Beta ketoacyl acyl carrier. Medical search. Frequent questions

β-Ketoacyl-(acyl carrier protein) reductase (FabG) catalyzes the key reductive reaction in the elongation cycle of fatty acid synthesis (FAS), which is a vital metabolic pathway in bacteria and a promising target for new antibiotic development. (rcsb.org)
The heterotetramer with CBR4 has NADH-dependent 3-keto acyl-acyl carrier protein reductase activity, so it plays a role in the biosynthesis of mitochondrial fatty acids. (bocsci.com)
to get instant updates about '3-Oxoacyl-(Acyl-Carrier-Protein) Reductase' on your MyPage . (rediff.com)
Other names in common use include beta-ketoacyl-(ACP) reductase , beta-ketoacyl acyl carrier protein (ACP) reductase , beta-ketoacyl reductase , beta-ketoacyl thioester reductase , beta-ketoacyl-ACP reductase , beta-ketoacyl-acyl carrier protein reductase , 3-ketoacyl acyl carrier protein reductase , NADPH-specific 3-oxoacyl-reductase , and 3-oxoacyl-reductase . (rediff.com)
Characterization of the genes encoding beta-ketothiolase and acetoacetyl-CoA reductase. (expasy.org)
Starting from the N-terminus, these units include β-ketoacyl synthase (KS), acetyl/malonyl transacylase (AT/MT), β-hydroxyacyl dehydratase (DH), enoyl reductase (ER), β-ketoacyl reductase (KR), acyl carrier protein (ACP), and thioesterase (TE). (aging-us.com)

Schematic demonstrating mitochondrial fatty acid beta-oxidation and effects of long-chain acyl CoA dehydrogenase deficiency (LCHAD) deficiency. (medscape.com)

beta-Ketoacyl-acyl carrier protein synthetase. (brenda-enzymes.org)
Acyl CoA Synthetase: What is it/What does it do? (flashcardmachine.com)

These two different types of thiolase are found both in eukaryotes and in prokaryotes: acetoacetyl-CoA thiolase (EC:2.3.1.9) and 3-ketoacyl-CoA thiolase (EC:2.3.1.16). (wikipedia.org)
3-ketoacyl-CoA thiolase (also called thiolase I) has a broad chain-length specificity for its substrates and is involved in degradative pathways such as fatty acid beta-oxidation. (wikipedia.org)
Acetoacetyl-CoA thiolase (also called thiolase II) is specific for the thiolysis of acetoacetyl-CoA and involved in biosynthetic pathways such as beta-hydroxybutyric acid synthesis or steroid biogenesis. (wikipedia.org)
Two different types of thiolase are found both in eukaryotes and in prokaryotes: acetoacetyl-CoA thiolase (EC 2.3.1.9) and 3-ketoacyl-CoA thiolase (EC 2.3.1.16). (wikipedia.org)
In eukaryotes, there are two forms of 3-ketoacyl-CoA thiolase: one located in the mitochondrion and the other in peroxisomes. (wikipedia.org)
All thiolases, whether they are biosynthetic or degradative in vivo, preferentially catalyze the degradation of 3-ketoacyl-CoA to form acetyl-CoA and a shortened acyl-CoA species, but are also capable of catalyzing the reverse Claisen condensation reaction (reflecting the negative Gibbs energy change of the degradation, which is independent of the thiolase catalyzing the reaction). (wikipedia.org)
The other 2 activities of the protein are 2-enoyl coenzyme A (CoA) hydratase (LCEH) and long-chain 3-ketoacyl CoA thiolase (LCKT). (medscape.com)
Primary structure of 3-ketoacyl-coenzyme A thiolase from Escherichia coli and the structural organization of the fadAB operon. (expasy.org)

Beta-ketoacyl-ACP synthase I of Escherichia coli: nucleotide sequence of the fabB gene and identification of the cerulenin binding residue. (genebiosystems.com)
Similarity between the amino-terminal portion of mammalian 58-kD sterol carrier protein (SCPx) and Escherichia coli acetyl-CoA acyltransferase: evidence for a gene fusion in SCPx. (expasy.org)

Both saturated and unsaturated FAs are released from acyl-ACP by acyl-ACP thioesterase (FAT) [ 10 ] and exported to cytosol. (researchsquare.com)

HSD17B8 (Estradiol 17 beta-dehydrogenase 8) is a member of the short-chain dehydrogenase superfamily. (bocsci.com)
Long-chain 3-hydroxy acyl-coenzyme A dehydrogenase (LCHAD) is 1 of 3 enzymatic activities that make up the trifunctional protein of the inner mitochondrial membrane. (medscape.com)
The protein is an octamer composed of 4 alpha subunits that contain the LCEH and long-chain 3-hydroxy acyl-coenzyme A dehydrogenase activities, and 4 beta subunits that contain the LCKT activity. (medscape.com)
This enzyme complex metabolizes long-chain fatty acids, and the long-chain 3-hydroxy acyl-coenzyme A dehydrogenase activity is specific for compounds of C12-C16 chain length. (medscape.com)
Affected infants with long-chain 3-hydroxy acyl-coenzyme A dehydrogenase deficiency, which is inherited as an autosomal recessive trait, present in infancy with acute hypoketotic hypoglycemia. (medscape.com)
Some patients who are deficient in all 3 enzymatic activities of the protein have been described, although most have an isolated long-chain 3-hydroxy acyl-coenzyme A dehydrogenase deficiency, which results in the inability to metabolize long-chain fatty acids. (medscape.com)
Patients with long-chain 3-hydroxy acyl-coenzyme A dehydrogenase deficiency may develop a profound CNS deficiency of docosahexanoic acid ethyl ester (DHA), 22:6n-3. (medscape.com)
Occurrence frequency of either isolated long-chain 3-hydroxy acyl-coenzyme A dehydrogenase activity deficiency or trifunctional protein deficiency is unknown in the United States. (medscape.com)
Patients with long-chain 3-hydroxy acyl-coenzyme A dehydrogenase activity deficiency usually present with hypoketotic hypoglycemia, cardiomyopathy, hypotonia, and hepatomegaly at a median age of 6 months. (medscape.com)

Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+. (systemsbiology.net)

In the first step of both the degradative and biosynthetic reactions, the nucleophilic Cys89 (or its equivalent) attacks the acyl-CoA (or 3-ketoacyl-CoA) substrate, leading to the formation of a covalent acyl-enzyme intermediate. (wikipedia.org)
In the second step, the addition of CoA (in the degradative reaction) or acetyl-CoA (in the biosynthetic reaction) to the acyl-enzyme intermediate triggers the release of the product from the enzyme. (wikipedia.org)

Thiolases are ubiquitous enzymes that have key roles in many vital biochemical pathways, including the beta oxidation pathway of fatty acid degradation and various biosynthetic pathways. (wikipedia.org)

These thioesters are made by conjugating the fatty acid with the free SH group of the pantetheine moiety of either coenzyme A (CoA) or acyl carrier protein (ACP). (wikipedia.org)

Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). (nih.gov)
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (genebiosystems.com)
Thus, the clinical features may result from either toxicity due to long-chain acyl-CoA esters that cause cardiomyopathy and cardiac arrhythmias or from a block in long-chain fatty acid oxidation that leads to an inability to synthesize ketone bodies and/or adenosine triphosphate from long-chain fatty acids. (medscape.com)

The etiology of the severe peripheral neuropathy of trifunctional protein deficiency may result from the unique metabolite, 3-keto-acyl-CoA, after conversion to a methylketone via spontaneous decarboxylation. (medscape.com)

Mammalian nonspecific lipid-transfer protein (nsL-TP) (also known as sterol carrier protein 2) is a protein which seems to exist in two different forms: a 14 Kd protein (SCP-2) and a larger 58 Kd protein (SCP-x). (wikipedia.org)

C ) in the HADHA gene that encodes for mitochondrial LCHAD estimated a carrier frequency of 1:240 in Finland. (medscape.com)
How do Fatty Acyl-CoA's pass the mitochondrial intermembrane space? (flashcardmachine.com)

Glycosyl hydrolases family 2, Beta galactosidase small chain, Domain of unknown function(DUF4981) [Interproscan]. (ntu.edu.sg)
Pantoate-beta-alanine ligase [Interproscan]. (ntu.edu.sg)

The aggregation of both amyloid beta (Abeta) peptides extracellularly and Tau proteins intracellularly plays key roles in the pathological consequences of AD, which lead to cholinergic neurodegeneration and eventually death. (inra.fr)
What happens if you lack the proteins to transport Acyl-Coa into the matrix? (flashcardmachine.com)

The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. (nih.gov)

Poly-beta-hydroxybutyrate biosynthesis in Alcaligenes eutrophus H16. (expasy.org)

The protein is an octamer composed of 4 alpha subunits that contain the LCEH and LCHAD activities and 4 beta subunits that contain the LCKT activity. (medscape.com)

It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. (nih.gov)

The genes for the alpha and beta subunits have been localized to chromosome 2. (medscape.com)

Analysis of the frequency of the most common mutation (G1528C) revealed a carrier frequency of 1:240 in Finland. (medscape.com)

2. Effect of modification of the length and flexibility of the acyl carrier protein-thioesterase interdomain linker on functionality of the animal fatty acid synthase. (nih.gov)
7. Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity. (nih.gov)
12. Characterization of recombinant thioesterase and acyl carrier protein domains of chicken fatty acid synthase expressed in Escherichia coli. (nih.gov)
14. The reductase domain in a Type I fatty acid synthase from the apicomplexan Cryptosporidium parvum: restricted substrate preference towards very long chain fatty acyl thioesters. (nih.gov)
15. A mammalian type I fatty acid synthase acyl carrier protein domain does not sequester acyl chains. (nih.gov)
19. Heterologously expressed acyl carrier protein domain of rat fatty acid synthase functions in Escherichia coli fatty acid synthase and Streptomyces coelicolor polyketide synthase systems. (nih.gov)
Some INH-resistant organisms also have mutations in the inhA locus or a recently characterized gene (kasA) encoding a beta-ketoacyl-acyl carrier protein synthase. (nih.gov)
Antifungal activity is via inhibition of 1,3-beta-glucan synthase production of BETA-GLUCANS. (lookformedical.com)
The beta-ketoacyl-acyl carrier protein (ACP) synthase III encoded by mtfabH (mtFabH) links FAS-I and FAS-II, catalyzing the condensation of FAS-I-derived acyl-CoAs with malonyl-acyl carrier protein (ACP). (birmingham.ac.uk)
Type I polyketide synthases (PKSs) are multifunctional enzymes that are organized into modules, each of which minimally contains a beta-ketoacyl synthase, an acyltransferase (AT), and an acyl carrier protein. (firdi.org.tw)
3-ketoacyl-ACP synthase [Cuphea avigera var. (uma.es)
3-oxoacyl-[acyl-carrier-protein] synthase n=1 Tax=Cuphea avigera var. (uma.es)
A ácido graxo sintase (en inglés Fatty acid synthase ou FAS ) é un encima que nos humanos está codificado no xene FASN [ 1 ] situado no cromosoma 17 e que intervén na síntese de ácidos graxos . (wikipedia.org)
Finally, we also tested the deletion of two potential medium-chain acyl-CoA depleting reactions catalyzed by the thioesterase Tes1 and the medium-chain fatty acyl CoA synthase Faa2. (biomedcentral.com)

3. Structural insights into GDP-mediated regulation of a bacterial acyl-CoA thioesterase. (nih.gov)
The crystal structure of a myristoyl acyl carrier protein specific thioesterase (C14ACP-TE) from a bioluminescent bacterium, Vibrio harveyi, was solved by multiple isomorphous replacement methods and refined to an R factor of 22% at 2.1-A resolution. (inra.fr)

Over 70% identity was found to a protein from Mycobacterium leprae proposed to be part of an acyl-CoA carboxylase. (uni-bielefeld.de)

NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. (nih.gov)
In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. (nih.gov)
Schematic demonstrating mitochondrial fatty acid beta-oxidation and effects of long-chain acyl CoA dehydrogenase deficiency (LCHAD) deficiency. (medscape.com)

a) Kennedy pathway dependent on acyl-CoA and (b) the phospholipid diacylglycerol acyltransferase (PDAT) mediated alternative pathway, which uses fatty acids from lipids turnover. (biomedcentral.com)

Thiolases are ubiquitous enzymes that have key roles in many vital biochemical pathways, including the beta oxidation pathway of fatty acid degradation and various biosynthetic pathways. (wikipedia.org)
In the first step of both the degradative and biosynthetic reactions, the nucleophilic Cys89 (or its equivalent) attacks the acyl-CoA (or 3-ketoacyl-CoA) substrate, leading to the formation of a covalent acyl-enzyme intermediate. (wikipedia.org)
In the second step, the addition of CoA (in the degradative reaction) or acetyl-CoA (in the biosynthetic reaction) to the acyl-enzyme intermediate triggers the release of the product from the enzyme. (wikipedia.org)

17. Determinants of substrate specificity in a catalytically diverse family of acyl-ACP thioesterases from plants. (nih.gov)

9. Anatomy of the β-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate. (nih.gov)
the enzyme extended longer, physiologically relevant acyl-CoA primers when paired with AcpM, its natural partner, than with Escherichia coli ACP. (birmingham.ac.uk)
The overall tertiary architecture of the enzyme resembles closely the consensus fold of the rapidly expanding superfamily of alpha/beta hydrolases, although there is no detectable homology with any of its members at the amino acid sequence level. (inra.fr)

13. Mycobacteria Encode Active and Inactive Classes of TesB Fatty-Acyl CoA Thioesterases Revealed through Structural and Functional Analysis. (nih.gov)

5. Analysis and engineering of substrate shuttling by the acyl carrier protein (ACP) in fatty acid synthases (FASs). (nih.gov)

C) in the HADHA gene that encodes for mitochondrial LCHAD estimated a carrier frequency of 1:240 in Finland. (medscape.com)

Corynebacterium glutamicum thiosulfate sulfurtransferase (thtR) gene, partial cds, acyl CoA carboxylase (accBC) gene, complete cds. (uni-bielefeld.de)

The etiology of the severe peripheral neuropathy of trifunctional protein deficiency may result from the unique metabolite, 3-keto-acyl-CoA, after conversion to a methylketone via spontaneous decarboxylation. (medscape.com)

Mutation of Arg(46) revealed its more critical role in malonyl-AcpM decarboxylation than in the acyl-CoA binding role. (birmingham.ac.uk)

Compounds consisting of a short peptide chain conjugated with an acyl chain. (lookformedical.com)

The protein is composed of two domains, an N-terminal biotin carboxylase and a C-terminal biotin-carboxyl-carrier protein, that are highly similar to corresponding subunits from prokaryotic and eukaryotic biotin enzymes. (uni-bielefeld.de)

These results suggest that the synthetic pathway for the fatty acid moiety of rhamnolipids is separate from the general fatty acid synthetic pathway, starting with a specific ketoacyl reduction step catalyzed by the RhlG protein. (nih.gov)

Thus, the clinical features may result from either toxicity due to long-chain acyl-CoA esters that cause cardiomyopathy and cardiac arrhythmias or from a block in long-chain fatty acid oxidation that leads to an inability to synthesize ketone bodies and/or adenosine triphosphate from long-chain fatty acids. (medscape.com)

These alpha-alkyl, beta-hydroxy fatty acids are formed by the condensation of two fatty acids, a long meromycolic acid and a shorter C(24)-C(26) fatty acid. (birmingham.ac.uk)
The protein is an octamer composed of 4 alpha subunits that contain the LCEH and LCHAD activities and 4 beta subunits that contain the LCKT activity. (medscape.com)
The genes for the alpha and beta subunits have been localized to chromosome 2. (medscape.com)

Virtually all isolates resistant to rifampin and related rifamycins have a mutation that alters the sequence of a 27-amino-acid region of the beta subunit of ribonucleic acid (RNA) polymerase. (nih.gov)

people proceed into 7-mediated short carriers with less H+ sister cells. (evakoch.com)

Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases. (nih.gov)

Mammalian nonspecific lipid-transfer protein (nsL-TP) (also known as sterol carrier protein 2) is a protein which seems to exist in two different forms: a 14 Kd protein (SCP-2) and a larger 58 Kd protein (SCP-x). (wikipedia.org)
They exist as anions at physiological pH and, consequently, require a carrier for transport across the membranes of the enterohepatic tissues. (hmdb.ca)

Anatomy4

Organisms9

Chemicals and Drugs68

Analytical, Diagnostic and Therapeutic Techniques and Equipment15

Phenomena and Processes24

Technology, Industry, Agriculture1

Information Science3

Health Care1

Reductase6

Long-chain acyl CoA dehydroge1

Synthetase2

Thiolase8

Escherichia2

Thioesterase1

Dehydrogenase9

NADPH1

Intermediate2

Thiolases1

Coenzyme1

Fatty acid3

Metabolite1

Sterol carrier1

Mitochondrial2

Interproscan2

Proteins2

Gene1

Biosynthesis1

Activity1

Formation1

Genes1

Common1

Synthase14

Thioesterase2

Mycobacterium1

Dehydrogenase3

Acyltransferase1

Biosynthetic3

Specificity1

Enzyme3

Thioesterases1

Substrate1

Encodes1

Gene1

Deficiency1

Decarboxylation1

Peptide1

Enzymes1

Moiety1

Long chain1

Alpha3

Sequence1

Short1

Type1

Exist2