AnatomyDiseasesChemicals and DrugsPhenomena and ProcessesInformation Science
Core Binding Factor alpha SubunitsCore Binding FactorsCore Binding Factor Alpha 1 SubunitCore Binding Factor beta SubunitCore Binding Factor Alpha 2 SubunitChorionic Gonadotropin, beta Subunit, HumanCore Binding Factor Alpha 3 SubunitGlycoprotein Hormones, alpha SubunitTranscription Factor AP-2Smooth Muscle MyosinsTranscription FactorsChromosomes, Human, Pair 16DNA-Binding ProteinsMolecular Sequence DataChromosome InversionLeukemia, Myeloid, AcuteBase SequenceProtein SubunitsOncogene Proteins, FusionBinding SitesProtein BindingChromosomes, Human, Pair 21Neoplasm Proteins
ProteinsFive subunitsTranscription factorsNucleotideRegulatoryCBFBCatalyticBacterialSpecificityMRNAHoloenzymeGENESHistoneAnaerobicInterproscanPolymerasePhosphorylationRecombinantCollagenNuclearGuanineGeneRuntHelicesPutativeChromatinTranscriptionalRetinoblastoma bindingHeterodimerMoleculeEukaryotesComplexOxidoreductaseDomainAffinityPhosphatidylinositolFormsDimer
Proteins21
  • 3%). The organic phase is mainly formed by collagen type I fibers, which provide elasticity and flexibility to bone, but also non-collagenous proteins as well, such as cytokines, growth factors, and proteoglycans. (biomedcentral.com)
  • The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. (embl.de)
  • Regulators of small G-proteins like guanine nucleotide releasing factor GNRP (Ras-GRF) (which contains 2 PH domains), guanine nucleotide exchange proteins like vav, dbl, SoS and Saccharomyces cerevisiae CDC24, GTPase activating proteins like rasGAP and BEM2/IPL2, and the human break point cluster protein bcr. (embl.de)
  • Cytoskeletal proteins such as dynamin (see IPR001401 ), Caenorhabditis elegans kinesin-like protein unc-104 (see IPR001752 ), spectrin beta-chain, syntrophin (2 PH domains) and S. cerevisiae nuclear migration protein NUM1. (embl.de)
  • Oxysterol binding proteins OSBP, S. cerevisiae OSH1 and YHR073w. (embl.de)
  • Several S. cerevisiae proteins involved in cell cycle regulation and bud formation like BEM2, BEM3, BUD4 and the BEM1-binding proteins BOI2 (BEB1) and BOI1 (BOB1). (embl.de)
  • Together, these proteins form one version of a complex known as core binding factor (CBF). (medlineplus.gov)
  • While mRNA of alfa subunits (HIFs- α) are not altered by exposure to hypoxia, alfa, but not beta, proteins are stabilized by hypoxia. (biomedcentral.com)
  • DNA-binding motifs, first described in one of the HMGA PROTEINS: HMG-I(Y) PROTEIN. (lookformedical.com)
  • Characterisation of a cluster of genes encoding Theileria annulata AT hook DNA-binding proteins and evidence for localisation to the host cell nucleus. (lookformedical.com)
  • download of been proteins appears the architectural subunit of including acids within enzymes and represents the inhibitor gene conjugation SSA to intracellular families that initiate dramatically synaptic from those short at the thyroid beta. (erik-mill.de)
  • opposed factor is and stimulates group of transport proteins to DNA DSBs( Beamish et al. (erik-mill.de)
  • The involvement of viral DNA-binding proteins in the regulation of virulence genes, transcription, DNA replication, and repair make them significant targets. (mdpi.com)
  • FtsZ has two domains, one of which is a GTPasedomain with a fold related to one found in the proteins p21ras andelongation factor EF-Tu. (embl-heidelberg.de)
  • high bacteria are as proteins of pathway ATM rise, either as acids for greenhouse initiation or for the dehydrogenase of binding eIF2 disorders. (evakoch.com)
  • Proteins which bind to DNA. (lookformedical.com)
  • The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)
  • This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS. (lookformedical.com)
  • Podosomes are structurally divided into a core, which mainly contains proteins involved in actin polymerization (such as WASP, the Arp2/3 complex and cortactin ), and a surrounding ring populated by integrin receptors and adhesion proteins (for example, paxillin and focal adhesion kinase (FAK/Pyk2) ) [15] . (cellmigration.org)
  • Inhibitor of DNA binding/differentiation helix-loop-helix proteins mediate bone morphogenetic protein-induced osteoblast differentiation of mesenchymal stem cells. (uchicago.edu)
  • Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells. (uchicago.edu)
Five subunits1
  • RNA polymerase "core" from E. coli consists of five subunits: two alpha (α) subunits of 36 kDa, a beta (β) subunit of 150 kDa, a beta prime subunit (β′) of 155 kDa, and a small omega (ω) subunit. (wikipedia.org)
Transcription factors5
Nucleotide2
  • Association of single nucleotide polymorphisms in the nuclear respiratory factor-2 beta subunit-encoding the GABPB1 gene within the occupational environment. (nih.gov)
  • Each tubulinmonomer binds a guanine nucleotide, which is nonexchangeable when it isbound in the alpha subunit, or N site, and exchangeable when bound in thebeta subunit, or E site. (embl-heidelberg.de)
Regulatory6
  • pRB functions as a negative regulatory transcription factor during the G1 to S phase cell cycle transition. (medscape.com)
  • α subunit also contains elements for interaction with the regulatory factors. (sciencefacts.net)
  • Protein Phosphatase 2A (PP2A) is a widely expressed family of protein phosphatases made of a core dimer, composed of a catalytic (C) subunit and a structural (A) subunit, in association with a third variable regulatory (B) subunit. (ac.be)
  • The regulation of PP2A is mainly accomplished by the identity of the regulatory B-type subunit, which determines substrate specificity, subcellular localization and catalytic activity of the PP2A holoenzyme. (ac.be)
  • This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. (cancerindex.org)
  • LysR substrate binding domain, Bacterial regulatory helix-turn-helix protein [Interproscan]. (ntu.edu.sg)
CBFB1
  • This protein interacts with another protein called core binding factor beta or CBFβ (produced from the CBFB gene), which helps RUNX1 bind to DNA and prevents it from being broken down. (medlineplus.gov)
Catalytic1
  • The MutS requirements suppress with conformational enzymes binding other MLH and MutL, the later bind aromatic release family favour and catalytic cytokine to the MLH Canadians, widely eventually as RPA, EXO1, RFC, well long, and D-fructose less intrinsic lipids. (erik-mill.de)
Bacterial3
  • Eukaryotic and archaeal RNAPs have more subunits than bacterial ones do, and are controlled differently. (wikipedia.org)
  • Transcription initiation at a consensus bacterial promoter proceeds via a 'bind-unwind-load-and-lock' mechanism. (academictree.org)
  • Crosstalk between NF-kappaB and beta-catenin pathways in bacterial-colonized intestinal epithelial cells. (uchicago.edu)
Specificity2
  • Cleavage/polyadenylation specificity factor, A subunit, C-terminal [Interproscan]. (ntu.edu.sg)
  • The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. (hmdb.ca)
MRNA3
  • evm.model.tig00001501.4","tig00001501_g9219.t1","Cyanophora paradoxa","Pre-mRNA-processing factor 19 OS=Oryza sativa subsp. (ntu.edu.sg)
  • protein_coding" "Cz03g40300.t1","No alias","Chromochloris zofingiensis","Pre-mRNA processing factor 4 (PRP4)-like [Interproscan]. (ntu.edu.sg)
  • protein_coding" "Cz05g30030.t1","No alias","Chromochloris zofingiensis","mRNA splicing factor Cwf21 domain [Interproscan]. (ntu.edu.sg)
Holoenzyme3
  • A sigma (σ) factor binds to the core, forming the holoenzyme. (wikipedia.org)
  • When the sigma (σ) factor binds to the core, it forms the holoenzyme. (sciencefacts.net)
  • To bind to the promoter, the core RNAP binds to the sigma (σ), forming the holoenzyme (ββ′α2ω σ) with 6 subunits. (sciencefacts.net)
GENES5
  • It forms heterodimeric complexes with CORE BINDING FACTOR ALPHA SUBUNITS, and regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression. (wakehealth.edu)
  • The sigma (σ) factor of the RNA polymerase is encoded by nuclear genes. (sciencefacts.net)
  • This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. (nih.gov)
  • Transcription factor that binds to the interleukin-6 (il-6)-responsive elements identified in the promoters of various acute-phase protein genes. (lu.se)
  • p50 binds to the kappa-B consensus sequence 5'- GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. (hmdb.ca)
Histone3
  • A retinoblastoma-binding protein that is involved in CHROMATIN REMODELING, histone deacetylation, and repression of GENETIC TRANSCRIPTION. (lookformedical.com)
  • It is found as a subunit of protein complexes that are in involved in the enzymatic modification of histones including the Mi2 and Sin3 histone deacetylase complexes and the polycomb repressive complex 2. (lookformedical.com)
  • This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. (cancerindex.org)
Anaerobic1
  • protein_coding" "AAC73960","hcp","Escherichia coli","hybrid-cluster [4Fe-2S-2O] subunit of anaerobic terminal reductases [Ensembl]. (ntu.edu.sg)
Interproscan17
  • ARID DNA-binding domain [Interproscan]. (ntu.edu.sg)
  • FAD/NAD(P)-binding domain [Interproscan]. (ntu.edu.sg)
  • ATPase, AAA-type, core [Interproscan]. (ntu.edu.sg)
  • Pantoate-beta-alanine ligase [Interproscan]. (ntu.edu.sg)
  • Probable molybdopterin binding domain [Interproscan]. (ntu.edu.sg)
  • tRNA synthetase class II core domain (G, Seryl-tRNA synthetase N-terminal domain [Interproscan]. (ntu.edu.sg)
  • Molydopterin dinucleotide binding domain, Molybdopterin oxidoreductase Fe4S4 domain [Interproscan]. (ntu.edu.sg)
  • 4Fe-4S binding domain, 4Fe-4S dicluster domain [Interproscan]. (ntu.edu.sg)
  • DMSO reductase anchor subunit (DmsC) [Interproscan]. (ntu.edu.sg)
  • Nitrate reductase delta subunit [Interproscan]. (ntu.edu.sg)
  • Elongation factor TS [Interproscan]. (ntu.edu.sg)
  • Glycosyl hydrolases family 2, Beta galactosidase small chain, Domain of unknown function(DUF4981) [Interproscan]. (ntu.edu.sg)
  • YbaB/EbfC DNA-binding family [Interproscan]. (ntu.edu.sg)
  • Oxidoreductase FAD-binding domain, Oxidoreductase NAD-binding domain, 2Fe-2S iron-sulfur cluster binding domain [Interproscan]. (ntu.edu.sg)
  • Translation initiation factor 1A / IF-1 [Interproscan]. (ntu.edu.sg)
  • Tetratricopeptide repeat, Rubredoxin metal binding domain [Interproscan]. (ntu.edu.sg)
  • Translation initiation factor SUI1 [Interproscan]. (ntu.edu.sg)
Polymerase5
  • Depending on the organism, a RNA polymerase can be a protein complex (multi-subunit RNAP) or only consist of one subunit (single-subunit RNAP, ssRNAP), each representing an independent lineage. (wikipedia.org)
  • The core RNA polymerase complex forms a "crab claw" or "clamp-jaw" structure with an internal channel running along the full length. (wikipedia.org)
  • RNA polymerase I (RNAP I) synthesizes pre-rRNA 45S, which matures into the ribosome 's 28S, 18S, and 5.8S subunits. (sciencefacts.net)
  • Cheng A, Wan D, Ghatak A, Wang C , Feng D, Fondell JD, Ebright RH , Fan H. Identification and Structural Modeling of the RNA Polymerase Omega Subunits in Chlamydiae and Other Obligate Intracellular Bacteria. (academictree.org)
  • RNA polymerase clamp conformational dynamics: long-lived states and modulation by crowding, cations, and nonspecific DNA binding. (academictree.org)
Phosphorylation2
  • ITCH Phosphorylation p39 loss-of-function MAP2K1( visually activated as MEK1) is a single proneurotrophin and size concept binding that is and appears MAPK3( ERK1)( Ohren et al. (evakoch.com)
  • Notable features of the A chain are the N-terminal peptide (fibrinopeptide A (FPA, 1-16)), factor XIIIa crosslinking sites and 2 phosphorylation sites. (cellsystems.eu)
Recombinant1
  • Characterization of DNA binding, transcriptional activation, and regulated nuclear association of recombinant human NFATp. (colorado.edu)
Collagen1
  • The axonemal site of NOTCH1 and the collagen Ligand-binding WD40 cell of 40kDa are different benefits of pumps in accumulation epithelial Endoplasmic development - T-ALL( Welcker and Clurman 2008). (evakoch.com)
Nuclear2
  • A beta-hairpin comprising the nuclear localization sequence sustains the self-associated states of nucleosome assembly protein 1. (colorado.edu)
  • Antígeno nuclear que juega un papel en la síntesis y reparación del ADN, y en la progresión del ciclo celular. (bvsalud.org)
Guanine1
  • GDP binding is different from that typically found inGTPases and involves four phosphate-binding loops and a sugar-binding loopin the first domain, with guanine being recognized by residues in thecentral connecting helix. (embl-heidelberg.de)
Gene7
  • β′ is the largest subunit that is encoded by the rpoC gene. (sciencefacts.net)
  • β is the second large subunit and is encoded by the rpoB gene. (sciencefacts.net)
  • This gene encodes the GA-binding protein transcription factor, beta subunit. (nih.gov)
  • The RUNX1 gene provides instructions for making a protein called runt-related transcription factor 1 (RUNX1). (medlineplus.gov)
  • Recently, we described the characterisation of a parasite gene (TashAT2), whose polypeptide product bears AT hook DNA-binding motifs and may be transported from the parasite to the host nucleus. (lookformedical.com)
  • RNA interference-mediated gene silencing of vascular endothelial growth factor in colon cancer cells. (uchicago.edu)
  • How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? (lu.se)
Runt1
  • Pre-osteoblasts, a heterogeneous population of cells, including those transitioning from MSCs to mature osteoblasts, which express the transcription factor runt related transcription factor 2 (RUNX2) , a key player in the osteogenesis process. (biomedcentral.com)
Helices1
  • The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. (lookformedical.com)
Putative1
  • Mouse protein citron, a putative rho/rac effector that binds to the GTP-bound forms of rho and rac. (embl.de)
Chromatin4
  • Chromatin assembly factor 1. (lookformedical.com)
  • The 48 kDa subunit, RETINOBLASTOMA-BINDING PROTEIN 4, is also a component of several other protein complexes involved in chromatin remodeling. (lookformedical.com)
  • Although initially discovered as a retinoblastoma binding protein it has an affinity for core HISTONES and is a subunit of chromatin assembly factor-1 and polycomb repressive complex 2. (lookformedical.com)
  • The repeating structural units of chromatin, each consisting of approximately 200 base pairs of DNA wound around a protein core. (lookformedical.com)
Transcriptional2
  • Hypoxia-inducible factors (HIFs) are responsible for the transcriptional responses to hypoxic stress. (biomedcentral.com)
  • protein_coding" "AAC74319","hns","Escherichia coli","global DNA-binding transcriptional dual regulator H-NS [Ensembl]. (ntu.edu.sg)
Retinoblastoma binding1
  • A retinoblastoma-binding protein that has an affinity for core HISTONES. (lookformedical.com)
Heterodimer1
  • The alphabeta tubulin heterodimer is the structural subunit ofmicrotubules, which are cytoskeletal elements that are essential forintracellular transport and cell division in all eukaryotes. (embl-heidelberg.de)
Molecule1
  • Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids. (embl.de)
Eukaryotes1
  • The former is found in bacteria, archaea, and eukaryotes alike, sharing a similar core structure and mechanism. (wikipedia.org)
Complex2
  • A transcription factor and its associated transcription mediator complex must be attached to a DNA binding site called a promoter region before RNAP can initiate the DNA unwinding at that position. (wikipedia.org)
  • It provides unique identifiers, names and synonyms, list of complex members with their unique identifiers (UniProt, ChEBI, RNAcentral), function, binding and stoichiometry annotations, descriptions of their topology, assembly structure, ligands and associated diseases as well as cross-references to the same complex in other databases (e.g. (stanford.edu)
Oxidoreductase1
  • neighboring Expression represses to underlie identified by the oxidoreductase of Rev with importin-beta and B23 and signaling at the Syndecan transcription through proteases between acts and hours. (evakoch.com)
Domain8
  • Each α subunit has an N-terminal αNTD domain and a C-terminal αCTD domain. (sciencefacts.net)
  • The loops connecting the beta-strands differ greatly in length, making the PH domain relatively difficult to detect. (embl.de)
  • 6097 beta-lactamase domain protein CP001857 CDS Arcpr_0005 complement(6094. (go.jp)
  • 30270 beta-lactamase domain protein CP001857 CDS Arcpr_0037 complement(30271. (go.jp)
  • alpha of the intestinal rRNA, soluble to the density-fluctuation of bacterium requirements, domains in vasodilator of microenvironment from its domain. (erik-mill.de)
  • The carboxy-terminal domain, whose function isunknown, is a four-stranded beta-sheet tilted by 90 degrees against thebeta-sheet of the GTPase domain. (embl-heidelberg.de)
  • These regions bind to complimentary regions on the D domain of Fbn to form protofibrils. (cellsystems.eu)
  • Each of the 2 domains between the central node (E domain) and the C-terminal nodes (D domain) is composed of parallel -helical regions of the A , B and chains coiled around each other to form a coiled coil" with polar residues directed outward and nonpolar residues forming a hydrophobic core. (cellsystems.eu)
Affinity2
  • The σ factor reduces the core enzyme's affinity for binding to non-specific DNA sequences while binding to the promoter. (sciencefacts.net)
  • If you find that the five prime UTR is not optimized for expression then simply change the vector, the ribosome binding site, or adding an affinity tag at the N-terminus often enhances expression. (neb.com)
Phosphatidylinositol1
  • KEGG analysis indicated that most of these metabolites were involved in glucose metabolism, which is involved in the tumor necrosis factor (TNF), phosphatidylinositol 3 kinase/protein kinase B (PI3K/Akt), Glycolysis, and mitogen-activated protein kinase (MAPK) pathways. (bvsalud.org)
Forms1
  • The alpha- and beta-tubulins share 40% amino-acidsequence identity, both exist in several isotype forms, and both undergo avariety of posttranslational modifications. (embl-heidelberg.de)
Dimer1
  • Structure of the alpha beta tubulin dimer by electron crystallography. (embl-heidelberg.de)