Loading...
  • feces
  • Approximately 600 mg of bile salts are synthesized daily to replace bile acids lost in the feces, although, as described below, much larger amounts are secreted, reabsorbed in the gut and recycled. (wikipedia.org)
  • micelles
  • To estimate the nasal epithelial membrane and cytoplasmic damaging effect caused by sodium glycocholate (NaGC)-linoleic acid (15 m M:5 m M) mixed micelles, the release profiles of 5′-nucleotidase (5′-ND), lactate dehydrogenase (LDH), and carboxylesterase in the nasal perfusate were measured as a function of time. (ovid.com)
  • Mixed micelles composed of 15 m M NaGC and 5 m M linoleic acid are incapable of incorporating these esters into the micellar cavity, although NaGC micelle alone can actively solubilize them in a concentration-dependent manner. (ovid.com)
  • The bile micelles pass into the duodenum, where the detergent action of the bile salts emulsifies fats, which are then broken down by the enzyme lipase from the pancreas . (encyclopedia.com)
  • The main function of bile acids is to allow digestion of dietary fats and oils by acting as a surfactant that emulsifies them into micelles, allowing them to be colloidally suspended in the chyme before further processing. (wikipedia.org)
  • As amphipathic molecules with hydrophobic and hydrophilic regions, conjugated bile salts sit at the lipid/water interface and, at the right concentration, form micelles. (wikipedia.org)
  • Critical micellar concentration" refers to both an intrinsic property of the bile acid itself and amount of bile acid necessary to function in the spontaneous and dynamic formation of micelles. (wikipedia.org)
  • incubation
  • Using previously published methods, Barrett's-associated esophageal adenocarcinoma cell lines and primary cultures of Barrett's esophageal tissue were exposed to short pulses of acid or bile salts followed by incubation in culture media at pH 7.4. (biomedcentral.com)
  • Pathways
  • In addition, activation of signal transduction pathways associated with cell proliferation is observed with acid exposure. (biomedcentral.com)
  • markers
  • If present, changes in gene expression would provide an opportunity to determine how acid or bile salts contribute to malignant transformation, and may also identify disease-associated markers that are useful for assessing patient risk or as therapeutic targets. (biomedcentral.com)
  • genes
  • Further analysis using the Gene Ontology, however, showed that representation by genes associated with cell proliferation is not enhanced by acid exposure. (biomedcentral.com)
  • rats
  • however, the number of fecal lactic acid bacteria remained unchanged when rats were administered milk and fermented milks. (koreascience.or.kr)
  • ions
  • Hematoxylin Hematoxylin(Hydroxybrazilin) is a compound that forms strongly colored complexes with certain metal ions, notably Fe(III) and Al(III) salts and a kind of stain in histology. (antibody-antibodies.com)
  • This fluid is composed of four primary components: ions, digestive enzymes, mucus, and bile. (wikipedia.org)
  • Primary
  • Previous studies have shown that brief exposure of the Barrett's-associated adenocarcinoma cell line, SEG-1, or primary cultures of Barrett's esophageal tissues to acid or bile results in changes consistent with cell proliferation. (biomedcentral.com)
  • Similar experiments using short-term primary cultures of Barrett's esophagus also did not result in detectable changes in gene expression with either acid or bile salt exposure. (biomedcentral.com)
  • This study addresses whether exposure of Barrett's-associated adenocarcinoma cell lines or primary Barrett's esophageal tissues to acid or bile salts results in differences in gene expression patterns that support transformation to a malignant state. (biomedcentral.com)
  • human
  • The belief that bile had such a profound effect on human nature disappeared in the early nineteenth century, when humoral medicine was overtaken by the new scientific rationalism. (encyclopedia.com)
  • Human adults secrete between 12-18 g of bile acids into the intestine each day, mostly after meals. (wikipedia.org)
  • patients
  • Patients with IBS-D with increased bowel bile acid will be treated with colesevelam to determine if stool frequency and consistency improves via daily bowel diaries. (clinicaltrials.gov)