Bile acid cholic acid. Medical search. Frequent questions

Bile acids belong to a diverse family of bile salts, characterised by their planar and amphipathic nature. (randox.com)
It is used in the synthesis of bile salts, is present in bile in combination with cholic acid and can also be found in other organs and tissues such as lungs, muscles and nerves. (mcw.edu)
Bile salts and phospholipids are both found in bile. (seekinghealth.com)
Each serving contains an impressive 5000 IU of vitamin D3 and 50 mcg of vitamin K2 and delivers medium-chain triglycerides and bile salts for maximum benefits. (onestoppeshoppe.com)
D3 & K2 Vitamin provides a perfect blend of essential vitamins, medium-chain triglycerides, and bile salts, delivered in easy-to-swallow capsules that offer a convenient source of nutrition-wherever you go! (drberg.com)
However, it is not absolutely necessary to take this product with a meal because of the addition of medium-chain triglycerides and bile salts. (drberg.com)
The bile salts were separated by thin-layer chromatography and visualized by an ethanolic phosphomolybdic spray. (tennessee.edu)
The primary mechanism of disease in patients with PFIC1-2 is a defect in canalicular bile acid transport with primary retention of hydrophobic bile salts. (medscape.com)
The mechanism whereby the loss of FIC1 activity results in defective bile salts excretion is unknown, but it has been hypothesized that a mutation in this protein causes phospholipid membrane instability leading to reduced function of bile acid transporters. (medscape.com)

Y bile acid: cholic (CA) and chenodeoxycholic acid (CDCA), and their conjugates Tauro(glycol)cholic acid (T(G)CA) and Tauro(glycol) chenodeoxycholic acid (T(G)CDCA), which are actively transported into bile and turn out to be part with the circulating bile acid pool. (5htreceptor.com)
Inside the tiny intestine, T(G)CA and T(G)CDCA are converted to secondary bile acids: deoxycholic acid (DCA) and Lithocholic acid (LCA), respectively (Chiang, 2013). (5htreceptor.com)
Subsequent enzymatic reactions catalyzed by sterol 12 α -hydroxylase (CYP8B1) and sterol 27-hyroxylase (CYP27A1), respectively, yield the primary BAs, cholic acid (CA) and chenodeoxycholic acid (CDCA). (aspetjournals.org)
[ 4 ] In 1971, Salen found that chenodeoxycholic acid (CDCA), an important bile acid, was virtually absent in patients with clinical symptoms of the disease. (medscape.com)
Deficiency of the enzyme results in impaired synthesis of the mature bile acids CDCAoxycholic acid (CDCA) and cholic acid. (medscape.com)
The mature bile acids (primarily CDCA) are responsible for negative feedback on cholesterol 7-alpha-hydroxylase, which is the initial and rate-limiting step in bile acid synthesis. (medscape.com)
INT-747, so called obeticholic acid (OCA) or 6-alpha-ethyl chenodeoxycholic acid (6-ECDCA), is a 6-alpha-alkyl-substituted analog of CDCA selectively inducing FXR transactivation at 1 μM 15 . (nature.com)
Therefore, we determined pool size and turnover of deoxycholic (DCA), cholic (CA), and chenodeoxycholic acid (CDCA) in 23 female gallstone patients classified according to their gallbladder function and in 15 healthy female controls. (jci.org)
It is a multifactorial disorder characterised by elevated levels of bile acids in the blood, particularly chenodeoxycholic acid (CDCA) and cholic acid (CA) 4 . (randox.com)
Chenodeoxycholic acid (CDCA) (Chendol - Weddel) is one of two naturally occurring 'primary' bile acids (the other being cholic acid) made in the liver from cholesterol. (bmj.com)
CDCA is synthesised commercially from cholic acid and prescribed as gelatin-coated capsules containing 125 mg CDCA. (bmj.com)

Enterohepatic circulation of bile acids plays a central role within the regulation of bile acids synthesis, fatty acid, lipid, and lipoprotein synthesis, as well as glucose metabolism in the liver (KullakUblick et al. (5htreceptor.com)
2010). Meanwhile, bile acids can market the intestinal absorption of lipid-soluble vitamins such as vitamin A. In between vitamin A metabolism and bile acid synthesis, there's a unfavorable feedback regulatory partnership. (5htreceptor.com)
Cerebrotendinous xanthomatosis (CTX) is a rare genetic disorder of cholesterol and bile acid metabolism that results in systemic and neurologic abnormalities. (medscape.com)
Citations to Disorders of bile acid metabolism in cholesterol gallstone disease. (jci.org)
Disorders of bile acid metabolism in cholesterol gallstone disease. (jci.org)
The aim of the study was to evaluate the metabolism of individual bile acids in patients with cholesterol gallstone disease. (jci.org)
One key receptor associated with bile acid metabolism is the Farnesoid X receptor (FXR). (randox.com)
Cholic acid's role in regulating cholesterol levels, glucose metabolism, and energy homeostasis suggests potential applications in managing cardiovascular and liver-related diseases, diabetes, and metabolic disorders. (viochemicals.com)
Bile acid metabolism in mammals. (docksci.com)
Bile acid metabolism in mamn~als.VBII. (docksci.com)
In st~adiesof cholic acid metabolism using the isolated perfused rat liver system, an unknown conjugate of cholic acid was observed. (docksci.com)
Their function is indispensable in human metabolism and includes beta-oxidation of fatty acids, biosynthesis of ether phospholipids (including plasmalogen and platelet activating factor [PAF]), biosynthesis of cholesterol and other isoprenoids, detoxification of glycolate to glycine (the accumulation of glycolate leads to precipitation of calcium oxalate in various tissues, with subsequent deleterious effects), and oxidation of L-pipecolic acid (the function of which is incompletely understood). (medscape.com)

The results showed that the addition of capsaicin further decreased the fasting blood glucose and insulin, and increased beta-muricholic acid, deoxycholic acid, chenodeoxycholic acid, and 3 beta-ursodeoxycholic acid when compared to only high fiber diet. (ijpsonline.com)

When a higher fiber diet program is consumed, there's a greater excretion of bile acids in feces, thus significantly less can reach the liver for re-secretion. (5htreceptor.com)
Bile acids Bile acid turnover By-pass operation Crohn s disease Elimination Faecal excretion Faeces Ileal resection Abstract. (karger.com)
These findings suggest a defect in biliary excretion, particularly of chenodeoxycholic acid conjugates. (medscape.com)

CHOLBAM is a treatment for infants, children and adults who have a rare condition called bile acid synthesis disorders. (fda.gov)
CHOLBAM was studied for the treatment of bile acid synthesis disorders due to what are called single enzyme defects (SEDs). (fda.gov)
In the trials that supported the FDA approval of CHOLBAM, 64% of patients with rare bile acid synthesis disorders had improvement in body weight as a measure of growth as well as improvements in liver tests that are expected to be related to less liver damage. (fda.gov)
PubChem] Cholic acid, formulated as Cholbam capsules, is approved by the United States Food and Drug Administration as a treatment for children and adults with bile acid synthesis disorders due to single enzyme defects, and for peroxisomal disorders (such as Zellweger syndrome). (rcsb.org)
Mirum Pharmaceuticals, Inc. (NASDAQ: MIRM) and Travere Therapeutics, Inc. (NASDAQ: TVTX) today announced that they have entered into a definitive agreement for the sale of Travere's bile acid product portfolio that includes Cholbam® (cholic acid) and Chenodal® (chenodiol), two medications addressing rare diseases in high-need settings. (kanerepublican.com)
Mirum will acquire Travere's rights to Cholbam®, indicated for the treatment of bile acid synthesis disorders due to single enzyme deficiencies and adjunctive treatment of peroxisomal disorders in patients who show signs or symptoms of liver disease, and Chenodal®, indicated for the treatment of radiolucent stones in the gallbladder, which is also under Phase 3 clinical evaluation for cerebrotendinous xanthomatosis (CTX). (kanerepublican.com)

Ox Bile Extract (min. (tigerfitness.com)

Bromelain, Ox Bile, Pancreatin and Papain have been formulated to optimize the breakdown of fats, carbohydrates and protein for maximum assimilation. (supplementwarehouse.com)
A few people who use NOW Super Enzymes experience a reaction to the protein digesting enzymes in this formula (Pancreatin, Bromelain & Papain) or to the acid (Betaine HCl). (supplementwarehouse.com)
Bromelain, Ox Bile, Pancreatin and Papain. (supplementwarehouse.com)
Formulated with Bromelain , Ox Bile , Pancreatin and Papain to help with a healthy digestive system. (tigerfitness.com)

A major primary bile acid produced in the liver and usually conjugated with glycine or taurine. (rcsb.org)
as in aminoacetic acid, another name for glycine. (absp.org.uk)
La secretion de ce conjugu6 n'est pas due 5 une deficience en glycine oea en taurine. (docksci.com)
A considerable body of evidence supports the current dognaa that only conjugated bile acids are secreted into the bile and that conjugation of bile acids is restricted to the two amino acids, glycine and taurine. (docksci.com)
Precursor-ion scans reveal the presence of conjugating groups, i.e. taurine (T) or glycine (G), conjugated to the carboxylic acid group of bile acids through an amide bond, sulfuric acid (S) conjugated to a hydroxyl group through an ester bond, glucuronic acid (GlcA), N-acetylglucosamine (GlcNAc), and hexose (Hex) sugars assumed to be linked to a hydroxyl group through an acetal linkage. (lipidomicnet.org)
The relationship of dietary sulfate and the availability of taurine in the tissues to the relative conjugation of cholic acid with glycine and taurine to form the bile acids, glycocholic and taurocholic acids, in rats was investigated by feeding diets which contained different levels of total sulfur as sulfate and different neutral to inorganic sulfur ratios. (tennessee.edu)

as in arachidonic acid, an unsaturated fatty acid occurring in animal cells. (absp.org.uk)
applied to a type of fatty acid, found in butter and having a goatlike smell. (absp.org.uk)
as in dodecanoic acid, a crystalline fatty acid occurring as glycerides in natural fats and oils (especially coconut oil and palm-kernel oil). (absp.org.uk)
as in erucic acid, a crystalline fatty acid. (absp.org.uk)
In particular, the LA-GF diet induced a notable increase in short-chain fatty acid concentrations in mixed-breed hounds but not in Beagles. (petfoodindustry.com)
Mixed-breed hounds displayed higher macronutrient apparent total tract digestibility, a greater fecal total short-chain fatty acid concentration, and a higher fecal bile acid concentration. (petfoodindustry.com)
The LA-GF diet stood out for its unique effects, including lower fecal ammonia and indole concentrations but higher total short-chain fatty acid, acetate, propionate and primary bile acid concentrations. (petfoodindustry.com)
CE is followed by number of carbons:number of double bonds of the fatty acid esterified to the hydroxyl group at position 3. (lipidomicnet.org)
In the case of unproven structures and other sterol esters (SE) the shorthand notation is used as above followed by slash number of carbons:number of double bonds of the fatty acid esterified to the hydroxyl group. (lipidomicnet.org)
Another major function of the peroxisomal beta-oxidation system is related to the biosynthesis of polyunsaturated fatty acid (C22:6w3). (medscape.com)
Peroxisomes also work in conjunction with mitochondria to shorten fatty acid chains, which are in turn degraded to completion in the mitochondria. (medscape.com)

3β-hydroxy-Δ5-C27-steroid oxidoreductase or Δ4-3-oxosteroid-5β-reductase deficiencies are part of are a group of Bile Acid Synthesis Disorders (BASD) which are rare metabolic diseases caused by a lack of various liver enzymes involved in the synthesis of bile acids. (b3cnewswire.com)
Reddy S et al 1987), high intake of refined carbohydrates (Franceschi S et al 2001), poor vitamin and mineral intake, alcohol consumption, smoking, bile acids, fecal mutagens (DNA-damaging agents), fecal pH, and compromised detoxification enzymes (Winawer SJ et al 1992). (bioresonancetherapy.com.sg)
Besides providing a full array of gut microorganisms, the Vibrant Gut Zoomer determines enzymes and bile deficiencies that can promote inflammatory symptoms. (dralexjimenez.com)
This signal tells your gallbladder to secrete bile and digestive enzymes from your pancreas. (seekinghealth.com)

Activity of this enzyme determines the balance between cholic and chenodeoxycholic acids in humans. (wikipedia.org)
In vitro experiments showed that chenodeoxycholic acids could also disrupt cellular membranes in the alveoli, increasing cationic permeability and intracellular Ca 2+ concentration, leading to overloading of Ca 2+ in cells, and causing injury to type II pneumonocyte [ 13 ]. (hindawi.com)

These results provide essential background data for future studies of serum individual bile acids in intestinal and hepatic disease. (bmj.com)
Intestinal lamina propria of AIDS patients with concomitant Mycobacterium avium-intracellulare complex (MAC) infection may be packed with PAS-positive granules containing macrophages, but the intracellular bacilli are acid fast. (medscape.com)
This ox bile supplement can also be taken away from food to target a healthy balance of microbes in your upper intestinal tract. (seekinghealth.com)
Following stomach-tube feeding of cholic acid-24- 14 C, the relative conjugation, glycocholic:taurocholic ratio (G:T ratio), was determined by extracting the bile acids from the intestinal contents of the jejunum-ileum section of the small intestine. (tennessee.edu)

The best biomarker for diagnosis and follow-up of ICP is up to knowing percentage levels of bile acids (taurocholic and glycocholic acids) over 40% with TBA 14 mmol/L. The level of bile acid is found to be associated with fetal complications [ 1 , 4 ]. (hindawi.com)

The phylogenetically oldest and best documented function of taurine is conjugation with bile acids in bile salt synthesis [ 2 , 3 ]. (intechopen.com)
Requirements other than taurine availability which affect bile acid conjugation were also considered in relation to the present findings. (tennessee.edu)
The results of this study have been interpreted to imply that the level of inorganic sulfur in the diet may serve an important regulatory function in bile acid conjugation. (tennessee.edu)

The enzymatic defect that causes CTX is in mitochondrial sterol 27-hydroxylase, a key enzyme in the pathway necessary for synthesis of bile acids from cholesterol. (medscape.com)

This conjugate comprised 15-27% of the biliary bile acids in these experiments, was less polar than cholylglycine on thin-layer chromatography using butanol, acetic acid, and water, and had an apparent molecular weight greater than that of cholyltaurine on gas-liquid chromatography. (docksci.com)
During studies on the kinetics of cholic acid uptake and secretion by the isolated perfused rat liver we observed the biliary secretion of two conjugates other than cholylglycine and chslyltaurime. (docksci.com)
The lack of phospholipids produces unstable micelles that have a toxic effect on the bile ducts, leading to bile duct plugs and biliary obstruction. (medscape.com)

This study defines the effects of fasting (prolongation of an overnight fast for a further four hours), feeding (the response to eating the three main `solid' meals of the day), and cholecystokinin-induced gallbladder contraction (75-100 units of CCK given as a bolus intravenous injection) on serum individual bile acids in five to eight healthy control subjects. (bmj.com)

Administration of 0.05 g/kg capsaicin showed the highest of tauro-alpha-muricholic acid sodium salt and tauro-beta-muricholic acid sodium salt and 0.1 g/kg capsaicin resulted in the highest of lithocholic acid, cholic acid and hyodeoxycholic acid. (ijpsonline.com)

relating to bile, as in cholic acid, an acid found in bile. (absp.org.uk)

The goal of this minireview is to provide an update on the regulation of bile acid (BA) homeostasis by the nuclear receptor Farnesoid X receptor (FXR) and the effects on this regulation by exposure to environmental or therapeutic agents. (aspetjournals.org)

2004). In addition to, vitamin A also affected bile acid synthesis by regulating CYP7A1 expression (Schmidt et al. (5htreceptor.com)

These properties allow bile acids to emulsify and solubilize lipids, facilitating their digestion and absorption 1 . (randox.com)
The digestion of fats requires the activity of normal bile acids that irritate and damage cells lining the colon. (bioresonancetherapy.com.sg)
It contains 40% cholic acid to support high-strength, targeted fat digestion, and healthy gut bacteria balance. (seekinghealth.com)

The diet containing a high inorganic sulfur level (0.42 percent) and no added cysteine had the largest G:T ratio corresponding to the smallest relative amount of taurocholic acid. (tennessee.edu)

which exhibited low transcriptional activity, especially of genes involved in secondary bile acid biosynthesis and neuroendocrine signaling (i.e., production of neurotransmitters, indoles and ligands for cannabinoid receptors). (biomedcentral.com)

Here, we identify a role for nuclear receptor-dependent bile acid signaling in normal liver regeneration. (nih.gov)
Elevated bile acid levels accelerate regeneration, and decreased levels inhibit liver regrowth, as does the absence of the primary nuclear bile acid receptor FXR. (nih.gov)
The classic pathway of bile acid is predominant for AT1 Receptor Antagonist drug ruminants (Sheriha et al. (5htreceptor.com)
The impact of exposures on bile acid (BA) signaling and Farnesoid X receptor-mediated gut-liver crosstalk is emerging. (aspetjournals.org)
The farnesoid X receptor (FXR) regulates the homeostasis of bile acids, lipids and glucose. (nature.com)
We have previously shown that a bona fide aryl hydrocarbon receptor (AhR) agonist, cinnabarinic acid (CA), protects against alcohol-induced hepatocyte apoptosis via activation of a novel AhR target gene, stanniocalcin 2 (Stc2). (bvsalud.org)

1968). From our metabolomic final results, the contents of GCA and GCDCA (belonged to primary bile acid) in blood in the grass-fed group have been considerably greater than that on the grainfed group (Table two). (5htreceptor.com)
This makes their liver unable to produce enough of the main components of bile, called primary bile acids, such as cholic acid. (b3cnewswire.com)
When these primary bile acids are lacking, the body produces abnormal bile acids instead which can damage the liver, potentially leading to life-threatening liver failure. (b3cnewswire.com)
The serum conjugates of the two primary bile acids, cholic and chenodeoxycholic, were measured using sensitive specific radio-immunoassays. (bmj.com)
Thus, in patients with cholesterol gallstones, the pools of primary bile acids are diminished, unless gallbladder emptying is reduced. (jci.org)
These pathways produce primary bile acids, which are further modified to generate secondary and tertiary bile acids 2 . (randox.com)
The impact of breed on fecal primary bile acid concentrations was also apparent, with mixed-breed hounds displaying a higher concentration of cholic acid than Beagles. (petfoodindustry.com)
Consistently, high amounts of primary bile acids as well as sterols were found in their feces. (biomedcentral.com)

Nonetheless, the concentration of secondary bile acids and conjugates (DCA and GDCA) showed no difference in blood in between the two groups. (5htreceptor.com)
20 mmol/L) and have a predominance of cholic acid conjugates. (medscape.com)

Product Validation and Stability Testing of Pharmacy Compounded Cholic Acid Capsules for Dutch Patients with Rare Bile Acid Synthesis Defects. (stabilis.org)

PFIC2 is caused by a mutation in the ABCB11 gene on chromosome 2q24 that encodes the bile salt export pump (BSEP). (medscape.com)
BSEP is the major canalicular bile acid pump, and thus the loss of BSEP function results in severe hepatocellular cholestasis. (medscape.com)

as in hexanoic acid, an insoluble oily carboxylic acid. (absp.org.uk)

1972). The methyl esters were analyzed by thin-layer chromatography using chloroform - acetic acid - methanol, 70:25:5 (v/v/v). The bands were isolated and the radioactivity was determined. (docksci.com)

24-'4C]Cholic acid, specific activity 40 mCi/ mmol and [2,4-"H]cholic acid, specific activity 3.8 Ci/rnmol, were obtained from New England Nuclear (Boston, Mass.). Aliquots of these materials were taken to dryness under nitrogen, and 4 mg of nonr,adioactive cholic acid were added. (docksci.com)

Plasma parameters, gut microbiota, bile acid and short-chain fatty acids were analyzed to detect the improved effects and possible mechanisms. (ijpsonline.com)
and increased the short-chain fatty acids, especially acetic acid and butyric acid. (ijpsonline.com)
In addition, dietary fiber can be fermented by gut microbes into Short-Chain Fatty Acids (SCFAs), which have beneficial effects on the gut barrier and can mitigate obesity by regulating the endocrine activity[ 8 ]. (ijpsonline.com)
Mixed-breed hounds exhibited a higher concentration of total short-chain fatty acids and ammonia, while their indole levels were lower compared to Beagles. (petfoodindustry.com)

Levels of total bile acid (TBA), ALT, AST, TBIL, DBIL, and SP-A were determined and the lungs of fetal rats were analyzed for pathological changes. (hindawi.com)
Total bile acid (TBA) concentration is a commonly measured parameter to assess the severity of ICP. (randox.com)
To facilitate the accurate quantification of total bile acids in serum and plasma, the 5th Generation Total Bile Acids Assay has emerged as a reliable and advanced diagnostic tool. (randox.com)

as in acetic acid, a diluted form of which is vinegar. (absp.org.uk)
denoting a type of acid, aka acetic acid. (absp.org.uk)

In contrast, in SIBO microorganisms in the small intestine synthesize folic acid, which can lead to an increase in folate absorption and in turn to an increased serum folate concentration. (vin.com)

Taurine (2-aminoethanesulfonic acid) is a sulphur-containing compound characterized as an amino acid. (intechopen.com)
The presence of a sulfonic group, as opposed to a carboxyl group in other amino acids, gives taurine a pKa value of 1.5 and it is the most acidic amino acid. (intechopen.com)
Taurine was identified almost two centuries ago and was named after the ox, Bos taurus , since it was first isolated from the bile of ox [ 1 ]. (intechopen.com)
Taurine is an oxidized sulfur-containing derivative of the amino acid cysteine. (mcw.edu)

To determine the correlation between maternal bile acid (BA) level and fetal pulmonary surfactant in rats and study the effects of BA on fetal lung in rat model of intrahepatic cholestasis of pregnancy. (hindawi.com)
In this article, we will delve into the structural and functional aspects of bile acids and explore their significance in a condition called intrahepatic cholestasis of pregnancy (ICP). (randox.com)

The addition of the bile acid replacement therapies from Travere will strengthen our pipeline and offer an opportunity to leverage our unique expertise in the development and commercialization of treatments in rare and underserved liver diseases," said Chris Peetz, president and chief executive officer at Mirum. (kanerepublican.com)

Reversely, to get a less-fiber eating plan, since of dehydroxylation transited to DCA gradually inside the colon, the secondary bile acid is reabsorbed and inhibits the production of key bile acid (Sheriha et al. (5htreceptor.com)
Furthermore, dogs consuming LA-GF exhibited lower fecal secondary bile acid content than the other groups. (petfoodindustry.com)

Cholic acid naturally occurs in the human body and plays a crucial role in the digestive process and the absorption of lipophilic nutrients. (viochemicals.com)
I had digestive issues for many years, not knowing that I wasn't making enough bile. (seekinghealth.com)

Additionally, bile acids are crucial for the absorption of fat-soluble vitamins, such as vitamins A, D, E, and K. These vitamins are incorporated into micelles, facilitated by the presence of bile acids, enabling their uptake 3 . (randox.com)

Today, the U.S. Food and Drug Administration approved Kanuma (sebelipase alfa) as the first treatment for patients with a rare disease known as lysosomal acid lipase (LAL) deficiency. (news-medical.net)
Urinary pH was acid and urinary bicarbonate negligible in all patients. (karger.com)
He identified periodic acid-Schiff (PAS)-staining granules, most likely representing degenerating bacterial forms, within macrophages isolated from the small bowel as well as other tissue and fluid specimens (eg, pericardium, endocardium, lymph nodes, synovia, lung, brain, meninges) obtained from patients in whom Whipple disease was suspected. (medscape.com)
Rather than defective bile acid export, patients with PFIC3 have deficient hepatocellular phospholipid export. (medscape.com)

Proper fat breakdown is critical for the absorption of fat-soluble vitamins and essential fatty acids from foods. (seekinghealth.com)

With no inhibition of flux into the metabolic pathway, cholesterol-derived bile acid precursors accumulate in tissues and are thought to cause the symptoms of CTX. (medscape.com)
Bile acids (BAs) are fascinating molecules that play a pivotal role in our bodies metabolic processes. (randox.com)
Furthermore, bile acids exhibit signalling activity through various receptors, influencing metabolic responses. (randox.com)
In recent years, bile acids have been recognized as hormones involved in the control of diverse metabolic functions. (viochemicals.com)
They participate in important peroxisome-specific metabolic pathways, such as beta-oxidation of very-long-chain fatty acids (VLCFA) and detoxification of hydrogen peroxide. (medscape.com)

This synergistic acquisition of the bile acid portfolio along with the opportunity to sponsor the genetic testing program will help to reinforce our leadership position in pediatric hepatology. (kanerepublican.com)
GB-3 is a formula containing bile acids and synergistic factors. (wellnessshoppingonline.com)

as in butanoic or butyric acid, an acid found in butter. (absp.org.uk)

reported that bile acid aspiration induced severe chemical pneumonitis in a porcine lung model [ 14 ]. (hindawi.com)

Orphacol® is a medicine containing cholic acid, a substance found in the bile, which is used to digest fats. (b3cnewswire.com)

Cholic acid is a 3,7,12 tri-hydroxy bile acid and is one of the major bile acids in humans and many other animals. (wikipedia.org)
In humans it is regarded as a conditionally essential amino acid due to a limited ability to synthesize it [ 14 , 15 ]. (intechopen.com)

Bile acid kinetics were evaluated after. (karger.com)

as in cerotic acid, an acid found in beeswax and certain fats. (absp.org.uk)
If inadequate bile is available, undigested fats may cause side effects. (seekinghealth.com)

Activation of FXR regulates bile acid synthesis, delivery, and clearance, maintaining their levels within a safe range. (randox.com)

Cholestanol is formed in a pathway from the bile acid precursor 7-alpha-hydroxy-4-cholesten-3-one. (medscape.com)
Bile acids are primarily synthesized in the liver through two pathways: the classic (neutral) pathway and the alternate (acidic) pathway. (randox.com)

Anatomy17

Organisms5

Diseases12

Chemicals and Drugs64

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes12

Disciplines and Occupations1

Technology, Industry, Agriculture2

Salts9

CDCA11

Metabolism12

Deoxycholic acid1

Excretion3

CHOLBAM6

Extract1

Pancreatin4

Glycine6

Fatty acid11

Enzymes4

Chenodeoxycholic acids2

Intestinal4

Levels of bile acids1

Conjugation3

Synthesis of bile acids1

Biliary3

Individual bile acids1

Lithocholic acid1

Found in bile1

Regulation of bile1

Cyp7a11

Digestion3

Taurocholic1

Biosynthesis1

Receptor6

Primary8

Conjugates2

Capsules1

BSEP2

Carboxylic acid1

Analyzed by thin-layer chromato1

Mmol1

Short-Chain4

Total bile3

Acetic acid2

Small intestine1

Taurine4

Intrahepatic Cholestas2

Liver Diseases1

Secondary2

Digestive2

Uptake1

Patients4

Absorption1

Metabolic5

Synergistic2

Butyric1

Porcine1

Orphacol1

Humans2

Kinetics1

Fats2

Regulates1

Pathway2