• Penams have values in the range 0.40-0.50 Å, while carbapenems and clavams have values of 0.50-0.60 Å, being the most reactive of the β-lactams toward hydrolysis. (wikipedia.org)
  • In studies comparing the same beta-lactam, we observed no difference between study groups with regard to all-cause fatality, RR 1.01 (95% CI 0.75-1.35) and clinical failure, RR 1.11 (95% CI 0.95-1.29). (nih.gov)
  • 1 This strategy will frequently lead to suboptimal regimens, including therapies that may be inferior to beta-lactam-based regimens or those that may have unnecessarily broad or inappropriately narrow spectrums of activity. (pharmacytimes.com)
  • The clavulanic acid is designed to overwhelm all beta-lactamase enzymes, bind irreversibly to them, and effectively serve as an antagonist so that the amoxicillin is not affected by the beta-lactamase enzymes. (princeton.edu)
  • 11-13 Because most beta-lactams have high renal excretion and renal dysfunction prolongs drug elimination, prolonging drug infusion is unlikely to improve PTA in patients receiving these agents. (uspharmacist.com)
  • lactam derivativeof the formula (I) by removing a carboxyl-protecting group from a .beta. (patentgenius.com)
  • lactam derivative having protected carboxyl group and represented by the formula ##STR4## wherein R represents a benzyl group having an electron-donating group as a substituent onthe phenyl ring, a diphenylmethyl group which may have an electron-donating group as a substituent on the phenyl ring or a tert-butyl group. (patentgenius.com)
  • Heretofore elimination of carboxyl-protecting group has been accomplished by, for example, subjecting the .beta. (patentgenius.com)