broadinstitute.org)
For example, the binding of acetylcholine to muscarinic tracheal smooth-muscle receptors (M3) results in smooth muscle contractions. (wikipedia.org)
When freely binding receptors interact with agonist- chemicals that activate receptors - and antagonists- that inhibit/ block activation - the opportunity for selective drugs to bind with the intended receptor cells decreases as most receptors are already accounted for. (wikipedia.org)
Therefore, the drugs are more likely to bind to other receptors relative to the intended receptor, causing different effects. (wikipedia.org)
Pharmacodynamic interactions can occur on: Pharmacological receptors: Receptor interactions are the most easily defined, but they are also the most common. (wikipedia.org)
In prokaryotes, PBPs function as receptors for ATP-binding cassette or tripartite ATP-independent transporters and chemotaxis systems. (rcsb.org)
HA proteins bind to sialoside receptors on the host cell surface. (cdc.gov)
Although a recent study ( 22 ) reported enhanced avidity of H5N6 viruses for human-type receptors, recombinant clade 2.3.4.4 highly pathogenic influenza A virus H5 proteins from virus isolates in North America show a strict avian receptor-binding preference ( 23 ). (cdc.gov)

In addition, it was discovered that the thyroid receptor-coregulator binding patterns vary with ligand and that this differential binding can be used to predict biological responses. (nih.gov)
Signaling is initiated when the Wnt ligand binds to the Frizzled receptor on the cell membrane and the LDL receptor-associated protein 5/6 (LRP5/6) co-receptor. (frontiersin.org)
Simply provide your ligand and receptor PDB or structure files , proposing specific residue contacts between the binding partners if desired. (dnastar.com)
In two-body docking, the proteins involved are often a ligand (e.g., an antigen) and a receptor (e.g., an antibody). (dnastar.com)
A docking algorithm must consider the structure of each individual protein molecule and use this information to predict the structure of the bound complex, while also considering protein flexibility, multiple point interactions between the ligand and receptor, molecular energy and biophysical interactions. (dnastar.com)
Theoretical calculation of protein-protein and protein-ligand binding free energies is a grand challenge in computational biology. (utoronto.ca)
In this talk we develop an efficient approach (Interaction Entropy) to computing quantitative residue-specific contributions to protein-protein and protein-ligand binding free energies. (utoronto.ca)
Studies for an extensive set of realistic protein-protein interaction systems and for specific protein-ligand binding systems showed that by including the entropic contribution, the computed residue-specific binding free energies are in better agreement with the corresponding experimental data. (utoronto.ca)
1. Duan, L.L., X. Liu, and J.Z.H. Zhang, Interaction Entropy: A New Paradigm for Highly Efficient and Reliable Computation of Protein-Ligand Binding Free Energy. (utoronto.ca)
Computational Alanine Scanning with Interaction Entropy for Protein-Ligand Binding Free Energies, J. Chem. (utoronto.ca)
Moreover dedicated peptide, protein interaction and ligand binding work is provided. (uni-tuebingen.de)
By fragment screening using x-ray crystallography we identified four ligands revealing ligand-binding sites in conserved interfaces between SARS-CoV-2 nsp10 and nsp14/nsp16. (lu.se)

This suggests that the immunophilin-heat shock protein-steroid receptor interaction is ubiquitous and not limited to immune systems. (broadinstitute.org)
By constant-pH Monte Carlo simulations and the PROCEEDpKa method, we have mapped the electrostatic epitopes for four monoclonal antibodies and the angiotensin-converting enzyme 2 (ACE2) on both SARS-CoV-1 and the new SARS-CoV-2 S receptor binding domain (RBD) proteins. (nih.gov)
They, in turn, can be: Pure agonists, if they bind to the main locus of the receptor, causing a similar effect to that of the main drug. (wikipedia.org)
These include: Competitive antagonists, if they compete with the main drug to bind with the receptor. (wikipedia.org)
The amount of antagonist or main drug that binds with the receptor will depend on the concentrations of each one in the plasma. (wikipedia.org)
Uncompetitive antagonists, when the antagonist binds to the receptor irreversibly and is not released until the receptor is saturated. (wikipedia.org)
In principle, the quantity of antagonist and agonist that binds to the receptor will depend on their concentrations. (wikipedia.org)
Upon binding of thyroid hormone, the thyroid receptor releases corepressor proteins and undergoes a conformational change that allows for the interaction of coactivating proteins necessary for gene transcription. (nih.gov)
To further understand the principles underlying thyroid receptor-coregulator selectivity, we designed a high-throughput in vitro binding assay to measure the equilibrium affinity of thyroid receptor to a library of potential coregulators in the presence of different ligands including the endogenous thyroid hormone T3, synthetic thyroid receptor beta-selective agonist GC-1, and antagonist NH-3. (nih.gov)
Knowledge of the evolution of receptor-binding specificity of these viruses, which might affect host range, is urgently needed. (cdc.gov)
We report that emergence of these viruses is accompanied by a change in receptor-binding specificity. (cdc.gov)
Altered receptor-binding specificity of virus clade 2.3.4.4 H5 proteins might have contributed to emergence and spread of H5Nx viruses. (cdc.gov)
Changes in HA receptor-binding properties might affect virus host range and within-host virus properties. (cdc.gov)
To overcome the α-adrenergic receptor blockade, new α-receptor protein must be synthesized in the inhibited receptor internalized by the cell and degraded. (pharmacology2000.com)

The X-ray structure shows that these two residues are very far apart (C α -C α ≈ 27.9 Å), leading us to suggest that the metal-induced NMR perturbations are due to the interaction of two protein molecules with a single metal ion. (unl.pt)
finally, Cu I is transferred to the cluster-binding region, upon the interaction of two protein molecules. (unl.pt)
This influences drug molecules to bind to secondary targets, which may result in an array of unwanted side-effects. (wikipedia.org)
A quenching of 50(± 2)% is observed upon filling only half of the subunits with either one molecule of dT(pT) 34 or two molecules of dT(pT) 15 , which agrees with the quenching and site size observed in the (SSB) 35 polynucleotide binding mode. (utmb.edu)
Accurate prediction of critical residues along with their specific and quantitative contributions to protein-protein binding free energy is extremely helpful to reveal binding mechanisms and identify drug-like molecules that alter protein-protein interactions. (utoronto.ca)
These 'networks' were inferred to be dynamic and poorly-ordered, consisting of several DNA loops between distally bound ParB molecules. (elifesciences.org)
The nsp14/10 interaction is weak and therefore could be disrupted by small molecules. (lu.se)

These regions are highly conserved amongst mastadenovirus pVI proteins. (microbiologyresearch.org)
We found both previously predicted, highly conserved residues as well as additional residues in the RBD to be essential for C1 RNA binding. (korea.ac.kr)

Importantly, this surface is not conservedinthe FHA2 domainof Rad53, suggesting that the FHA domains of Rad53 gain specificity by engaging additional interaction interfaces beyond their phosphoepitope-binding site.Ingeneral, our results point to FHA domains functioning as complex logic gates rather than mere phosphoepitope-targeting modules. (elsevierpure.com)

Thus, structures in which aluminum is interacting with the carbonyl group are only slightly exothermic, and they become even less favorable if the interaction implies additionally the peptide nitrogen. (worktribe.com)
By contrast, oligopeptide-binding proteins bind their ligands through interactions with the peptide backbone but do not distinguish between different side chains. (rcsb.org)
It is also rec- important target organ in the safety assessment of drugs and ognized that different types of immune-mediated responses can be triggered by different classes of compounds and that some immune chemicals, as well as protein- or peptide-based products. (cdc.gov)

To determine how the ASAP complex interacts with the EJC core, we performed in vitro coprecipitation assays 3 with Tandem Affinity Purification (TAP)-tagged recombinant proteins corresponding to full-length human SAP18, RNPS1 and ACINUS. (nature.com)

Periplasmic binding proteins (PBPs) constitute a protein superfamily that binds a wide variety of ligands. (rcsb.org)
The resulting oligosaccharide derivatives were tested for binding to Erythrina cristagalli lectin (ECL), Aleuria aurantia lectin (AAL) and Ulex europaeus agglutinin-I (UEA I). We found that ligands containing an aryl azido photoactivable group were successfully attached to lectins. (uzh.ch)

Two regions, between amino acid residues 48-74 and 233-239 of pVI, were required for the interaction with hexon. (microbiologyresearch.org)
These results demonstrate that although the RBD is the primary determinant of C1 RNA binding, residues in the C1-C1 interaction domain also influence the RNA binding activity of the protein. (korea.ac.kr)
The approach provides explicit contribution of the entropic loss in binding free energy of individual residues directly from fluctuation of the interaction energy in MD simulation. (utoronto.ca)
The HP model has favorable interactions between adjacent, not directly bound hydrophobic residues. (lu.se)

The experimental approach we described should be generally applicable for the screening and identification of amino acids that play a role in the binding of proteins to nucleic acid substrates. (korea.ac.kr)

and positive regulation of protein phosphorylation. (nih.gov)
Mechanism of SNARE protein binding and regulation of Cav2 channels by phosphorylation of the synaptic protein interaction site. (bvsalud.org)
Here we identify two separate microdomains that each bind syntaxin 1A and SNAP-25 in vitro and are regulated by PKC phosphorylation at serines 774 and 898 and CaMKII phosphorylation at serines 784 and 896. (bvsalud.org)
Our results support a bipartite model for the synprint site in which each SNARE -binding microdomain is controlled by a separate PKC and CaMKII phosphorylation site that regulates channel modulation by SNARE proteins . (bvsalud.org)
The Rad53-Dbf4 interaction is phosphorylation-independent and involves a novel non-canonical interface on the FHA1 domain. (elsevierpure.com)
Post-translational modifications (PTMs) of proteins, including phosphorylation, acetylation, ubiquitination, and SUMOylation, can regulate the function of proteins, determine the active state and subcellular location of proteins, and dynamically interact with other proteins related to carcinogenesis and progression ( 17 - 20 ). (frontiersin.org)
Pretreatment with roxithromycin attenuated NF-κB DNA-binding activity and WeκB phosphorylation/degradation PCI-32765 markedly. (ecolowood.com)

The RNA-binding domain (RBD) is comprised of ∼80-100 amino acids, and its structure has been determined. (korea.ac.kr)
However, relatively little is known about the role of specific amino acids of the RBD in the binding to RNA. (korea.ac.kr)
We have devised a phage display-based screening method for the rapid identification of amino acids in hnRNP C1 that are essential for its binding to RNA. (korea.ac.kr)

However, the affinity between the S RBD protein from the new SARS-CoV-2 and ACE2 is higher than for any studied antibody previously found complexed with SARS-CoV-1. (nih.gov)
Here, we show that human Abs can induce increased Fn-binding affinity in M proteins, likely by enhancing the weak A-B domain binding. (lu.se)
The identified mutants were further tested for binding to poly(U)-Sepharose, a substrate to which wild type hnRNP C1 binds with high affinity. (korea.ac.kr)

1995. Copper and zinc metabolism in health and disease: Speciation and interactions. (cdc.gov)

In the cellular environment, molecular recognition occurs when one protein binds with another in a specific fashion based on traits such as steric complementarity ("shape recognition"), charge complementarity, and other nonbonded forces (e.g., van der Waals forces, hydrogen binding, electrostatic, solvation contributions). (dnastar.com)

In addition, we found that the FKBP59-hsp complexes are more complicated than previously thought, involving other proteins such as actin and a 63-kDa protein, p63. (broadinstitute.org)
Here, using recombinant complex reconstitution and transcriptome-wide analysis, we showed that the EJC peripheral protein complexes ASAP and PSAP form distinct complexes with the EJC core and can confer to EJCs distinct alternative splicing regulatory activities. (nature.com)
However, how these complexes bind the EJC core and whether they function differently as part of EJC is still unknown. (nature.com)
The modeling of macromolecular complexes is an exciting and rapidly advancing niche for the protein software industry. (dnastar.com)
These nucleoprotein complexes act as a positional marker of the origin and earmark this region for segregation in a manner somewhat analogous to eukaryotic centromeres and their binding partners. (elifesciences.org)
In particular, the relationship between these dynamic nucleoprotein complexes and the molecular architecture of the ParB protein is unclear and is the subject of the work presented here. (elifesciences.org)

Based on physical chemical analysis and free energies estimates, we can shed some light on the involved molecular recognition processes, their clinical aspects, the implications for drug developments, and suggest structural modifications on the CR3022 antibody that would improve its binding affinities for SARS-CoV-2 and contribute to address the ongoing international health crisis. (nih.gov)
The ability of GAS to bind to fibronectin (Fn), a high molecular weight glycoprotein of the extracellular matrix, has long been known to be essential for the pathogen's evolutionary success and fitness. (lu.se)
Molecular docking study supported the argument that PSF hinders the binding of viral DNA with IN. (biomedcentral.com)
A program that focuses on the scientific study of the biochemical and biophysical characteristics of drugs at the molecular level and their interaction with, and effects on, biological macromolecules and cellular structures and processes. (mymajors.com)
Funciona como andamio molecular para localizar y estabilizar estas proteínas en los sitios de recombinación homóloga. (bvsalud.org)
It functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. (bvsalud.org)

Interaction of the retinol/cellular retinol-binding protein complex with isolated nuclei and nuclear components. (rupress.org)
We have previously reported that purified cellular retinol-binding (CRBP) will mediate specific binding of retinol to nuclei isolated from rat liver. (rupress.org)
MIR-1265 regulates cellular proliferation and apoptosis by targeting calcium binding protein 39 in gastric cancer and, thereby, impairing oncogenic autophagy. (nih.gov)
The different interactions between viral proteins and cellular host proteins are required for efficient replication of HIV-1. (biomedcentral.com)
Various reports implicated host cellular proteins as a key factor that either interact directly with HIV-1 integrase (IN) or get involved in the integration process of virus resulting in the modulation of integration step. (biomedcentral.com)
Identification of these interacting host cellular protein provide better understanding of mechanism of viral replication and subsequently development of new therapeutic approaches. (biomedcentral.com)
SUMOylation of proteins is an important mechanism in cellular responses to environmental stress ( 21 , 22 ). (frontiersin.org)
Brown, MS & Goldstein, JL 1998, ' Seventeenth Marabou Symposium on Diet and Genetic Interactions: Sterol regulatory element binding proteins (SREBPs): Controllers of lipid synthesis and cellular uptake ', Nutrition Reviews , vol. 56, no. 2 II, pp. (elsevierpure.com)

Despite the broad occurrence of carbohydrate-protein interactions in biology, the low binding affinities of such interactions hamper the characterization of carbohydrate binding sites in the absence of three-dimensional structural models. (uzh.ch)

1994). High-res- belongs to the family of intracellular lipid bind- olution crystal structures (Sacchetti ni et al. (lu.se)

Together our results suggest a novel synergistic interplay of GAS and host proteins which ultimately benefits the bacterium. (lu.se)
The integration process is catalyzed by viral protein integrase which utilizes different host proteins for integration of viral DNA [ 1 ]. (biomedcentral.com)

The binding of retinol to these sites may affect gene expression. (rupress.org)

We found that this enhanced Fn binding leads to a reduction in Ab-mediated phagocytosis, indicating that this constitutes a GAS immune escape mechanism. (lu.se)
Drug interactions occur when a drug's mechanism of action is affected by the concomitant administration of substances such as foods, beverages, or other drugs. (wikipedia.org)
The general mechanism of herb-warfarin interaction almost remains unknown, yet several pharmacokinetic and pharmacodynamic factors were estimated to influence the effectiveness of warfarin. (hindawi.com)

PKC and CaMKII phosphorylate the synprint site and inhibit SNARE protein binding in vitro . (bvsalud.org)
The interaction of the Escherichia coli single strand binding (SSB) protein with single-stranded DNA is complex, since a number of different binding modes have been observed, with different DNA site sizes and binding properties and the transitions among these binding modes are strongly influenced by solution conditions in vitro. (utmb.edu)
Structural analysis of the C-terminal domain reveals a dimer with a lysine-rich surface that binds DNA non-specifically and is essential for DNA condensation in vitro. (elifesciences.org)

Here, we present the crystal structure of a T. maritima cellobiose-binding protein (tm0031) that is homologous to oligopeptide-binding proteins. (rcsb.org)

These observations suggest that EB1:F-actin interactions may negatively regulate EB1:MT interactions, and we speculate that this interaction may assist cells in differentially regulating MT stability in the actin-rich cortex as opposed to the cell interior. (umn.edu)
Polypyrimidine tract binding protein and associated splicing factor (PSF) has diverse functions inside the cell such as transcriptional regulation, DNA repair, acts as nucleic acids binding protein and regulate replication and infectivity of different viruses. (biomedcentral.com)

To allow the identification of proteins interacting with specific carbohydrate epitopes, we have developed new photoactivable oligosaccharide probes. (uzh.ch)

The heterogeneous nuclear ribonucleoprotein (hnRNP) C proteins, among the most abundant pre-mRNA-binding proteins in the eukaryotic nucleus, have a single RNP motif RNA-binding domain. (korea.ac.kr)

The change in an organism's response upon administration of a drug is an important factor in pharmacodynamic interactions. (wikipedia.org)
In pharmacodynamic interactions, one drug alters the sensitivity or responsiveness of tissues to another drug by having the same (agonistic) or a blocking (antagonistic) effect. (msdmanuals.com)

We show that the MT binding protein EB1 (end-binding protein 1), a key regulator of MT dynamics, can bind directly to filamentous actin (F-actin) F-actin. (umn.edu)
We determined that the EB1:F-actin interaction is salt sensitive and weak under physiological salt concentrations but might be relevant in contexts where the local concentration of actin is high. (umn.edu)
Using bioinformatics and mutagenesis, we found that the EB1:F-actin binding site partially overlaps the well-characterized EB1:MT binding interface. (umn.edu)
Congruently, competition experiments indicate that EB1 can bind to F-actin or MTs but not both simultaneously. (umn.edu)

We also identified three mutations in the leucine-rich C1-C1 interaction domain near the carboxyl terminus of the protein that both abolished C1 oligomerization and reduced RNA binding. (korea.ac.kr)

Both synergy and antagonism can occur during different phases of the interaction between a drug and an organism. (wikipedia.org)

Antibody responses targeting the M protein have been shown to favor the conserved C region. (lu.se)
To examine interactions between G proteins and the H + -ATPase, we performed immunocytochemical studies on perfusion-fixed sections of rat kidney using polyclonal anti-G protein antibodies and E11, a mouse monoclonal antibody to the 31-kDa subunit of the vacuolar H + -ATPase. (wustl.edu)
This video gives an overview of Lasergene Protein, consisting of Protean 3D, plus the optional services NovaFold, NovaFold Antibody and NovaDock. (dnastar.com)
After the addition of biotinylated T3 and streptavidin-coated microparticles, the still-free binding sites of the labeled antibody become occupied, with formation of an antibody-hapten complex. (cdc.gov)

hi, I try to purify a protein from yeast to assay some structural studies. (bio.net)
The role of adenovirus structural proteins in the regulation of adenovirus infection. (microbiologyresearch.org)
However, a new structural paradigm has recently been proposed, in which aluminum interacts directly with the backbone of the proteins, provoking drastic changes in their secondary structure and leading ultimately to their denaturation. (worktribe.com)
In a collaborative effort, the Lund Protein Production Platform (LP3) , the FragMAX platform at the BioMAX beamline of the MAX IV laboratory, the Deuteration and Macromolecular Crystallization (DEMAX) of the European Spallation Source ESS and the group of Professor F. Kozielski at University College London published new results on non-structural protein from SARS-CoV-2. (lu.se)

Such antibodies (Abs) circumvent antigenic escape and efficiently bind to various M types. (lu.se)
The sample is incubated with biotinylated Tg and the antibodies of the sample bind the antigen. (cdc.gov)
After the addition of anti-Tg antibodies labeled with ruthenium complex and streptavidin-coated microparticles, the immunocomplex produced becomes bound to the solid phase via interaction of biotin and streptavidin. (cdc.gov)

The covalent interaction explains the drug's long duration of action. (pharmacology2000.com)

We also calculated free energy of interactions and shown that the S RBD proteins from both SARS viruses binds to ACE2 with similar affinities. (nih.gov)

Bound or free: interaction of the C-terminal domain of E. coli single-stranded DNA binding protein (SSB) with the tetrameric core of SSB. (cipps.org.au)

Temperature sensitivity of processing of viral proteins. (microbiologyresearch.org)
In an attempt to study the host interacting protein of IN, we have identified a new interacting host protein PSF which is a splicing factor and elucidated its role in integration and viral replication. (biomedcentral.com)
Experimental as well as in silico analysis inferred that the host protein causes not only change in the integration events but also targets the incoming viral DNA or the integrase-viral DNA complex. (biomedcentral.com)
MD trajectory analyses provided a strong clue of destabilization of Integrase-viral DNA complex occurred due to PSF interaction with the conserved bases of viral DNA ends that are extremely crucial contact points with integrase and indispensable for integration. (biomedcentral.com)
The balance between activities of HA and NA proteins has a critical role in optimal viral fitness, tropism, and transmission ( 21 ). (cdc.gov)

Avian and human influenza A viruses prefer binding to sialic acids linked to a penultimate galactose by an α2-3 or α2-6 linkage, respectively ( 18 ). (cdc.gov)

In addition, we found evidence to indicate that conformation as well as sequence was important for good hexon binding in our assays. (microbiologyresearch.org)

1998. Interaction of blood lead and *-aminolevulinic acid dehydratase genotype on markers of heme synthesis and sperm production in lead smelter workers. (cdc.gov)

Surface plasmon resonance (SPR) biosensor has become a standard technology for measuring kinetics of bimolecular interactions without the need for labeling. (edu.hk)
Kinetic parameters obtained with either of the binding partners immobilized on the matrix were compared to evaluate the effects of the matrix on the binding kinetics. (edu.hk)

We have identifieda crucial non-canonical interaction between the N-terminal FHA1 domain of the checkpoint effector kinase Rad53 and the BRCT domain of the regulatory subunit of the Dbf4-dependent kinase that is critical to suppress late origin firing and to stabilize stalled forks during replication stress. (elsevierpure.com)

Drug interaction predictors enable risk assessment of multiple drugs simultaneously with visualizations of risk per therapeutic class, to indicate a spectrum from no risk to high risk. (wikipedia.org)

We therefore elucidated X-ray crystal structures of the Lymnaea stagnalis acetylcholine binding protein (Ls-AChBP) and its Gln55Arg mutant, more closely resembling insect nAChRs, in complex with a nitromethylene imidacloprid analog (CH-IMI) and desnitro-imidacloprid metabolite (DN-IMI) as well as commercial neonicotinoids, imidacloprid, clothianidin, and thiacloprid. (rcsb.org)

NovaDock explores protein flexibility when docking, resulting in more accurate protein-protein interaction predictions. (dnastar.com)
Utilizing the SwarmDock algorithm, NovaDock explores protein flexibility when docking, resulting in more accurate predictions. (dnastar.com)
Predictions of hot stops for some important protein-protein interactions are discussed. (utoronto.ca)

Large-scale inference of protein tissue origin in gram-positive sepsis plasma using quantitative targeted proteomics. (lu.se)

Guanosine 5′-triphosphate (GTP)-binding proteins (G proteins) are expressed in a heterogeneous manner in the mammalian kidney. (wustl.edu)

Moreover, the free C-terminal domain can rapidly decondense ParB networks independently of its ability to bind DNA. (elifesciences.org)

In cells, they are presumably anchored at parS sites by sequence-specific interactions but must also contain many interactions with non-specific DNA (nsDNA), as well as self-association interactions that bridge ParB protomers to form DNA loops. (elifesciences.org)
Folding a protein sequence into its minimum-energy structure represents such a problem. (lu.se)
Protein folding, going from sequence to structure by mini- a quadratic Hamiltonian requires additional spin variables and mizing an energy function, represents a difficult optimization implementing interactions such as self-avoidance becomes problem. (lu.se)

This interaction is mediated by a conserved motif, termed the NR box, found in many coregulators. (nih.gov)

Instead, they have been found to additionally bind Fn via the A-B domains of their M proteins. (lu.se)
Forkhead-associated (FHA) and BRCA1 C-terminal (BRCT) domains are overrepresented in DNA damage and replication stress response proteins. (elsevierpure.com)
HDAC6: one protein, two domains, diverse therapeutic opportunities. (ugent.be)

Thus, CRBP delivers retinol to the interior of the nucleus, to specific binding sites which are primarily, if not solely, on the chromatin. (rupress.org)

1990. A review on biochemical roles, toxicity and interactions of zinc, copper and iron: IV. (cdc.gov)
If possible, drugs with a wide safety margin should be used so that any unforeseen interactions do not cause toxicity. (msdmanuals.com)

Each binding partner can consist of one or multiple protein chains. (dnastar.com)

The risk of a drug-drug interaction (DDI) increases with the number of drugs used. (wikipedia.org)
Over a third (36%) of the elderly in the U.S. regularly use five or more medications or supplements, and 15% are at risk of a significant drug-drug interaction. (wikipedia.org)
A drug-drug interaction may increase or decrease the effects of one or both drugs. (msdmanuals.com)

Drug interactions can be additive (the result is what you expect when you add together the effect of each drug taken independently), synergistic (combining the drugs leads to a larger effect than expected), or antagonistic (combining the drugs leads to a smaller effect than expected). (wikipedia.org)
Direct interactions between drugs are also possible and may occur when two drugs are mixed before intravenous injection. (wikipedia.org)
Interactions with other drugs (eg, cimetidine, beta-blockers) can also affect lidocaine drug levels. (medscape.com)
immunotoxicology--protein part of the safety assessment of drugs, chemicals, and other allergy. (cdc.gov)
The effects, desired and undesired, of all drugs taken should be determined because these effects usually include the spectrum of drug interactions. (msdmanuals.com)
When unexpected clinical responses occur, prescribers should determine serum concentrations of selected drugs being taken, consult the literature or an expert in drug interactions, and adjust the dosage until the desired effect is produced. (msdmanuals.com)

Hydrophobic interactions are generally weak, but important. (pharmacology2000.com)

Orange protein (ORP) is a small bacterial protein, of unknown function, that contains a unique molybdenum/copper heterometallic cluster, [S 2 Mo VI S 2 Cu I S 2 Mo VI S 2 ] 3- (Mo/Cu), non-covalently bound. (unl.pt)
They function primarily as phosphoepitope recognition modules but can also mediate non-canonical interactions. (elsevierpure.com)
Proteins associated with the Wnt/β-catenin pathway have been identified as SUMOylated substrates, and evidences suggested that the initiation and progression of cancers depended on the function of the SUMOylation ( 23 ). (frontiersin.org)
Platelet-dependent neutrophil function is dysregulated by M protein from Streptococcus pyogenes. (lu.se)

Anatomy4

Organisms3

Chemicals and Drugs24

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Phenomena and Processes30

Disciplines and Occupations4

Information Science16

Health Care3

Receptors10

Ligand12

Receptor14

Molecules7

Highly conserved2

Specificity1

Peptide3

Recombinant proteins1

Ligands2

Residues4

Nucleic acid1

Phosphorylation7

Amino Acids3

Affinity3

Metabolism1

Electrostatic1

Complexes6

Molecular6

Cellular8

Characterization1

Lipid1

Host proteins2

Gene1

Mechanism3

Vitro3

Homologous1

Regulate2

Epitopes1

Eukaryotic1

Pharmacodynamic2

Actin4

Mutations1

Organism1

Antibody4

Structural4

Antibodies3

Drug's1

Affinities1

Single-stranded1

Viral5

Viruses1

Conformation1

Synthesis1

Kinetics2

Stabilize1

Predictors1

Acetylcholine1

Predictions3

Proteomics1

Heterogeneous1

Ability to bind1

Sequence3

Motif1

Domains3

Nucleus1

Toxicity2

Chains1

Drug-drug intera3

Drugs6

Weak1

Function4