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  • acetyl
  • In biochemistry and metabolism, beta-oxidation is the catabolic process by which fatty acid molecules are broken down in the cytosol in prokaryotes and in the mitochondria in eukaryotes to generate acetyl-CoA, which enters the citric acid cycle, and NADH and FADH2, which are co-enzymes used in the electron transport chain. (wikipedia.org)
  • The overall reaction for one cycle of beta oxidation is: Cn-acyl CoA + FAD + NAD+ + H 2O + CoA → Cn-2-acyl CoA + FADH 2 + NADH + H+ + acetyl CoA Fatty acid catabolism consists of: Activation and membrane transport of free fatty acids by binding to coenzyme A. Oxidation of the beta carbon to a carbonyl group. (wikipedia.org)
  • The final cycle produces two separate acetyl CoAs, instead of one acyl CoA and one acetyl CoA. (wikipedia.org)
  • enzymatic
  • The enzymatic steps involved in the elongation process are principally the same as those carried out by FAS, but the four principal successive steps of the elongation are performed by individual proteins, which may be physically associated. (wikipedia.org)
  • pathway
  • section describes the metabolic pathway(s) associated with a protein. (uniprot.org)
  • This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism. (uniprot.org)
  • The reaction sequence is carried out by a series of individual soluble proteins that are each encoded by a discrete gene, and the pathway intermediates are shuttled between the enzymes. (wikipedia.org)
  • carbon chain
  • The growing fatty acid chain is carried between these active sites while attached covalently to the phosphopantetheine prosthetic group of an acyl carrier protein (ACP), and is released by the action of a thioesterase (TE) upon reaching a carbon chain length of 16 (palmitic acid). (wikipedia.org)
  • chain
  • Electron transfer from electron carriers to the electron transport chain in oxidative phosphorylation. (wikipedia.org)
  • If the fatty acyl-CoA has a long chain, then the carnitine shuttle must be utilized: Acyl-CoA is transferred to the hydroxyl group of carnitine by carnitine palmitoyltransferase I, located on the cytosolic faces of the outer and inner mitochondrial membranes. (wikipedia.org)
  • genes
  • Type II FASs are dissociated systems, meaning the component enzymes are independent proteins encoded by a series of separate genes. (wikipedia.org)
  • RhlA and RhlB respectively, are expected to form a complex because of the operonic nature of the genes which encode these two proteins and because both proteins are necessary for production of rhamnolipids. (wikipedia.org)
  • Annotation
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein. (uniprot.org)
  • sequence
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • different
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)