ReductaseFabGSuperfamilySubunitGenomeDehydrogenaseEnsemblRibosomalInterproscanSynthesisSpeciesGeneCatalysisSequencesEnzymeLipidSCOPeHitsPlaysHumanSynthasePutativeExperimentallyBiosynthesisDegradationPeriplasmicFattyOperonInner membranePathwayModificationEnzymesUblastMotifExperimentalDomainAlphaTranslationActivitySearchFoundStructureExportDataComplex
Reductase4
- β-Ketoacyl-(acyl carrier protein) reductase (FabG) catalyzes the key reductive reaction in the elongation cycle of fatty acid synthesis (FAS), which is a vital metabolic pathway in bacteria and a promising target for new antibiotic development. (rcsb.org)
- The heterotetramer with CBR4 has NADH-dependent 3-keto acyl-acyl carrier protein reductase activity, so it plays a role in the biosynthesis of mitochondrial fatty acids. (bocsci.com)
- Enoyl-(Acyl carrier protein) reductase [Interproscan]. (ntu.edu.sg)
- Starting from the N-terminus, these units include β-ketoacyl synthase (KS), acetyl/malonyl transacylase (AT/MT), β-hydroxyacyl dehydratase (DH), enoyl reductase (ER), β-ketoacyl reductase (KR), acyl carrier protein (ACP), and thioesterase (TE). (aging-us.com)
FabG1
- Here we report the findings of structural, enzymatic, and binding studies of the FabG protein found in the causative agent of cholera, Vibrio cholerae (vcFabG). (rcsb.org)
Superfamily1
- HSD17B8 (Estradiol 17 beta-dehydrogenase 8) is a member of the short-chain dehydrogenase superfamily. (bocsci.com)
Subunit1
- protein_coding" "AAC73960","hcp","Escherichia coli","hybrid-cluster [4Fe-2S-2O] subunit of anaerobic terminal reductases [Ensembl]. (ntu.edu.sg)
Genome3
- GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. (lbl.gov)
- Rapid whole-genome sequencing identifies a homozygous novel variant, His540Arg, in HSD17B4 resulting in D-bifunctional protein deficiency disorder diagnosis. (nih.gov)
- More importantly, most maize genes encoding lipid-related transcription factors, triacylglycerol (TAG) biosynthetic enzymes, pentose phosphate pathway (PPP) and Calvin Cycle proteins were not regulated during seed oil synthesis, despite the presence of many homologs in the maize genome. (researchsquare.com)
Dehydrogenase1
- protein_coding" "AAC74323","adhE","Escherichia coli","fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase [Ensembl]. (ntu.edu.sg)
Ensembl4
- protein_coding" "AAC74319","hns","Escherichia coli","global DNA-binding transcriptional dual regulator H-NS [Ensembl]. (ntu.edu.sg)
- protein_coding" "AAC74185","ptsG","Escherichia coli","fused glucose-specific PTS enzymes: IIB component/IIC component [Ensembl]. (ntu.edu.sg)
- protein_coding" "AAC74850","yeaD","Escherichia coli","D-hexose-6-phosphate epimerase-like protein [Ensembl]. (ntu.edu.sg)
- protein_coding" "AAC74888","manY","Escherichia coli","mannose-specific enzyme IIC component of PTS [Ensembl]. (ntu.edu.sg)
Ribosomal2
- Ribosomal protein S20 [Interproscan]. (ntu.edu.sg)
- Ribosomal protein L35 [Interproscan]. (ntu.edu.sg)
Interproscan11
- Glycosyl hydrolases family 2, Beta galactosidase small chain, Domain of unknown function(DUF4981) [Interproscan]. (ntu.edu.sg)
- Bor protein [Interproscan]. (ntu.edu.sg)
- Protein of unknown function (DUF1158) [Interproscan]. (ntu.edu.sg)
- Protein of unknown function (DUF2526) [Interproscan]. (ntu.edu.sg)
- Protein of unknown function (DUF441) [Interproscan]. (ntu.edu.sg)
- LysR substrate binding domain, Bacterial regulatory helix-turn-helix protein [Interproscan]. (ntu.edu.sg)
- YebO-like protein [Interproscan]. (ntu.edu.sg)
- Protein of unknown function (DUF2511) [Interproscan]. (ntu.edu.sg)
- Copper resistance protein D [Interproscan]. (ntu.edu.sg)
- Pantoate-beta-alanine ligase [Interproscan]. (ntu.edu.sg)
- Protein of unknown function (DUF520) [Interproscan]. (ntu.edu.sg)
Synthesis1
- Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. (systemsbiology.net)
Species1
- Further, the "HomoloGene" function of the NCBI was used to conduct conserved functional domain analysis of the FASN protein in different species. (aging-us.com)
Gene4
- The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. (nih.gov)
- Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). (nih.gov)
- The corresponding gene, AtWRINKLED1 ( AtWRI1, At3g54320), encodes a protein with two APETALA2-ethylene responsive element-binding protein (AP2/EREBP) motifs that is a signature for plant-specific transcription factors involved in a wide range of developmental processes [ 5 , 6 ]. (biomedcentral.com)
- Additionally, several features (e.g., gene expression, survival prognosis, genetic alteration, DNA methylation, protein phosphorylation, immune cells, or relevant cellular pathways) were gathered to evaluate the regulatory mechanism of FASN in the tumorigenesis of cancers. (aging-us.com)
Catalysis1
- Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+. (systemsbiology.net)
Sequences1
- Environmental sequences of ten novel plastid lineages and structural innovations in plastid proteins confirm that plastids in apicomplexans and their relatives are widespread and share a common, photosynthetic origin. (elifesciences.org)
Enzyme2
- GapMind searches the predicted proteins for candidates by using ublast (a fast alternative to protein BLAST) to find similarities to characterized proteins or by using HMMer to find similarities to enzyme models (usually from TIGRFams ). (lbl.gov)
- Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam ). (lbl.gov)
Lipid1
- Although lipids are a distinct class of biomolecules, we shall see that they often occur combined, either covalently or through weak bonds, with members of other classes of bio-molecules to yield hybrid molecules such as glycolipids , which contain both carbohydrate and lipid groups, "and lipoproteins , which contain both lipids and proteins. (medmuv.com)
SCOPe1
- SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)
Hits2
Plays1
- The aggregation of both amyloid beta (Abeta) peptides extracellularly and Tau proteins intracellularly plays key roles in the pathological consequences of AD, which lead to cholinergic neurodegeneration and eventually death. (inra.fr)
Human1
- The human FASN protein is composed of six catalytic units. (aging-us.com)
Synthase4
- Antifungal activity is via inhibition of 1,3-beta-glucan synthase production of BETA-GLUCANS. (lookformedical.com)
- Type I polyketide synthases (PKSs) are multifunctional enzymes that are organized into modules, each of which minimally contains a beta-ketoacyl synthase, an acyltransferase (AT), and an acyl carrier protein. (firdi.org.tw)
- The lnm cluster spans 61.3 kb of DNA and consists of 27 genes encoding nonribosomal peptide synthetase (NRPS), polyketide synthase (PKS), hybrid NRPS-PKS, resistance, regulatory, and tailoring enzymes, as well as proteins of unknown function. (firdi.org.tw)
- A ácido graxo sintase (en inglés Fatty acid synthase ou FAS ) é un encima que nos humanos está codificado no xene FASN [ 1 ] situado no cromosoma 17 e que intervén na síntese de ácidos graxos . (wikipedia.org)
Putative1
- protein_coding" "AAC73829","ybgE","Escherichia coli","putative inner membrane protein in cydABX-ybgE operon [Ensembl]. (ntu.edu.sg)
Experimentally2
- Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam ). (lbl.gov)
- We used strong primary sequence conservation based on experimentally proved proteins as the main criterion, followed by verification with tertiary structure superpositions, mechanisms, and catalytic residue positions, to accurately define TE families. (inra.fr)
Biosynthesis1
- These findings unveiled a previously unknown PKS architecture that is characterized by a discrete, iteratively acting AT protein that loads the extender units in trans to "AT-less" multifunctional type I PKS proteins for polyketide biosynthesis. (firdi.org.tw)
Degradation1
- Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity). (nih.gov)
Periplasmic3
- Periplasmic binding protein [Interproscan]. (ntu.edu.sg)
- Copper binding periplasmic protein CusF [Interproscan]. (ntu.edu.sg)
- Periplasmic binding proteins and sugar binding domain of LacI family [Interproscan]. (ntu.edu.sg)
Fatty3
- c) Proteins related to lipid accumulation via the Kennedy pathway increased their abundance at 48 h, synchronous with the previously reported diversification of fatty acids after 48 h. (biomedcentral.com)
- A broad category of membrane transport proteins that specifically transport FREE FATTY ACIDS across cellular membranes. (lookformedical.com)
- The enhanced P. falciparum quiescence capacity of artemisinin-resistant parasites results from an increased ability to manage oxidative damage and an altered cell cycle gene regulation within a complex network involving the unfolded protein response, the PI3K/PI3P/AKT pathway, the PfPK4/eIF2α cascade and yet unidentified transcription factor(s), with minimal energetic requirements and fatty acid metabolism maintained in the mitochondrion and apicoplast. (biomedcentral.com)
Operon1
- Cyd operon protein YbgE (Cyd_oper_YbgE) [Interproscan]. (ntu.edu.sg)
Inner membrane1
- Binding-protein-dependent transport system inner membrane component [Interproscan]. (ntu.edu.sg)
Pathway1
- Piecemeal evidence associates artemisinin resistance with increased unfolded protein response (UPR), dysregulation of the pre-replication phase and the PI3K/PI3P/AKT pathway. (biomedcentral.com)
Modification1
- This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. (nih.gov)
Enzymes1
- The protein is composed of two domains, an N-terminal biotin carboxylase and a C-terminal biotin-carboxyl-carrier protein, that are highly similar to corresponding subunits from prokaryotic and eukaryotic biotin enzymes. (uni-bielefeld.de)
Ublast2
Motif1
- Following the analysis of transposon Tn5432-induced mutants of Corynebacterium glutamicum ATCC 13032, a gene encoding a protein with a biotin-binding motif was cloned. (uni-bielefeld.de)
Experimental1
- Hits to curated proteins without experimental data as to their function are never considered high confidence. (lbl.gov)
Domain1
- CONTAINS InterPro DOMAIN/s: Protein-tyrosine phosphatase-like, PTPLA (InterP. (riken.jp)
Alpha1
- Transcription by RNA POL II is bona fide assumed for protein coding genes but must be supported by alpha-amanitin data if the end product is an RNA. (expasy.org)
Translation1
- GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. (lbl.gov)
Activity2
- The only AT activity identified within the lnm gene cluster is a discrete AT protein encoded by lnmG. (firdi.org.tw)
- Regulates E3 ubiquitin-protein ligase activity of RNF19A (By similarity). (nih.gov)
Search1
- If a UniProtKB accession is associated with this protein, a search link will be provided below. (burkholderia.com)
Found1
- Over 70% identity was found to a protein from Mycobacterium leprae proposed to be part of an acyl-CoA carboxylase. (uni-bielefeld.de)
Structure2
- Protein structure predictions using a neural network model developed by DeepMind . (burkholderia.com)
- The crystal structure of a myristoyl acyl carrier protein specific thioesterase (C14ACP-TE) from a bioluminescent bacterium, Vibrio harveyi, was solved by multiple isomorphous replacement methods and refined to an R factor of 22% at 2.1-A resolution. (inra.fr)
Export1
- The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. (nih.gov)
Data1
- Physiological adaptations to N− not apparent from transcriptome data were unveiled: (a) abundance of proteins related to photosynthesis only slightly decreased in the first 48 h, indicating that photosynthesis is still working efficiently, and protein amounts adjust gradually with reduction in chloroplast size. (biomedcentral.com)
Complex1
- Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (nih.gov)