• To explore the structural basis of this m144 function, we have determined the three-dimensional structure of an m144/beta2-microglobulin (beta2m) complex at 1.9A resolution. (rcsb.org)
  • Each antigen comprised a glycosylated polypeptide of 43 000 molecular weight that is noncovalently associated with beta2-microglobulin (beta2m). (ox.ac.uk)
  • It is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). (genetici-technologies.com)
  • Don't fight Amyloidosis Beta2M alone. (rareguru.com)
  • Connect with other caregivers and patients with Amyloidosis Beta2M and get the support you need. (rareguru.com)
  • In contrast, NOD-scid beta2m(null) and NOD-scid IL2Rgamma(null) mice show rapid tumor engraftment, although tumor growth is variable in NOD-scid beta2m(null) mice. (nih.gov)
  • Taking advantage of the increased metastatic potential of RhoC-expressing human (A375) melanoma cells, we evaluate four immunodeficient mouse strains: severe combined immunodeficiency (scid), nonobese diabetic (NOD)-scid, NOD-scid beta2m(null), and NOD-scid IL2Rgamma(null) as xenograft tumor recipients. (nih.gov)
  • NK cells were detected in all strains except NOD-scid IL2Rgamma(null), and in vitro activated scid, NOD-scid, and NOD-scid beta2m(null) NK cells kill human melanoma lines and primary melanoma cells. (nih.gov)
  • Sequence analysis of HFE, beta2M, and both human heme oxygenase genes failed to identify any causal mutations in nuclear NH families but our study points to the existence of a cohort of patients likely to suffer from an autosomal recessive trait. (nih.gov)
  • We present the cellular, biochemical, and structural characterization of m153, which is a heavily glycosylated homodimer, that does not require beta2m or peptide and is expressed at the surface of MCMV-infected cells. (nih.gov)
  • Because there are multiple conformational epitopes formed by various molecular interactions among heavy chain, peptide, and beta2M, this capture assay can assess the fidelity of each aspect of multimer structure, depending on the availability of antibodies. (bioxcell.com)
  • The mouse monoclonal antibody IVA26 recognizes an extracellular epitope on MHC class I (alpha + beta2m chains) expressed in various animals. (exbio.cz)