Bilayer membrane. Medical search. Frequent questions

Synaptotagmin (SYT) and SNAREs have been identified as critical proteins that regulate membrane fusion in concert with Ca 2+ [1, 2]. (aiche.org)
In this work, molecular dynamics simulations used to understand the interactions of SYT with phospholipid bilayers and SNARE proteins in an effort to elucidate the process of membrane fusion at the atomic level. (aiche.org)
Motion constraints on lipids in lipid bilayers are also imposed by presence of proteins in biological membranes, especially so in the annular lipid shell 'attached' to surface of integral membrane proteins. (wikipedia.org)
This phase separation plays a critical role in biochemical phenomena because membrane components such as proteins can partition into one or the other phase and thus be locally concentrated or activated. (wikipedia.org)
2008). Reticulon proteins are enriched in membranes of the endoplasmic reticulum where they contribute to the shape of the endoplasmic reticulum network. (medscape.com)
Reticulon-domain containing proteins contribute to the architecture of organelle membranes by adopting a hairpin insertion into the lipid bilayer. (medscape.com)
The insert shows membrane-shaping proteins implicated in axon degeneration and respective human disorders are indicated in brackets. (medscape.com)
Membrane-shaping properties by hairpin loop insertion were also proposed for REEP1, REEP2, spastin, and proteins of the atlastin family, ATL1 and ATL3 (respective domains are given in dark pink). (medscape.com)
Of note, alternative models for the membrane insertion have been proposed for some of the proteins. (medscape.com)
In this review we will give an update about the different membrane-shaping proteins involved in axonopathies and summarize current knowledge on their function. (medscape.com)
Cell membranes are not only the physical barriers that partition cells into units with discrete subcompartments, they are also dynamic, heterogeneous structures comprising multiple types of fats, proteins, and sugars which allow the cell to communicate with its environment. (nih.gov)
Biological membranes are composed by a lipid-bilayer and proteins. (tcd.ie)
The amphiphilic nature of membrane proteins makes it difficult to work with them. (tcd.ie)
Considering the wide biological functions of membrane protein, it is not surprising that about 30% of all encoded proteins are membrane spanning peptides (Venter et al, 2001, Engelmann et al, 2001). (tcd.ie)
The important function of membrane-proteins in the organization of complex structures predestinates them to important targets for medical drugs against various diseases. (tcd.ie)
2001). These membrane-proteins translates an outer signal into an internal signal and amplifies it: Upon binding of a ligand at the receptor, the structure of the GPCR-protein is changed slightly and allows the activation of internal messenger cascades. (tcd.ie)
Though the modes by which lipids fulfill their regulatory role are complex and diverse, they can be conditionally divided into specific, i.e., acting through direct chemical interaction with membrane-embedded proteins, and integral, i.e., acting through the changes in membrane physical properties. (nih.gov)
The plasma membrane is composed of proteins, carbohydrates, cholesterol and phospholipids. (ipl.org)
It also needs proteins, which are involved in cross-membrane transport and cell communication. (ipl.org)
Membrane proteins are critically involved in cell function and cell communication to the exterior and they execute their function in a complex membrane environment. (uu.nl)
For our studies we use functional bilayer preparations and, more recently, examine membrane proteins in natural bacterial and eukaryotic membranes, membrane envelopes and entire cells. (uu.nl)
These genes provide instructions for producing proteins that are found on the membranes of red blood cells. (medlineplus.gov)
Mutations in red blood cell membrane proteins result in an overly rigid, misshapen cell. (medlineplus.gov)
Dysfunctional membrane proteins interfere with the cell's ability to change shape when traveling through the blood vessels. (medlineplus.gov)
Structural insight into the biogenesis of β-barrel membrane proteins. (nih.gov)
Insertion of proteins and lipopolysaccharide into the bacterial outer membrane. (nih.gov)
From Constructs to Crystals - Towards Structure Determination of β-barrel Outer Membrane Proteins. (nih.gov)
They contain a variety of lipid types, diverse proteins, and structures which influence the properties and function of the cell and the membrane itself. (nanion.de)
Working with proteins reconstituted in artificial membranes or native, purified membrane fragments are both strategies to reduce the complexity of such studies. (nanion.de)
Proteins involved in membrane transport, however, are generally low-conducting. (nanion.de)

Unlike liquid phase bilayers, the lipids in a gel phase bilayer are locked in place and exhibit neither flip-flop nor lateral mobility. (wikipedia.org)
This was especially clear for the carbon nanotube system, for which the density of lipids, the bilayer thickness, the projection of lipid head-to-tail vectors onto the membrane plane, and lipid lateral diffusion coefficients exhibited undulatory behavior as a function of the distance from the surface of the channel. (ox.ac.uk)
Both the local structure and dynamic behavior of lipids around membrane-embedded nanopores are sensitive to the geometry and nature of the outer surface of the macromolecule/molecular assembly forming the pore. (ox.ac.uk)
As a starting point, Dr. Pastor has focused on describing the characteristics of simplified membranes: bilayers and monolayers containing lipids such as dipalmitoylphosphatidylcholine (DPPC). (nih.gov)
As Dr. Pastor continues to refine computational models for simple lipids, he is also aiming to introduce new levels of complexity to the simulation with the addition of new lipids, membrane components, and phases. (nih.gov)
Meanwhile, he has also turned his attention to how lipids interact with peptides in membranes. (nih.gov)
At first view this is seemingly contradictory, but the two functions are closely related to the structural and chemical composition of biological membranes: The first is a property of the membrane lipids, which build up a barrier for water and water soluble solvents such as salts and sugars. (tcd.ie)
Membrane lipids are no longer regarded as a kind of filler or passive solvent for the membrane protein machinery. (nih.gov)
1. They purified membrane lipids from red blood cell (they chose these because they have lack internal membranes). (ipl.org)
The plasma membrane needs lipids, which make a semi-permeable barrier between the cell and its environment. (ipl.org)
To achieve control over NP distribution, this project proposes the use of asymmetric membranes: Membranes with lateral asymmetries or domains that form through the phase separation of membrane lipids, and membranes with transversal asymmetries due to the asymmetric distribution of lipids in the two leaflets that constitute the bilayer membrane. (europa.eu)
AEG12, based on the protein's crystal structure (green and gray), inserts some of its lipids (green squiggles) into the viral membrane, destabilizing it. (nih.gov)
Senior author Geoffrey Mueller, Ph.D., head of the NIEHS Nuclear Magnetic Resonance Group, said at the molecular level, AEG12 rips out the lipids, or the fat-like portions of the membrane that hold the virus together. (nih.gov)

Riboflavin, a water-soluble fluorescent probe, was shown to be trapped in bilayer vesicles of some triple-chain amphiphiles. (elsevierpure.com)
87.16.Dg Membranes, bilayers, and vesicles - 87.68. (epj.org)
We have investigated DMDGALA as a component in large unilamellar vesicles (LUVs) and demonstrate pH-triggered fusion of peptide containing LUVs with stable target giant unilamellar vesicles (GUVs), which were used as simple mimics of cell membranes. (dtu.dk)
Solid supported membrane (SSM)-based electrophysiology differs from conventional electrophysiology such as patch-clamp since no living cells are required, but rather diverse native or artificial membrane vesicles. (nanion.de)
The fusion of membranes and vesicles: pathway and energy barriers from dissipative particle dynamics. (mpg.de)
Tension-induced fusion of bilayer membranes and vesicles. (mpg.de)
The active zone (AZ) of chemical synapses is a specialized area of the presynaptic bouton in which vesicles fuse with the plasma membrane and release neurotransmitters. (jneurosci.org)
Consequently, UNC-13-dependent "docked" vesicles contacting the plasma membrane are primarily confined to this same region. (jneurosci.org)

Interleaflet cavitation in lipid bilayer membranes, or, shortly, intramembrane cavitation (IMC), is the formation of gas bubbles between the two leaflets of the membrane. (nih.gov)

A study of voltage fluctuations in bilayer lipid membranes during electroporation and under current-clamp conditions is presented. (epj.org)

SYT, a C2-domain family protein is thought to act as a Ca 2+ sensor, although there is still debate as to the precise mechanism through which SYT enhances membrane fusion. (aiche.org)
The potential of mean force (PMF) between SYT and phospholipid bilayers is calculated using the adaptive biasing technique [7] and shows that Ca 2+ binding to SYT is required creates favorable protein bilayer interactions that lead to the insertion of SYT. (aiche.org)
To better understand the nature of such perturbations, we have undertaken a systematic molecular dynamics simulation study of lipid bilayer structure and dynamics around three different classes of nanopore: a carbon nanotube, three related cyclic peptide nanotubes differing in the nature of their external surfaces, and a model of a β-barrel nanopore protein. (ox.ac.uk)
Omp2a β-barrel outer membrane protein has been reconstituted into supported lipid bilayers (SLBs) to compare the nanomechanical properties (elastic modulus, adhesion forces, and deformation) and functionality of the resulting bioinspired system with those of Omp2a-based polymeric nanomembranes (NMs). (unige.ch)
Protein reconstitution into lipid bilayers has been performed using different strategies, the most successful one consisting of a detergent-mediated process into preformed liposomes. (unige.ch)
Accordingly, the protein is softer than the lipid bilayer, whereas the latter exhibits less mechanical strength than polymeric NMs. (unige.ch)
Still, the mechanisms of membrane-protein interaction and the constraints upon the lipid composition of organelles and cell membranes imposed by Nature are poorly understood. (nih.gov)
Examples from our laboratory demonstrate that this stress can be varied by the choice of the lipid species used for membrane formation and manifests itself in modifying the energetics of hydrophobic inclusions thus influencing protein-lipid interactions and regulating membrane distributions of lipid-soluble drugs, such as volatile anesthetics. (nih.gov)
Structural insight into mitochondrial β-barrel outer membrane protein biogenesis. (nih.gov)
Structural Insights into Substrate Recognition and Catalysis in Outer Membrane Protein B (OmpB) by Protein-lysine Methyltransferases from Rickettsia. (nih.gov)
Evidence of Distinct Channel Conformations and Substrate Binding Affinities for the Mitochondrial Outer Membrane Protein Translocase Pore Tom40. (nih.gov)
Outer membrane protein biogenesis in Gram-negative bacteria. (nih.gov)
Hydrogel-supported protein-tethered bilayer lipid membranes: a new approach toward polymer-supported lipid membranes. (mpg.de)
The RNP-M complex migrates to an area of the plasma membrane containing glycoprotein inserts, and the M-protein initiates coiling. (cdc.gov)
The samples used range from reconstituted protein in proteoliposomes to membrane preparations from organelles or plasma membranes. (nanion.de)
In Escherichia coli , the Phage shock stress A (PspA) protein is involved in the maintenance of the integrity of its inner membrane in response to the damage produced by exposure to stress conditions. (frontiersin.org)
A role in thylakoid membrane maintenance and reorganization has been proposed for Vesicle Inducing Protein in Plastid 1 (VIPP1), the putative PspA ortholog in Arabidopsis thaliana . (frontiersin.org)

Indeed, when two monolayers of a non-lamellar lipid are brought together to form a planar bilayer membrane, the resulting structure is under elastic stress. (nih.gov)
Polysaccharide-supported planar bilayer lipid model membranes. (mpg.de)
Planar lipid bilayers separating two aqueous compartments offer a nonconductive matrix for membrane-active molecules. (nanion.de)

The plasma membranes functions are to protect the contents of the cell and control the migration of particles moving throughout the cell. (ipl.org)
Within the central nervous system (CNS), there is preferential viral budding from plasma membranes. (cdc.gov)

For example, many antimicrobial peptides lie on the surface of membranes until they reach a sufficiently high concentration to aggregate and form pores that completely disrupt cell function. (nih.gov)
In contrast, viral peptides can cause fusion events that safeguard the integrity of the cell membrane but allow viral entry and replication. (nih.gov)
Dr. Pastor and his colleagues are simulating the interaction of multiple peptides with lipid bilayers to discover precisely how they position themselves and where they put stress on the membrane. (nih.gov)
Despite that all of these receptors have a general architecture of seven trans-membrane alpha-helices, they recognize a wide variety of different ligands, including hormones, peptides, ions, amino-acids and photons. (tcd.ie)
Peptides capable of mediating fusion between lipid membranes are widely observed in nature, and have attracted considerable attention in the liposome drug delivery field. (dtu.dk)
However, studies that are proving the benefit of small synthetic fusion peptides as components in drug delivery systems remain sporadic and there is a strong need to characterize and increase our understanding of the membrane fusion properties of these peptides. (dtu.dk)

For a lipid to flip from one leaflet to the other, its hydrated headgroup must cross the hydrophobic core of the bilayer, an energetically unfavorable process. (wikipedia.org)
This topology may create positive membrane curvature because the bulk of hydrophobic residues occupies space in the outer leaflet of the lipid bilayer. (medscape.com)
The middle layer of the membrane consists of the hydrophobic region. (ipl.org)
The membrane of these GUVs is a composite material, designed with tunable characteristics: It consists of a bilayer of amphiphilic molecules and contains nanoparticles embedded within the hydrophobic core of the bilayer. (europa.eu)

These fluctuations follow an increase of the membrane conductance due to the opening of hydrophilic pores induced by the transmembrane voltage, a phenomenon called electroporation . (edpsciences.org)

One property of a lipid bilayer is the relative mobility (fluidity) of the individual lipid molecules and how this mobility changes with temperature. (wikipedia.org)
In both phases the lipid molecules are constrained to the two dimensional plane of the membrane, but in liquid phase bilayers the molecules diffuse freely within this plane. (wikipedia.org)
In contrast to this large in-plane mobility, it is very difficult for lipid molecules to flip-flop from one side of the lipid bilayer to the other. (wikipedia.org)
The phase behavior of lipid bilayers is largely determined by the strength of the attractive Van der Waals interactions between adjacent lipid molecules. (wikipedia.org)
Bilayers need not be composed of a single type of lipid and, in fact, most natural membranes are a complex mixture of different lipid molecules. (wikipedia.org)
In addition to providing insights into relatively simple membrane systems and molecules, Dr. Pastor's goal is to lay the proper foundations for a truly comprehensive model of the membrane as computational power rises to meet its challenges. (nih.gov)
Once several molecules of LF and EF have latched onto PA, the cell membrane tries to destroy these unwanted hangers-on by wrapping them up in an "endosome," a small bubble of membrane that gets pinched off and moved into the cell's interior. (nist.gov)
The latter may be generally referred to as "membrane mechanics" and includes such parameters as membrane stiffness, thickness, bending moduli, and distribution of elastic forces along the lipid molecules. (nih.gov)
The placement of two electrodes on either side of the membrane, which contains embedded molecules, enables the application of precise voltages and the recording of sub-picoampere level ionic currents. (nanion.de)

Simulations are also used to understand the hypothesized binding of SYT to the tv-SNARE complex during membrane fusion. (aiche.org)
Dr. Pastor applies information collected from computer simulations and statistical mechanics to biophysics, with an emphasis on cell membranes. (nih.gov)
Molecular dynamics (MD) simulations carried out in his laboratory have successfully reproduced experimental data including NMR relaxation times and deuterium order parameters, X-ray structure factors, lateral diffusion constants, and elastic constants of assorted bilayers. (nih.gov)
He has focused on developing molecular mechanics force fields suitable for atomic level simulations of simple and complex bilayers. (nih.gov)
In 1993, he and his colleagues published MD simulations of a simple lipid bilayer in Science-considered a breakthrough in biophysical computing-that required 6 months on an NIH supercomputer. (nih.gov)
In both experiments and Molecular Dynamics simulations we found a significantly tighter binding of tubulin to DOPE membranes than DOPC membranes. (nih.gov)
Rotational dynamics for stably bound α-tubulin on DOPE membranes from ANTON MD simulations studied as time evolution of the stable α-tubulin tethering on the DOPE membrane surfaces. (nih.gov)
Improved dissipative particle dynamics simulations of lipid bilayers. (mpg.de)
Visualizing soft matter: mesoscopic simulations of membranes, vesivles and nanoparticles. (mpg.de)
Equilibrium structure and lateral stress distribution of amphiphilic bilayers from dissipative particle dynamics simulations. (mpg.de)
Results from Brownian dynamics simulations also reveal that crowded membranes promote the clustering of integrins, especially when they transition into extended conformations within crowded regions, such as lipid rafts. (usi.ch)

With the overall goal of simulating a cell membrane in all its biological complexity, Dr. Pastor is in a relatively rare research situation of creating foundational tools to take advantage of computing power that will most likely exist ten to twenty years in the future. (nih.gov)
Lipid peroxidation is a degenerative oxidative process that modifies the structure of membranes, influencing their biological functions. (hal.science)
Membranes are one of the most fascinating structures in biological cells. (tcd.ie)
Historically, our lab has been one of the leading facilities for investigating red blood cell mechanical properties and the stability of biological membranes. (rochester.edu)
9. Mimicking membrane-related biological events by DNA origami nanotechnology. (nih.gov)

Recently, these theoretically predicted kinetics were obtained experimentally, too, for the crystalline to gel phase transition of dipalmitoylphosphatidylcholine (DPPC) membranes. (mssm.edu)
Partitioning of homologous nicotinic acid ester prodrugs (nicotinates) into dipalmitoylphosphatidylcholine (DPPC) membrane bilayers. (nih.gov)
The partitioning behavior of a series of perhydrocarbon nicotinic acid esters (nicotinates) between aqueous solution and dipalmitoylphosphatidylcholine (DPPC) membrane bilayers is investigated as a function of increasing alkyl chain length. (nih.gov)

The model results are compared with the available experimental data taken from DPPC and dimiristoylphosphatidylcholine (DMPC) bilayer membranes. (mssm.edu)
Similarly, the DPH anisotropy results demonstrate an alteration of the bilayer organization in the liposomes as a consequence of the chain length-dependent partitioning of the nicotinates into DPPC bilayers. (nih.gov)

Here, a capacitive read-out from the transporter population has proven successful, either from liposomes or native membrane fractions immobilized on a solid-supported membrane-coated electrode. (nanion.de)

I'm in the National Heart, Lung, Blood Institute, and my laboratory is the Laboratory of Membrane Biophysics. (nih.gov)
And you are the Chief of Laboratory Membrane Biophysics? (nih.gov)

This disruption creates extra free space within the bilayer which allows additional flexibility in the adjacent chains. (wikipedia.org)
Using a molecular dynamics simulation, we here found that even under a weak external electric field that was lower than the membrane breakdown intensity a cationic nanoparticle directly translocates across a model cell membrane without membrane disruption. (nii.ac.jp)

accurate descriptions of cell membranes. (scirp.org)
This functionality is one of the reasons that cell membranes are usually composed of fluid phase bilayers. (wikipedia.org)
Led by Dr. Richard Pastor, the lab is combining experiments on simplified membranes with the fundamental principles and simulation techniques of physics to understand and model cell membranes on the atomic level. (nih.gov)
The latest version of the CHARMM lipid force field C36-published by Dr. Pastor and his colleagues in 2010-represents a comprehensive tool for the study of heterogeneous cell membranes. (nih.gov)
One toxin, called PA, attaches to the cell membrane, where its surface serves as a sort of landing pad for the other two toxins, called LF and EF. (nist.gov)
Researchers in this area investigate the mechanisms controlling solute and water movement across cell membranes and resultant pathologies. (otago.ac.nz)
Chapter 5: Cell Membranes Homework 1. (ipl.org)
average cell membrane in mm? (ipl.org)
The average cell membrane is 0.000006 mm to 0.00001 mm thick. (ipl.org)
Cell membranes consist of a phospholipid bilayer where each repeating unit is comprised of two fatty acid tails bound to a phosphate head including a polar group attached to the glycerol region. (ipl.org)
this study was to understand how cell membranes are able to store pigments in their intracellular compartments which then prevents the pigments from entering the general cytoplasm using different concentrations of a solution which in this case was detergent (Huber, et al. (ipl.org)
2018).Several slices of Beetroot were immersed in water and three different concentrations of Tween 20.It was then hypothesized that Higher concentrations of Tween 20 will increase the cell membrane permeability of Beetroot. (ipl.org)
functions of the cell wall, cell membrane, and outer membrane. (ipl.org)
Cell membrane- the blue outside layer on my model: The cell membrane is made up of a phospholipid bilayer. (ipl.org)
We are particularly interested in learning about the molecular mechanisms underlying the control of cell deformability and cell adhesion, and the role that mechanical forces and membrane stabilit. (rochester.edu)
Maintaining mechanical stability appears to be critical for the successful completion of red blood cell maturation, as it appears that instabilities in the cell surface lead to loss of cell membrane and cell death if the membranes are not properly supported mechanically as they mature. (rochester.edu)
The fusion of the rabies virus envelope to the host cell membrane (adsorption) initiates the infection process. (cdc.gov)
Conversely, virus in the salivary glands buds primarily from the cell membrane into the acinar lumen. (cdc.gov)
Lipid bilayers are the main structural component of any cell membrane. (nanion.de)
In biomedical applications utilizing nanoparticles, the nanoparticles are often required to translocate across a cell membrane. (nii.ac.jp)
At the contact interface between the nanoparticle and the cell membrane, the electric potential across the membrane is locally enhanced by superimposing the nanoparticle surface potential on the externally applied potential, resulting in the nanoparticle direct translocation. (nii.ac.jp)
We also observed the nanoparticle translocation across artificial cell membrane by using a planer lipid bilayer experimental set-up. (nii.ac.jp)
Our models also show that integrin conformational activation is correlated with the efficiency of membrane protrusion, which is important for directed cell motion. (usi.ch)

This functional involvement naturally explains why cells exquisitely control the lipid composition of their membranes. (nih.gov)
Membrane on a chip: A functional tethered lipid bilayer membrane on silicon oxide surfaces. (mpg.de)
Functional tethered bilayer lipid membranes on aluminum oxide. (mpg.de)
2. Functional and Biomimetic DNA Nanostructures on Lipid Membranes. (nih.gov)

This response is known as the phase behavior of the bilayer. (wikipedia.org)
Overall, the differences in lipid behavior as a function of the nanopore structure reveal local adaptation of the bilayer structure and dynamics to different embedded nanopore structures. (ox.ac.uk)
The NIST/USAMRIID team explored the behavior of full-length toxins using an artificial membrane that mimics a cell's exterior. (nist.gov)
Independent techniques of differential scanning calorimetry and 1,6-diphenyl-1,3,5-hexatriene (DPH) fluorescence anisotropy measurements are used to analyze the thermotropic phase behavior and lipid bilayer fluidity as a function of nicotinate concentration. (nih.gov)

Lateral and transverse diffusion in two-component bilayer membranes. (mpg.de)

The concentration and distribution of the nanoparticles in the bilayer determine the permeability and deformability of the GUV membrane. (europa.eu)
Importantly, if the nanoparticles are responsive to an external stimuli, these membrane properties can be tuned on demand, at a certain time and at a certain location, through an external actuation. (europa.eu)
Our finding implies that by controlling the nanoparticle-induced local enhancement of the membrane potential the cellular delivery of nanoparticles can be realized. (nii.ac.jp)

Artificial bilayer recordings reveal the actions of single ion channels in real-time, thereby gaining detailed insights into ion channel function, and how bilayer or buffer compositions affect the ion channel. (nanion.de)
Tomato SlVIPP1 , like its Arabidopsis VIPP1 ortholog, is one of such genes, whose studies in both model species reveal that the formation and maintenance of thylakoid membranes is an essential process for plant growth and survival. (frontiersin.org)

The elastic modulus obtained for the lipid bilayer and Omp2a are ∼19 and 10.5 ± 1.7 MPa, respectively. (unige.ch)
Shape fluctuations and elastic properties of two-component bilayer membranes. (mpg.de)

Structural features and lipid binding domain of tubulin on biomimetic mitochondrial membranes. (nih.gov)
Photopolymerization of diacetylene lipid bilayers and its application to the construction of micropatterned biomimetic membranes. (mpg.de)

For the first time, we observe long-living voltage fluctuations in a bilayer membrane of diphytanoyl phosphatidylcholine held in current-clamp conditions. (edpsciences.org)

these can be activated by light, producing localized heating of the GUV membrane and thus changes in membrane permeability or even membrane rupture. (europa.eu)

In an aqueous environment, such as the gastrointestinal tract, water permeates through the membrane into the tablet core, causing the drug to go into suspension and the push layer to expand. (rxlist.com)

Oxygenic photosynthesis occurs in the thylakoids, membrane-bound compartments consisting of an ordered internal membrane network surrounding a thylakoidal lumen. (frontiersin.org)

In my lab, we combine modeling approaches at different length and time scales to evaluate the effects of force and lipid membranes on the slow dynamics of integrin receptors and their role in conformational activation, adhesion assembly and membrane protrusions. (usi.ch)

A recent hypothesis is that LF and EF completely unfold and then squeeze through the narrow hole that PA forms in the endosomal membrane," says NIST physical scientist John Kasianowicz. (nist.gov)
The viral membranes fuse to the endosomal membranes, causing the release of viral RNP into the cytoplasm (uncoating). (cdc.gov)

We show that both compounds penetrate into DOPC and PLPC lipid bilayers and adopt similar positions and orientations, which therefore does not explain the difference in their lipid peroxidation inhibition activity. (hal.science)

Lipid Bilayer Membrane Perturbation by Embedded Nanopores: A Simulation Study. (ox.ac.uk)
Artificial lipid bilayers offer an ideal model system for the electrophysiological investigation of ion channels, porins, and other pore-forming species including toxins or artificially designed nanopores. (nanion.de)

In a phosphatidylcholine-based bilayer this process typically occurs over a timescale of weeks. (wikipedia.org)

These processes are based upon selective permeability of one or more of the liquid constituents through the membrane according to the driving forces. (intechopen.com)

Introduction Cells are held together by a lipid bilayer membrane07-May-2020. (noplag.com)
One thing that all cells share is that they all have a Plasma Membrane. (ipl.org)
How do the membranes of cells and the organelles they contain control the movement of materials? (ipl.org)
Since membranes play essential roles in all living beings, all cells have developed mechanisms for efficient and fast repair of membrane damage. (frontiersin.org)
While some membranes of plant cells have been extensively studied, the biosynthesis and maintenance of chloroplast thylakoid membrane remains poorly known. (frontiersin.org)

The Orbit and the SURFE 2 R product families offer complete control over experimental conditions beyond physiological constraints, allowing in-depth knowledge of parameters affecting membrane function. (nanion.de)

Proton transport through a peptide-tethered bilayer lipid membrane by the H+-ATP synthase from chloroplasts measured by impedance spectroscopy. (mpg.de)

The effect of SYT binding on local water structure and bilayer properties is determined. (aiche.org)
This discrepancy can be understood in terms of the basic structure of the bilayer. (wikipedia.org)
These results have then been used to refine and develop models for the structure and dynamics of membranes. (nih.gov)
Halothane changes the domain structure of a binary lipid membrane. (nih.gov)
The dense projection is a more complex structure than previously anticipated, with filaments radiating from a core structure that directly contact SVs in the interior of the bouton as well as SVs docked at the plasma membrane. (jneurosci.org)

18. Dynamic assembly/disassembly processes of photoresponsive DNA origami nanostructures directly visualized on a lipid membrane surface. (nih.gov)
The complexity of such systems poses a challenge when investigating isolated processes occurring in lipid bilayers. (nanion.de)

The presence of cholesterol exerts a profound but complicated influence on lipid bilayer properties because of its unique physical characteristics. (wikipedia.org)

and octyl (C8H17)) partition into the lipid bilayer at sufficient levels to eliminate the pretransition, and decrease and broaden the gel to fluid phase transition temperature. (nih.gov)
Thermally induced proliferation of pores in a model fluid membrane. (mpg.de)
The function of DITROPAN XL ® depends on the existence of an osmotic gradient between the contents of the bilayer core and the fluid in the gastrointestinal tract. (rxlist.com)

The computational route from bilayer membranes to vesicle fusion. (mpg.de)

These bilayers undergo the characteristic crystal-to-liquid crystal-phase transition, as confirmed by differential scanning calorimetry (DSC) and by fluorescence depolarization of a diphenylhexatriene probe. (elsevierpure.com)

A macromolecular nanopore inserted into a membrane may perturb the dynamic organization of the surrounding lipid bilayer. (ox.ac.uk)

Pathway of membrane fusion with two tension-dependent energy barriers. (mpg.de)

Anatomy34

Organisms5

Diseases2

Chemicals and Drugs102

Analytical, Diagnostic and Therapeutic Techniques and Equipment40

Phenomena and Processes67

Disciplines and Occupations5

Technology, Industry, Agriculture11

Information Science6

Health Care2

Proteins30

Lipids13

Vesicles8

Cavitation in lipid bilayer membranes1

Lipid membranes during electrop1

Protein17

Planar3

Plasma membranes2

Peptides6

Hydrophobic4

Electroporation1

Molecules9

Simulations11

Biological5

Dipalmitoylphosphatidylcholine3

DPPC2

Liposomes1

Biophysics2

Disruption2

Cell23

Functional4

Behavior4

Lateral1

Nanoparticles3

Reveal2

Elastic2

Biomimetic2

Voltage fluctuations1

Changes in membrane1

Aqueous1

Compartments1

Adhesion1

Endosomal2

DOPC1

Nanopores2

Phosphatidylcholine1

Permeability1

Cells5

Constraints1

Peptide1

Structure5

Processes2

Characteristics1

Fluid3

Computational1

Characteristic1

Organization1

Barriers1