• To identify proteins interacting with alpha A-crystallin (CRYAA) and to investigate the potential role that these protein interactions play in the function of CRYAA using a human proteome (HuProt) microarray. (molvis.org)
  • CRYAA is one of the major lens proteins, accounting for 35% of all crystallins. (molvis.org)
  • Alpha-crystallins also act as molecular chaperones that bind to denatured proteins, keep them in solution and thereby maintain the translucency of the lens. (lookformedical.com)
  • The proteins exist as large oligomers that are formed from ALPHA-CRYSTALLIN A CHAIN and ALPHA-CRYSTALLIN B CHAIN subunits. (lookformedical.com)
  • Folding and stability of the isolated Greek key domains of the long-lived human lens proteins gammaD-crystallin and gammaS-crystallin. (protabank.org)
  • The transparency of the eye lens depends on the high solubility and stability of the lens crystallin proteins. (protabank.org)
  • Proteins have segments of their polypeptide chain/chains that can be repeatedly coiled or folded into helix and pleated structures, respectively. (stackexchange.com)
  • [13] [14] Because proteins share a common structural feature known as the polypeptide backbone, all proteins have the potential to misfold under some circumstances. (wikipedia.org)
  • Current phylogenetic evidence suggests that the 15 or so distinct proteins known to have alpha/beta structures arose by convergent evolution. (cureffi.org)
  • Bioinformatics analysis showed that the proteins encoded by these five HcHSPs contained typical α-crystallin domains. (bvsalud.org)
  • We constructed and expressed polypeptide chains corresponding to the isolated N- and C-terminal domains of human gammaD-crystallin, as well as the isolated domains of human gammaS-crystallin. (protabank.org)
  • Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. (lookformedical.com)
  • This is due to hydrogen bonds between partially charged oxygen and hydrogen atoms in the repetitive polypeptide backbone (which excludes the amino acid side chains). (stackexchange.com)
  • Is it a result of both hydrogen bonds in the polypeptide backbone, and interactions between amino acid side chains? (stackexchange.com)
  • My reasoning is that, it does not make sense to say that hydrogen bonds between the atoms of different amino acids in a polypeptide backbone, bring separate amino acids closer together, before interactions between amino acid side chains (R groups) occur (especially since some of these interactions between R groups are hydrogen bonds themselves). (stackexchange.com)
  • CRYBA4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 216 amino acids (1-196 a.a.) and having a molecular mass of 24.5kDa. (prospecbio.com)
  • The order of amino acids as they occur in a polypeptide chain. (lookformedical.com)
  • The decrease in stability of the N-terminal domain of human gammaD-crystallin with respect to the complete protein indicated that the interdomain interface contributes of 4.2 kcal/mol to the overall stability of this very long-lived protein. (protabank.org)
  • Micrograph of a section of the cerebral cortex from a person with Alzheimer's disease , immunostained with an antibody to amyloid beta (brown), a protein fragment that accumulates in amyloid plaques and cerebral amyloid angiopathy . (wikipedia.org)
  • [9] However, some proteinaceous lesions lack birefringence and contain few or no classical amyloid fibrils, such as the diffuse deposits of amyloid beta (Aβ) protein in the brains of people with Alzheimer's. (wikipedia.org)
  • amyloid beta precursor protein binding. (gsea-msigdb.org)
  • A ubiquitously expressed G-protein-coupled receptor kinase subtype that has specificity for the agonist-occupied form of BETA-ADRENERGIC RECEPTORS and a variety of other G-PROTEIN-COUPLED RECEPTORS. (lookformedical.com)
  • Why do hydrogen bonds between atoms of the polypeptide backbone, form both helix and pleated structures, instead of only one structural type? (stackexchange.com)
  • My guess is that one structure (either a helix or pleated structure) is lower in potential energy compared to the other (because one structure likely maximises the number of hydrogen bonds that can form, compared to the other), which begs the question, why do both structures form, if they are largely a result of hydrogen bonds in the polypeptide backbone, rather than only one structure forming? (stackexchange.com)
  • Beta-crystallin A4 (CRYBA4) is a member of the beta/gamma-crystallin family which are the dominant structural components of the vertebrate eye lens. (prospecbio.com)
  • The transcription of the beta-globin genes in mouse erythroleukemia cells has been examined by hybridizing labeled RNA obtained from isolated nuclei after chain elongation in the presence of [alpha-32P]UTP. (shengsci.com)
  • Total RNA was isolated on P16, and the relative abundance of mRNA of the crystallin structural genes, redox components, and apoptotic cascade were ascertained with real-time PCR with reference to the internal control β-actin . (molvis.org)
  • Real-time PCR analysis showed the crystallin genes ( αA- , βB1- , γD- ) and redox cycle components ( Cat , SOD-1 , Gpx ) were downregulated, the apoptotic components were upregulated, and antiapoptotic Bcl-2 was downregulated in Group II. (molvis.org)
  • C-PC treatment possibly prevented cataractogenesis triggered by sodium selenite, by regulating the lens crystallin, redox genes, and apoptotic cascade mRNA expression and thus maintains lens transparency. (molvis.org)
  • Description: A sandwich ELISA kit for detection of Integrin Beta 6 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (antibody-tech.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Integrin Beta 6 (ITGb6) in samples from tissue homogenates, cell lysates or other biological fluids. (antibody-tech.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Integrin Beta 6 (ITGb6) in Tissue homogenates, cell lysates and other biological fluids. (antibody-tech.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Integrin Beta 6 (ITGb6) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (antibody-tech.com)
  • Beta-crystallins construct aggregates of various sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. (prospecbio.com)
  • One of the subunits of alpha-crystallins. (lookformedical.com)
  • In such a structure, there is a core β-barrel consisting of several beta sheets, either all parallel or mixed parallel/antiparallel, surrounded by a cage of alpha helices. (cureffi.org)
  • In linear sequence, the alpha helices and beta sheets alternate. (cureffi.org)
  • Prior investigation of the refolding of human gammaD-crystallin revealed that the C-terminal domain folds first and nucleates the folding of the N-terminal domain. (protabank.org)
  • Induced transcription of the mouse beta-globin transcription unit in erythroleukemia cells. (shengsci.com)
  • Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants. (lookformedical.com)
  • There is induction of at least 30-fold of beta maj globin transcription after cells are treated with either dime. (shengsci.com)
  • protein_coding" "Cz01g02060.t1","No alias","Chromochloris zofingiensis","Nascent polypeptide-associated complex NAC domain [Interproscan]. (ntu.edu.sg)
  • 12. cDNA, genomic sequence and overexpression of crystallin alpha-B Gene (CRYAB) of the Giant Panda. (nih.gov)
  • Crystallinopathy felt by the buy Spin of the alphaB-crystallin( CryAB) applicant, back is as metabolic training( DRC) and separates PSCs. (augenta.net)
  • EC 2.5.1.18) are soluble proteins with typical molecular masses of around 50 kDa, and each is composed of two polypeptide subunits. (biomedcentral.com)
  • A subclass of ANTIFREEZE PROTEINS that are globular, 6.5 kDa in size and contain compact beta-sheet structures. (lookformedical.com)
  • The order of amino acids as they occur in a polypeptide chain. (lookformedical.com)
  • The transcription of the beta-globin genes in mouse erythroleukemia cells has been examined by hybridizing labeled RNA obtained from isolated nuclei after chain elongation in the presence of [alpha-32P]UTP. (shengsci.com)
  • Description: JTB Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 98 amino acids (31-105 a.a.) and having a molecular mass of 10.7kDa. (2sars.com)
  • Description: NAP1L4 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 398 amino acids (1-375) and having a molecular mass of 45.2 kDa. (hiv-pharmacogenomics.org)
  • VAMP5 produced in E.Coli is a single,non-glycosylated polypeptide chain containing 109 amino acids (1-72 a.a.) and having a molecular mass of 12.7 kDa.VAMP5 is fused to 37 amino acids His Tag at N-terminus and purified by proprietary chromatographic techniques. (neobiolab.com)
  • PARP2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 376 amino acids (233-583a.a) and having a molecular mass of 42.5kDa. (kendallscientific.com)
  • PMM1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 282 amino acids (1-262 a.a.) and having a molecular mass of 31.9kDa. (neobiolab.com)
  • An 84 bp element located between nucleotides -162 and -79 of the chicken alpha A-crystallin gene exhibits lens-specific enhancer activity. (eurekamag.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Major Histocompatibility Complex Class II DR Beta 1 (MHCDRb1) in serum, plasma, tissue homogenates and other biological fluids. (therabio.org)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Major Histocompatibility Complex Class II DR Beta 1 (MHCDRb1) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (therabio.org)