Bind schizosaccharomyces pombe proteins. Medical search. Frequent questions

Professor Forsburg studies how chromosome duplication and maintenance contributes to overall genome stability using a simple model genetic system, the fission yeast Schizosaccharomyces pombe . (usc.edu)
In the fission yeast Schizosaccharomyces pombe, the DNA damage response protein Brc1 binds phospho-histone H2A (Î³H2A)-marked chromatin during S-phase, but how Brc1 protects genome integrity remains unclear. (thebiogrid.org)
In this study, we demonstrate that S-palmitoylation mediated by Erf2-Erf4 and Akr1 palmitoylacyltransferases is required at multiple meiotic stages in the fission yeast Schizosaccharomyces pombe . (life-science-alliance.org)
A model system where the targeting of the chromosomes to the spindle can be studied is meiosis I in the fission yeast Schizosaccharomyces pombe ( S. pombe ). (nature.com)
The budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe have Yta7 and Abo1 as orthologs of ATAD2, respectively. (molcells.org)
Background: In the fission yeast Schizosaccharomyces pombe, cell growth takes place exclusively at both ends of the cylindrical cell. (escholarship.org)
Here, we have improved the AID system for the fission yeast Schizosaccharomyces pombe by optimizing all three components: the AID degron, the small-molecule inducer, and the inducer-responsive F-box protein. (nibs.ac.cn)

Several of these were isolated by virtue of their binding to either strand of an upstream element of c-myc (MSSPs), or by phenotypic complementation of cdc2 and cdc13 mutants of yeast (scr2), or as a potential human repressor of HIV-1 and ILR-2 alpha promoter transcription (YC1). (wikipedia.org)
Role of the constant uridine in binding of yeast tRNAPhe anticodon arm to 30S ribosomes. (colorado.edu)
Here we show that the triphosphatase (Pct1) and guanylyltransferase (Pce1) enzymes of the fission yeast capping apparatus bind independently to the elongation factor Spt5. (mskcc.org)
In situ assay for analyzing the chromatin binding of proteins in fission yeast. (ox.ac.uk)
An in situ technique for studying the chromatin binding of proteins in single fission yeast cells (Schizosaccharomyces pombe) is described. (ox.ac.uk)
Thestructure reveals a buried autoacetylated lysine residue that we show is alsoacetylated in the Rtt109 protein purified from yeast cells. (embl.de)
In order to shed light on this process we carried out structural investigations on the essential fission yeast protein Sap1. (le.ac.uk)
Homologues of the yeast Oxa1 protein are found in chloroplasts of plants and in a wide variety of bacteria. (tcdb.org)
To explore the conservation of Src homology 3 (SH3) domain-mediated networks in evolution, we compared the specificity landscape of these domains among four yeast species, Saccharomyces cerevisiae, Ashbya gossypii, Candida albicans, and Schizosaccharomyces pombe, encompassing 400 million years of evolution. (upf.edu)
This analysis revealed a striking example of binding motif divergence in a C. albicans Rvs167 paralog, which cannot be explained by overall SH3 sequence or interface residue divergence, and we validated this specificity change with a yeast two-hybrid (Y2H) assay. (upf.edu)
We report the adaptation to Schizosaccharomyces pombe of the anchor-away technique, originally designed in budding yeast by Laemmli lab. (tau.ac.il)
We show that Sp Hal3 and/or its N-terminal domain retain the ability to bind to and modestly inhibit in vitro S. cerevisiae Ppz1 as well as its S. pombe homolog Pzh1, and also exhibit PPCDC activity in vitro and provide PPCDC function in vivo, indicating that Sp Hal3 is a monogenic PPCDC in fission yeast. (singerinstruments.com)
Some proteins known to contain a SUN domain are listed below: - Fission yeast spindle pole body-associated protein Sad1. (expasy.org)
Yeast uncharacterized protein SLP1. (expasy.org)
Fission yeast spindle pole body-associated protein Sad1. (expasy.org)
At the onset of meiosis I in the fission yeast S. pombe , the KCs are far apart from SPBs and telomeres, and SPBs are clustered together 2 . (nature.com)
In a new study in the Journal of Agricultural and Food Chemistry , Wang and coworkers were able to toughen up budding yeast against caffeine by adding bfr1 , a gene from Schizosaccharomyces pombe that encodes the ABC transporter that shunts caffeine out of the cell. (yeastgenome.org)

This gene encodes a member of a small family of proteins which bind single stranded DNA/RNA. (wikipedia.org)
Background: This gene encodes one of seven subunits of the human Arp2/3 protein complex. (icbinhibitor.com)
Here we describe the isolation and characterization of pfh1 + , a Schizosaccharomyces pombe gene that encodes a Pif1-like protein. (princeton.edu)
Here we describe the isolation and characterization of pfh1+, a Schizosaccharomyces pombe gene that encodes a Pif1-like protein. (princeton.edu)
The Schizosaccharomyces pombe ORF SPAC15E1.04 (renamed as Sp hal3) encodes a protein whose amino-terminal half is similar to Sc Hal3 whereas its carboxyl-terminal half is related to thymidylate synthase (TS). (singerinstruments.com)

RNA-binding motif, single-stranded-interacting protein 1 is a protein that in humans is encoded by the RBMS1 gene. (wikipedia.org)
These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. (wikipedia.org)
When a cell needs to make a particular protein, it first copies the instructions from the matching gene into a molecule known as a messenger RNA (or an mRNA for short). (elifesciences.org)
This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. (icbinhibitor.com)
Genetic analysis of protein function requires a rapid means of inactivating the gene under study. (tau.ac.il)
Additionally, we show that the 70 kDa Sp Hal3 protein is not proteolytically processed under diverse forms of stress and that, as predicted, Sp hal3 is an essential gene. (singerinstruments.com)
RNA polymerase II components and Rrn7 form a preinitiation complex on the HomolD box to promote ribosomal protein gene expression in Schizosaccharomyces pombe. (anid.cl)
Term] id: PR:000013977 name: Rho-related GTP-binding protein RhoB def: "A Rho-related small GTPase that is a translation product of the human RHOB gene or a 1:1 ortholog thereof. (proconsortium.org)

and the contribution of chromatin-modifying proteins to replication and repair. (usc.edu)
This procedure removes soluble proteins, but proteins that are bound to insoluble cell structures such as chromatin are retained, and overall cell morphology is maintained. (ox.ac.uk)
This method allows the chromatin association of proteins to be correlated with other cell cycle events without the need for cell synchronization. (ox.ac.uk)
The accumulation of hTopBP1 on chromatin and its subsequent interaction with hRad9 lead to cell cycle arrest, a process mediated by Chk1 phosphorylation and ataxia telangiectasia and Rad3-related protein (ATR) activation. (biomedcentral.com)
The DNA in the cell is packaged with histone proteins into chromatin. (usc.edu)

Mutation affects the oligomeric state in the ZIP13 protein. (icbinhibitor.com)
To minimize undesirable side effects of the inducer, we adopted a bulky analog of auxin, 5-adamantyl-IAA, and paired it with the F-box protein OsTIR1 that harbors a mutation (F74A) at the auxin-binding pocket. (nibs.ac.cn)

proteins that bind specifically to single-stranded G-rich DNA, proteins that bind to double-stranded DNA and proteins that interact with telomeric factors. (biomedcentral.com)
For example, TRF1 can control telomerase access through its interaction with TIN2, PTOP/PIP1 and the single-stranded telomeric DNA-binding protein POT1. (biomedcentral.com)

Lem2 does not directly bind RNA but instead interacts with the exosome-targeting MTREC complex and its human homolog PAXT to promote RNA recruitment. (uni-muenchen.de)

In addition, phosphorylation of a serine in a conserved short stretch within an acidic domain of T. reesei CRE1 has been demonstrated to regulate its DNA binding [ 13 ]. (biomedcentral.com)

The nuclear localization of LaTRF, its association and co-localization with parasite telomeres and its high identity with TbTRF protein, support the hypothesis that LaTRF is a Leishmania telomeric protein. (biomedcentral.com)

In lower multicellular fungi, the C2H2 zinc finger CreA/CRE1 protein has been shown to act as the transcriptional repressor in this process. (biomedcentral.com)

These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. (wikipedia.org)
Known as "destabilising motifs", these sequences attract the attention of a group of proteins called Ccr4-Not. (elifesciences.org)
In addition, we show that position-weighted matrices (PWM) compiled from SPOT assays can be used for binding motif screening in potential binding partners and present cases where motifs are either conserved or lost among homologous SH3 interacting proteins. (upf.edu)
We demonstrate that diphosphorylated pSer-Asp-pThr-Asp motifs, recently identified as multicopy docking sites within Mdc1, are evolutionarily conserved Nbs1 binding targets. (ox.ac.uk)

The CST complex is a phylogenetically conserved protein complex consisting of CTC1/Cdc13, Stn1 and Ten1 that protects telomeres on linear chromosomes. (nih.gov)

Although Cdc4p has one potentially functional calcium-binding site, it does not bind calcium in vitro. (ubc.ca)
The C-terminal domain of the 990-amino acid Schizosaccharomyces pombe Spt5 protein, composed of repeats of a nonapeptide motif (consensus sequence TPAWNSGSK), is necessary and sufficient for binding to the capping enzymes in vivo (in a two-hybrid assay) and in vitro. (mskcc.org)
As few as four nonamer repeats suffice for Spt5 binding to Pct1 in vitro, whereas six repeats are required for Spt5 binding to Pce1. (mskcc.org)
Pct1 and Pce1 can bind simultaneously to the Spt5 CTD in vitro. (mskcc.org)
Native and full length LaTRF and a mutant bearing the putative Myb-like domain expressed in bacteria bound double-stranded telomeric DNA in vitro . (biomedcentral.com)

Implications forunderstanding histone substrate and chaperone binding by Rtt109 are discussed. (embl.de)
Unexpectedly, Abo1 weakly binds DNA regardless of ATP, and neither histone nor DNA stimulates the ATP hydrolysis activity of Abo1. (molcells.org)

This family contains the fungal KAT11 protein (previously known as RTT109) which is required for H3K56 acetylation. (embl.de)

Saccharomyces cerevisiae Hal3 and Vhs3 are moonlighting proteins, forming an atypical heterotrimeric decarboxylase (PPCDC) required for CoA biosynthesis, and regulating cation homeostasis by inhibition of the Ppz1 phosphatase. (singerinstruments.com)

Here we report that the non-homologous end-joining (NHEJ) protein Ku becomes critical for survival of replication stress in brc1âˆ† cells. (thebiogrid.org)
Replication protein A 70 kDa DNA-binding subunit C OS=Oryza sativa subsp. (uu.nl)
The mechanism by which specific protein-DNA complexes induce programmed replication fork stalling in the eukaryotic genome remains poorly understood. (le.ac.uk)
Sap1 was identified as a protein involved in mating-type switching in Schizosaccharomyces pombe, and has been shown to be involved in programmed replication fork stalling. (le.ac.uk)
At the mating-type locus dimers of Sap1 bind the SAS1 sequence in a head-to-head arrangement, while they bind to replication fork blocking sites at rDNA and Tf2 transposons in a head-to-tail mode. (le.ac.uk)
Human DNA topoisomerase II-binding protein 1 (hTopBP1) plays an important role in DNA replication and the DNA damage checkpoint pathway. (biomedcentral.com)
Human DNA topoisomerase II-binding protein 1 (TopBP1) and its orthologs play important roles in DNA replication and checkpoint control [ 1 ]. (biomedcentral.com)
He further utilized the model organism, Schizosaccharomyces pombe , to investigate the role of the SPN/FACT complex in eukaryotic DNA replication. (usc.edu)
Replication origins in the DNA nucleate the ordered assembly of protein factors to form a prereplication complex (preRC) that is poised for DNA synthesis. (usc.edu)

A role of Akr1 S-palmitoylating the nuclear fusion protein Tht1 to function in karyogamy is identified. (life-science-alliance.org)
Here we demonstrate that Schizosaccharomyces pombe Lem2, an NE protein, regulates nuclear-exosome-mediated RNA degradation. (uni-muenchen.de)
Western blot and indirect immunofluorescence combined with fluorescence in situ hybridization showed that LaTRF, similarly to hTRF2, is a nuclear protein that also associates with parasite telomeres. (biomedcentral.com)
This method relies on a rapamycin-mediated interaction between the FRB- and FKBP12-binding domains to relocalize nuclear proteins of interest to the cytoplasm. (tau.ac.il)
We demonstrate a rapid nuclear depletion of abundant proteins as proof of principle. (tau.ac.il)
SUN} {BEGIN} ********************** * SUN domain profile * ********************** Sad1/UNC-84 (SUN)-domain proteins are inner nuclear membrane (INM) proteins that are part of bridging complexes linking cytoskeletal elements with the nucleoskeleton. (expasy.org)
In addition to the SUN domain, these proteins contain a transmembrane sequence and at least one coiled-coil domain and localize to the inner nuclear envelope. (expasy.org)
SUN proteins are anchored in the inner nuclear envelope by their transmembrane segment and oriented in the membrane such that the C-terminal SUN domain is located in the space between the inner and outer nuclear membrane. (expasy.org)
Here, the SUN domain can interact with the C- terminal tail of an outer nuclear envelope protein that binds to the cytoskeleton, including the centrosome [1,2,3]. (expasy.org)
Caenorhabditis nuclear migration and anchoring protein UNC-84. (expasy.org)
DOI=10.1083/jcb.200601062 [ 3] Graumann K., Runions J., Evans D.E. "Characterization of SUN-domain proteins at the higher plant nuclear envelope. (expasy.org)
Characterization of SUN-domain proteins at the higher plant nuclear envelope. (expasy.org)

Unlike the two S. cerevisiae Pif1 subfamily proteins, the S. pombe Pfh1p was essential. (princeton.edu)
Whereas the Sp Hal3 N-terminal domain partially mimics Sc Hal3 functions, the entire protein and its carboxyl-terminal domain rescue the S. cerevisiae cdc21 mutant, thus proving TS function. (singerinstruments.com)
His PhD dissertation entitled "Genetic approaches to the study of Rheb GTPase" utilized the model organisms, Saccharomyces cerevisiae and Schizosaccharomyces pombe , to elucidate Rheb's function in arginine uptake and nutrient sensing. (usc.edu)

The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. (icbinhibitor.com)

The chloroplast albino 3 (ALB3) protein appears to integrate the light harvesting chlorophyll-binding protein into thylakoid membranes using a pathway that is distinct from the chloroplast Sec translocation pathway. (tcdb.org)

STUDY QUESTION: Are the single nucleotide polymorphisms (SNPs) rs2075230, rs6259 and rs727428 at the sex hormone-binding globulin (SHBG) locus, which were identified by genome-wide association studies (GWASs) for testosterone levels, associated with testosterone levels in Japanese men? (bvsalud.org)
The three genes encoding these proteins were inserted individually into vaccinia virus GLV-1h68 genome under the control of an identical promoter. (uni-wuerzburg.de)
Mitochondrial TAT transports folded proteins in those eukaryotes with TatA and TatC subunits encoded in the mitochondrial genome. (tcdb.org)
Rho-related small GTPase [Term] id: PR:Q23862 name: Rho-related protein racE (Dictyostelium discoideum) def: "A Rho-related GTP-binding protein RhoB that is encoded in the genome of Dictyostelium discoideum. (proconsortium.org)
Rhob (rat) [Term] id: PR:P62745 name: Rho-related GTP-binding protein RhoB (human) def: "A Rho-related GTP-binding protein RhoB that is encoded in the genome of human. (proconsortium.org)

Posttranslational protein S-palmitoylation regulates the localization and function of its target proteins involved in diverse cellular processes including meiosis. (life-science-alliance.org)

RNA-binding proteins contribute to specificity by interacting with both Ccr4-Not and target mRNAs, but this is not fully understood. (elifesciences.org)
We also produced a specificity profile for each SH3 domain from manually aligned top SPOT hits and compared the within-family binding motif consensus. (upf.edu)
Finally, by comparing pairwise SH3 sequence identity to binding profile correlation we show that for 75% of all analyzed families the SH3 specificity profile was remarkably conserved over a large evolutionary distance. (upf.edu)
Thus, a high sequence identity within an SH3 domain family predicts conserved binding specificity, whereas divergence in sequence identity often coincided with a change in binding specificity within this family. (upf.edu)

First identified in Drosophila, the conserved Polycomb group (Pc-G) protein complexes were shown to be both writers (Polycomb Repressive Complex 2, PRC2) and readers (Polycomb Repressive Complex 1, PRC1) of H3K27me3 [ 19 , 20 , 21 ]. (biomedcentral.com)
Kinetochores are protein complexes on the chromosomes, whose function as linkers between spindle microtubules and chromosomes is crucial for proper cell division. (nature.com)

In mammalian cells, S-palmitoylate is added by a family of 23 transmembrane zinc finger DHHC (Asp-His-His-Cys)-containing protein acyl transferases and is removed by fatty acyl protein thioesterases ( Malgapo & Linder, 2021 ). (life-science-alliance.org)
2022 ). The YidC transmembrane (TM) groove is essential for a high- affinity interaction, and the hydrophilic nature of the YidC groove plays an important role in protein transport across the cytoplasmic membrane bilayer to the periplasmic side. (tcdb.org)
Two of the mutations, S36 and D340 were in the nucleotide binding domain (NBD) and the third, Y497, was in the transmembrane domain (TMD). (yeastgenome.org)

Telomeres are specialized structures at the end of chromosomes and consist of stretches of repetitive DNA (5'-TTAGGG-3' in vertebrates and trypanosomatids) and associated proteins [ 5 ]. (biomedcentral.com)

Conditional degron technologies, which allow a protein of interest to be degraded in an inducible manner, are important tools for biological research, and are especially useful for creating conditional loss-of-function mutants of essential genes. (nibs.ac.cn)

There are at least six types of lipids including fatty acids, isoprenoids, sterols, phospholipids, glycosylphosphatidylinositol anchors, and lipid-derived electrophiles, which can be covalently attached to proteins ( Chen et al, 2018 ). (life-science-alliance.org)
2018 ). Through YidC, proteins are inserted into the lipid bilayer via the SecYEG-dependent complex, but YidC functions as a chaperone in protein folding processes. (tcdb.org)

ATP-binding cassette transporter, subfamily I, member 4, ABC component protein PpABCI4 [Physcomitrella patens subsp. (cornell.edu)

Among CRE1 repressed transcripts, genes encoding unknown proteins and transport proteins were overrepresented. (biomedcentral.com)
CreA/CRE1 binds to the promoters of the respective target genes via the consensus motif 5'-SYGGRG-3', whose function in vivo has been shown both in Aspergillus nidulans and Trichoderma reesei [ 9 - 12 ]. (biomedcentral.com)

They then export some of these proteins as well some mitochondrially-encoded proteins to the inter membrane space, or they insert them into the inner membrane. (tcdb.org)
Bacteria also export (to the periplasm) N-tails of membrane proteins synthesized without leader sequences by a Sec (Type IIPS)-independent mechanism. (tcdb.org)
Insertion of a membrane protein via the Oxa1p export machinery follows the 'positive-inside' rule for membrane protein topology. (tcdb.org)
The matrix exposed C-terminal α-helical domain of Oxa1 can bind mitochondrial ribosomes to facilitate co-translational insertion of proteins into the mitochondrial membrane ( Jia et al . (tcdb.org)
2001 ). Mitochondria have two, one for co-translational, and one for post-translational insertion of membrane proteins. (tcdb.org)
2007 ). Several Oxa1-type insertases in the ER serve as catalytically active core subunits in the ER membrane protein complex (EMC), the guided entry of tail-anchored (GET) and the GET- and EMC-like (GEL) complex. (tcdb.org)
At different stages of the insertion process, conformational changes in YidC's TM domain and membrane core have a mechanistic effect on Pf3 coat protein insertion. (tcdb.org)
The NBD is where ATP binds to the transporter to supply the energy to move caffeine across the membrane. (yeastgenome.org)

We find that Spt5 is essential for viability of S. pombe and that it interacts in vivo with S. pombe Spt4 via a central domain distinct from the Spt5 CTD. (mskcc.org)

Analysis of binding kinetics reveals that this is primarily due to differences in dissociation rate constants. (elifesciences.org)
Transgenic retina-specific expression of AD5 reveals that stable AD5 protein is initially localized in the nucleus but later found in the cytoplasm concurrent with progressing rod outer segment degeneration and apoptosis. (uni-wuerzburg.de)
Crystal structure of Schizosaccharomyces pombe riboflavin kinase reveals a novel ATP and riboflavin-binding fold. (mpg.de)

Other non-telomeric proteins, such as the DNA repair proteins Mre11 and Rad51, also play important roles at telomeres [ 7 , 8 ]. (biomedcentral.com)

Results: Pom1 kinase physically interacts with Rga4, which has a GAP (GTPase-activating protein) domain for Rho-family GTPase. (escholarship.org)

The importance of telomeric proteins for telomere maintenance has increased our interest in the identification of homologues within the genus Leishmania . (biomedcentral.com)
The mammalian TRF1 and TRF2 proteins, for example, bind double-stranded telomeres via a Myb-like DNA-binding domain and are involved with telomere length regulation and chromosome end protection. (biomedcentral.com)

NOTCH proteins regulate signaling pathways involved in cellular differentiation, proliferation and death. (refine.bio)

In this study, we have solved the crystal structure of the Sap1 DNA binding domain and we observe that Sap1 molecules interact in the crystal using a head-to-tail arrangement that is compatible with DNA binding. (le.ac.uk)

Amino-acid sequence and structure comparison suggested that the enzyme belongs to a group of enzymes classified as archaeal Holliday junction-resolving enzymes, which are typically divalent metal ion-binding dimers that are able to cleave X-shaped dsDNA-Holliday junctions (Hjs). (iucr.org)

We show that SP117 leads to an unstable protein that is mislocalized to the rod cytoplasm. (uni-wuerzburg.de)
Mitochondria import nuclearly-encoded proteins, made in the cell cytoplasm, into the mitochondrial matrix where their mitochondrial targeting sequences are removed by proteolysis. (tcdb.org)

Rho-related GTP-binding protein RhoB [Term] id: PR:000040021 name: Rho-related GTP-binding protein RhoB isoform 1 def: "A Rho-related GTP-binding protein RhoB that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P62745-1 or a 1:1 ortholog thereof. (proconsortium.org)
We chose a 36-amino-acid sequence of the Arabidopsis IAA17 protein as the degron and employed three tandem copies of it to enhance efficiency. (nibs.ac.cn)

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human ARPC1A. (icbinhibitor.com)
ClustalW and bl2seq sequence analysis showed that LaTRF shared sequence identity with the Trypanosoma brucei TRF (TbTRF) protein and had the same degree of sequence similarities with the dimerization (TRFH) and the canonical DNA-binding Myb-like domains of both mammalian TRFs. (biomedcentral.com)

By using NMR spectroscopy, we demonstrate that purified Cdc4p is a monomeric protein with two structurally independent domains, each exhibiting a fold reminiscent of the EF-hand class of calcium-binding proteins. (ubc.ca)

Extraction of proteins is monitored by fluorescence microscopy, either using fluorescently tagged proteins or by indirect immunofluorescence. (ox.ac.uk)

However, genetic analysis demonstrated that maintenance of telomeric DNA was not the sole essential function of S. pombe Pfh1p. (princeton.edu)

Erf2-Erf4 has an additional substrate of the spore coat protein Isp3. (life-science-alliance.org)

One regulator first induced in these precursors is the DNA binding protein Tcf-1, a T-cell specific mediator of Wnt signaling. (refine.bio)

About 10% of eukaryotic proteins are supposed to be S-palmitoylated, identified by high-throughput screens (SwissPalm database) ( Blanc et al, 2015 ). (life-science-alliance.org)

In each case, the amino acid substitution only leads to small perturbations in the conformation of the protein. (ubc.ca)

Based on the structure of Cdc4p, possible models for interallelic complementation including interactions with partner proteins and the formation of a myosin complex with Cdc4p fulfilling the role of both an essential and regulatory light chain are proposed. (ubc.ca)
Through its interactions with other proteins via its BRCT domains, hTopBP1 performs diverse functions [ 1 ]. (biomedcentral.com)

The Mre11/Rad50/Nbs1 protein complex plays central enzymatic and signaling roles in the DNA-damage response. (ox.ac.uk)

ABC transporter family protein, exp. (cornell.edu)
Zinc/ Iron/Cadmium ion transporter protein IRT1 of 355 aas and 9 TMSs. (tcdb.org)

A 116-amino acid fragment of the guanylyl-transferase Pce1 suffices for binding to the Spt5 C-terminal domain (CTD) but not for binding to the Po1-II CTD. (mskcc.org)
Taxonomic distribution of proteins containing KAT11 domain. (embl.de)
The complete taxonomic breakdown of all proteins with KAT11 domain is also avaliable . (embl.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing KAT11 domain in the selected taxonomic class. (embl.de)
Here we describe how the structured C-terminal half of Chp1 binds the Tas3 N-terminal domain, revealing the tight association of Chp1 and Tas3. (rcsb.org)
The former but not the latter has a ribosome binding domain ( Preuss et al . (tcdb.org)
Our new approach was successfully tested on the improvement of the solution NMR structures of the Ras-binding domain of Byr2 from Schizosaccharomyces pombe, the Ras-binding domain of RalGDS from human calculated from a limited set of NMR data, and the immunoglobulin binding domain from protein G from Streptococcus by their corresponding X-ray structures. (uni-regensburg.de)
Caenorhabditis SUN domain-containing protein 1 (sun-1), involved in centrosome attachment to the nucleus. (expasy.org)
Of the three, only D340 in the nucleotide binding domain conferred caffeine resistance. (yeastgenome.org)

We first aligned and catalogued the families of SH3-containing proteins in these four species to determine the relationships between homologous domains. (upf.edu)
In this work, we identified and characterized a Leishmania protein (LaTRF) homologous to both mammalian TRF1 and TRF2. (biomedcentral.com)

We thank Vincent Olieric and Aaron Finke for assistance in using beam line PXIII, Chris Lima for supplying expression vectors, and Eishi Noguchi for the S. pombe sap1-3FLAG-kanR strain. (le.ac.uk)

Structure of MrsD, an FAD-binding protein of the HFCD family. (mpg.de)
During this highly polarized growth, micro-tubules are responsible for the placement of the cell-end marker proteins, the Teal-Tea4/Wsh3 complex, which recruits the Pom1 DYRK-family protein kinase. (escholarship.org)

Anatomy5

Organisms5

Chemicals and Drugs19

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes31

Information Science3

Health Care1

Fission yeast Schizosaccharomyces pombe7

Yeast17

Encodes5

Gene8

Chromatin5

Mutation2

Single-stranded2

Homolog1

Phosphorylation1

Telomeric protein1

Transcriptional1

Motifs4

Cdc131

Vitro5

Histone2

Fungal1

Phosphatase1

Replication9

Nuclear12

Cerevisiae3

Subunit1

Translocation1

Genome5

Regulates1

Specificity4

Complexes2

Transmembrane3

Chromosomes1

Mutants1

20182

Subfamily1

Genes2

Membrane8

Viability1

Reveals3

Repair proteins1

Interacts1

Telomere2

Regulate1

Crystal1

Enzymes1

Cytoplasm2

Amino Acid Seq2

Sequence2

Demonstrate1

Fluorescence microscopy1

Genetic1

Substrate1

Mediator1

Eukaryotic1

Conformation1

Interactions2

Mre111

Transporter2

Domain9

Homologous2

Vectors1

Family2