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  • Catalytic
  • Taylor s approach, described as "nucleic acid-triggered catalytic drug release," is essentially a sophisticated drug releasing system, one that is able to recognize and use cancerous sequences as triggering mechanisms for the very drugs that fight them. (innovations-report.com)
  • So, the prodrug and the catalytic components each contain a PNA strand that is complementary to the cancer cell s mRNA, allowing them to bind right next to one another in the cancer cell. (innovations-report.com)
  • proteins
  • The peptide length (5-20 aa) and offset number or the degree of overlapping amino acids (2-5 aa) is determined by the length of the full length proteins, overall experiment objectives and the cost. (genemedsyn.com)
  • This group embodies proteins such as thrombospondin, tenascin, and hevin that do not serve as integral components of matrix elements but rather function through binding to matrix proteins as well as to cell surface receptors. (google.com)
  • Lectins are proteins that are defined by their ability to bind carbohydrates specifically and to agglutinate cells. (google.com)
  • The structure is reminiscent of both proteins and nucleic acids, hence the name, and has led to considerable interest in its possible role in prebiotic chemistry. (schoolbag.info)
  • probe
  • Methods for preparing a biochip are provided herein wherein the biomolecular probe to be used with the biochip is alternatively bound to a hydrogel prepolymer prior to or simultaneously with polymerization of the prepolymer. (google.com)
  • In particularly preferred embodiments, a polyurethane-based hydrogel prepolymer is derivatized with an organic solvent soluble biomolecule, such as a peptide nucleic acid probe in aprotic, organic solvent. (google.com)
  • strand
  • A second PNA strand then binds to the major groove of the hybrid to form a very stable PNA 2 -DNA triplex. (schoolbag.info)
  • The benefit is that a single strand of RNA actually binds tighter to a strand of PNA than it does to itself. (innovations-report.com)
  • tightly
  • As a manifestation of its inertness, [Co(NH3)l3 can be recrystallized unchanged from concentrated hydrochloric acid: the NH3 is so tightly bound to the Co(III) centers that it does not dissociate to allow its protonation. (rexresearch.com)
  • affinity
  • beta-Ala-(T10)-beta-Ala-NH2 : A10 binding is very specific and didn't show any affinity with noncomplementry DNAs. (nsti.org)
  • transcription
  • Initiation of human immunodeficiency virus type 1 (HIV-1) reverse transcription occurs by extension of the cellular tRNA 3 Lys which anneals to the primer-binding site (PBS) on the 5′ non-translated region of the viral RNA genome. (pubmedcentralcanada.ca)
  • We have earlier shown that a polyamide nucleic acid (PNA) targeted to the PBS region of the viral genome, blocks the initiation of reverse transcription ( 19 ). (pubmedcentralcanada.ca)
  • conformational
  • Swarnamukhi PL, Sharma SK, Bajaj P, Surolia N, Surolia A, Suguna K., Crystal structure of dimeric FabZ of Plasmodium falciparum reveals conformational switching to active hexamers by peptide flips. (jncasr.ac.in)
  • Journal
  • A. Verma, N Karar, A. Bakshi, Harish Chander, S.M. Shivaprasad and S. A. Agnihotri, Structural, morphological and photoluminescence characteristics of sol-gel derived nano-phase CeO2 films deposited using citric acid, Journal of Nanoparticle Research 9 , (2006). (jncasr.ac.in)
  • base
  • In nucleic acids, Nature has already determined the rules of base pairing -- A binds with T and G pairs with C -- a system called "Watson-Crick base-pairing," named for the discoverers of the double helix. (innovations-report.com)