• We characterized 9 New Delhi metallo-β-lactamase-producing Enterobacteriaceae (5 Klebsiella pneumoniae , 2 Escherichia coli , 1 Enterobacter cloacae , 1 Salmonella enterica serovar Senftenberg) isolates identified in the United States and cultured from 8 patients in 5 states during April 2009-March 2011. (medscape.com)
  • Isolates were resistant to β-lactams, fluoroquinolones, and aminoglycosides, demonstrated MICs ≤1 μg/mL of colistin and polymyxin, and yielded positive metallo-β-lactamase screening results. (medscape.com)
  • [ 4 , 14 , 15 ] The widespread dissemination of NDM-producing isolates and the apparent ease of mobility of bla NDM is a major threat to public health on a global scale. (medscape.com)
  • To complement reports of individual cases, [ 8 , 10 , 12 ] we performed extensive laboratory characterization of 9 clinical isolates of NDM-producing Enterobacteriaceae collected from patients in the United States during April 2009-March 2011. (medscape.com)
  • Enterobacteriaceae were most commonly isolated (13 of 25 isolates), of which 6 (46%) produced ESBL and were resistant to gentamicin. (biomedcentral.com)
  • ABSTRACT The aim of this study was to detect extended-spectrum β-lactamases (ESBL) in Enterobacteriaceae isolates in the intensive care unit (ICU) of Tlemcen hospital in north-western Algeria. (who.int)
  • In all, 28 Enterobacteriaceae isolates were isolated from specimens recovered from patients in the ICU and 2 from surfaces of the unit. (who.int)
  • Of these, 11 isolates (4 Escherichia coli, 5 Klebsiella pneumoniae and 2 Enterobacter cloacae) produced ESBL of the CT-X-M-15 type. (who.int)
  • As of June 2010[update], there were three reported cases of Enterobacteriaceae isolates bearing this newly described resistance mechanism in the US, the Centers for Disease Control and Prevention (CDC) stated that "All three U.S. isolates were from patients having received recent medical care in India. (wikipedia.org)
  • Carbapenemases are a class of enzymes that can confer resistance to carbapenems and other Beta-lactam antibiotic drugs, but not all carbapenemase-producing isolates are carbapenem-resistant. (cdc.gov)
  • 6. Clinical significance and impact on mortality of extended-spectrum beta lactamase-producing Enterobacteriaceae isolates in nosocomial bacteremia. (nih.gov)
  • 9. Clinical significance of infections caused by extended-spectrum β-lactamase-producing Enterobacteriaceae blood isolates with inducible AmpC β-lactamase. (nih.gov)
  • This study was designed to screen fungal isolates obtained from the Microbiology branch, Biological Sciences Department, Faculty of Science, Sana'a University for their ability to produce L-asparaginase enzyme. (journaltocs.ac.uk)
  • These 29 fungal isolates were screened for their ability to produce L-asparaginase using the agar well diffusion method. (journaltocs.ac.uk)
  • 12 fungal isolates out of 29 showed the ability to produce extracellular L-asparaginase. (journaltocs.ac.uk)
  • This study aims to investigate the prevalence of extended-spectrum β-lactamase (ESBL) and carbapenemase-producing uropathogenic isolates of Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae). (journaltocs.ac.uk)
  • 41 isolates harbouring different Enterobacteriaceae species were analysed by plasmid multilocus sequence typing (pMLST). (eurosurveillance.org)
  • The novel metallo-β-lactamase named New Delhi metallo-β-lactamase (NDM-1) was identified from Klebsiella pneumoniae and Escherichia coli isolates in Sweden from a patient previously hospitalized in India ( 1 ). (cdc.gov)
  • Strain genotyping was performed by multilocus sequence typing to determine the sequence type (ST) of the isolate and to establish a comparison with previously reported NDM-1-producing isolates. (cdc.gov)
  • Multilocus sequence typing identified K. pneumoniae KLZA as an ST25 strain, which significantly differs from the ST14 type found in the index NDM-1-producing strain and from other isolates originating from India ( 1 ) and then in other countries. (cdc.gov)
  • We also genetically characterised the isolates of MDR bacteria including Extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E), methicillin-resistant Staphylococcus aureus (MRSA), and Carbapenemase-producing Enterobacteriacae (CPE) using the real-time polymerase chain reaction method. (preprints.org)
  • ESBL-producing E . coli isolates were tested by polymerase chain reaction (PCR) assay for bla TEM , bla SHV , bla CTX-M , bla OXA-I , and bla OXA-II genes. (atmph.org)
  • finally, isolates were tested for the presence of five different beta-lactamase gene families. (atmph.org)
  • In the present study ESBLs genotypes were correlated with susceptibility to cephalosporins among ESBL-producing Escherichia coli and Klebsiella pneumoniae isolates acquired in the community. (aku.edu)
  • This is a rapid molecular test that detects OXA-48-like beta-lactamase and VIM metallo-beta-lactamase DNA associated with antimicrobial resistance in isolates of gram-negative bacilli. (mayocliniclabs.com)
  • A step towards the discrimination of beta-lactamase-producing clinical isolates of Enterobacteriaceae and Pseudomonas ae. (mysciencework.com)
  • A total of 113,027 isolates from the Enterobacteriaceae family were analyzed. (biomedcentral.com)
  • The current study aimed at detecting the frequency of qnrA , qnrB, and qnrS genes, novel plasmid-mediated quinolone-resistance genes, among extended-spectrum β-lactamases (ESBL)-positive and ESBL-negative Klebsiella pneumoniae isolates. (iranpath.org)
  • 10.8% (n=14), 15.4% (n=20), and 20.8% (n=27) of ESBL-producing K. pneumonia were positive for qnrA, qnrS , and qnrB , respectively, and 13.8% (n=18) of the isolates harbored 2 or 3 qnr genes. (iranpath.org)
  • Some of the most important bla genes found in clinical isolates of Enterobacteriaceae are listed below. (microbenotes.com)
  • The structure of the New Delhi metallo-beta-lactamase 1 is given by 6C89. (wikipedia.org)
  • Among the known carbapenemases are Klebsiella pneumoniae carbapenemase, or KPC, and Verona integrin-encoded metallo-Beta-lactamase, or VIM. (cdc.gov)
  • If testing for Klebsiella pneumoniae carbapenemase (KPC) or New Delhi metallo-beta-lactamase (NDM) is desired, order KPNRP / KPC ( bla KPC) and NDM ( bla NDM) in Gram-Negative Bacilli, Molecular Detection, PCR. (mayocliniclabs.com)
  • The high sensitivity of amplification by polymerase chain reaction requires the specimen to be processed in an environment in which contamination of the specimen by oxacillin-hydrolyzing beta-lactamase (OXA-48-like) or Verona integron-encoded metallo-beta-lactamase ( VIM) DNA is unlikely. (mayocliniclabs.com)
  • Thirty-one (12%) of these Enterobacteriaceae strains were shown to be positive by the DD synergy test, suggesting the presence of ESBLs. (nih.gov)
  • Since the beginning of the 21st century, an explosive spread of CTX-M-type extended-spectrum β-lactamases (ESBLs) in E . coli has occurred ( 2 ). (cdc.gov)
  • In the mid-1980s, this new group of enzymes, the extended-spectrum β-lactamases (ESBLs), was detected (first detected in 1979). (wikipedia.org)
  • ESBLs are beta-lactamases that hydrolyze extended-spectrum cephalosporins with an oxyimino side chain. (wikipedia.org)
  • Thus ESBLs confer multi-resistance to these antibiotics and related oxyimino-beta lactams. (wikipedia.org)
  • however, none of the examined Enterobacteriaceae harbored ESBLs. (dovepress.com)
  • This phenomenon has been attributed to the emergence of strains that can produce extended-spectrum beta-lactamase (ESBLs). (atmph.org)
  • The plasmids may also carry the genes encoding extended-spectrum β-lactamases (ESBLs) such as SHV, TEM, CTX-M, KPC-2, aac(6')-Ib-cr and AmpC genes (6-10). (iranpath.org)
  • This resistance is brought by β-lactamase enzymes produced by a variety of bla genes such as SHV, TEM, CTX-M, KPC-2, aac(6')-Ib-cr and AmpC and the presence of qnr genes in the strains producing ESBLs. (iranpath.org)
  • K. pneumoniae is capable of producing ESBLs and is a common cause of nosocomial infections. (iranpath.org)
  • However, the blaNDM-1 gene produces NDM-1, which is a carbapenemase beta-lactamase - an enzyme that hydrolyzes and inactivates these carbapenem antibiotics. (wikipedia.org)
  • other types of carbapenemase are class A or class D beta-lactamases. (wikipedia.org)
  • Phenotypic and Molecular Epidemiology of ESBL-, AmpC-, and Carbapenemase-Producing Escherichia coli in Northern and Eastern Europe. (ut.ee)
  • Positive on a phenotypic test for carbapenemase production (e.g., metallo-β-lactamase test, modified Hodge test, Carba NP, Carbapenem Inactivation Method [CIM], or modified CIM). (cdc.gov)
  • Objectives: Infections caused by carbapenemase-producing Enterobacteriaceae are increasing worldwide, especially in ICUs, and have been associated with high mortality rates. (uu.nl)
  • carriage on patient outcome in two Greek ICUs with carbapenemase-producing Enterobacteriaceae endemicity. (uu.nl)
  • Setting: Two ICUs with carbapenemase-producing Enterobacteriaceae endemicity. (uu.nl)
  • Measurements and Main Results: Carbapenemase-producing Enterobacteriaceae colonization was established through screening in perineum swabs obtained at admission and twice weekly and inoculated on chromogenic plates. (uu.nl)
  • Risk factors for ICU mortality were evaluated using cause-specific hazard ratios and subdistribution hazard ratios, with carbapenemase-producing Enterobacteriaceae colonization as time-varying covariate. (uu.nl)
  • One thousand seven patients were included, 36 (3.6%) were colonized at admission, and 96 (9.5%) acquired carbapenemase-producing Enterobacteriaceae colonization during ICU stay, and 301 (29.9%) died in ICU. (uu.nl)
  • Conclusions: Patients colonized with carbapenemase-producing Enterobacteriaceae have on average a 1.79 times higher hazard of dying in ICU than noncolonized patients, primarily because of an increased length of stay. (uu.nl)
  • During the past decade, there has been an emergence of carbapenem-resistant Enterobacteriaceae that produce carbapenemases, enzymes that efficiently hydrolyze carbapenems, as well as most β-lactam drugs. (medscape.com)
  • Beta-lactamases (β-lactamases) are enzymes (EC 3.5.2.6) produced by bacteria that provide multi-resistance to beta-lactam antibiotics such as penicillins, cephalosporins, cephamycins, monobactams and carbapenems (ertapenem), although carbapenems are relatively resistant to beta-lactamase. (wikipedia.org)
  • A few years later, resistance appeared in bacterial species not naturally producing AmpC enzymes (K. pneumoniae, Salmonella spp. (wikipedia.org)
  • The gene for NDM-1 is one member of a large gene family that encodes beta-lactamase enzymes called carbapenemases. (wikipedia.org)
  • The carbapenems were developed to overcome antibiotic resistance mediated by bacterial beta-lactamase enzymes. (wikipedia.org)
  • My lab is also using molecular techniques to characterize the spread of plasmid-borne extended-spectrum beta-lactamase (ESBL) enzymes among Enterobacteriaceae. (seattlechildrens.org)
  • [4] The strains can produce plasmid-mediated enzymes capable of hydrolyzing cephalosporins and monobactams, and represent major challenges and serious consequences for antibiotic therapy. (atmph.org)
  • Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. (lookformedical.com)
  • These genes encode for β-lactamase enzymes that hydrolyze the β-lactam ring of β-lactam antibiotics such as penicillins, cephalosporins, carbapenems, aztreonam, etc. (microbenotes.com)
  • bla genes encode for the synthesis of β-lactamase enzymes. (microbenotes.com)
  • Different types of bla genes code for different variants of β-lactamase enzymes, and each of them may have different activity toward different members of β-lactam antibiotic class. (microbenotes.com)
  • Other variants of bla TEM genes are also reported to encode enzymes that can hydrolyze aztreonam, monobactam, the 3rd and 4th generation cephalosporins, and some β-lactamase inhibitors. (microbenotes.com)
  • They encode for TEM- β-lactamase enzymes, Class-A β-lactamases. (microbenotes.com)
  • A total of 259 Enterobacteriaceae strains were isolated between 1995 and 1998 from patients at the Yaounde Central Hospital in Cameroon. (nih.gov)
  • Chromosomal-mediated AmpC β-lactamases represent a new threat, since they confer resistance to 7-alpha-methoxy-cephalosporins (cephamycins) such as cefoxitin or cefotetan but are not affected by commercially available β-lactamase inhibitors, and can, in strains with loss of outer membrane porins, provide resistance to carbapenems. (wikipedia.org)
  • 1 In the past year, new, multidrug-resistant strains of carbapenem-resistant Enterobacteriaceae (CRE) have appeared at an accelerating rate. (ahrq.gov)
  • Carbapenem-resistant strains have emerged among species belonging to the Enterobacteriaceae family. (cdc.gov)
  • Clostridioides (formerly Clostridium ) difficile -Induced Diarrhea Toxins produced by Clostridioides difficile strains in the gastrointestinal tract cause pseudomembranous colitis, typically after antibiotic use. (msdmanuals.com)
  • They are mainly reported in ESBL-producing E. coli and K. pneumoniae strains. (microbenotes.com)
  • Restriction profiles of the remaining New Delhi metallo-β-lactamase plasmids, including 2 from the same patient, were diverse. (medscape.com)
  • Beta-lactam antibiotics are typically used to target a broad spectrum of gram-positive and gram-negative bacteria. (wikipedia.org)
  • Beta-lactamases produced by gram-negative bacteria are usually secreted, especially when antibiotics are present in the environment. (wikipedia.org)
  • It was first isolated by Abraham and Chain in 1940 from Gram-negative E. coli even before penicillin entered clinical use, but penicillinase production quickly spread to bacteria that previously did not produce it or produced it only rarely. (wikipedia.org)
  • The prevalence of ESBL-producing bacteria have been gradually increasing in acute care hospitals. (wikipedia.org)
  • NDM-1 is an enzyme that makes bacteria resistant to a broad range of beta-lactam antibiotics. (wikipedia.org)
  • Bacteria that produce carbapenemases are often referred to in the news media as "superbugs" because infections caused by them are difficult to treat. (wikipedia.org)
  • Carbapenems are a class of beta-lactam antibiotics that are capable of killing most bacteria by inhibiting the synthesis of one of their cell wall layers. (wikipedia.org)
  • Introduction: Invading extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-PE), non-ESBL E. coli, and other bacteria form a complex environment in the gut. (researchgate.net)
  • 12. Does Quick Sepsis-Related Organ Failure Assessment Suggest the Use of Initial Empirical Carbapenem Therapy in Bacteremia Caused by Extended-Spectrum β-Lactamase-Producing Bacteria? (nih.gov)
  • Sehgal R , Gaind R , Chellani H , Agarwal P . Extended-spectrum beta lactamase-producing gram-negative bacteria: clinical profile and outcome in a neonatal intensive care unit. (cdc.gov)
  • In a retrospective, matched-cohort analysis of patients admitted to the hospital with UTI in the US, patients with infections caused by extended-spectrum β-lactamase (ESBL) producing bacteria experienced IIAT 61.8% of the time as compared to 5.5% for patients with ESBL negative infections. (biomedcentral.com)
  • For many years, extended-spectrum-beta-lactamase (ESBL)-producing bacteria were problems mainly located in medical facilities. (atmph.org)
  • Within the last decade, however, ESBL-producing bacteria have started spreading into the community and the hospital. (atmph.org)
  • Infections due to these bacteria are mostly treated with beta-lactam antibiotics, often conveniently combined with aminoglycosides and, in some cases, with fluoroquinolones. (biomedcentral.com)
  • Carbapenem antibiotics are often used as the last line of treatment for infections caused by highly resistant bacteria, including those in the Enterobacteriaceae family. (cdc.gov)
  • Infections with bacteria of the family ENTEROBACTERIACEAE. (lookformedical.com)
  • Beta-lactamase genes ( bla genes) are the largest group of antibiotic-resistant genes found in Enterobacteriaceae and other bacteria that confer resistance against the β-lactam antibiotics. (microbenotes.com)
  • Enterobacteriaceae infections are limited. (cdc.gov)
  • In many cases, even common infections caused by ESBL-producing germs require more complex treatments. (cdc.gov)
  • Despite being one of the most exhaustively studied free-living organisms in biology, the Escherichia coli bacterium continues to produce a massive burden of disease, including extraintestinal syndromes such as urinary tract infections (UTI) and bloodstream infections. (seattlechildrens.org)
  • Challenges in the management of infections due to carbapenem-resistant Enterobacteriaceae. (seattlechildrens.org)
  • 7. Appropriateness of empirical antibiotic prescription for bloodstream infections in an emergency department from 2006 to 2018: impact of the spread of ESBL-producing Enterobacterales. (nih.gov)
  • 11. Beta-lactam/beta-lactamase inhibitors versus carbapenem for bloodstream infections due to extended-spectrum beta-lactamase-producing Enterobacteriaceae: systematic review and meta-analysis. (nih.gov)
  • Enterobacteriaceae OXA-48 were found in 118 patients (KP (n=99), Escherichia coli (n=56), ≥1 Enterobacteriaceae OXA-48 species (n=52)), of whom 21 had clinical infections. (eurosurveillance.org)
  • Entasis is developing ETX0282 in combination with cefpodoxime, an orally available cephalosporin approved for treating a variety of bacterial infections but lacking in efficacy due to beta-lactamase mediated resistance. (biospace.com)
  • Relay oral therapy in febrile urinary tract infections caused by extended spectrum beta-lactamase-producing Enterobacteriaceae in children: A French multicenter study. (e-lactancia.org)
  • Concern was expressed regarding increasing resistant infections in the community, such as those associated with drug-resistant gonorrhea and extended-spectrum beta-lactamase-producing Enterobacteriaceae, which has increased since 2000. (infectiousdiseaseadvisor.com)
  • These antibiotics all have a common element in their molecular structure: a four-atom ring known as a beta-lactam (β-lactam) ring. (wikipedia.org)
  • 2. Non-intravenous carbapenem-sparing antibiotics for definitive treatment of bacteraemia due to Enterobacteriaceae producing extended-spectrum β-lactamase (ESBL) or AmpC β-lactamase: A propensity score study. (nih.gov)
  • The aims of this study were to detect ESBL-producing uropathogenic Escherichia coli (UPEC), susceptibility to antibiotics, and β-lactamase genes. (atmph.org)
  • This study aimed at analyzing the development of resistance of Enterobacteriaceae to selected beta-lactam, fluoroquinolone and aminoglycoside antibiotics in the University Hospital Olomouc and assessing the effect of selection pressure of these antibiotics. (biomedcentral.com)
  • The presence of bla genes can be phenotypically presumed by performing antimicrobial sensitivity testing using different groups of beta-lactam antibiotics, but, for the identification of actual genes involved in the process, molecular detection methods are very effective. (microbenotes.com)
  • [ 5 ] However, recent reports of producing IMP- and VIM-type MBLs K. pneumoniae [ 6 , 7 ] have increased concerns over additional transmissible carbapenem resistance mechanisms in Enterobacteriaceae . (medscape.com)
  • Penicillinase-resistant beta-lactams such as methicillin were developed, but there is now widespread resistance to even these. (wikipedia.org)
  • Extended-spectrum beta-lactamase (ESBL) resistance is a growing concern in and outside hospitals. (urotoday.com)
  • This study investigated the diversity of mobile genetic elements involved with antimicrobial resistance (AMR) gene carriage in extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli that colonized travellers to Laos. (researchgate.net)
  • The increasing emergence of resistance to currently available oral treatments against Enterobacteriaceae creates a serious medical need which we are addressing with the development of ETX0282," said Manos Perros, CEO. (biospace.com)
  • Sulbactam is a generic beta-lactam which has intrinsic activity against A. baumannii but suffers from widespread beta-lactamase-mediated resistance. (biospace.com)
  • In a recent point-prevalence study from four different LTCF in Italy, the prevalence of extended-spectrum beta-lactamase (ESBL)-carriage was 57% and of methicillin-resistant Staphylococcus aureus (MRSA) 17% [ 4 ]. (biomedcentral.com)
  • Plasmids carrying bla NDM frequently carried AmpC or extended spectrum β-lactamase genes. (medscape.com)
  • 1. Mortality impact of empirical antimicrobial therapy in ESBL- and AmpC-producing Enterobacteriaceae bacteremia in an Australian tertiary hospital. (nih.gov)
  • We report a clinical case of neonatal meningitis caused by CTX-M-producing NMEC and the influence of CTX-M production on virulence. (cdc.gov)
  • The presentations featured ETX0282, Entasis' next-generation oral beta-lactamase inhibitor with activity against an extended spectrum of Class A and C beta-lactamases, and ETX2514, Entasis' I.V. broad-spectrum beta-lactamase inhibitor currently in Phase 1 clinical trials. (biospace.com)
  • TEM-1 enzyme encoded by the bla TEM-1 gene was the first plasmid-mediated β-lactamase enzyme identified in 1963. (microbenotes.com)
  • Extended-spectrum beta-lactamase-producing Enterobacteriaceae related urinary tract infection in adult cancer patients: a multicenter retrospective study, 2015-2019. (bvsalud.org)
  • The qnr genes produce Qnr proteins (Qnr A, B, and S), which protect DNA gyrase from quinolone inhibition. (iranpath.org)
  • Antibiotic resistantance genes such as Beta-lactamase genes ( bla genes), colistin-resistant genes, tetracycline-resistant genes, and aminoglycoside-resistant genes are the most important antibiotic-resistant genes in Enterobacterales . (microbenotes.com)
  • bla TEM gene family contains the most prevalent bla genes in Enterobacteriaceae. (microbenotes.com)
  • bla TEM genes are β-lactamase enzyme encoding genes. (microbenotes.com)
  • Genotypes and cephalosporin susceptibility in extended-spectrum beta-l" by Daniel Maina, Gunturu Revathi et al. (aku.edu)
  • We report a patient with neonatal meningitis caused by a CTX-M-1-producing Escherichia coli K1 strain. (cdc.gov)
  • Lavigne JP , Blanc-Potard AB , Bourg G , Moreau J , Chanal C , Bouziges N , Virulence genotype and nematode-killing properties of extra-intestinal Escherichia coli producing CTX-M beta-lactamases. (cdc.gov)
  • Branger C , Zamfir O , Geoffroy S , Laurans G , Arlet G , Thien HV , Genetic background of Escherichia coli and extended-spectrum beta-lactamase type. (cdc.gov)
  • Boyer-Mariotte S , Duboc P , Bonacorsi S , Lemeland JF , Bingen E , Pinquier D . CTX-M-15-producing Escherichia coli in fatal neonatal meningitis: failure of empirical chemotherapy. (cdc.gov)
  • The main pathogens associated with community-acquired IAIs are Enterobacteriaceae (predominantly E coli ) and anaerobes, particularly Bacteroides fragilis . (uspharmacist.com)
  • Home Article Distribution of ESBL producing Uropathogenic Escherichia coli and carriage of selected β-lactamase. (atmph.org)
  • Therefore, ESBL-producing E . coli from UTIs constitute a feasible bacterial population for a comparative study. (atmph.org)
  • Our preclinical work demonstrates the broader utility of ETX2514 in combination with beta-lactams against multiple drug-resistant Gram-negative pathogens," said Ruben Tommasi, CSO. (biospace.com)
  • ETX2514 restores the in vitro activity of multiple beta-lactams against Gram-negative, multi-drug resistant (MDR) pathogens. (biospace.com)
  • It appeared initially in a limited number of bacterial species (E. cloacae, C. freundii, S. marcescens, and P. aeruginosa) that could mutate to hyperproduce their chromosomal class C β-lactamase. (wikipedia.org)
  • Pediatric Infection and Intestinal Carriage Due to Extended-Spectrum-Cephalosporin-Resistant Enterobacteriaceae. (seattlechildrens.org)
  • Several outbreaks caused by carbapenem-resistant Enterobacteriaceae , or CRE, have been recorded in health care facilities around the world, and in some places, CRE have become endemic. (cdc.gov)
  • We mainly rely on updating and strengthening the existing anti-infective system in order to control the spread of multi-drug resistant organisms, such as A. baumannii, extended spectrum beta-lactamase-producing Enterobacteriaceae, and carbapenem-resistant P. aeruginosa. (medbc.com)
  • 15. Predictors of outcome in patients with severe sepsis or septic shock due to extended-spectrum β-lactamase-producing Enterobacteriaceae. (nih.gov)
  • MADRID - Patients who are carriers of extended-spectrum beta lactamase-producing Enterobacteriaceae (ESBL-B) before colorectal surgery are at more than double the risk of surgical site infection , despite a standard prophylactic antibiotic regimen. (the-hospitalist.org)
  • This report of an NDM-1-producing K. pneumoniae in Croatia adds to those of other cases in patients from patients hospitalized in the Balkan area. (cdc.gov)
  • Brink AJ, Richards GA, Colombo G, Bortolotti F, Colombo P, Jehl F. Multicomponent antibiotic substances produced by fermentation: implications for regulatory authorities, critically ill patients and generics. (ijccm.org)
  • Through hydrolysis, the enzyme lactamase breaks the β-lactam ring open, deactivating the molecule's antibacterial properties. (wikipedia.org)
  • The alpha-beta fold (InterPro: IPR012338) resembles that of a DD-transpeptidase, from which the enzyme is thought to have evolved from. (wikipedia.org)
  • Enterobacteriaceae is a family of Gram-negative rod-shaped Gammaproteobacteria in the order Enterobacterales in the phylum Pseudomonadota. (microbenotes.com)
  • 3. Should we consider faecal colonisation with extended-spectrum β-lactamase-producing Enterobacteriaceae in empirical therapy of community-onset sepsis? (nih.gov)
  • citation needed] NDM-1 functions through two zinc ions present in the active site that cause hydrolysis of the beta-lactams, rendering them ineffective. (wikipedia.org)
  • 4. Bloodstream infection with extended-spectrum beta-lactamase-producing Enterobacteriaceae at a tertiary care hospital in New Zealand: risk factors and outcomes. (nih.gov)
  • CXA-201 is the combination of a novel cephalosporin (CXA-101) with the beta-lactamase inhibitor tazobactam. (news-medical.net)
  • Characteristics of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae and Contact to Animals in Estonia. (ut.ee)
  • Serine β-lactamases are grouped by sequence similarity into types A, C, and D. The other type of beta-lactamase is of the metallo type ("type B"). Metallo-beta-lactamases (MBLs) need metal ion(s) (1 or 2 Zn2+ ions) on their active site for their catalytic activities. (wikipedia.org)
  • Penicillinase is a specific type of β-lactamase, showing specificity for penicillins, again by hydrolysing the β-lactam ring. (wikipedia.org)
  • The purpose of the research is to determine the stability of anthocyanins using molecular simulations and determine the best mixing sequence of ingredients to produce the most stable anthocyanin mixture. (journaltocs.ac.uk)
  • Members of this family commonly express β-lactamases (e.g. (wikipedia.org)
  • In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). (lookformedical.com)
  • NDM-1 β-lactamase was also found in an K. pneumoniae isolate from Croatia, and the patient arrived from Bosnia and Herzegovina. (wikipedia.org)