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Chemokine CCL4Receptors, ChemokineMacrophage Inflammatory ProteinsChemokines, CCChemokine CCL5Chemokine CCL3Receptors, CXCR4Receptors, CCR5Chemokine CXCL12ChemokinesReceptors, CCR1Receptors, CCR2Receptors, CXCR3Chemokines, CXCChemokine CCL2Receptors, CCR3Receptors, CCR4Chemokine CXCL10Chemokine CCL21Chemokine CCL19Chemokine CCL17Receptors, Interleukin-8BReceptors, CCR7Chemokine CCL22Chemokine CXCL1Receptors, Interleukin-8AReceptors, CCR8Chemokine CX3CL1Chemotaxis, LeukocyteChemokine CXCL9Chemokine CCL7Receptors, CCRReceptors, CXCRReceptors, CCR10Chemokine CCL1Receptors, CytokineChemotaxisChemokine CCL20Chemokine CXCL11Chemokine CCL11Receptors, CXCR5Receptors, CCR6Cell MovementChemokine CXCL2Chemokine CXCL13Receptors, HIVChemokine CXCL6Interleukin-1betaChemokine CCL8Monocyte Chemoattractant ProteinsChemokine CCL27Cells, CulturedMice, Inbred C57BLRNA, MessengerHeterocyclic CompoundsChemokine CXCL5Flow CytometrySignal TransductionLigandsMice, KnockoutCytokinesCell LineDuffy Blood-Group SystemT-LymphocytesInterleukin-8beta 2-MicroglobulinChemokines, CX3CMonocytesHIV-1Chemokine CCL24Molecular Sequence DataReverse Transcriptase Polymerase Chain ReactionGene Expression RegulationUp-RegulationCD4-Positive T-LymphocytesMacrophagesChemotactic FactorsDendritic CellsInflammationMice, Inbred BALB CReceptors, Adrenergic, betaIntegrin beta3Amino Acid SequenceAntigens, CD4Gene ExpressionHIV Envelope Protein gp120Cell Migration InhibitionTransforming Growth Factor betaImmunohistochemistryChemotactic Factors, EosinophilTransfectionDown-RegulationCell AdhesionT-Lymphocyte SubsetsNeutrophilsTh2 CellsRecombinant ProteinsMonokinesDisease Models, AnimalLeukocytes
Expression of the chemokine receptorCCR7CCR5CCL19CCR2CytokineMotif chemokine receptorCCR3ChemotacticAtypical chemokineChemotaxisAntigen receptorAgonistsInflammationGenesCCL2GeneSignal transductionCXCL12CytokinesInterleukin-8 receptBindsImmuneProtein tyrosine phCellsChemoattractantInterferonMoleculeChemerinMonocyteSpecificityPeptidesMigrationCCL20SuperfamilyLigandsSubunitInflammatoryProteinsLymphocytesHuman
Expression of the chemokine receptor3
  • T follicular helper (Tfh) cells represent a recently defined CD4(+) T cell subset characterized by the expression of the chemokine receptor CXCR5 and an enhanced ability to support B cells to mount antibody responses. (nih.gov)
  • IL-15 and IL-2 oppositely regulate expression of the chemokine receptor CX3CR1. (prosci-inc.com)
  • The expression of the chemokine receptor CCR5 in tick-borne encephalitis. (cdc.gov)
CCR73
  • ACKR4 plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. (lsbio.com)
  • It is expressed at high levels in the lymph nodes, thymus and appendix, and elicits its effects on its target cells by binding to the chemokine receptor chemokine receptor CCR7. (quanterix.com)
  • Binds to chemokine receptor CCR7. (cusabio.com)
CCR512
  • We describe the role of allelic polymorphism in the gene coding for the CCR5 chemokine receptor with regard to susceptibility to and disease course of HIV infection. (cdc.gov)
  • The receptors are widely distributed on homozygous for the CCR5 32 bp deletion. (cdc.gov)
  • Several human chemokine receptors have been sons than for those homozygous for the wild classified as such on the basis of similarity of type CCR5 (12,17-19,23). (cdc.gov)
  • The discovery of the gene sequences and predicted protein structures, role of CCR5 alleles has prompted studies of but their ligands have not been identified the possible role of many other host genes in (orphan receptors). (cdc.gov)
  • The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. (microbiologyresearch.org)
  • MIP-1-beta signals through the chemokine receptor CCR5 to chemoattract immune cells. (enquirebio.com)
  • A CC chemokine with specificity for CCR1 RECEPTORS and CCR5 RECEPTORS. (lookformedical.com)
  • Chemokine CCL8 has specificity for CCR3 RECEPTORS and CCR5 RECEPTORS. (lookformedical.com)
  • The ccr5 protein belongs to the beta chemokine receptors family of integral membrane proteins. (hoselito.com)
  • The chemokine receptors CCR5 and CXCR4 belong to the class of 7 transmembrane G-protein-coupled receptors, and their natural ligands are key players in the recruitment of immune cells to sites of inflammation. (medscape.com)
  • CCR5 and CXCR4 are the 2 main co-receptors essential for HIV entry. (medscape.com)
  • The beta-chemokine RANTES (regulated on activation, normal T cell expressed and secreted) are important ligands for CCR5. (medscape.com)
CCL193
  • Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. (nature.com)
  • MIP-3β (macrophage inflammatory protein-3-beta ), also known as (Chemokine (C-C motif) ligand 19 (CCL19) and EBI1 ligand chemokine (ELC) is a small cytokine belonging to the CC chemokine family. (quanterix.com)
  • CCR receptors with specificity for CHEMOKINE CCL19 and CHEMOKINE CCL21. (lookformedical.com)
CCR23
  • Here we show that these mechanisms specifically require CC-chemokine receptor 2 (CCR2) expression in bone marrow cells (BMCs). (nih.gov)
  • Indeed, transplantation of CCR2-deficient BMCs enhanced the mnesic deficit and increased the amount of soluble Aβ and expression of transforming growth factor (TGF)-β1 and TGF-β receptors. (nih.gov)
  • It has specificity for CCR2 RECEPTORS. (lookformedical.com)
Cytokine2
  • Astrocyte-derived chemokine C-C motif ligand 20 (CCL20) was identified using cytokine arrays, and its role in glioblastoma development was evaluated in orthotopic xenografts. (cancerindex.org)
  • Macrophage inflammatory protein-1 beta (MIP-1-beta), also known as CCL4, is produced by macrophages and functions as a mitogen-inducible cytokine. (enquirebio.com)
Motif chemokine receptor2
CCR31
Chemotactic2
Atypical chemokine2
  • Atypical chemokine receptor 4 (ACKR4) controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. (lsbio.com)
  • Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. (cusabio.com)
Chemotaxis2
  • 1999). "Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis" . (wikidoc.org)
  • Smooth muscle cells in human atherosclerotic plaques express the fractalkine receptor CX3CR1 and undergo chemotaxis to the CX3C chemokine fractalkine (CX3CL1). (prosci-inc.com)
Antigen receptor1
  • Infiltration, accumulation, and survival of chimeric antigen receptor T (CAR-T) cells in solid tumors is crucial for tumor clearance. (nature.com)
Agonists2
  • Type I interferon signaling in dendritic cells and in nonhematopoietic cells selectively stimulates Tfh cell development in response to antigen in conjunction with Toll-like receptor (TLR)3 or TLR4 agonists. (nih.gov)
  • Structural analysis of type I IFN receptor with different type I IFN ligand subtypes revealed a similar binding site for the different agonists. (wikidoc.org)
Inflammation4
Genes6
  • Earlier HIV infec- receptor gene polymorphism in HIV infection, tion diagnosis, inhibition of ongoing HIV replica- only genes of the HLA system were thought to tion with antiretroviral therapy (in industrialized protect against HIV infection. (cdc.gov)
  • Molecular cloning and characterization of rat genes encoding homologues of human beta-defensins. (lookformedical.com)
  • Here, we report the identification of two genes encoding beta-defensin homologues in the rat. (lookformedical.com)
  • The beta-defensin genes mapped closely on rat chromosome 16 and were closely linked to the alpha-defensins genes, suggesting that they are part of a gene cluster, similar to the organization reported for humans. (lookformedical.com)
  • This chemokine is encoded by multiple genes. (lookformedical.com)
  • Polymorphisms in chemokine receptor 5 and Toll-like receptor 3 genes are risk factors for clinical tick-borne encephalitis in the Lithuanian population. (cdc.gov)
CCL21
Gene7
  • Chemokine receptor 6 also known as CCR6 is a CC chemokine receptor protein which in humans is encoded by the CCR6 gene. (wikipedia.org)
  • C-C chemokine receptor type 9 is a protein that in humans is encoded by the CCR9 gene . (wikidoc.org)
  • The protein encoded by this gene is a member of the beta chemokine receptor family. (wikidoc.org)
  • This gene is mapped to the chemokine receptor gene cluster region. (wikidoc.org)
  • This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. (cancerindex.org)
  • One gene was highly similar to the human beta-defensin-1 (HBD-1) gene and mouse beta-defensin-1 gene at both the nucleic acid and amino acid levels and was termed rat beta-defensin-1 (RBD-1). (lookformedical.com)
  • A functional Toll-like receptor 3 gene (TLR3) may be a risk factor for tick-borne encephalitis virus (TBEV) infection. (cdc.gov)
Signal transduction1
  • Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. (lsbio.com)
CXCL121
  • V160I) in the fourth transmembrane region of CXCR4 was detected in one colon cancer cell line (PD) and one melanoma cell line (LB). CXCR4 was expressed and functional in both PD and LB cells, PD and LB cells migrated specifically toward the receptor ligand, CXCL12 and P-Erk was specifically induced by CXCL12. (cnr.it)
Cytokines2
  • The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. (wikidoc.org)
  • ABSTRACT The role of inflammatory cytokines in the pathophysiology of beta-thalassaemia is still unclear. (who.int)
Interleukin-8 recept4
  • Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Interleukin 8 Receptor Beta (IL8Rb) were tested 20 times on one plate, respectively. (biomatik.com)
  • Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Interleukin 8 Receptor Beta (IL8Rb) were tested on 3 different plates, 8 replicates in each plate. (biomatik.com)
  • This assay has high sensitivity and excellent specificity for detection of Interleukin 8 Receptor Beta (IL8Rb). (biomatik.com)
  • No significant cross-reactivity or interference between Interleukin 8 Receptor Beta (IL8Rb) and analogues was observed. (biomatik.com)
Binds1
  • This chemokine receptor is special because it binds only one chemokine ligand CCL20 in compare to other chemokine receptors. (wikipedia.org)
Immune3
  • The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. (genome.jp)
  • 2000). "Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity" . (wikidoc.org)
  • Toll-like receptors (TLRs) are the major pattern recognition receptors of the innate immune system that sense a wide range of "danger" signals or pathogen-associated molecular patterns (PAMPs) ( 6 - 8 ). (frontiersin.org)
Protein tyrosine ph1
Cells12
  • This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dendritic cells and T cells during inflammatory and immunological responses. (wikipedia.org)
  • Some Th17 cells migrate via chemokine gradient of CCL20 to inflammatory sites and themselves can express more CCL20 to bring in more Th17 cells and regulatory T-cells (Treg). (wikipedia.org)
  • One major discovery was that members of the chemokine receptor family serve as cofactors for HIV entry into cells. (cdc.gov)
  • In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. (genome.jp)
  • Here, we demonstrate that lymph-node-resident CXCR5(+) Tfh cells and gut-homing integrin alpha(4)beta(7)-expressing T helper cells are generated as separate subsets in the gut-draining mesenteric lymph nodes. (nih.gov)
  • In addition, the presence of EVs reduced inflammatory responses in Pam 3 CSK 4 -treated endothelial cells and HEK Dual reporter cells, demonstrating that TLR2-EVs can act as decoy receptors. (frontiersin.org)
  • While CD4 T cells are by far the most abundant HIV-infected cell, DCs express a variety of HIV co-receptors and lectin receptors that modulate HIV uptake, antigen processing, and trans-infection to T cells, thus contributing to a wide variety of immunological outcomes. (jscimedcentral.com)
  • In addition, the ability of HIV to exploit DC surface receptors or intracellular routing mechanisms to avoid antigen-processing machinery also contributes to viral persistence and promotes trans or cis-infection of CD4 T cells. (jscimedcentral.com)
  • To give insight into the function of the mutant CXCR4 receptor, human A431, epidermoid carcinoma cells, were stably transfected with both mutant and wild type CXCR4. (cnr.it)
  • GRO-beta functions as a chemoattractant for leukocytes and hematopoietic stem cells. (enquirebio.com)
  • Together with the disruption of mucosal and skin barriers, the presence of cells with up-regulated HIV-1 co-receptors in H ducreyi -infected lesions provides an environment that facilitates the acquisition of HIV-1 infection. (medscape.com)
  • In this study production levels of interleukins (IL)-12 and IL-13 were measured by commercial ELISA in culture supernatants of mitogen-stimulated peripheral blood mononuclear cells from 30 non-splenectomized beta-thalassaemia cases with iron overload and 20 age- and sex-matched healthy individuals. (who.int)
Chemoattractant2
  • Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. (genome.jp)
  • A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. (lookformedical.com)
Interferon2
  • NMR structure of the interferon-binding ectodomain of the human interferon receptor. (wikidoc.org)
  • Increased concentration of interferon lambda-3, interferon beta and interleukin-10 in the cerebrospinal fluid of patients with tick-borne encephalitis. (cdc.gov)
Molecule1
  • The encoded seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1. (prosci-inc.com)
Chemerin1
  • ChemR23 is a G protein-coupled receptor that is triggered by two ligands, the peptide chemerin and the eicosapentaenoic acid-derived lipid mediator resolvin E1 (RvE1). (aai.org)
Monocyte1
  • Role of CX3CR1 receptor in monocyte/macrophage driven neovascularization. (prosci-inc.com)
Specificity5
Peptides4
  • Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands. (lookformedical.com)
  • beta-Defensins are cationic peptides with broad-spectrum antimicrobial activity that are produced by epithelia at mucosal surfaces. (lookformedical.com)
  • In this study, we characterized the expression of HBD-1 and HBD-2 mRNAs within the major salivary glands, tongue, gingiva, and buccal mucosa and detected beta-defensin peptides in salivary secretions. (lookformedical.com)
  • beta-Defensins are cationic peptides with broad-spectrum antimicrobial activity that may play a role in mucosal defenses of several organs. (lookformedical.com)
Migration2
  • Chemokines and their receptors are key regulators of thymocyte migration and maturation in normal and inflammatory conditions. (wikidoc.org)
  • Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. (lookformedical.com)
CCL201
  • The ligand of this receptor is CCL20 or in the other name - macrophage inflammatory protein 3 alpha (MIP-3 alpha). (wikipedia.org)
Superfamily1
  • This protein belongs to family A of G protein-coupled receptor superfamily. (wikipedia.org)
Ligands1
  • They represent the first line of defense against pathogens in the lower airspace and recognize microbial ligands via pattern recognition receptors ( 4 , 5 ). (frontiersin.org)
Subunit3
  • IFNAR is a heteromeric cell surface receptor composed of two subunits, referred to as the low affinity subunit, IFNAR1 , and the high affinity subunit, IFNAR2 . (wikidoc.org)
  • Ligand binding to either subunit is required for and precedes dimerization and activation of the receptor. (wikidoc.org)
  • interleukin 11 receptor subunit alp. (gsea-msigdb.org)
Inflammatory2
  • The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). (cancerindex.org)
  • MIP-1-beta induces inflammatory responses, including neutrophil superoxide production. (enquirebio.com)
Proteins1
  • As a member of the endoplasmic reticulum protein family, POGLUT2 functions to prevent the secretion of all endoplasmic reticulum resident proteins via receptor-ligand interaction with a protein in the Golgi apparatus by a Lys-Asp-Glu-Leu or KDEL motif located at its C-terminus ( 7 , 8 ). (frontiersin.org)
Lymphocytes2
Human5
  • Human cytomegalovirus G protein-coupled receptor US28 promotes latency by attenuating c-fos. (uc.edu)
  • Two human beta-defensins, HBD-1 and HBD-2, were discovered in 1995 and 1997, respectively. (lookformedical.com)
  • Human beta-defensins may play an important role in the innate defenses against oral microorganisms. (lookformedical.com)
  • The chemokine receptor CXCR4 is widely expressed in human cancers and regulates cell invasion, proliferation and survival. (cnr.it)
  • The MIP-1-alpha and MIP-1-beta heterodimer exhibits antiviral activity against the human immunodeficiency virus 1 (HIV-1). (enquirebio.com)