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  • flow of bile
  • The cause of these complications may be related to either abnormal flow of bile within the ducts or the presence of gallstones Direct hyperbilirubinemia They were classified into 5 types by Todani in 1977. (wikipedia.org)
  • epithelial
  • These studies investigate the role of transforming growth factor-beta 1, a potent inhibitor of epithelial cell proliferation and stimulator of extracellular matrix biosynthesis, during intrahepatic bile duct hyperplasia and biliary fibrosis. (nih.gov)
  • These results suggest that transforming growth factor-beta 1 may play a role in both the termination of the bile duct epithelial cell proliferative response and the induction of fibrogenesis after common bile duct ligation. (nih.gov)
  • Human intrahepatic biliary epithelial cells were isolated from the livers of patients with primary biliary cirrhosis and from normal livers and established in primary culture. (bmj.com)
  • These data show that pro-inflammatory cytokines increase expression of intercellular adhesion molecule-1, HLA class I, and HLA class II on human intrahepatic biliary epithelial cells in vitro and are consistent with the hypothesis that these locally acting factors may play a part in the pathogenesis of immune mediated disorders such as primary biliary cirrhosis in which immune mediated bile duct damage occurs. (bmj.com)
  • cancer
  • The true incidence of bile duct cancer is unknown, however, because establishing an accurate diagnosis is difficult. (cancer.gov)
  • Bile duct cancer may occur more frequently in patients with a history of primary sclerosing cholangitis, chronic ulcerative colitis, choledochal cysts, or infections with the liver fluke Clonorchis sinensis . (cancer.gov)
  • Intrahepatic bile duct cancer may be relatively indolent and difficult to clinically differentiate from metastatic adenocarcinoma deposits in the liver. (cancer.gov)
  • Complete resection with negative surgical margins offers the only chance of cure for bile duct cancer. (cancer.gov)
  • Improvements in treatment since then may result in a better outlook for people now being diagnosed with bile duct cancer. (cancer.org)
  • These statistics come from the National Cancer Institute's SEER program and are based on people diagnosed with bile duct cancer in the years 2000 to 2006. (cancer.org)
  • Liver and bile duct cancer. (cancer.org)
  • Expert-reviewed information summary about the treatment of bile duct cancer. (oncolink.org)
  • This PDQ cancer information summary has current information about the treatment of bile duct cancer. (oncolink.org)
  • Having colitis or certain liver diseases can increase the risk of bile duct cancer. (oncolink.org)
  • Tests that examine the bile ducts and nearby organs are used to detect (find), diagnose, and stage bile duct cancer. (oncolink.org)
  • Different procedures may be used to obtain a sample of tissue and diagnose bile duct cancer. (oncolink.org)
  • This type of cancer forms in the bile ducts inside the liver. (oncolink.org)
  • The most common subtypes are hepatocellular carcinoma (ICD10 C22.0, cancer occurring in the liver cells), and intrahepatic bile duct carcinoma (ICD10 C22.1, cancer originating in the sections of bile ducts that are inside the liver). (ncin.org.uk)
  • Intrahepatic bile duct carcinoma is the second most common primary liver cancer subtype and the causes of this cancer are unclear. (ncin.org.uk)
  • Blockage of the bile duct by gallstones, scarring from injury, or cancer prevents the bile from being transported to the intestine and the active ingredient in the bile (bilirubin) instead accumulates in the blood. (wikipedia.org)
  • Recent studies have proved that it is definite cancer-causing agent in the liver (carcinoma) and bile duct (CCA). (wikipedia.org)
  • cysts
  • Choledochal cysts are treated by surgical excision of the cyst with the formation of a roux-en-Y anastomosis hepaticojujenostomy/ choledochojujenostomy to the biliary duct. (wikipedia.org)
  • primary sclerosing
  • In the Western world, the most common of these is primary sclerosing cholangitis (PSC), an inflammatory disease of the bile ducts which is closely associated with ulcerative colitis (UC). (wikipedia.org)
  • blockage
  • It can be used to relieve a blockage in the bile duct, either permanently or as a temporary solution before definite treatment such as surgery. (wikipedia.org)
  • contrast
  • In contrast, the bile duct epithelium in bile duct-ligated rats stained strongly positive for transforming growth factor-beta 1 at 1 and 4 wk after ligation. (nih.gov)
  • ligation
  • In addition, the mannose 6-phosphate/insulin-like growth factor II receptor was up-regulated in hyperplastic bile duct epithelium 1 and 4 wk after ligation. (nih.gov)
  • atrophy
  • Atrophy of the hepatic segment or lobe drained by the involved bile ducts, associated with hypertrophy of the unaffected segments, can occur, especially with chronic high-grade strictures. (medscape.com)
  • Focal
  • There are two patterns of Caroli disease: focal or simple Caroli disease consists of abnormally widened bile ducts affecting an isolated portion of liver. (wikipedia.org)
  • fibrosis
  • Transforming growth factor-beta 1 and mannose 6-phosphate/insulin-like growth factor-II receptor expression during intrahepatic bile duct hyperplasia and biliary fibrosis in the rat. (nih.gov)
  • After the injury, an inflammatory response ensues, which is followed by collagen deposition, fibrosis, and narrowing of the bile duct lumen. (medscape.com)
  • Intrahepatic bile duct atresia (Alagille syndrome) (ALGS2 MIM:610205 and ALGS1 MIM:118450) Extrahepatic bile duct atresia Autosomal recessive polycystic kidney disease Congential hepatic fibrosis Caroli's disease Von Meyenburg complex Trisomy 17, 18 and 21 Cystic fibrosis Alpha 1 antitrypsin deficiency Trihydroxycoprostanic acidemia Byler's disease Bile duct injury and loss can result from autoimmune destruction. (wikipedia.org)
  • swollen
  • On autopsy, he observed that the corpse had swollen liver (hepatomegaly) and distended bile ducts, which he noted were blocked by "small, dark, vermicular-looking bodies. (wikipedia.org)