Bind adhesins bacterial. Medical search. Frequent questions

The best characterized bacterial adhesin is the type 1 fimbrial FimH adhesin. (wikipedia.org)
Mature FimH is displayed on the bacterial surface as a component of the type 1 fimbrial organelle. (wikipedia.org)
The effectiveness of anti-adhesin antibodies is illustrated by studies with FimH, the adhesin of uropathogenic Escherichia coli (UPEC). (wikipedia.org)
These infections are initiated by adhesion of uropathogenic E. coli to uroplakin receptors in the uroepithelium via the FimH adhesin located at the tips of type 1 pili. (wustl.edu)
Here, we provide for the first time binding data of the molecular events underlying type 1 fimbrial adherence, by crystallographic analyses of the FimH receptor binding domains from a uropathogenic and a K-12 strain, and affinity measurements with mannose, common mono- and disaccharides, and a series of alkyl and aryl mannosides. (wustl.edu)
Our results illustrate that the lectin domain of the FimH adhesin is a stable and functional entity and that an exogenous butyl α-D-mannoside, bound in the crystal structures, exhibits a significantly better affinity for FimH (K d = 0.15 μM) than mannose (K d = 2.3 μM). (wustl.edu)
Aryl mannosides and fructose can also bind with high affinities to the FimH lectin domain, with a 100-fold improvement and 15-fold reduction in affinity, respectively, compared with mannose. (wustl.edu)
The tyrosine gate as a potential entropic lever in the receptor-binding site of the bacterial adhesin FimH. (cnrs.fr)
Methods of inhibition of FimH activity in a human subject are also provided for the treatment of diseases such as bacterial infection, Crohn's disease (CD) and Inflammatory Bowel Disease (IBD). (justia.com)
Animal models of UTI have revealed that the mannose-binding FimH adhesin of type 1 pili is critical for the colonization of and invasion into the bladder epithelium by UPEC, as well as other uropathogenic members of the Enterobacteriaceae family, such as Klebsiella, Enterobacter , and Citrobacter species. (justia.com)
The distal FimH adhesin protein is connected to the the pilus rod by the flexible tip fibrillum, which is composed of one copy each of FimF and FimG. (justia.com)
The adhesin tip protein FimH is a two-domain protein comprised of a pilin domain (FimHp), which allows it to incorporate into the pilus, and a lectin domain (FimHL) that contains a conserved mannose binding pocket. (justia.com)
The X-ray crystal structure of FimH bound to mannose showed that mannose is bound in a negatively charged pocket on FimH. (justia.com)
The mannose binding site is highly conserved as it is invariant in 300 fimH genes sequenced from clinical UPEC strains. (justia.com)
In all of these models the adhesin FimH has been shown to play an integral role in pathogenesis, highlighting it as an excellent therapeutic target. (justia.com)
The fundamental interaction between FimH and the host is believed to occur with binding to high-mannose containing glycans, such as uroplakins and other proteins expressed on the surface of bladder epithelial cells, that coat the luminal surface of the bladder. (justia.com)
A, The high-mannose sugar chain (green) of the decoy modules branching out from a filament of UMOD (shades of blue) is bound by the FimH sugar-binding domain at the tip of bacterial adhesive filaments (magenta). (phys.org)
This acts as a decoy by mimicking high-mannose sugar chains on the surface of the urinary tract , to which bacteria would normally attach using a sugar-binding protein called FimH at the tip of their hair-like appendages. (phys.org)
Alena Stsiapanava et al, Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH, Nature Structural & Molecular Biology (2022). (phys.org)
The first subunit to be engaged is FimH, the adhesin at the very tip of the pilus, and subsequent subunits are added one at a time from the base up. (esrf.fr)
We have recently solved a new crystal structure describing the first step in pilus biogenesis - the FimD usher bound to its cognate FimC:FimH substrate - using diffraction data collected at beamline ID23-1 ( Figure 107 ). (esrf.fr)
The adhesin subunit FimH is in green (FimH L and FimH p stand for the lectin and the pilin domains respectively) and the periplasmic chaperone FimC is in yellow. (esrf.fr)
A striking feature of the active usher conformation is that the FimC:FimH complex is bound to a newly identified site on the C-terminal domains (CTDs) of FimD. (esrf.fr)

Moreover, although the abundance of most protein groups reflected that of related bacterial populations, we found a specific independent regulation of bacteria-derived cell envelope proteins. (bmj.com)
Salivary proteins modulate bacterial colonization in the oral cavity and interact with systemic pathogens that pass through the oropharynx. (lu.se)
We found that only a capsule-free mutant of S. pneumoniae TIGR4 binds to salivary proteins, most prominently to mucin MUC7, but that this binding was not mediated through PsrP or recognition of sialic acid. (lu.se)
Fibrillar adhesins are proteins located on the bacterial cell surface, which mediate interactions with the environment, e.g. with host cells or other bacteria. (embl-em.de)
These proteins usually have a stalk, which helps them cross the bacterial cell surface and be projected closer to their targets - regardless of what they are trying to bind to. (embl-em.de)
Host defense against bacterial invasion depends on phagocytosis by polymorphonuclear granulocytes and the bactericidal effect of serum, mediated in large part by complement proteins. (medscape.com)
Bacteria are able to compete effectively for iron bound to host proteins because of the secretion of high-affinity, low molecular weight iron chelators known as siderophores. (medscape.com)
This is necessary because most host iron is bound to intracellular and extracellular proteins. (medscape.com)
In order to deprive bacteria of iron, the host also secretes iron-binding proteins. (medscape.com)
As no surface expressed α-actinin was found on any of the eight cell lines examined, and as Opc interactions with endothelial cells in the presence of serum lead to bacterial entry into the target cells, we examined the possibility of the two proteins interacting intracellularly. (bris.ac.uk)
Here we present a protocol for visualisation and quantification of the colocalisation of the bacterium with intracellular proteins after bacterial entry into human endothelial cells, although the procedure is also applicable to human epithelial cells. (bris.ac.uk)
This study of bacterial biofilm proteins can be used in the manufacture of kits for the detection of infectious diseases such as caries in the oral cavity. (kemdikbud.go.id)
A team led by Karolinska Institutet has combined Artificial Intelligence (AI) with structural biology to gain insights into two similar proteins that prevent bacterial infection in the urinary tract and the gastrointestinal system. (phys.org)
The adhesin SiiE mediates the first contact to the host cell and thereby positions the SPI1-T3SS to initiate the translocation of a cocktail of effector proteins. (omicsdi.org)
In contrast to expectations, none of the major S-layer proteins of the IPEC-1 -adhering strains mediated bacterial adherence. (biomedcentral.com)
Collectively, these surface-bound proteins provide species with a coat of many colors, enabling multiple romantic contacts and interplays between the bacterial Didox cell and the host. (isme-la2019.org)
The quadrants are labeled to indicate the processes of adherence, environmental sensing, biofilm formation, and virulence that may be orchestrated by the expression of surface-bound or secreted proteins. (isme-la2019.org)
Various phage-encoded autolysins that act as peptidoglycan hydrolases have been seen to contain conserved amidase motifs of bacterial amidases, eukaryotic glutathionylspermidine amidase, NLP-/P60 family proteins, and glutamyl L-diamino endopeptidases. (creative-biolabs.com)
The antiphospholipid (aPL) autoantibodies bind moieties on negatively charged PLs or moieties formed by the interaction of negatively charged PLs with other lipids, PLs, or proteins. (medscape.com)

Mannose-binding type 1 pili are important virulence factors for the establishment of Escherichia coli urinary tract infections (UTIs). (wustl.edu)
Type 1 pili are anchored in the bacterial outer membrane and are largely composed of repeating FimA protein subunits which form a helically wound cylinder that comprises the thick pilus rod. (justia.com)
Type 1 purchase GANT61 pili bind to mannose-containing uroplakin molecules purchase GANT61 on the surfaces of superficial umbrella cells of the bladder epithelium, mediating bacterial entry (26-28). (mycareerpeer.com)
GF CC Type IV pili are bacterial virulence-associated adhesins that #=GF CC promote bacterial attachment to host cells. (xfam.org)

Bacterial virulence factors, especially fimbrial adhesins, have been conclusively shown to promote host cell invasion. (biomedcentral.com)
E. coli encode a variety of virulence factors that facilitate colonisation of the urinary tract, such as fimbrial adhesins (type 1, P, S, and Dr fimbriae) and toxins (α-hemolysin and cytotoxic necrotising factor 1 (CNF1)) [ 7 ]. (biomedcentral.com)
In vitro and in vivo studies have exhibited direct functions for many streptococcal adhesins as colonization or virulence factors, making them attractive targets for therapeutic and preventive strategies against streptococcal infections. (isme-la2019.org)

Adherence is an essential step in bacterial pathogenesis or infection, required for colonizing a new host. (wikipedia.org)
Expression of these adhesins at different phases during infection play the most important role in adhesion based virulence. (wikipedia.org)
This has led to the exploration of adhesin activity interruption as a method of bacterial infection treatment. (wikipedia.org)
Additionally, Adhesins are attractive vaccine candidates because they are often essential to infection and are surface-located, making them readily accessible to antibodies. (wikipedia.org)
Viral and Bacterial Adhesion Network Training (ViBrANT) places adhesion at the heart of virulence: it plays the first and decisive role in the infection process of pathogens. (europa.eu)
Similarly, this kind of close-up on bacterial interactions is essential for infection biology, to help researchers map what molecular mechanisms help pathogens find, invade host cells, and then survive and proliferate within them. (embl-em.de)
Blocking of bacterial adhesion is able to prevent infection. (wustl.edu)
Recent data from preclinical studies suggest a role for neutrophil myeloperoxidase and lipopolysaccharide-binding protein in host defense against K pneumoniae infection. (medscape.com)
Bacterial infection of the urinary tract is a common clinical problem with E. coli being the most common urinary pathogen. (biomedcentral.com)
Bacterial uptake into epithelial cells is increasingly recognised as an important feature of infection. (biomedcentral.com)
Studies from our group have shown that mice deficient in C3 are resistant to ascending infection and complement can alter bacterial uptake by mouse proximal tubular epithelial cells (PTECs), a primary target of E. coli during the acute phase of pyelonephritis [ 12 ]. (biomedcentral.com)
Lectins and adhesins are involved in bacterial adhesion to host tissues and mucus during early steps of infection. (qub.ac.uk)
Uromodulin (UMOD) is a protein whose filaments play an important role in preventing urinary tract infection , the most common form of non-epidemic bacterial infection that affects about 150 million people per year. (phys.org)
The human urinary tract is one of the most common sites of bacterial infection and most of them are caused by uropathogenic Escherichia coli (UPEC). (esrf.fr)

The majority of bacterial pathogens exploit specific adhesion to host cells as their main virulence factor. (wikipedia.org)
Many bacterial pathogens are able to express an array of different adhesins. (wikipedia.org)
Pathogens use adhesins to colonize tissues and cause infections, to bind host molecules for immune evasion and, for bacteria, to create antibiotic-resistant biofilms on implanted devices. (europa.eu)
Table 16.7 lists common adhesins found in some of the pathogens we have discussed or will be seeing later in this chapter. (pressbooks.pub)
A number of viral, bacterial, and fungal pathogens possess the ability to interrupt proinflammatory and antiapoptotic NF-B signaling (41). (mycareerpeer.com)
As adhesion to host tissues is essential for many gastro-intestinal pathogens, the paradigm of competitive exclusion through competition for binding sites has evolved. (biomedcentral.com)
Moreover, growth inhibition experiments demonstrated the ability of the two strains alone and in combination to antagonize diverse Gram-negative and Gram-positive bacterial pathogens during sessile and planktonic growth. (frontiersin.org)

Adhesins are cell-surface components or appendages of bacteria that facilitate adhesion or adherence to other cells or to surfaces, usually in the host they are infecting or living in. (wikipedia.org)
In the crudest sense, bacterial adhesins serve as anchors allowing bacteria to overcome these environmental shear forces, thus remaining in their desired environment. (wikipedia.org)
Most fimbria of gram-negative bacteria function as adhesins, but in many cases it is a minor subunit protein at the tip of the fimbriae that is the actual adhesin. (wikipedia.org)
In gram-positive bacteria, a protein or polysaccharide surface layer serves as the specific adhesin. (wikipedia.org)
To effectively achieve adherence to host surfaces, many bacteria produce multiple adherence factors called adhesins. (wikipedia.org)
Adhesins are expressed by both pathogenic bacteria and saprophytic bacteria. (wikipedia.org)
The study of adhesins as a point of exploitation for vaccines comes from early studies which indicated that an important component of protective immunity against certain bacteria came from an ability to prevent adhesin binding. (wikipedia.org)
This work has fed into WP3 and WP4, demonstrating that biosensors can be used to detect the presence of adhesins on the outside of bacteria, opening a route to point-of-care diagnostics (WP4). (europa.eu)
1993). Accordingly, specific LF-binding microbial targets exist in a variety of Gram-positive and Gram-negative bacteria (Naidu et al. (ift.org)
The green sulfur bacterial epibionts are related to more 'typical' green sulfur bacteria, complete with chlorosomes and an autotrophic reverse TCA pathway to assimilate carbon. (asmblog.org)
The bacteria also produce multiple adhesins. (medscape.com)
Three models of Mtb biofilm formation have been proposed to study the factors regulating biofilm formation, the physiology of the resident bacteria, and the nature of the biomaterial that holds these bacterial masses together. (microbialcell.com)
There are many advantages of studying bacteria in the planktonic cultures such as development of a homogenous population of bacterial cells having similar transcriptomic, proteomic and metabolomic profile etc. (microbialcell.com)
Methicillin is of a class of antibiotics known as β-lactams which bind to the penicillin binding protein (PBP) of the bacteria. (randox.com)
Instead, the bacteria bind to the sugar chain of UMOD and are eventually removed through the urine. (phys.org)
Although the sugar chains that bind bacteria are attached to different regions of the GP2 and UMOD sequence, the 3D structures show that, in both cases, their base is positioned within the crevice. (phys.org)
Therefore, knowledge about Lactobacillus surface components and their roles as adhesins is of major importance when developing strategies based on the administration of commensal bacteria to promote piglet health. (biomedcentral.com)
Bacteria are known to utilize several different proteases involved in the assembly and disassembly of bacterial cell walls during bacterial growth and cell division. (creative-biolabs.com)
Most bacterial nosocomial pneumonias occur by aspiration of bacteria colonizing the oropharynx or upper gastrointestinal tract of the patient. (cdc.gov)
Many pathogenic bacteria utilize the transferrin-binding complex to acquire their supply of iron from serum. (bvsalud.org)

P-fimbriae plays major role in bacterial adherence to the uroepithelium through the Galα1-4Gal-binding PapG adhesin. (microbiologyresearch.org)
Intracellular events, such as blocking of microbial attachment factors such as fimbriae (hairlike structures) and other adhesins (putative receptors), have been observed (Naidu and Bidlack, 1998). (ift.org)
Type 1 fimbriae mediated-binding is essential for C3-dependent internalisation as shown by phenotypic association, type 1 fimbrial blockade with soluble ligand (mannose) and by assessment of a type 1 fimbrial mutant. (biomedcentral.com)
Type 1 fimbrial adhesin allows the fimbriae of ETEC cells to attach to the mannose glycans expressed on intestinal epithelial cells. (pressbooks.pub)

The typical structure of a bacterial adhesion is that of a fimbria or pilus. (wikipedia.org)
Many of these infections are initiated by a critical interaction between host ligands (frequently polysaccharide moieties) and bacterial adhesins (frequently expressed at the distal tip of polymeric pilus fibers assembled by the chaperone-usher pathway). (justia.com)
Despite a wealth of other structural and biochemical information, little is known about how pilus formation is orchestrated at the bacterial cell surface. (esrf.fr)
We thus conclude that the usher has two binding sites (NTD and CTDs) that act in concert, such that the growing pilus remains anchored to one, while the next subunit in assembly is recruited by the other ( Figure 108 ). (esrf.fr)
Isoforms purchase GANT61 of the P pilus adhesin recognize different globoseries glycolipids on host kidney epithelia, resulting in species specificity of this interaction. (mycareerpeer.com)
GF CC Mutagenesis studies suggest that residues on an alpha-beta loop #=GF CC and the C terminal disulphide-bonded region of PilS might be #=GF CC involved in binding specificity of the pilus [2]. (xfam.org)

Recall that an adhesin is a protein or glycoprotein found on the surface of a pathogen that attaches to receptors on the host cell. (pressbooks.pub)
Borrelia burgdorferi , an emerging bacterial pathogen, is maintained in nature by transmission from one vertebrate host to another by ticks. (cdc.gov)

The N-terminal domain is a novel TNF-alpha-like fucose-binding lectin, while the C-terminal part is similar to a superfamily of calcium-dependent bacterial lectins. (qub.ac.uk)
The protective effect afforded by the secretor gene might be due to the ability of glycocompounds in the body fluids of secretors to inhibit adhesins (attachment lectins) on the surface of the yeast. (n-equals-one.com)

This basic structure is conserved across type 1 fimbrial adhesins though recent studies have shown that in vitro induced mutations can lead to the addition of C-terminal domain specificity resulting in a bacterial adhesion with dual bending sites and related binding phenotypes. (wikipedia.org)

ESR12 studied the interactions of M-protein, the main virulence factor and adhesin of Streptococcus pyogenes. (europa.eu)

IL-6 can be secreted by cell lines of urinary system epithelial source in response to excitement with gram-negative bacterial LPS, IL-1, lab strains of stress Hu734 (1, 3, 15, 38). (mycareerpeer.com)
Any drug impairing crucial processes for bacterial life will inevitably lead to the development of drug-resistant strains, whereas the inhibition of biofilm formation might prevent the onset of bacterial resistance. (intechopen.com)
Three of the L. amylovorus strains studied adhered to IPEC-1 cells, while four strains inhibited the adherence of E. coli , indicating additional mechanisms other than competition for binding sites being involved in the inhibition. (biomedcentral.com)
None of the strains bound to porcine mucus. (biomedcentral.com)

Bacterial adhesins provide species and tissue tropism. (wikipedia.org)
They belong to a large family of diverse glycopolymers that differ among bacterial species. (asmblog.org)
S (surface) layers are the outermost cell envelope structures commonly found on the surface of lactobacilli and other bacterial species. (biomedcentral.com)

A large number of bacterial adhesins with individual receptor specificities have been identified. (wikipedia.org)
Multilocus sequence typing and genotypic analysis of PorA variable regions (VRs) ( porA VR1 and VR2), ferric enterochelin receptor VR ( fetA ), neisserial heparin-binding antigen ( nhba ), neisserial adhesin A ( nadA ), and factor H binding protein ( fhbp ) encoding regions were performed by using described protocols ( 11 , 12 ). (cdc.gov)
In part, this innate defense hinges on recognition of lipopolysaccharide (LPS) and other bacterial products by members of the Toll-like receptor (TLR) family expressed on immune cells, such as macrophages, and epithelial cells (reviewed recently in reference 2). (mycareerpeer.com)
Complejo de proteínas que forma un receptor para la TRANSFERRINA en BACTERIAS. (bvsalud.org)

The bacterial adhesion consists primarily of an intramembranous structural protein which provides a scaffold upon which several extracellular adhesins may be attached. (wikipedia.org)

We have identified endothelial surface-located integrins as major receptors for Opc, a process which requires Opc to first bind to integrin ligands such as vitronectin and via these to the cell-expressed receptors1. (bris.ac.uk)
Most toxins bind to specific target cell receptors. (msdmanuals.com)

Using a custom-spotted glycoprotein and neoglycoprotein dot blot array, we identify candidate glycan motifs recognized by PsrP and by the putative S. pneumoniae adhesin that could perhaps be responsible for pneumococcal binding to salivary MUC7 and glycoproteins on RBCs. (lu.se)
During recent years, evidence has shown that glycoprotein 2 (GP2), a UMOD-like molecule produced in the pancreas and the intestine, plays a similar role in counteracting bacterial infections in the gastrointestinal system. (phys.org)
The aCL antibodies bind to b2GPI, or a complex formed by this b2GPI is a platelet adhesin glycoprotein and cardiolipin. (medscape.com)

The Opc protein of Neisseria meningitidis (Nm, meningococcus) is a surface-expressed integral outer membrane protein, which can act as an adhesin and an effective invasin for human epithelial and endothelial cells. (bris.ac.uk)
In this study, we further assessed whether C3-dependent internalisation by human tubular epithelial cells is a general feature of uropathogenic E. coli and investigated features of the bacterial phenotype that may account for any heterogeneity. (biomedcentral.com)
CD46 was not involved in the binding of E. coli to epithelial cells. (biomedcentral.com)
In attachment studies, preincubation of certain bacterial spores with boiled secretor saliva significantly reduced their ability to bind to epithelial cells. (n-equals-one.com)

Consists of thick polysaccharide capsule (slime layer adhesin). (powershow.com)

But the bacterial growth in biofilms requires a varied but coordinated transcriptional, proteomic and metabolomic profile. (microbialcell.com)
Bacterial murein hydrolases, also known as autolysins, are involved in the production of biofilms. (creative-biolabs.com)

However, capsule-specific opsonic antibodies can bind to the bacterial capsule and facilitate phagocytosis. (msdmanuals.com)

Streptococcus pneumoniae also expresses a serine-rich repeat (SRR) adhesin, PsrP, which is a homologue to oral Mitis group SRR adhesins, such as Hsa of Streptococcus gordonii and SrpA of Streptococcus sanguinis. (lu.se)

In addition, the capsule prevents bacterial death caused by bactericidal serum factors. (medscape.com)

Two black lines indicate the position of the usher within the bacterial outer-membrane. (esrf.fr)

Entry of UPEC into superficial umbrella cells activates the formation and maturation of intracellular bacterial communities (21). (mycareerpeer.com)
The intracellular bacterial community maturation cascade is part of a mechanism that allows UPEC to subvert early innate defenses. (mycareerpeer.com)

Endotoxin triggers humoral enzymatic mechanisms involving the complement, clotting, fibrinolytic, and kinin pathways and causes much of the morbidity in gram-negative bacterial sepsis. (msdmanuals.com)

Impedance-based biosensors allowed ESR4 to show that only the glycosylated host protein vitronectin binds YadA (Meuskens et al. (europa.eu)

A major impediment to this process is the mucosal barrier, which exists in a secreted or membrane bound form. (bmj.com)
The Helicobacter pylori adhesin BabA binds mucosal ABO/Le(b) blood group (bg) carbohydrates. (diamond.ac.uk)

Sections on the prevention of bacterial pneumonia in mechanically ventilated and/or critically ill patients, care of respiratory-therapy devices, prevention of cross-contamination, and prevention of viral lower respiratory tract infections (e.g., respiratory syncytial virus {RSV} and influenza infections) have been expanded and updated. (cdc.gov)

Adhesion and bacterial adhesins are also a potential target for prophylaxis or treatment of bacterial infections. (wikipedia.org)
Urinary tract infections (UTIs) are among the most common bacterial infections. (microbiologyresearch.org)
Both classic-pathway and alternate-pathway complement activation have been described, but the latter, which does not require the presence of immunoglobulins directed against bacterial antigens, appears to be the more active pathway in K pneumoniae infections. (medscape.com)
A particulate matter: How environmental irritants and particulate matter increase sensitivity to bacterial respiratory tract infections. (lu.se)

They are able to activate complement, which causes selective deposition of C3b onto LPS molecules at sites distant from the bacterial cell membrane. (medscape.com)
This inhibits the formation of the membrane attack complex (C5b-C9), which prevents membrane damage and bacterial cell death. (medscape.com)
Their effects on bacterial cell membrane integrity were investigated by transmission electron microscopy and a fluorescence-based permeability assay. (biomedcentral.com)
Transmission electron microscopy analysis and a permeabilization assay brought evidence that the bacterial cell membrane was the target of green tea polyphenols. (biomedcentral.com)
One such method involves the application of amniotic membrane which has anti-inflammatory, anti-bacterial, anti-fibrosis, anti-scarring properties with low immunogenicity, epithelialization effects, and secretory leukocyte protease inhibitor (SLPI). (kemdikbud.go.id)
This leads to actin remodeling, membrane ruffle formation and bacterial internalization. (omicsdi.org)

In addition, they also serve as adhesins for binding to host cells and for biofilm formation. (asmblog.org)

Considered generally recognized as safe (GRAS) by the Food and Drug Administration and recently approved by the U.S. Dept. of Agriculture for use on fresh beef, ALF can be sprayed onto carcasses to help prevent bacterial contamination during processing or can be applied to a subprimal or finished beef surface prior to final packaging to inhibit bacterial growth and extend shelf life. (ift.org)

The new generation of whole-cell vaccines is based on an unencapsulated serotype that allows the expression of many bacterial antigens at a lower cost than a recombinant vaccine. (mdpi.com)

Also it could change anti-bacterial lipids and prolong survival of MRSA in wound. (powershow.com)
Anti-bacterial agents. (bvsalud.org)

Additionally, a carbohydrate-binding pocket has been identified at the tip of the N-terminal adhesive domain. (wikipedia.org)
Anyone working on bacterial adhesive structures can find the AlphaFold structure model from Monzon's paper , as well as the random forest prediction results in this institutional repository of the University of Cambridge . (embl-em.de)

Conclusions This study provides the first evidence that quantifiable bacterial protein signals are associated with CD, which can have a profound impact on future molecular diagnosis. (bmj.com)
However, the molecular mechanisms underlying how cells use this adhesin (a hypothetical fusogen) to recognize kin and transition towards a multicellular lifestyle remain largely unexplored. (nature.com)

This adhesin is responsible for D-mannose sensitive adhesion. (wikipedia.org)
BC2L-C is therefore a superlectin that binds independently to mannose/heptose glycoconjugates and fucosylated human histo-blood group epitopes. (qub.ac.uk)
The apo form of the C-terminal domain crystallized as a dimer, and calcium and mannose could be docked in the binding site. (qub.ac.uk)
We propose that BC2L-C binds to the bacterial surface in a mannose/heptose-dependent manner via the C-terminal domain. (qub.ac.uk)

As the latter bind to salivary glycoproteins through recognition of terminal sialic acids, we wanted to determine whether S. pneumoniae also binds to salivary. (lu.se)

BabA facilitates bacterial attachment to gastric surfaces, increasing strain virulence and forming a recognized risk factor for peptic ulcers and gastric cancer. (diamond.ac.uk)

ViBrANT provided Europe-wide world-class training to our 15 students (ESR1-15) through bottom-up research: clinical microbiology, functional studies of adhesins, elucidating structures and designing new diagnostic tests and devices. (europa.eu)
Its ability to bind two Fe +3 ions with high affinity, in cooperation with two HCO 3 - ions, contributes to its major structure-functional properties, including antimicrobial activity. (ift.org)
TraB contains a predicted β-barrel domain and an OmpA cell wall binding domain and is required for TraA to form a functional adhesin for OME 8 , 13 . (nature.com)
In this study, we characterized the functional domains of the Haemophilus influenzae HMW1B protein, a TpsB protein that interacts with the H. influenzae HMW1 adhesin. (duke.edu)

As known for other T1SS substrates, such as E. coli HlyA, Ca2+ ions bound by conserved D residues within the BIg domains stabilize the protein and facilitate secretion. (omicsdi.org)

By state-of-the-art sequencing ESR6&7 showed that Bartonella henselae adhesin A (BadA) is nearly 4000 residues long (not ≈3000), and with ESR12 determined which parts of this very long protein bound human fibronectin as a promising basis for novel antimicrobial therapies. (europa.eu)

This process leads to bacterial invasion of endothelial cells2. (bris.ac.uk)

After removal of PsrP, an additional previously masked lectin-like adhesin activity mediating agglutination of sialidase-treated RBCs becomes revealed. (lu.se)
SiiE binds to host cell apical membranes in a lectin-like manner. (omicsdi.org)

Lipopolysaccharide-binding protein facilitates transfer of bacterial cell wall components to inflammatory cells. (medscape.com)

Therefore, we hypothesised that other bacterial factors may be involved in C3-dependent E. coli internalisation. (biomedcentral.com)

Because intubation and mechanical ventilation alter first-line patient defenses, they greatly increase the risk for nosocomial bacterial pneumonia. (cdc.gov)

Anatomy25

Organisms43

Diseases12

Chemicals and Drugs78

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes60

Information Science5

Health Care1

FimH23

Proteins19

Pili4

Virulence factors3

Infection14

Pathogens7

Bacteria20

Fimbriae4

Pilus6

Pathogen2

Lectins2

Fimbrial adhesins1

Main virulence factor1

Strains4

Species3

Receptor4

Extracellular1

Receptors2

Glycoprotein3

Epithelial4

Polysaccharide1

Biofilms2

Antibodies1

Streptococcus1

Capsule1

Outer membrane1

Intracellular2

Gram-negative bacterial1

Vitronectin1

Mucosal2

Viral1

Infections4

Membrane6

Biofilm formation1

Inhibit1

Antigens1

Anti-bacterial2

Adhesive2

Molecular2

Mannose4

Pneumoniae1

Attachment1

Functional4

Secretion1

Fibronectin1

Invasion1

Lectin2

Cells1

Coli1

Nosocomial1