Beta propiolactone. Medical search. Frequent questions

Using this procedure, the barrier properties of several polymeric materials were evaluated against nine carcinogenic liquids including benzene (71432), trichloroethylene (79016), and beta-propiolactone (57578). (cdc.gov)

β-Propiolactone is prepared industrially by the reaction of formaldehyde and ethenone in the presence of aluminium- or zinc chloride as catalyst: In the research laboratory, propiolactones have been produced by the carbonylation of epoxides. (wikipedia.org)

Vaccines in which the infectious microbial nucleic acid components have been destroyed by chemical or physical treatment (e.g., formalin, beta-propiolactone, gamma radiation) without affecting the antigenicity or immunogenicity of the viral coat or bacterial outer membrane proteins. (umassmed.edu)

Beta-propiolactone is a powerful and toxic disinfectant with multiple uses. (naturalnews.com)
Βeta-Propiolactone is a disinfectant. (vaccineresistancemovement.org)

β-Propiolactone is "reasonably anticipated to be a human carcinogen" (IARC, 1999). (wikipedia.org)

The Sinopharm vaccine contains SARS-CoV-2 that has undergone treatment with a chemical called beta-propiolactone. (co.zw)

These reactions are thought to be due to the presence of a small amount of human serum albumin that has been rendered allergenic by the *gb-propiolactone used in making HDCV (9,10). (cdc.gov)
Human serum albumin is not a component of the medium used to grow the rabies virus for RVA and, therefore, is not present when *gb-propiolactone is added to inactivate the virus. (cdc.gov)

The virus is inactivated with *gb-propiolactone and concentrated by adsorption to aluminum phosphate (AlPO4). (cdc.gov)

Then they doused the viruses with a chemical called beta-propiolactone. (evaggelatos.com)

β-Propiolactone CAS No. 57-57-8" - US Department of Health and Human Services, Report on Carcinogens, National Toxicology Program, Thirteenth Edition, 2 October 2014. (wikipedia.org)

citation needed] 3-Oxetanone, an isomer of β-propiolactone Malonic anhydride (2,4-oxetanone) α-Propiolactone NIOSH Pocket Guide to Chemical Hazards. (wikipedia.org)

Description: Zika virus (Strain MR 766), inactivated by Beta-propiolactone and UV irradiation. (mytaq.com)

WN antigen, prepared on Vero E6 cells and inactivated by beta-propiolactone, was added. (medscape.com)

β-Propiolactone is "reasonably anticipated to be a human carcinogen" (IARC, 1999). (wikipedia.org)
Based on experimental trials, it has been determined that propiolactone is a human carcinogen. (drugbank.com)

β-Propiolactone is prepared industrially by the reaction of formaldehyde and ethenone in the presence of aluminium- or zinc chloride as catalyst: In the research laboratory, propiolactones have been produced by the carbonylation of epoxides. (wikipedia.org)
Industrially, beta-alanine emerge through a reaction of ammonia with beta-propiolactone [ 3 ]. (fintys.com.au)

3 The degradation products of propiolactone are not toxic. (drugbank.com)
In its biosynthesis, beta-alanine is forming through the degradation of dihydrouracil and carnosine. (fintys.com.au)

The virus is harvested from infected human diploid cells, MRC-5 strain, concentrated by ultrafiltration and is inactivated by beta-propiolactone. (nih.gov)

β-Propiolactone, often simply called propiolactone, is an organic compound of the lactone family, with a four-membered ring. (wikipedia.org)
This compound belongs to the class of organic compounds known as beta propiolactones. (drugbank.com)

Propiolactone is a lactone compound with a four-membered ring. (drugbank.com)
ChEBI: Beta-Butyrolactone is a beta-lactone. (chemicalbook.com)

Hazard review of beta-propiolactone (BPL). (cdc.gov)

Propiolactone was used for vaccines, tissue grafts, surgical instruments, and enzymes, as a sterilant of blood plasma, water, milk and nutrient broth as a vapor-phase disinfectant in enclosed spaces. (drugbank.com)
The half-life of propiolactone in water is of 225 minutes. (drugbank.com)
BETA-BUTYROLACTONE is hydrolyzed by water and aqueous alkali. (chemicalbook.com)

Beta-propiolactone, a residual component of the manufacturing process, is present in less than 50 parts per million. (nih.gov)
When you go to the shop, looking for creatine and/or beta-alanine, the crucial part of the process is to know what to look for, so we will cover that as well. (fintys.com.au)

The principal use of propiolactone is an intermediate in the synthesis of other chemical compounds. (wikipedia.org)
citation needed] 3-Oxetanone, an isomer of β-propiolactone Malonic anhydride (2,4-oxetanone) α-Propiolactone NIOSH Pocket Guide to Chemical Hazards. (wikipedia.org)

Propiolactone is highly bound to proteins showing an almost 2-fold binding increase when compared to DNA and RNA. (drugbank.com)

Propiolactone is completely hydrolyzed after 3 hours of being in an aqueous solution and this time can be even faster in the presence of cellular debris and cell culture media. (drugbank.com)

β-Propiolactone is an excellent sterilizing and sporicidal agent, but its carcinogenicity precludes that use. (wikipedia.org)
Propiolactone is an alkylating agent that acts through alkylation of carboxyl- and hydroxyl- groups. (drugbank.com)

Propiolactone was once widely produced as an intermediate in the production of acrylic acid and its esters. (wikipedia.org)

The enhancement of the carcinogenicity of benzo(a)pyrene (B[a]P) and beta-propiolactone (BPL) by the mouse skin cocarcinogens phorbol myristate acetate (PMA) and catechol were examined in female SENCAR mice, 30 per group. (nih.gov)