Most biliary tract cancers go undetected until an advanced stage, at which point many patients are ineligible for surgery and have few treatment options," Scot Ebbinghaus, MD, vice president of Global Clinical Development at Merck Research Laboratories, said in the press release. (cancernetwork.com)
The FDA has given an orphan drug designation to BDC-1001 for the treatment of patients with gastric cancers, including gastroesophageal junction cancer. (onclive.com)
In addition to gastric cancer, we are also evaluating BDC-1001 in 3 other tumor types with significant unmet medical need: HER2-positive breast, colorectal, and endometrial cancers," Perez stated in the press release. (onclive.com)
She is specifically interested in therapeutic endoscopic advances, clinical research aimed at improving patient care for esophageal, gastric, pancreatic and colorectal cancers, and biliary strictures in patients with a history of liver transplant. (ohsu.edu)
Roux-en-Y G3
This study compared the long-term consequences of two common forms of bariatric surgery: one-anastomosis gastric bypass (OAGB) and Roux-en-Y Gastric Bypass (RYGB) in a preclinical rat model. (nature.com)
Our results represent the first large multicenter evaluation of a newly described Laparoscopy-Assisted Endoscopic Retrograde Cholangiopancreatography (LA-ERCP) procedure that is indicated in patients who had Roux-en-Y Gastric Bypass (RYGB) for pancreaticobiliary endoscopic interventions. (gi.org)
The more extensive surgeries, such as biliary-pancreatic diversion surgery or more extended Roux-en-Y gastric bypass surgery, may result in more protein malabsorption . (medscape.com)
Esophageal cancer1
Organic causes of dyspepsia are peptic ulcer, gastroesophageal reflux disease, gastric or esophageal cancer, pancreatic or biliary disorders, intolerance to food or drugs, and other infectious or systemic diseases. (nih.gov)
Duodenal4
Pathophysiological mechanisms underlying FD are delayed gastric emptying, impaired gastric accommodation to a meal, hypersensitivity to gastric distension, altered duodenal sensitivity to lipids or acids, altered antroduodenojenunal motility and gastric electrical rhythm, unsuppressed postprandial phasic contractility in the proximal stomach, and autonomic nervous system-central nervous system dysregulation. (nih.gov)
Here, we reviewed registers from 855 patients with Crohn's disease treated in our service from January 2007 to December 2020 and found 4 cases of duodenal fistula and 1 case of gastric fistula. (bvsalud.org)
They then underwent surgical treatment with resection of the affected segment and duodenal or gastric closure with covering by an omental patch. (bvsalud.org)
Vagotomy is an essential component of surgical management of peptic (duodenal and gastric) ulcer disease (PUD). (medscape.com)
Cancer24
Current consensus guidelines from the Americas Hepato-Pancreato-Biliary Association recommend re-resection for patients with T1b, T2 or T3 gallbladder cancer that is incidentally identified in a cholecystectomy specimen, unless this surgery is contraindicated because of advanced disease or poor performance status. (medscape.com)
Neoadjuvant chemoradiotherapy is not currently a standard option for patients with biliary tract cancer. (medscape.com)
The regulatory agency has set a Prescription Drug User Fee Act date of February 7, 2024 for pembrolizumab plus chemotherapy as a treatment for patients with advanced or metastatic biliary tract cancer. (cancernetwork.com)
Supporting data for the sBLA came from the phase 3 KEYNOTE-966 trial (NCT04003636), in which investigators assessed the efficacy and safety of pembrolizumab plus chemotherapy vs chemotherapy alone in the treatment of patients with advanced unresectable or metastatic biliary tract cancer. (cancernetwork.com)
The FDA has accepted a supplemental biologics license application (sBLA) for pembrolizumab (Keytruda) plus gemcitabine and cisplatin for the treatment of those with locally advanced unresectable or metastatic biliary tract cancer, according to a press release from Merck. (cancernetwork.com)
We look forward to working with the FDA to bring a new option to patients with advanced or unresectable biliary tract cancer that may help them live longer. (cancernetwork.com)
Biliary tract cancer is rising in incidence worldwide, and unfortunately most patients are diagnosed with this devastating type of cancer at an advanced stage, when the 5-year survival rate is less than 5%," Robin Kate Kelley, MD, professor of Clinical Medicine in the Division of Hematology/Oncology at the University of California, San Francisco, said at the time of the data readout. (cancernetwork.com)
Patients 18 years and older with a histologically confirmed diagnosis of advanced or unresectable biliary tract cancer and measurable disease based on RECIST v1.1 criteria were eligible to enroll on the trial. (cancernetwork.com)
[ 1 ] In contrast, bile duct tumors located outside of the liver had been classified with gallbladder cancer as extrahepatic biliary tract tumors. (tri-kobe.org)
In a discussion of the paper, David H. Wang, MD, PhD, an associate professor in the Department of Internal Medicine at University of Texas Southwestern Medical Center, Dallas, pointed out that "zolbetuximab is the first molecularly targeted therapy, exclusive of immune checkpoint inhibitors, to demonstrate a statistically significant survival benefit in first-line treatment of advance gastric cancer since trastuzumab. (medscape.com)
One reason may be that claudin 18 positivity may be associated with a better prognosis for patients with diffuse gastric cancer, he explained. (medscape.com)
Overall, Wang believes that these results validate claudin 18 as a new predictive biomarker for advanced gastric cancer, although he noted that widespread implementation for this indication may be limited, as the assay to determine claudin 18 levels is not widely available. (medscape.com)
However, data on its expression pattern and clinical relevance in gastric cancer are not sufficient. (jcancer.org)
The expression level of CDK10 was analyzed using qRT-PCR, western blotting, and immunohistochemistry on tissue samples from 189 post-resection gastric cancer patients. (jcancer.org)
Immunohistochemistry data indicated that CDK10 expression was significantly decreased in 92 of 189 (48.7%) gastric cancer cases. (jcancer.org)
Our data suggest that reduced CDK10 expression independently predicts a poor prognosis in patients with gastric cancer. (jcancer.org)
With a total of 989,600 new cancer cases and 738,000 deaths worldwide in 2008, gastric cancer (GC) is the fourth most common malignant tumor and the second most common cause of cancer-related deaths, accounting for 10.4% of cancer-related deaths ( 1 , 2 ). (jcancer.org)
Unfortunately, in China, most gastric cancer patients are diagnosed at an advanced stage of disease, thus precluding the use of curative gastrectomy ( 3 - 5 ). (jcancer.org)
Multidisciplinary treatment has been applied for gastric cancer patients with improved treatment outcomes in recent years ( 6 ). (jcancer.org)
However, gastric cancer is still lacking efficient medicines. (jcancer.org)
Conclusion: Biliary bypass surgery for unresectable pancreatic cancer may improve patient survival, although prolongs hospital stay. (scirp.org)
This study aimed to evaluate our experience in Morocco on treating patients, by surgical biliary bypass or endoscopic stenting, presented by obstructive jaundice from advanced cancer head pancreas and to compare the patient's outcome in terms of post procedure mortality, morbidity, assess cost effectiveness, re-hos- pitalization and overall survival in these patients. (scirp.org)
Outcomes for the commonest forms of upper gastro-intestinal (UGI) cancer (oesophagus, gastric, pancreatic, gallbladder and biliary tract) are poor worldwide [1]. (findaphd.com)
Application of machine learning algorithm in predicting distant metastasis of T1 gastric cancer. (cdc.gov)
Primary biliary c6
What Should I Know About Primary Biliary Cirrhosis (PBC)? (emedicinehealth.com)
Primary biliary cirrhosis (PBC) is a chronic disease characterized by progressive inflammation and destruction of the small bile ducts within the liver. (emedicinehealth.com)
What Is the Medical Definition of Primary Biliary Cirrhosis (PBC)? (emedicinehealth.com)
Since cirrhosis occurs only in the later stage of PBC, the name primary biliary cirrhosis is actually a misnomer for patients in the earlier stages of the illness. (emedicinehealth.com)
formerly known as primary biliary cirrhosis) is an autoimmune liver disorder characterized by the progressive destruction of intrahepatic bile ducts, leading. (msdmanuals.com)
Gastrointestinal4
Endoscopic ultrasound is an imaging technique used to assess and stage gastrointestinal malignancies including esophageal, gastric, biliary, pancreatic, and colonic. (nursingcenter.com)
Visceral Surgery deals with all aspects of the surgical treatment of benign and malignant diseases of abdominal organs (hepato-biliary and pancreatic surgery including transplantation, splenic surgery), the entire gastrointestinal tract (esophageal, gastric, bariatric), endocrine organs, the abdominal wall (hernia surgery and abdominal wall closure) and the peritoneum (peritonitis, sepsis and peritoneal carcinomatosis). (frontiersin.org)
proposed that H. pylori All patients received diagnostic upper to the QIAamp spin column in a 2 present in human bile samples might rep- gastrointestinal endoscopy and gastric mL collection tube were processed ac- resent a risk factor for gallstone formation biopsies were taken to confirm the cording to Qiagen protocol. (who.int)
Gastrin-producing tumors or gastrinomas cause excessive gastric acid secretion, leading to these ulcers of the upper gastrointestinal (GI) tract, as well as diarrhea and severe abdominal pain (see the following image). (medscape.com)
Tumors1
Hendriquez R, Keihanian T, Goyal J, Abraham RR, Mishra R, Girotra M. Radiofrequency ablation in the management of primary hepatic and biliary tumors. (wjgnet.com)
Stimulates gastric1
Research [1] shows that coffee consumption does change the composition of the gut microbiota and stimulates gastric, biliary, and pancreatic secretion. (nchc.org)
Peptic ulcer2
The right vagus gives rise to a posterior gastric branch called the criminal nerve of Grassi-so called because it is often missed during vagotomy and is then responsible for recurrence of peptic ulcer-which traverses to the left and supplies the cardia and fundus. (medscape.com)
The supernatant was to peptic ulcer disease, gastritis and gastric excluded from the study. (who.int)
ERCP1
This makes the access to the biliary or pancreatic trees exceedingly difficult by the conventional per oral ERCP procedure. (gi.org)
Gastritis1
In conclusion, RYGB results in a better long-term outcome than OAGB, as chronic signs of biliary reflux or reactional gastritis were reported post-OAGB even after reducing the BPL length in a preclinical rat model. (nature.com)
Gastroesophageal junction1
SAN FRANCISCO ― An experimental monoclonal antibody combined with chemotherapy could offer a new standard of care for patients with claudin-18.2+ (CLDN18.2+) / HER2− advanced gastric or gastroesophageal junction (mG/GEJ) adenocarcinoma, say researchers in reporting a phase 3 trial. (medscape.com)
Surgery1
My main interest is in oesophago-gastric (stomach and gullet) surgery and in particular laparoscopic surgery (keyhole surgery). (spirehealthcare.com)
Ducts4
The biliary system consists of a network of ducts that carry bile from the liver to the small bowel and is classified by its anatomic location (Figure 1 ). (tri-kobe.org)
The bile ducts carry bile, a fluid that is produced by the liver cells (hepatocytes) and modified by the biliary lining (epithelial) cells as it flows through the ducts to the small intestine. (emedicinehealth.com)
This study documents variations in the origin of the cystic artery and its location in relation to the biliary ducts among 106 Sudanese people and compared the variations between the sexes and races. (who.int)
3%). No cases arising from other arteries to the biliary ducts among Sudanese people were noted. (who.int)
Bypass2
Moreover, a debate on outcome results in these patients who receive plastic biliary endoprothesis versus surgical bypass as palliation of obstructive jaundice. (scirp.org)
Vitamin K is primarily absorbed in the jejunum and the ileum, which are not as extensively bypassable, although the jejunum is considerable depending on the length of the gastric bypass or, in particular, with biliary pancreatic diversion. (medscape.com)
Jejunum1
However, in addition to locations in the duodenum and pancreas, gastrinomas have been described in the lymph nodes, liver/biliary tree, gastric antrum, and jejunum. (medscape.com)
Bariatric2
Each year I perform over 100 laparoscopic cholecystectomies, 100 laparoscopic anti-reflux throat procedures and 400 laparoscopic gastric band insertions for bariatric obesity. (spirehealthcare.com)
I have set up and led the well-known Heartlands Hospital NHS surgical obesity service which serves approximately 10% of the population of England and hold a bariatric clinic at Spire Parkway Hospital, performing gastric band insertions. (spirehealthcare.com)
Ulcers2
Roberts' Formula is a Western herbal preparation that blends multiple herbs for a synergistic effect to treat intestinal inflammation associated with gastric ulcers or inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis (UC). (ndnr.com)
Although no controlled research trials have been performed on Bastyr's Formula, this old naturopathic remedy is recognized for helping many individuals with IBD, irritable bowel syndrome (IBS), arthritis, gastric ulcers, and various digestive issues. (ndnr.com)
Antrum1
After giving rise to the celiac and hepatic branches, respectively, the right and left vagal trunks continue along the lesser curvature of the stomach (in close company with the vascular arcade formed by the left and right gastric vessels) as the posterior and anterior gastric nerves of Latarjet, which supply the corpus (body), antrum, and pylorus of the stomach. (medscape.com)
Diseases2
ABSTRACT Earlier reports on the detection of Helicobacter DNA in the gallbladder tissue of patients with biliary diseases have shown discordant results. (who.int)
These results do not rule out the possibility of Helicobacter infection as a contributing agent or cofactor in the development of biliary diseases. (who.int)
Mucosa1
Zolbetuximab is a monoclonal antibody that targets the cell surface molecule CLDN18.2, which is expressed in normal gastric mucosa cells and is retained in mG/GEJ tumor cells. (medscape.com)
Bile duct1
Surgical resection includes cholecystectomy, en bloc hepatic resection (typically of segments IVb and V), and lymphadenectomy with or without bile duct excision, depending on the location of the tumor. (medscape.com)
Patients1
Providing a reliable access to the biliary or pancreatic trees is crucial in these patients. (gi.org)
Surgical1
OAGB, as all Omega-loop surgical strategies, is characterized by the direct anastomosis of the biliopancreatic loop to the stomach, instead of interposing an alimentary loop as in the Roux-en-Y procedures. (nature.com)
Malabsorption1
Yet, no association could be established between the esogastric lesions and malabsorption, weight loss, or gastric bile acid concentrations. (nature.com)