Bind hla b8 antigen. Medical search. Frequent questions

HLA-A*02 (A*02) is a human leukocyte antigen serotype within the HLA-A serotype group. (wikipedia.org)
The role of genes ceptibility to HIV infection and the course of HIV of the human leukocyte antigen (HLA) system in disease. (cdc.gov)
The human leukocyte antigen ( HLA ) is a gene complex that encodes the major histocompatibility complex ( MHC ) proteins . (amboss.com)
The presence of human leukocyte antigen B8 (HLA-B8) and human leukocyte antigen DR3 (HLA-DR3) in the mother predisposes the infant to neonatal lupus erythematosus and congenital heart block. (heraldopenaccess.us)

A sequence pattern for peptides presented to cytotoxic T lymphocytes by HLA B8 revealed by analysis of epitopes and eluted peptides. (ox.ac.uk)
HLA-A*0201 presents TAP-dependent peptide epitopes to cytotoxic T lymphocytes in the absence of tapasin. (ox.ac.uk)
We show here that while tapasin is required for HLA-A*0201 (HLA-A2) molecules to bind to TAP, its absence does not block the presentation of HLA-A2-restricted TAP-dependent epitopes to cytotoxic T lymphocytes indicating that, unlike HLA-A1, HLA-B8 and HLA-B4402, HLA-A2 has access to the TAP-dependent peptide pool even in the absence of tapasin. (ox.ac.uk)
The thyroid antigen shares epitopes with antigens on the orbital muscles, so that cytotoxic T-cells attack these tissues causing them to swell. (brainkart.com)
In the large-scale benchmark calculation consisting of 216 known HIV epitopes covering all 12 recognized HLA supertypes, the NetCTL-1.2 method was shown to have a sensitivity among the 5% top-scoring peptides above 0.72. (biomedcentral.com)

Support for this pattern came from sequencing peptides eluted from purified HLA B8 molecules, where lysines were predominant at positions 3 and 5. (ox.ac.uk)
In fact, we identified a junctional nonapeptide (SSKALQRPV) which binds to HLA-A2.1 molecules. (pasteur.fr)
This peptide, as well as those binding to HLA-A3, -A11, and -B8 molecules (previously identified by others), elicits primary CTL responses in vitro from PBLs of both healthy donors and CML patients. (pasteur.fr)
Tapasin is a 48-kDa endoplasmic reticulum (ER)-resident glycoprotein that binds to the transporter associated with antigen processing (TAP) and mediates an interaction between TAP and newly synthesized MHC class I molecules. (ox.ac.uk)
Nevertheless, the overall efficiency with which HLA-A2 was loaded with optimal, stabilizing peptides was impaired in the cell line .220, resulting in a significant increase in the fraction of HLA-A2 molecules being released from the ER in a "peptide-receptive" state. (ox.ac.uk)
In the cellular immune response, recognition by CTL-TCRs of viral antigens presented as peptides by HLA class I molecules, triggers destruction of the virally infected cell (Townsend, A.R.M., J. Rothbard, F.M. Gotch, G. Bahadur, D. Wraith, and A.J. McMichael. (ox.ac.uk)
Once inside the ER, the peptides may bind to MHC class I molecules, which are subsequently transported to the cell surface, where the complexes may be recognized by passing CTLs. (biomedcentral.com)
The HLA molecules and their counterparts in rodents were subsequently shown to be directly responsible for immune response differences between individuals and for determining the likelihood of graft rejection. (musculoskeletalkey.com)
In each individual, T cells are generally restricted to recognize antigens presented by the person's own HLA molecules. (musculoskeletalkey.com)
The allelic variations among different HLA molecules are a major factor accounting for differences in the types of antigenic peptides to which an individual responds or in the types of T cells that are used in an immune response. (musculoskeletalkey.com)
HLA class I molecules consist of a 45-kD α chain encoded within the MHC that is noncovalently associated with the 12-kD β 2 -microglobulin chain (encoded on chromosome 15). (musculoskeletalkey.com)
HLA class II molecules consist of noncovalently associated α (32 kD) and β (28 kD) chains, both of which are encoded within the MHC. (musculoskeletalkey.com)
HLA class I and class II molecules are cell surface glycoproteins, anchored to the membrane by hydrophobic transmembrane segments. (musculoskeletalkey.com)

The amino acid sequence of the peptide epitope was compared to six other known virus peptides known to be restricted by HLA B8 and a sequence homology was identified, which predicted nonamer and octamer epitope sequences. (ox.ac.uk)
In other words, certain HLAs may be incapable of binding any of the short peptides produced by proteolysis of pathogenic proteins. (wikipedia.org)
If HLAs bind none of the peptides produced by a pathogen, then there is no way for the immune system to tell that a cell is infected. (wikipedia.org)
This is a significant decrease and is almost certainly a result of the abnormally efficient binding of HLA-A*02 to peptides originating from EBV. (wikipedia.org)
This high affinity increases the probability of CD8+ t-cell recognition of EBV peptides held by HLA-A*02 complexes. (wikipedia.org)
Such CTL recognize HLA-matched, BCR-ABL-positive leukemic cells, implying efficient natural processing and presentation of these junctional peptides. (pasteur.fr)
The variant peptides cause changes in the recognition surface by three mechanisms: changes contributed directly by the peptide, effects transmitted to the exposed peptide surface, and induced effects on the exposed framework of the peptide binding groove. (ox.ac.uk)
The most restrictive step involved in antigen presentation is binding of the peptide to MHC class I. It is estimated that only 1 out of 200 peptides will bind a given MHC class I allele with sufficient strength to elicit a CTL response [ 9 ]. (biomedcentral.com)

For example, cer- countries), and prevention and treatment of tain distributions of HLA class I alleles were opportunistic infections and cancers delay the observed in uninfected female commercial sex onset of AIDS and increase the life expectancy workers in Africa (13,14) and Thailand (11), who of HIV-infected persons. (cdc.gov)
Thhe information includes the result of prediction from various algorithms including B cell epitope (LBtope), MHC class I binding alleles (Propred1), MHC class II binding alleles (Propred), CTL epitope (CTLpred), HLA alleles (nHLApred), interferon-gamma inducing potential (IFNepitope), Interleukin-4 inducing capacity (IL4pred). (osdd.net)
In the case of systemic lupus erythematosus (SLE) and related illnesses, many of the HLA class II alleles are associated with the presence of specific autoantibodies or clinical phenotypes. (musculoskeletalkey.com)

Six HLA B8-positive influenza immune donors that we have tested respond to this peptide as part of their influenza-specific CTL response. (ox.ac.uk)
In essence, there are indicators, albeit from a small study comparing HLA expression in fertile and infertile couples, that HLA-A*02 may induce increased maternal immune response to the fetus. (wikipedia.org)
The innate immune system develops in utero and, unlike the adaptive (acquired) immune system , does not require imprinting or adaptation to specific antigens nor does it provide permanent pathogen -specific immunity . (amboss.com)
The primary endpoint was safety and tolerability, the secondary endpoint was induction of antigen specific immune responses monitored at baseline and at weeks 5, 9 and 17. (biomedcentral.com)
A total of 26/33 evaluable patients treated at 1280 μg developed an immune response, directed against multiple antigens in 15 out of 33 patients. (biomedcentral.com)
Overall primary concerns are: extrapolating human clinical studies, seeding durable effective T cell resident memory (Trm), population human leucocyte antigen (HLA) coverage, and the potential for T cell-mediated immune escape. (mdpi.com)
Molecular docking, molecular dynamic simulation, and immune simulation were performed to ensure the binding between HLA and TLR4. (springeropen.com)

HLA-A*02 is one particular class I major histocompatibility complex (MHC) allele group at the HLA-A locus. (wikipedia.org)
OBJECTIVE- HLA-DRB1* 03 -DQB1* 0201 /DRB1* 04 -DQB1* 0302 ( DR3/4-DQ8 ) siblings who share both major histocompatibility complex (MHC) haplotypes identical-by-descent with their proband siblings have a higher risk for type 1A diabetes than DR3/4-DQ8 siblings who do not share both MHC haplotypes identical-by-descent. (diabetesjournals.org)
Patients with DH and CD may have the same association with histocompatibility antigens (HLA), the presence of circulating IgA against transglutaminase autoantigens and clinical remission on gluten-free diet. (scielo.br)
This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)

HLA-A*02 appears to stimulate peripheral blood mononuclear cells in a manner that inhibits HIV replication. (wikipedia.org)
Pre- hematopoietic and other cells, but the Duffy sence of one copy of the deleted CCR5 gene also antigen of erythrocytes (DARC) is the only influences the course of disease as the onset of member expressed on cells of erythroid lineage. (cdc.gov)
Proinflammatory islet antigen reactive CD4 T cells are linked with response to alefacept in type 1 diabetes. (immunetolerance.org)
Activated B cells and memory T cells can recognize specific antigens on pathogens. (amboss.com)
In a phase I/II trial in patients with metastatic melanoma, direct intra-dermal injection of mRNA coding for relevant tumor-associated antigens was well tolerated and influenced the frequency of vaccine-antigen directed CD4 and CD8 T cells as well as regulatory T cells (T Regs). (biomedcentral.com)
By the mid-1980s, the second generation of hepatitis B vaccines became commercially available- Recombivax-HB and Engerix-B . These vaccines utilized recombinant DNA technology to express a nonglycosylated hepatitis B surface antigen in yeast cells, a process that was more cost-effective and scalable than the plasma-derived method. (uw.edu)
P-Tex cells could aggregate in the antigen-presenting cell niches and activate certain signaling pathways. (elifesciences.org)
Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)
CD8 + CTL-recognizing minor H antigens on tumor cells can be isolated posttransplant and could contribute to the graft- versus -tumor effect. (aacrjournals.org)
positive controls may include Western blot data generated against recombinant proteins or lysates from cell lines known to express high levels of the target antigen, whereas negative controls might be microscopy images from plated cells which have been treated with siRNA. (biozol.de)

It is also essential for the proper antigen presenting function of HLA-A*0101 (HLA-A1), HLA-A*0801 (HLA-B8) and HLA-B*4402 (HLA-B4402). (ox.ac.uk)

3 ] This vaccine contained purified plasma-derived hepatitis B surface antigen (HBsAg) and was safe and highly successful in preventing HBV infection. (uw.edu)

The Col 4α3NC1 epitope is thought to be less accessible for anti-GBM binding in the lung, and partial denaturation of NC1 domains may be required for full exposure of this sequestered epitope to the antibody. (medscape.com)
The constructed multi-epitope vaccine showed a strong binding affinity with the receptor molecule TLR4. (springeropen.com)
The polymorphisms associated with the "shared epitope" are located on the α-helical rim (DRB1 chain) of the peptide-binding cleft, where they may interact with either the bound peptide antigen or the T cell receptor. (musculoskeletalkey.com)
Monoclonal antibodies recognise a single antigenic epitope, and are often preferred since an unlimited antibody supply can be guaranteed for the lifetime of the assay, yet they are only suitable for a sandwich assay format if the other antibody in the sandwich does not bind the same epitope. (biozol.de)

as of December 2013 there are 456 different HLA-A*02 proteins. (wikipedia.org)
computer simulations of proteolysis of marburg and ebola-zaire filovirus coded proteins to generate nonapeptides with motifs of known hla class i haplotypes and detection of antigenic domains in the viral glycoproteins. (liverpool.ac.uk)
the primary amino acid sequences of the proteins coded by marburg and ebola-zaire filoviruses were studied by computer programs to search for putative proteolytic cleavages which yield nonapeptides with motifs of binding to known hla class i haplotypes. (liverpool.ac.uk)
a few nonapeptides with motifs hla class i a24, b8, b27 and b35 were predicted in marburg virus proteins. (liverpool.ac.uk)

HLA B8-restricted cytotoxic T lymphocytes (CTL) specific for influenza A virus were generated and shown to recognize the nucleoprotein (NP). (ox.ac.uk)
The junctional region of the BCR-ABLb3a2 molecule represents a potential leukemia-specific antigen which could be recognized by cytotoxic T lymphocytes (CTL). (pasteur.fr)

In summation, HLA-A*02 appears to be somewhat less effective than other HLA-As at protecting against HIV infections. (wikipedia.org)

Vaccination with messenger RNA (mRNA) encoding full-length tumor antigens is a novel option for immunotherapy. (biomedcentral.com)

These vaccines contain both the S antigen and either the pre-S2 or the pre-S2 and pre-S1 HBV antigens. (uw.edu)

Following secretion, they bind with an extremely high degree of specificity to the foreign antigen which stimulated their production. (biozol.de)

The serotype is determined by the antibody recognition of the α2 domain of the HLA-A α-chain. (wikipedia.org)
Some forms of the antibody impair the ability of acetylcholine to bind to receptors. (doctorbhatia.com)
Interestingly, the recent data in RA indicate that the major HLA-DR associations are with anti-CCP antibody positive disease, suggesting that control of autoantibody responses may be a primary mechanism underlying these associations in RA as well. (musculoskeletalkey.com)
During a typical immunodetection assay, the process begins with incubation in a blocking agent to minimise non-specific binding, before the addition of a primary antibody that binds specifically to the target antigen. (biozol.de)
The secondary reagent is most commonly an anti-species antibody which has been raised against the host species of the primary antibody, and is usually conjugated to a detection moiety such as a fluorophore or an enzyme to allow confirmation of the presence of the antigen in the test sample. (biozol.de)
FIG Antibody binding in a competitive ELISA, a form of immunodetection. (biozol.de)
Its presence is confirmed through the binding of an antigen-specific primary antibody, followed by the addition of a labelled secondary antibody. (biozol.de)
If the test sample were to contain the antigen, a reduction in signal would be seen since the primary antibody would bind to this and be removed from the assay during subsequent wash steps, rather than becoming attached to the microplate. (biozol.de)

The three HLA-DQß1 amino acid positions are located together at the peptide binding groove, suggesting their functional importance in antigen presentation. (bvsalud.org)
However, upon further investigation of the entire peptide-binding groove by including genomic data from MHC-I exon 2 and MHC-IIA exon 2, this turned out to be false. (bvsalud.org)
Thus, comparisons between MHC-I and MHC-II that included both domains of the peptide-binding groove showed no differences in polymorphism nor diversifying selection between the classes. (bvsalud.org)

There is a slight genetic predisposition: particular HLA types seem to predispose for MG (B8 and DR3 with DR1 more specific for ocular myasthenia). (doctorbhatia.com)
Non-HLA genetic factors also influence sus- followed HIV-infected persons. (cdc.gov)
Our study reveals genetic contributions to HIC risk that may be associated with class II MHC molecule antigen presentation. (bvsalud.org)

For A*02, the α chain is encoded by the HLA-A*02 gene and the β chain is encoded by the B2M locus. (wikipedia.org)
Earlier HIV infec- receptor gene polymorphism in HIV infection, tion diagnosis, inhibition of ongoing HIV replica- only genes of the HLA system were thought to tion with antiretroviral therapy (in industrialized protect against HIV infection. (cdc.gov)

In addition, there are several HLA-A*02 haplotypes that appear to contribute heavily to higher or lower viral loads in HIV patients. (wikipedia.org)
HLA-A*02-C*16 and HLA-A*02-B*45 have been shown to contribute to significantly increased viral loads (greater than 100,000 copies per milliliter). (wikipedia.org)

Anti-GBM autoantibodies that are present in the circulation of patients with anti-GBM disease cross the fenestrated endothelium in the glomerulus and bind with the underlying GBM, inducing renal injury. (medscape.com)

Several HLA genes or haplotypes immunodeficiency virus (HIV) as of mid-1996 (1). (cdc.gov)

Graves' disease results from production of an autoanti-body that binds to the TSH receptor and causes contin-uous gland stimulation. (brainkart.com)

the computer analyses predicted that numerous nonapeptides with motifs to bind hla class i a68 and a2 haplotypes were detected. (liverpool.ac.uk)

an enzyme immunoassay system has been developed for the detection of ebola virus antigen. (liverpool.ac.uk)

We have examined the high resolution crystal structures of four of these APLs in complex with HLA B8 to determine alterations in the shape, chemistry, and local flexibility of the TCR binding surface. (ox.ac.uk)

Firstly it is essential that is specific for the target antigen, since off-target binding can lead to misinterpretation of results. (biozol.de)

The follow-up vaccine CV9104 including the additional antigens prostatic acid phosphatase (PAP) and Muc1 is currently being tested in a randomized phase IIb trial to assess the clinical benefit induced by this new vaccination approach. (biomedcentral.com)

In 2010 the World Health Organization Naming Committee for Factors of the HLA System revised the nomenclature for HLAs. (wikipedia.org)
development of the immunoenzyme test-system for detection of ebola virus antigen]. (liverpool.ac.uk)

deletion (20-22), no cases of HIV infection had while others are selective in terms of ligand been reported in studies of more than 60 persons binding. (cdc.gov)

Some HLAs bind pathogenic peptide fragments with very high affinity. (wikipedia.org)

In this example, the target antigen has been captured on the surface of a microplate. (biozol.de)

HLA-A*02 has been linked with decreased risk of developing Epstein-Barr virus (EBV)-positive Hodgkin lymphoma(HL). (wikipedia.org)
the biochemical and hemostatic parameters were compared in guinea pigs after inoculation of ebola virus strains lethal and nonlethal for them and of inactivated antigen of this virus. (liverpool.ac.uk)

HIV produces a protein called Nef that binds to the cytoplasmic tail of HLA-A and B and diverts it to the lysosomes for destruction. (wikipedia.org)

Thus any alteration to the HLA that induces decreased binding to a certain peptide or increased binding to a certain peptide, is expressed as, respectively, increased susceptibility to disease or decreased susceptibility to disease. (wikipedia.org)

it permits a highly accurate and sensitive rapid detection of the antigen. (liverpool.ac.uk)
Their highly specialised binding makes antibodies a hugely powerful research tool, and they have been used for decades in a wide variety of immunodetection techniques including Western blotting, immunocytochemistry, immunohistochemistry (IHC), flow cytometry, ELISA and lateral flow assays to name just a few. (biozol.de)

Memory response becomes more potent and faster after subsequent exposures to an antigen . (amboss.com)

Recurrence after treatment may be more likely in those with HLA association. (brainkart.com)

Among patients with EBV+ HL, only 35.5% of people expressed HLA-A*02 compared to 50.9% in the EBV-HL group and 53% in the control group. (wikipedia.org)
Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
CD8 + CTL clones recognizing minor H antigens were isolated from five patients studied. (aacrjournals.org)

Anatomy19

Organisms14

Diseases11

Chemicals and Drugs141

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes38

Disciplines and Occupations2

Humanities2

Information Science3

Named Groups1

Health Care3

Human leukocy4

Epitopes5

Molecules13

Peptides8

Alleles3

Immune7

Histocompatibility5

Cells10

08011

HBsAg1

Epitope4

Proteins4

Cytotoxic2

Infections1

Tumor1

Vaccines1

Specificity1

Antibody8

Peptide bindin3

Genetic3

Gene2

Viral2

Renal1

Genes1

Stimulation1

Class1

Enzyme1

COMPLEX1

Specific1

Vaccination1

System2

Infection1

Affinity1

Surface1

Virus2

Destruction1

Disease1

Highly2

Response1

Association1

Patients3