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  • opioid
  • Beta-endorphin suppressed the proliferative response of equine lymphocytes to mitogens through interaction with opioid receptors. (lsu.edu)
  • Beta-endorphin is also a possible mediator of the effects of acute and chronic exercise on equine immune function, as demonstrated by up- and downregulation of opioid receptors on equine lymphocytes. (lsu.edu)
  • plasma
  • Thus, the origins of plasma and cerebrospinal fluid beta-endorphin may be different, with the former secreted from the hypophysis and the latter from nervous tissue. (uniss.it)
  • increase
  • On the other hand, a significant increase in cerebrospinal fluid beta-endorphin concentration occurred after spinal ischemia, while surgical stress had no significant effect. (uniss.it)
  • Specific
  • Specific, saturable receptors for beta-endorphin were identified on equine lymphocytes which appeared to be a mu/delta receptor complex, with a K$\sb{\rm d}$ of 17 pM and B$\sb{\rm max}$ of 0.538 fmoles/10$\sp6$ cells. (lsu.edu)
  • concentration
  • On the other hand, a significant increase in cerebrospinal fluid beta-endorphin concentration occurred after spinal ischemia, while surgical stress had no significant effect. (uniss.it)
  • Observed changes in cerebrospinal fluid beta-endorphin concentration could be related to the ischemic lesion of nervous tissue while the changes in plasma levels may reflect general stressing factors such as the surgery in our experiments. (uniss.it)
  • synthesis
  • It triggers the synthesis of vitamin D and endorphins in the skin, but it also causes skin cancer and other damage, including wrinkles. (wikipedia.org)
  • morphine
  • Both [beta]-endorphin and morphine, in a dose dependent manner given intraventricularly suppressed the signs of 14 hour acute morphine abstinence. (umich.edu)
  • On a molar basis, [beta]-endorphin was more active than morphine in suppressing the signs of morphine abstinence. (umich.edu)
  • When given intravenously in much larger doses, [beta]-endorphin was ineffective in contrast to morphine which was effective in suppressing abstinence. (umich.edu)
  • occurs
  • Neuroregulation by β-endorphin occurs through interference with the function of another neuropeptide, either by direct inhibition of neuropeptide release or induction of a signaling cascade that reduces a neuropeptide's effects. (wikipedia.org)
  • secondary
  • The structure of β-endorphin in part accounts for this through its resistance to proteolytic enzymes, as its secondary structure makes it less vulnerable to degradation. (wikipedia.org)
  • Plasma
  • Thus, the origins of plasma and cerebrospinal fluid beta-endorphin may be different, with the former secreted from the hypophysis and the latter from nervous tissue. (uniss.it)
  • General anesthesia and preoperative changes in plasma beta-endorphin]. (semanticscholar.org)
  • Relative rates of alpha-MSH and NAc beta-end release following stimulation with CRH in vitro match plasma level changes in vivo, and this indicates that the CRH pathway does act in vivo. (ru.nl)
  • effects
  • Global function of β-endorphin is related to decreasing bodily stress and maintaining homeostasis resulting in pain management, reward effects, and behavioral stability. (wikipedia.org)
  • The origin of this variable response was investigated by (1) studying the effects of corticotropin-releasing hormone (CRH) on alpha-MSH and NAc beta-end release in vitro, (2) establishing where in the second messenger pathway coupled to CRH receptors melanotrope responsiveness is determined, and (3) testing modulatory actions of other hypothalamic factors (here opioid beta-endorphin). (ru.nl)
  • Role
  • The investigators aim to test whether beta-endorphin, a substance our bodies make in response to painful and stressful stimuli, plays a causative role in radiation-induced fatigue that cancer patients receiving radiation therapy commonly experience. (clinicaltrials.gov)
  • Studies
  • In behavioral research, studies have shown that β-endorphin is released via volume transmission into the ventricular system in response to a variety of stimuli, and novel stimuli in particular. (wikipedia.org)
  • action
  • The two main methods by which β-endorphin is utilized in the body are peripheral hormonal action and neuroregulation. (wikipedia.org)
  • however
  • Acytelation of the N-terminus of β-endorphin, however, inactivates the neuropeptide, preventing it from binding to its receptor. (wikipedia.org)
  • epidermis
  • Supporting this possibility, CB 2 immunolabeling was detected on β-endorphin-containing keratinocytes in stratum granulosum throughout the epidermis of the hindpaw. (pnas.org)
  • stimulates
  • The portal system carries the CRH to the anterior lobe of the pituitary, where it stimulates corticotropes to secrete adrenocorticotropic hormone (ACTH) and other biologically-active substances (β-endorphin). (wikipedia.org)
  • alpha
  • IDE, which migrates at 110 kDa during gel electrophoresis under denaturing conditions, has since been shown to have additional substrates, including the signaling peptides glucagon, TGF alpha, and β-endorphin. (wikipedia.org)